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행동기반 안전관리(Behavior-Based Safety) 프로그램이 근로자의 안전행동과 사고에 미치는 영향: 사례연구
Danielle Geissler,문광수,오세진 대한안전경영과학회 2014 대한안전경영과학회 학술대회논문집 Vol.2014 No.11
Despite over eighty percent of industrial accidents were caused by unsafe behaviors, most safety programs still focus on changing workers’ internal status such as thinking and attitude rather than directly changing safe related behaviors. The purpose of this paper is to introduce the basic concepts and procedures of Behavior-Based Safety (BBS) which originated in applied behavior science (ABS), BBS attempts to change safety related behaviors by manipulating antecedents and consequences of workers’ behaviors. Also this paper introduces several case studies conducted globally in various industrial fields. These case studies highlight the procedures of BBS, their impacts on safety performance and accidents rate, and other business results. Based on these results, this paper proposes new guidelines for safety management.
Bucher Christian H.,Berkmann Julia C.,Burkhardt Lisa-Marie,Paschke Carolin,Schlundt Claudia,Lang Annemarie,Wolter Angelique,Damerau Alexandra,Geissler Sven,Volk Hans-Dieter,Duda Georg N.,Schmidt-Bleek 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
With increasing age, the risk of bone fractures increases while regenerative capacity decreases. This variation in healing potential appears to be linked to adaptive immunity, but the underlying mechanism is still unknown. This study sheds light on immunoaging/inflammaging, which impacts regenerative processes in aging individuals. In an aged preclinical model system, different levels of immunoaging were analyzed to identify key factors that connect immunoaged/inflammaged conditions with bone formation after long bone fracture. Immunological facets, progenitor cells, the microbiome, and confounders were monitored locally at the injury site and systemically in relation to healing outcomes in 12-month-old mice with distinct individual levels of immunoaging. Bone tissue formation during healing was delayed in the immunoaged group and could be associated with significant changes in cytokine levels. A prolonged and amplified pro-inflammatory reaction was caused by upregulated immune cell activation markers, increased chemokine receptor availability and a lack of inhibitory signaling. In immunoaged mice, interleukin-22 was identified as a core cell signaling protein that played a central role in delayed healing. Therapeutic neutralization of IL-22 reversed this specific immunoaging-related disturbed healing. Immunoaging was found to be an influencing factor of decreased regenerative capacity in aged individuals. Furthermore, a novel therapeutic strategy of neutralizing IL-22 may successfully rejuvenate healing in individuals with advanced immune experiences.
Andreas Probst,Alanna Ebigbo,Stefan Eser,Carola Fleischmann,Tina Schaller,Bruno Märkl,Stefan Schiele,Bernd Geissler,Gernot Müller,Helmut Messmann 대한소화기내시경학회 2023 Clinical Endoscopy Vol.56 No.1
Background/Aims: Endoscopic submucosal dissection (ESD) has been established as a treatment modality for superficial esophagealsquamous cell carcinoma (ESCC). Long-term follow-up data are lacking in Western countries. The aim of this study was to analyzelong-term survival in a Western center. Methods: Patients undergoing ESD for ESCC were included. The analysis was performed retrospectively using a prospectively collecteddatabase. Results: R0 resection rate was 96.7% (59/61 lesions in 58 patients). Twenty-seven patients (46.6%) fulfilled the curative resection criteria(M1/M2) (group A), 11 patients (19.0%) had M3 lesions without lymphovascular invasion (LVI) (group B), and 20 patients (34.5%)had lesions with submucosal invasion or LVI (group C). Additional treatment was recommended after non-curative resection. It wasnot performed in 20/31 patients (64.5%), mainly because of comorbidities (75%). Twenty-nine out of 58 (50.0%) patients died during amean follow-up of 3.7 years. Death was related to ESCC in 17.2% (5/29) of patients. The disease-specific survival rate after curative resectionwas 100%. Overall survival rates after 5 years were 61.5%, 63.6% and 28.1% for groups A, B, and C, respectively. The overallsurvival was significantly worse after non-curative resection (p=0.038). Conclusions: Non-curative resection is frequent after ESD for ESCC in Western patients. The long-term prognosis is limited andmainly determined by comorbidity. Early diagnosis and pre-interventional assessments need to be improved.