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ORLICZ-TYPE INTEGRAL INEQUALITIES FOR OPERATORS
Neugebauer, C.J. Korean Mathematical Society 2001 대한수학회지 Vol.38 No.1
We examine Orlicz-type integral inequalities for operators and obtain as a corollary a characterization of such inequalities for the Hardy-Littlewood maximal operator extending the well-known L(sup)p-norm inequalities.
A. Eckert,R. Neugebauer,M. Rossinger,M. Wahl,F. Schulz 한국소성가공학회 2011 기타자료 Vol.2011 No.8
This paper deals with the determination of application limits of an already presented method [1] to predict distortion of joined car body assemblies caused by mechanical joining technologies. The investigated method is particularly developed concerning the demands coming from the application in the automotive body production. Parameter studies in simulation and experiment are presented which show the influence of pre-straining and clamping on the joints properties and dimensional accuracy of the assembly. The gained cognitions allow conclusions about the quality of prediction of dimensional accuracy using the proposed simplified model in different joining situations. Finally, the investigated method is applied to a car body assembly.
Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis
Echtermeyer, Frank,Bertrand, Jessica,Dreier, Rita,Meinecke, Ingmar,Neugebauer, Katja,Fuerst, Martin,Lee, Yun Jong,Song, Yeong Wook,Herzog, Christine,Theilmeier, Gregor,Pap, Thomas Nature Publishing Group 2009 Nature medicine Vol.15 No.9
Aggrecan cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 5 (ADAMTS-5) is crucial for the breakdown of cartilage matrix during osteoarthritis, a degenerative joint disease that leads to the progressive destruction of articular structures. The mechanisms of ADAMTS-5 activation and their links to the pathogenesis of osteoarthritis remain poorly understood, but syndecans have been shown to be involved in the activation of ADAMTS-4 (ref. 3). Here we show that syndecan-4 is specifically induced in type X collagen–producing chondrocytes both in human osteoarthritis and in murine models of the disease. The loss of syndecan-4 in genetically modified mice and intra-articular injections of syndecan-4–specific antibodies into wild-type mice protect from proteoglycan loss and thereby prevent osteoarthritic cartilage damage in a surgically induced model of osteoarthritis. The occurrence of less severe osteoarthritis-like cartilage destruction in both syndecan-4–deficient mice and syndecan-4–specific antibody–treated wild-type mice results from a marked decrease in ADAMTS-5 activity. Syndecan-4 controls the activation of ADAMTS-5 through direct interaction with the protease and through regulating mitogen-activated protein kinase (MAPK)-dependent synthesis of matrix metalloproteinase-3 (MMP-3). Our data suggest that strategies aimed at the inhibition of syndecan-4 will be of great value for the treatment of cartilage damage in osteoarthritis.
Korean Red Ginseng extract treatment prevents post-antibiotic dysbiosis-induced bone loss in mice
Ho Jun Kang,Nicholas Chargo,Soumya Chennupati,Kerri Neugebauer,Jae Youl Cho,Robert Quinn,Laura R. McCabe,Narayanan Parameswaran The Korean Society of Ginseng 2023 Journal of Ginseng Research Vol.47 No.2
Background: The intestinal microbiota is an important regulator of bone health. In previous studies we have shown that intestinal microbiota dysbiosis, induced by treatment with broad spectrum antibiotics (ABX) followed by natural repopulation, results in gut barrier dysfunction and bone loss. We have also shown that treatment with probiotics or a gut barrier enhancer can inhibit dysbiosis-induced bone loss. The overall goal of this project was to test the effect of Korean Red Ginseng (KRG) extract on bone and gut health using antibiotics (ABX) dysbiosis-induced bone loss model in mice. Methods: Adult male mice (Balb/C, 12-week old) were administered broad spectrum antibiotics (ampicillin and neomycin) for 2 weeks followed by 4 weeks of natural repopulation. During this 4-week period, mice were treated with vehicle (water) or KRG extract. Other controls included mice that did not receive either antibiotics or KRG extract and mice that received only KRG extract. At the end of the experiments, we assessed various parameters to assess bone, microbiota and in vivo intestinal permeability. Results: Consistent with our previous results, post-ABX- dysbiosis led to significant bone loss. Importantly, this was associated with a decrease in gut microbiota alpha diversity and an increase in intestinal permeability. All these effects including bone loss were prevented by KRG extract treatment. Furthermore, our studies identified multiple genera including Lactobacillus and rc4-4 as well as Alistipes finegoldii to be potentially linked to the effect of KRG extract on gut-bone axis. Conclusion: Together, our results demonstrate that KRG extract regulates the gut-bone axis and is effective at preventing dysbiosis-induced bone loss in mice.
Atomic scale processes of phase transformations in nanocrystalline NiTi shape-memory alloys
Ko, W.S.,Maisel, S.B.,Grabowski, B.,Jeon, J.B.,Neugebauer, J. Elsevier Science 2017 Acta materialia Vol.123 No.-
<P>Molecular dynamics simulations are performed to investigate temperature- and stress-induced phase transformations in nanocrystalline nickel-titanium shape-memory alloys. Our results provide detailed insights into the origins of the experimentally reported characteristics of phase transformations at the nanoscale, such as the decrease of the transformation temperature with grain size and the disappearance of the plateau in the stress-strain response. The relevant atomic scale processes, such as nucleation, growth, and twinning are analyzed and explained. We suggest that a single, unified mechanism dominated by the contribution of a local transformation strain explains the characteristics of both temperature- and stress-induced phase transformations in nanocrystalline nickel-titanium. (C) 2016 Acta Materialia Inc. Published by Elsevier Ltd.</P>
Yao, M.J.,Dey, P.,Seol, J.B.,Choi, P.,Herbig, M.,Marceau, R.K.W.,Hickel, T.,Neugebauer, J.,Raabe, D. Elsevier Science 2016 Acta materialia Vol.106 No.-
<P>We report on the investigation of the off-stoichiometry and site-occupancy of kappa-carbide precipitates within an austenitic (gamma), Fe-29.8Mn-7.7Al-1.3C (wt.%) alloy using a combination of atom probe tomography and density functional theory. The chemical composition of the kappa-carbides as measured by atom probe tomography indicates depletion of both interstitial C and substitutional Al, in comparison to the ideal stoichiometric L'12 bulk perovskite. In this work we demonstrate that both these effects are coupled. The off-stoichiometric concentration of Al can, to a certain extent, be explained by strain caused by the kappa/gamma mismatch, which facilitates occupation of Al sites in kappa-carbide by Mn atoms (Mn-Al(gamma) anti-site defects). The large anti-site concentrations observed by our experiments, however, can only be stabilized if there are C vacancies in the vicinity of the anti-site. (C) 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</P>