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전자 현미경상 Epinephrine 과립이 관찰된 Zuckerkandl 기관에 발생한 Norepinephrine 분비성 갈색세포종 1예
이원석,김의숙,이강룡,이정아,장지정,선우인철,김대하,이광섭,백영주 대한내분비학회 1996 Endocrinology and metabolism Vol.11 No.2
Extraadrenal pheochromocytomas developed from the paraganglia other than adrenal medulla are uncommon tumors. Such lesions have been reported that as much as 10% of retroperitoneal paragliomas arise outside the adrenal gland. But their incidence and prognosis are changing partly as a result of progression in developmental mechanism, diagnostic tools and concepts including ultrastructure, immunohistochemistry. The ultrastructure of chromaffine neoplasm from adrenal and extraadrenal tissues has been studied with chrornaffine granule specificity and type of catecholamine content. With rare exceptions, extraadrenal chrornaffine tumor mainly has high concentration of norepinephrine which is suggested as dict relationship to numoruos electrone dense granular bodies in the cell cytoplasrm. High or intermediate level of epinephrine in tissue is associated with cytoplasmic granular bodies of much less density. Recently we experienced the exception, a case of norepinephrine secreting pheochrom-ocytoma in the organ of Zuckerkandl with epinephrine granules in cytoplasm and this discrepancy probably due to the plasticity - the differences in developmental process and local factors between adrenal medulla and extraadrenal tissues(J Kor Soc Endocrinol 11:233 ~239, 1996).
New Hairpin RNAi Vector with Brassica rapa ssp. pekinensis Intron for Gene Silencing in Plants
Lee, Gi-Ho,Lee, Gang-Seob,Park, Young-Doo Korean Society of Horticultural Science 2017 원예과학기술지 Vol.35 No.3
Homology-specific transcriptional and post-transcriptional silencing, an intrinsic mechanism of gene regulation in most eukaryotes, can be induced by anti-sense, co-suppression, or hairpin-based double-stranded RNA. Hairpin-based RNA interference (RNAi) has been applied to analyze gene function and genetically modify crops. However, RNAi vector construction usually requires high-cost cloning steps and large amounts of time, or involves methods that are protected by intellectual property rights. We describe a more effective method for generating intron-spliced RNAi constructs. To produce intron-spliced hairpin RNA, an RNAi cassette was ligated with the first intron and splicing sequences of the Brassica rapa ssp. pekinensis histone deacetylase 1 gene. This method requires a single ligation of the PCR-amplified target gene to SpeI-NcoI and SacI-BglII enzyme sites to create a gene-specific silencing construct. We named the resulting binary vector system pKHi and verified its functionality by constructing a vector to silence DIHYDROFLAVONOL 4-REDUCTASE (DFR), transforming it into tobacco plants, and confirming DFR gene-silencing via PCR, RT-qPCR, and analysis of the accumulation of small interfering RNAs. Reduction of anthocyanin biosynthesis was also confirmed by analyzing flower color of the transgenic tobacco plants. This study demonstrates that small interfering RNAs generated through the pKHi vector system can efficiently silence target genes and could be used in developing genetically modified crops.
LIMIT WEAK SHADOWABLE TRANSITIVE SETS OF C<sup>1</sup>-GENERIC DIFFEOMORPHISMS
Lee, Man-Seob,Lu, Gang Korean Mathematical Society 2012 대한수학회논문집 Vol.27 No.3
In this paper, we prove that locally maximal transitive set of a $C^1$-generic diffeomorphism is hyperbolic if and only if it is limit weak shadowable.
학술연구 : 기업벤처캐피탈이 IPO 성과에 미치는 효과 분석
이기환 ( Lee Gi Hwan ),김강혁 ( Kim Gang Hyeog ),윤병섭 ( Yun Byeong Seob ) 한국중소기업학회 2003 기업가정신과 벤처연구 Vol.6 No.1
This study explores the short-term performance of initial public offerings of corporate venture capital-backed firms. The aftermarket performance is empirically examined by utilizing 97 firms listed on the KOSDAQ market from January 2000 to February 2002. We analyse the impact of corporate venture capital through exhibiting the difference in performance, business history, holding ratio between CVC-backed and non-CVC-backed firms. In order to conduct our research, we classify the sample into three groups : corporate venture capital directly-backed firms, corporate venture capital indirectly-backed firms and non venture capital-backed firms. Using ANOVA, the difference on initial returns, business history between three groups is explored. And using t-test method, the change of corporate venture capital`s holding between two CVC-backed groups after listing on KOSDAQ is analyzed. The major results of this thesis are as follows. First, we find that as the time after the listing day passes, corporate venture capital directly-backed firmsl` excess return shows higher than non-venture capital-backed firmsl` abnormal return. However, corporate venture capital indirectly-backed firmsl` return exhibits lower than non-venture capital-backed firmsl` return. In KOSDAQ`s IPOs market, corporate venture capitals could not reduce statistically the information asymmetry between public investors and issuing firms. Secondly, our empirical analysis shows that the business history of corporate venture capital indirectly-backed firms are shorter than that of non-venture capital-backed firms. But it fails to find that the business history of corporate venture capital directly-backed firms would be longer than that of corporate venture capital in directly-backed firms. This is inconsistent with the result of Gompers(1996) which found the grandstanding in the US IPOs market. Thirdly, this study also investigates whether there is the difference in the changes of corporate venture capitalsl holdings between corporate venture capital directly-backed firms and corporate venture capitalist indirectly-backed firms before and after going public. The holdings of corporate venture capital indirectly-backed firms are decreased more than corporate venture capital directly-backed firms.
진균구로 오인된 낭포내 응혈을 보인 23세 여자에서의 선천성 낭포성 유선종 폐기형 1례
이강룡 ( Gang Ryong Lee ),이군순 ( Kun Sun Lee ),주인규 ( In Kyu Joo ),박준옥 ( June Ock Park ),최승준 ( Seung Jun Choi ),이원석 ( Won Seok Lee ),김의숙 ( Eui Sook Kim ),이규현,김대하 ( Dae Ha Kim ),이광섭 ( Gwang Seob Lee ),한영숙 ( 대한결핵 및 호흡기학회 1999 Tuberculosis and Respiratory Diseases Vol.46 No.1
Development of traditional wine using biomass from alcoholic fermentation by Phellinus sp. mycelium
Hak-Seob Lim,Gang-Young Lee,Eun-Jung Jung,Won-Su Lee,Young-Kwang Ju,Min-Jeong Seo,Ji-Eun Kim,Tae-Yeon Kim,Hey-Rin Lee,Kyung Tae Chung,Byung Tae Choi,Young Hee Kim,Yong Kee Jeong 한국생명과학회 2006 한국생명과학회 심포지움 Vol.47 No.-