Dislocation Density-Based Constitutive Model and Processing Map for T2 Copper During Isothermal and Time-Variant Deformation

Gang Chen,Yu Jin,Jing Wang,Cheng Zhang,Qiang Chen,Hongming Zhang,Xingjian Zhao,Zhiyong Li,Changhai Xie,Zhiming Du 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.9

Isothermal compression tests were carried out to study the hot deformation behavior of T2 copper under various conditions. The deformation parameters, such as temperature and strain rate, have strong influence on flow stress and microstructureevolution of the alloy. A unified dislocation density-based model considering dynamic recovery and recrystallization wasestablished. And material parameters of the developed model were optimized by genetic algorithm. Comparisons betweenthe experimental and model data demonstrates that the developed model can precisely describe the flow behavior at quitewide range of deformation conditions. Meanwhile, the designed iterative procedure allows the model to be applied in timevariantdeformation conditions. Processing map and microstructure examination were constructed to optimize the processingwindow of the studied alloy. According to the processing maps, flow instability mainly appeared at low temperatures of500–650 °C and strain rates higher than 0.1 s−1. The optimum deformation parameters of T2 copper was concluded as thetemperature range of 700–800 °C and the strain rate of 0.1–1 s−1.

Genetic Analysis of the Liver Putative Tumor Suppressor (LPTS) Gene in Gastric Cancer

Hai Bing Zhang,Qu Zhang,Li Sa Wang,Fei Yan,Yun Lu,Zhi Qiang Wang,Jing Li,Liang Liang Zhang,Ying Yan Yu,Zheng Gang Zhu,Xiang Yin Kong,Lan Dian Hu 한국유전학회 2005 Genes & Genomics Vol.27 No.4

An electrode universal and self-healable integrated supercapacitor fabricated by physical adsorption based on mussel-inspired highly adhesive gel electrolyte

Gang Qin,Yue Wang,Wenjie He,Da Zhang,Xiaojuan Yu,Fenghan Gong,Hengyi Yu,Xiang Yu,Jia Yang,Qiang Chen 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.122 No.-

Integrated supercapacitor with stable electrochemical performance under complex deformations is theprospective energy storage device for wearable electronics. However, there is often a conflict betweenthe mechanical performance and the specific capacitance of the conventional conductive polymerbasedintegrated supercapacitor. In this work, a novel integrated supercapacitor based on adhesive gelelectrolyte has been prepared by physical adsorption, which not only avoids the drawbacks of the conventionalintegrated supercapacitor but also exhibits the electrode universality including powder electrodematerial. The adhesive triple network polyacrylamide/polydopamine/agar/H3PO4 gel electrolyteis fabricated with high ionic conductivity, toughness and adhesion. Based on this, the integrated supercapacitoris assembled by spraying activated carbon powder on both sides of the pre-stretched biaxiallygel electrolyte. Due to the strong interfacial adhesion, such a device exhibits low interfacial resistance andhigh specific capacitance of 155 mF/cm2 at 0.5 mA/cm2. More impressively, the capacitance retention canreach 92.4% after 10 cutting/healing cycles and even keep the brilliant self-healabillity at 20 C. Additionally, it can hold stable electrochemical performance when exposed to harsh environments. The physical adsorption strategy would offer novel inspiration for the development of integrated supercapacitorand has great practical applications in wearable and portable electronics.

Differences in Epidermal Growth Factor Receptor Gene Mutations and Relationship with Clinicopathological Features in NSCLC Between Uygur and Han Ethnic Groups

Zhang, Yan,Wang, Qiang,Han, Zhi-Gang,Shan, Li Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Objective: To investigate differences in mutations of epidermal growth factor receptor (EGFR) gene and relationships with clinicopathological features in patients with non-small cell lung cancer (NSCLC) between Uygur and Han ethnic groups. Methods: The Scorpions amplification refractory mutation system (Scorpions ARMS) was used to measure mutations in exons 18, 19, 20 and 21 of the EGFR gene in paraffin-embedded tumor tissue from NSCLC cases, and statistical analysis was performed to investigate links with clinicopathological features in different histological types of NSCLC. Results: Results from ARMS testing showed EGFR mutations in tumor tissues from six (6) of 50 NSCLC patients of Uygur ethnic group, with a positive rate of 12.0%; four of them (4) had exon 19 deletion in EGFR, and two (2) had L858R point mutation in exon 21 of EGFR. Statistically significant difference was noted in EGFR genetic mutation between adenocarcinoma and non-adenocarcinoma (P < 0.05), but no differences with gender, age group, smoking status, or stage (P > 0.05). EGFR mutations were detected in tumor tissues from 27 of 49 NSCLC patients of Han ethnic group, with a positive rate of 55.1%; 19 of them had exon 19 deletions, seven (7) had L858R point mutations in exon 21 of EGFR and one (1) had mutations in both exon 18 G719X and exon 20 T790M of EGFR. Statistically significant differences were noted in EGFR genetic mutations between genders and between adenocarcinoma and non-adenocarcinoma (P<0.05), but not with age group, smoking status, or stage (P > 0.05). Conclusion: Statistically significant differences were noted in the positive rates of EGFR genetic mutations in NSCLC patients between Uygur and Han ethnic groups, with lower positive rates for the Uygur cases.

Microstructures and Mechanical Properties of In-Situ Al3Ti/2024 Aluminum Matrix Composites Fabricated by Ultrasonic Treatment and Subsequent Squeeze Casting

Gang Chen,Xusheng Chang,Jingxuan Zhang,Yu Jin,Cheng Sun,Qiang Chen,Zude Zhao 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.10

Squeeze casting is a near net shaping technology which is advantageous to refining the microstructures and improving themechanical properties. In the present work, in-situ Al3Ti/2024 Aluminum matrix composites with different amount of Al3Tireinforcements were successfully fabricated by ultrasonic treatment and subsequent squeeze casting. The effects of specificpressure and the amount of reinforcements on microstructures and mechanical properties were studied. The results show thatwhen the specific pressure is increased from 0 to 150 MPa, the average grain sizes of α-Al matrix are decreased by 39.8%, andthe yield strength and compressive strength are increased by 16.8% and 22.9%, respectively. However, severe segregationsof eutectic structures were generated under an excessive specific pressure of 200 MPa, which also results in deterioration inthe mechanical strength. The mass fraction of Al3Tiphases has significant influence on morphology of eutectic structures. When the mass fraction of Al3Tiphases is increased from 4 to 16 wt%, the eutectic structures was changed from continuousnetwork to dispersed structures gradually. The compressive strength was increased from 611.2 to 712.0 MPa (increasedby 16.5%), as the Al3Ticontent increasing from 0 to 16 wt%. However, as the mass fraction of Al3Tiphases increased, thevariation in the yield strength is not monotonically increasing.

Promoter demethylation mediates the expression of ZNF645, a novel cancer/testis gene

( Gang Bai ),( Yun Qiang Liu ),( Hao Zhang ),( Dan Su ),( Da Chang Tao ),( Yuan Yang ),( Yong Xin Ma ),( Si Zhong Zhang ) 생화학분자생물학회 (구 한국생화학분자생물학회) 2010 BMB Reports Vol.43 No.6

Cancer/testis (CT) antigens exhibit highly tissue-restricted expression and are considered promising targets for cancer vaccines. Here we identified a novel CT gene ZNF645 which restrictively expresses in normal human testes and lung cancer patients (68.3%). To investigate the promoter methylation status of ZNF645, we carried out bisulfite genomic sequencing and found that the CpG island in its promoter was heavily methylated in normal lung tissues without the expression of ZNF645, whereas there was high demethylation in normal human testes and lung carcinoma tissues with its expression. Also ZNF645 could be remarkably activated in A549 and HEK293T cells treated by DNA demethylation agent 5`-aza-2`-deoxycytidine. And the dual luciferase assay revealed that the promoter activity of the ZNF645 was inhibited by methylation of the CpG island region. Therefore, we proposed that ZNF645 is a CT gene and activated in human testis and lung cancers by demethylation of its promoter region. [BMB reports 2010; 43(6): 400-406]

Influence of Adipocytokines and Periprostatic Adiposity Measurement Parameters on Prostate Cancer Aggressiveness

Zhang, Qiang,Sun, Li-Jiang,Qi, Jun,Yang, Zhi-Gang,Huang, Tao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4

Background: The relationship between obesity and prostate cancer aggressiveness is controversial in recent studies, partly because BMI is the only generally applied marker of obesity. Our study aimed at evaluating the correlation of periprostatic fat (PF) on magnatic resonance imaging (MRI) and adipocytokines with prostate cancer aggressiveness. Patients and method: A total of 184 patients who underwent radical retropubic prostatectomy (RRP) were analyzed retrospectively; different fat measurements on MRI slices and levels of adipocytokines were compared with the clinical and pathologic factors using SSPS ver.13.0. Result: The PF rates showed a statistically significant variation (p=0.019, 0.025) among groups, that is to say, more adipose tissue was distributed in periprostatic areas of high risk patients. Logistic regression analysis adjusted for age revealed a statistically association between the PF, the ratio and the risk of having high-risk disease (p=0.031, 0.024). The levels of IL-6, leptin and c-reactive protein (CRP) significantly increased with the aggressiveness of prostate cancer, and also with PF and its ratio. The strongest correlation was seen between IL-6 and PF (Pearson r coefficient=0.67, P<0.001). No association was observed between adipocytokines and BMI. Conclusion: Periprostatic adiposity not only affects prostate cancer aggressiveness, but also influences the secretion of adipocytokines. IL-6, PF and CRP have promoting effects on progression of prostate cancer.

Selective extraction of thorium to directly form self-assembly solid from HNO3 solution

Fang Zhang,Qiang Wu,Lei-Tao Sha,Yang Li,Xu-Xin Li,Ze-Yang Wang,Xuan Fu,Qing-Gang Huang,Bin Liu,Ze-Yi Yan 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-

Based on ions exchange between [DMDSA]+[Cl]- (Dimethyl distearyl ammonium chloride) and N,Ndialkyl-succinamide acid (SCA), three novel bifunctional [DMDSA]+[SCA]- ionic liquids (ILs) were firstlysynthesized for extraction of thorium (IV) by self-assembly strategy. The simultaneous extraction andsolidification of Th(IV) were unexpectedly realized in one-step operation using the present ILs in HNO3solution, and more than 99% thorium (IV) was enriched and immediately aggregated into selfassemblysolid at the biphasic interface. The self-assembly solid was further identified by FT-IR, SEM withelement mapping EDS and XPS analysis, and revealing that the self-assembly extraction (SAE) was triggeredby the amphiphilic [DMDSA]+ cations. A three-step extraction mechanism dominated by [SCATh(NO3)4]- was proposed based on the slope analysis method and HRMS analysis. The self-assembly extractionof Th(IV) exhibited the extremely excellent selectivity in the presence of U(VI) and typical lanthanideelements including La(III), Eu(III) and Lu(III), and the separation factors reached 2516 for Th/U, 1885 forTh/La, 1512 for Th/Eu and 558 for Th/Lu, respectively. The proposed SAE strategy was proved to be anefficient method for one-step separation and solidification of thorium ions from U(VI) and/or lanthanides.

Comparative Effectiveness of Risk-adapted Surveillance vs Retroperitoneal Lymph Node Dissection in Clinical Stage I Nonseminomatous Germ Cell Testicular Cancer: A Retrospective Follow-up Study of 81 Patients

Fan, Gang,Zhang, Lin,Yi, Lu,Jiang, Zhi-Qiang,Ke, Yang,Wang, Xiao-Shan,Xiong, Ying-Ying,Han, Wei-Qin,Zhou, Xiao,Liu, Chun,Yu, Xie Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8

Purpose: To retrospective assess the potential predictors for relapse and create an effective clinical mode for surveillance after orchidectomy in clinical stage I non-seminomatous germ cell testicular tumors (CSI-NSGCTs). Materials and Methods: We analyzed data for CSI-NSGCTs patients with non-lymphatic vascular invasion, %ECa < 50% (percentage of embryonal carcinoma < 50%), and negative or declining tumor markers to their half-life following orchidectomy (defined as low-risk patients); these patients were recruited from four Chinese centers between January 1999 and October 2013. Patients were divided into active surveillance group and retroperitoneal lymph node dissection (RPLND) group according to different therapeutic methods after radical orchidectomy was performed. The disease-free survival rates (DFSR) and overall survival rates (OSR) of the two groups were compared by Kaplan-Meier analysis. Results: A total of 121 patients with CSI-NSGCT were collected from four centers, and 81 low-risk patients, including 54 with active surveillance and 27 with RPLND, were enrolled at last. The median follow-up duration was 66.2 (range 6-164) months in the RPLND group and 65.9 (range 8-179) months in the surveillance group. OSR was 100% in active surveillance and RPLND groups, and DFSR was 89.8% and 87.0%, respectively. No significant difference was observed between these two groups ($X_2=0.108$, P=0.743). No significant difference was observed between the patients with a low percentage of embryonal carcinoma (<50%) and those without embryonal carcinoma (87.0% and 91.9%, $X_2=0.154$, P=0.645). No treatment-related complications were observed in the active surveillance group whereas minor and major complications were observed in 13.0% and 26.1% of the RPLND group, respectively. Conclusions: Active surveillance resulted in similar DFSR and OSR compared with RPLND in our trial. Patients with low-risk CSI-NSGCTs could benefit from risk-adapted surveillance after these patients were subjected to radical orchidectomy.

Effect of Annealing on the Microstructure, Texture and Tensile Deformation Properties of Cu–3 wt%Ag–0.5 wt%Zr Thin Sheets Rolled at Room and Cryogenic Temperature

Peng Zhang,Han Wang,ShengJie Yao,ChuanJie Wang,Qiang Zhu,Gang Chen 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.2

The Cu–3 wt%Ag–0.5 wt%Zr are rolled with the same reduction process at room (RT) and cryogenic (CT) temperature,respectively. The electron backscatter diffraction and transmission electron microscope are used to analyze and comparethe evolutions of material microstructure and texture. The results show that the stability of as-rolled CT sheets is differentfrom that of the RT samples, which can be verified by the lower temperature for the occurrence of recrystallization andAg-base particles precipitation. Besides the Brass, Copper and S textures which are exhibited in the two kinds of as-rolledsheets, there are also Q and P texture components in the as-rolled CT sheets. The constitutive equation basing on evolutionof dislocation mean free path (L) and dislocation cell size (dDC) with plastic strain indicates that the initial values of L, dDCand mobile dislocation density (ρm) are associated with annealing condition closely. Furthermore, the strain ranges of thestable and instable plastic deformation are related to the degree of recovery and recrystallization.