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허리뼈 수술환자의 정 측면 영상을 얻기 위한 촬영법 연구
김가을(Gaeul Kim),이상복(Sangbaok Lee),이준행(Junhaeng Lee),안병주(Byeungju An) 한국방사선학회 2015 한국방사선학회 학술대회 논문집 Vol.2015 No.춘계
본 연구는 어떤 원인에서 허리뼈의 압박골절, 분쇄골절 및 탈구 골절 된 병변들을 가진 환자들은 정형외과에서 허리뼈에 스텐트 삽입 수술을 하는데 수술과정에서 두 개의 스프린트를 삽입 하게 된다. 그리고 수술 성공여부 판독하기 위해서 수술 후 반드시 허리뼈 일반촬영 요구를 하는데 이 과정에서 허리뼈 정면사진과 측면사진을 촬영하고 있다. 그러나 허리뼈 정면촬영에서는 어려움이 없으나 측면촬영 영상에서 두 스텐트가 하나의 일직선으로 맞는 촬영한 영상을 요구한다. 그래서 본 연구자는 엑스선 일반촬영 기기 및 인체 팬톰을 이용하여 두 개의 스텐트를 삽입하고 엑스선관 각도를 변경하고 인체 팬톰을 내측기울기, 외측기울기하여 스텐트 일진석 여불를 실험 연구 하였다. 실험 결과 엑스선관 각도는 수직(90°) 또한 인체팬톰을 수직(90°)로 촬영하는 것이 가장 정확한 스텐트 겹침 영상을 얻었다. (A)Study in any kind of cause, the patients having the lesions which the compression fracture of the lumbar vertebra and comminuted fracture and dislocation is fractured operate on the stent in placement operation in the orthopedics to the lumbar vertebra and insert two sprints in the operative procedure. And certainly by mouth demands the lumber bertebra general radiography request and in order to read the yes or no on operation success in this process, the lumbar vertebra Anterior-Posterior radiograpy and lateral radiograpy is taken a picture of However, in the lumbar vertebra Anterior radiography, there is no difficulty but 2 stents request one shot image fitted in a straight line in the Posterior radiography image. So, by using the X-rays general radiograpy instrument and human body phantom slept this research, the shovel admission high X-ray tube angle two stents were changed and the internal and external did the human body phantom and the experiment studied the stent straight line yes or no. The experimental result X-ray tube angle overlapped the exactest stent to take a radiograpy the human body phantom with the verticality(90°), the verticality (90°) obtained the image.
Heavy metal concentrations in hair of newly imported China-origin rhesus macaques (Macaca mulatta)
Jae-Il Lee,Won-Young Jung,Gaeul Lee,Min-Sun Kim,Young-Seo Kim,Chung-Gyu Park,Sang-Joon Kim 한국실험동물학회 2012 Laboratory Animal Research Vol.28 No.3
Macaque monkeys are good sentinel to humans for environmental pollutions because their similarities in genetic and physiological characteristics. So, their reference values about exposures to heavy metals are required for proper data interpretation. Here, we report several heavy metals concentrations in the hair of rhesus monkeys which are widely used in biomedical research. The hair of 28 imported rhesus monkeys from an animal farm in southwest China were examined for the presence of eight heavy metals (Arsenic, Beryllium, Cadmium, Chromium, Iron, Lead, Mercury, and Selenium). The analyzed data in parts per million (ppm) for hair concentrations of heavy metals in rhesus monkeys were as follow: As (0.654±0.331), Be (0.005±0.003), Cd (0.034±0.022), Cr (11.329±4.259), Fe (87.106±30.114), Pb (0.656±0.613), Hg (0.916±0.619), and Se (3.200±0.735). The concentrations of Be, Cr, and As showed significant higher in females than in males (P<0.05). We present here the reference values of several heavy metals in healthy China-origin rhesus monkeys. These data may provide valuable information for veterinarians and investigators using rhesus monkeys in experimental studies.
Immunogenic Effect of Hyperthermia on Enhancing Radiotherapeutic Efficacy
Lee, Sungmin,Son, Beomseok,Park, Gaeul,Kim, Hyunwoo,Kang, Hyunkoo,Jeon, Jaewan,Youn, HyeSook,Youn, BuHyun MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.9
<P>Hyperthermia is a cancer treatment where tumor tissue is heated to around 40 °C. Hyperthermia shows both cancer cell cytotoxicity and immune response stimulation via immune cell activation. Immunogenic responses encompass the innate and adaptive immune systems, involving the activation of macrophages, natural killer cells, dendritic cells, and T cells. Moreover, hyperthermia is commonly used in combination with different treatment modalities, such as radiotherapy and chemotherapy, for better clinical outcomes. In this review, we will focus on hyperthermia-induced immunogenic effects and molecular events to improve radiotherapy efficacy. The beneficial potential of integrating radiotherapy with hyperthermia is also discussed.</P>
Lee, Sungmin,Son, Beomseok,Jeon, Jaewan,Park, Gaeul,Kim, Hyunwoo,Kang, Hyunkoo,Youn, HyeSook,Jo, Sunmi,Song, Jie-Young,Youn, BuHyun S. Karger AG 2018 Cellular physiology and biochemistry Vol.47 No.6
<P><B><I>Background/Aims:</I></B> Non-alcoholic fatty liver disease (NAFLD) is an emerging metabolic disease. Although it leads to severe hepatic diseases including steatohepatitis, cirrhosis, and hepatic cancer, little is known about therapy to prevent and cure hepatic steatosis, the first step of NAFLD. We conducted this investigation to unveil the mechanism of hepatic steatosis. <B><I>Methods:</I></B> We established a novel chronic NAFLD mouse model through whole body irradiation and verified the model through histological and biochemical analysis. To find molecular mechanism for hepatic steatosis, we analyzed hepatic transcriptomic profiles in this model and selected target molecule. To induce the expression of lactotransferrin (Ltf) and regulate the NAFLD, growth hormone (GH) and coumestrol was introduced to hepatocyte and mice. The universal effect of coumestrol was confirmed by administration of coumestrol to NAFLD mouse model induced by high-fructose, high-fat, and MCD diet. <B><I>Results:</I></B> It was observed that decreased hepatic Ltf expression led to excessive hepatic lipid accumulation in NAFLD mouse. Furthermore, we found that GH was decreased in irradiated mice and functioned as an upstream regulator of Ltf expression. It was observed that GH could stimulate Ltf expression and prevent uptake of dietary lipids in hepatocytes, leading to rescue of NAFLD. Finally, we suggested that coumestrol, a kind of isoflavonoid, could be used as an inducer of hepatic Ltf expression through cooperation with the GH signaling pathway both <I>in vitro</I> and <I>in vivo</I>. <B><I>Conclusions</I></B><I>:</I> Hepatic Ltf prevents hepatic steatosis through inhibition of dietary lipid uptake in radiation-induced NAFLD mouse model. We also suggest coumestrol as a drug candidate for prevention of NAFLD.</P>
서비스직 근로자들의 영수증 접촉 정도에 따른 비스페놀A 노출량 조사
이유나,이유진,장지원,한가을,고영림,Lee, Yuna,Lee, Yujin,Jang, Jiwon,Han, Gaeul,Kho, Younglim 한국환경보건학회 2014 한국환경보건학회지 Vol.40 No.6
Objectives: Bisphenol A, or BPA, is a chemical component in polycarbonate plastic with which many people come into contact every day. A great deal of controversy has arisen over its safety since this material, which is known to disrupt the human endocrine system and cause neurological difficulties and cancer, is commonplace in beverage containers, food can liners, and receipt paper rolls. In this study, we determined the levels of exposure to BPA of workers in the service industry depending on the number of receipts contacted. Methods: The participants were 16 male and 18 female workers employed in the service industry. Using a questionnaire, we investigated general and job characteristics. Urine samples were collected and analyzed by the LC-MS/MS technique after enzymatic hydrolysis and solid phase extraction (SPE). Results: The geometric mean (GM) concentration of urinary BPA from all subjects was 1.02 ng/ml. Workers were exposed significantly to more BPA according to the number of receipts they contacted, their work experience, and working hours per day. The BPA concentration of those who touched more than 100 receipts per day was 3.09 ng/ml, while that of the other participants was 0.61 ng/ml. It was shown that wearing gloves can protect from BPA exposure. Conclusion: We determined the urinary BPA concentrations of workers in service industry and found that the contact with receipts could increase the BPA exposure of service workers.