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[논문]설마천 유역의 토양수분 변화양상의 장기관측과 분석
이가영,김기훈,김상현 부산대학교 환경문제연구소 2004 環境硏究報 Vol.22 No.-
Monitoring and Anaysis of Spatial-temporal Distribution of Soil Moisture for Sulmachun Watershed
민병형,김가현,이승휘,이정환,강대석 東亞大學校 海洋資源硏究所 2003 硏究論文集 Vol.15 No.-
The security of Busan waterfront space mostly depends on the reclamation of the coastal zone. The temperature variation is caused by the reclamation, and the model formula of correlation with the reclamation quantity in the coastal zone of Busan is derived(X=logl0α, α=the total of the reclamation quantity). For the determinating coefficient γ²=0.86609 Y= - 157.06659 + 91.766855X - 16.6357X² + 1.0534768X³- 0.006741X⁴ From this, the later temperature increase followed by increase of the reclamation quantity is predicted.
도근영,김가현,이승휘,옥치율,강대석 東亞大學校 海洋資源硏究所 2003 硏究論文集 Vol.15 No.-
This study started with the measured experiment of climatic characteristic at the coastal reclamation area formed by the reclamation and development which is inevitable selection presently. As a result of the examination, the climate variation is predicted to be large in summer and the salt concentration is shown in the order of top layer, bottom layer and intermediate layer. Therefore, the greens space and wind path are occupied at the coastal reclamation.
김병우,류지근,박우진,박계원,김미정,임지은,백대현,최재덕,최윤호,이가현,이관,김덕수 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.1
수면, 기억 그리고 학습의 연관성은 실제 매우 복잡하다. 많은 연구에도 불구하고 명확한 연구결과는 아직 없다. 우리는 이 연구에서 평소와는 달리 시험 전날 수면 변화 양상이 집중력에 어느 정도 영향력을 미치는지 알아보고자 하였고, 이를 이용해 효율적인 수면 관리를 할 수 있는 기초자료로 삼고자 하였다. 동국대 의대 본과 1학년생 중 지원자 30명과 본과 2학년생 10명을 대상으로 평상시 상태와 시험 직후 수면이 부족한 상태에서 각각 K-PES TEST를 실시하여 총 8항목에 걸쳐 암기력, 판단력, 단순반응의 변화정도를 검사하였다. 또 설문조사를 병행하여 결과에 영향을 미칠 수 있는 다른 인자들도 파악하였다. 수면량에 대한 부호 숫자 짝짓기(순간 판단력)을 검사한 결과, 인간의 최대 생리학적 기능은 꼭 수면부족에 의해 좌우되는 것은 아니다. 그러나, 수면감소는 피로를 증가시키고, 동기부여를 감소시키나 단, 새로운 사실을 학습하는 데에는 큰 영향을 끼치지 않는다. 즉, 수면부족으로 장시간 깨어있는 것은 정확성과 반응성을 떨어뜨린다. 흡연에 대한 부호 숫자 짝짓기(순간 판단력)을 검사한 결과, 니코틴의 수면에 대한 상호관계는 알려지지 않았고, 인간의 감정이나 의식, 인식에 영향을 주는 것으로 알고있지만, 장기적은 측면에서 흡연이나 알코올은 인식능력과 무관한 것 같다. 카페인에 대한 숫자 외우기(암기력)검사 결과, 카페인은 spacial selective attention에는 특별한 영향을 주지 않지만 지각과정이나 주의 집중에 큰 효과를 주며, 인간의 의식 수행에 긍정적인 효과를 준다. 즉 카페인은 활력, 혼란, 피로상태를 변화시키고 visual analog scales에서 휴식상태에 가까운 양상을 나타낸다. 또 48시간 동안 수면을 취하지 않은 사람에게 카페인은 집중력과 장시간의 좋은 기분을 유지하게 하였다. 그러나 규칙적, 비규칙적으로 먹는 사람간에는 인지수행력의 차이를 보이지 않으며 상용자에서는 상당한 내성이 보인다. 수면패턴에 대한 숫자 더하기(순간 판단력)검사 결과, 집중력은 수면패턴에 의해서도 영향을 받고, 수면패턴이 바뀌게 되면 순간판단력을 저하시킨다. This study was performed to evaluate relationship of sleep and attention, and to control sleep effectively. We conducted a K-PES test of 40 medical students. K-PES contains eight elements, for example, simple response, selective response, color pairing, OddEven discrimination, number addition, number-symbol matching, memory, right-tapping, left tapping. Through these, we tested changes of memory, judgement, simple response. And we conducted a questionnaire survey to exclude bias. Results are as follows. As a results of number-symbol matching test, we know that sleeplessness is not complete responsible for physiologic function for humans. But, decreased sleep increases fatigue and decreases motivation, but no influence on learning new materials. So, long term sleeplessness decreases precision and responsibility. As a results of number-symbol matching test on smoking, a relationship of nicotine and sleep is not certain. A point of view in long term period, smoking and drinking is not related cognition, even if we know that those influence mood, consciousness and cognition. As a results of memory work test on caffeine, caffeine does not influence spacial selective attention, but mainly does perception, attention and consiousness process. Namely caffeine changes energetic activities, chaos, fatigue states and shows resting state in visual analog scales In sleeplessness for 48 hours, caffeine produced attention and good mood for a long time. But, in case of cognitive process no significance shows in regular or irregular diet. Regular diet shows high resistance. As a results of number addition test on sleep patterns, seep patterns influence attention, changes of sleep patterns decrease a moment judgement.
Elderly Patients Exhibit Stronger Inflammatory Responses during Gout Attacks
Lee, Jae Hyun,Yang, Ji Ae,Shin, Kichul,Lee, Ga Hye,Lee, Won-Woo,Lee, Eun Young,Song, Yeong Wook,Lee, Eun Bong,Park, Jin Kyun KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.12
<P>Gout attacks are often accompanied by systemic inflammatory response. The aim of the retrospective study was to compare gout patients in different age groups in terms of their clinical features at gout attacks. Patients, who were treated for gout attack in two tertiary medical centers between January 2000 and April 2014, were divided into young (≤ 50 years), middle-aged, and elderly (> 65 years) groups. Patients in three age groups were compared in terms of presence of fever (> 37.8°C), C-reactive protein (CRP) levels, and erythrocyte sedimentation ratio (ESR) at the gout attacks. Monocytes, which were isolated from 10 consecutive patients who previously experienced gout attacks, were stimulated with monosodium urate (MSU) crystals and cytokine production was measured by flow cytometry. Among 254 patients analyzed in this study, 48 were young, 65 were middle-aged, and 141 were elderly. The elderly patients were more likely to have fever (51.1%) during the attack than the young (20.8%) and middle-aged (30.8%) patients (<I>P</I> < 0.001 by χ<SUP>2</SUP> test). They were also more likely to have higher ESR and CRP levels than the young patients (<I>P</I> = 0.002 for ESR, <I>P</I> < 0.001 for CRP). Patients' age correlated significantly with CRP and ESR levels (both <I>P</I> < 0.001). After stimulation with MSU, the production of interleukin-1β by monocytes increased with patients' age (<I>r</I> = 0.670, <I>P</I> = 0.03). In conclusion, gout attacks in elderly patients are associated with fever and higher ESR and CRP levels, often resembling a septic arthritis.</P>
Ga Hyun Lee(이가현),Sung June Lee(이성준),Sang Won Jeong(정상원),Hyun-Chul Kim(김현철),Jin Hyun Choi(최진현),Se Geun Lee(이세근) 한국고분자학회 2015 폴리머 Vol.39 No.6
의료용으로 사용되고 있는 고분자는 체내에 적용했을 경우 초기의 염증반응이 종종 문제점으로 대두되며, 이는 면역세포의 활성산소의 배출과 관련되어 있다. 본 연구에서는 이러한 부작용을 해결하기 위해 항산화제를 필름표면에 코팅하여 활성산소 발생 저해에 의한 항염증 효과를 평가하고자 하였다. Macrophage에 의한 염증 효과를 평가한 결과, 항산화제가 코팅된 polylactic acid 필름에서 pro-inflammatory cytokine의 생성이 저해됨을 확인하였다. 또한 항산화제 코팅 시 코팅제로 사용되는 고분자의 종류 및 분자량에 따른 방출 거동을 관찰한 결과, 고분자의 종류 및 분자량에 따라 항산화제의 방출 제어가 가능하였다. 이는 항염증 반응에 효과적으로 대응할 수 있는 항산화제 코팅 polylactic acid 필름을 제조함으로써 다양하고 광범위한 체내용도 전개가 가능할 것으로 생각된다. Polylactic acid (PLA) films have been widely used in medical devices for surgical treatments. However, their use has been associated with complications, such as inflammation around the PLA film implant area. Several antioxidant agents have been incorporated on the surface of PLA films to suppress initial excessive inflammatory reactions through the quenching of reactive oxygen species (ROS) released from macrophages. The suppression of inflammation was evaluated by measuring the levels of various pro-inflammatory cytokines produced by the macrophages. In addition, by measuring quercetin release behavior, we determined the optimum type and molecular weight of the film coating polymer for the effective suppression of inflammation. These results suggest that the incorporation and controlled release of quercetin could be a promising method to reduce inflammation induced by PLA films.