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Reconstruction of Cortical Connectivity with MEG Using Inverse Method
루안펑(Feng Luan),이찬희(Chany Lee),최종호(Jong-Ho Choi),정현교(Hyun-Kyo Jung) 대한전기학회 2010 대한전기학회 학술대회 논문집 Vol.2010 No.7
In this paper, the abilities of the Minimum norm estimates (MNE) method and the Beamforming method for detecting the cortical connectivity are studied and compared for a range of magnetoencephalography (MEG) reconstruction conditions in conjunction with different field spread effect. The results verify that the Beamforming method is a better choice when the field spread effect is relatively high, and the MNE method seems to be more effective to preserve the long distance coupling between cortical sources.
Anchao Feng,Houliang Tang,Yi Luan 한국고분자학회 2019 Macromolecular Research Vol.27 No.7
An alkyl halide containing monomer, 2-chloroethyl methacrylate (CEMA) was synthesized via the chorination of 2-hydroethyl methacryalte and polymerized by reversible addition-fragmentation chain transfer (RAFT) polymerization. The kinetics of the controlled/living radical polyemrization (CRP) was systematically investigated. The chain end livingness of poly(2-chloroethyl methacrylate) (PCEMA) was confirmed by the chain extension with methyl methacrylate (MMA) under RAFT polymerization conditions. PCEMA with dangling alkyl chloride groups was directly azidated through a nucleophilic substitution with sodium azide, affording a polymer with an azido group at each repeating unit. The resulting polymer was readily available for post-polymerization modifications by various click reactions. These strategies may open new perspectives toward more effective and milder conditions for azide involving reactions.
MUTYH Association with Esophageal Adenocarcinoma in a Han Chinese Population
Kong, Feng,Han, Xue-Ying,Luan, Yun,Qi, Tong-Gang,Sun, Chao,Wang, Jue,Hou, Hua-Ying,Jiang, Yu-Hua,Zhao, Jing-Jie,Cheng, Guang-Hui Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Adenocarcinoma of esophagus (AE) is a complex disease, affected by a variety of genetic and environmental factors. Much evidence has shown that the MutY glycosylase homologue (MUTYH) plays a key role in the pathogenesis of many cancers. However, there have been no reports on influence on AE in the Han Chinese population. The objective of this study was to investigate this issue. A gene-based association study was conducted using three single nucleotide polymorphisms(SNPs) reported in previous studies. The three SNPs (rs3219463, rs3219472, rs3219489) were genotyped in 207 unrelated AE patients and 249 healthy controls in a case-control study using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The results revealed that the genotype distribution of rs3219472 differed between the case and control groups (OR=1.66,95%CI=1.11-2.48, P=0.012), indicating that an association may exist between MUTYH and AE. These findings support a signifcant role for MUTYH in AE pathogenesis in the Han Chinese population.
Meng Lei,Feng Bin,Luan Liming,Fang Zhihao,Zhao Guangyu 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Methyl CpG binding protein 2 (MeCP2) is involved in nerve regeneration following ischemic stroke, but the related mechanism remains unclear. Here, we found low MeCP2 expression in hippocampal tissues. Using functional analysis, we demonstrated that MeCP2 accelerated FOXO3a methylation and subsequently inhibited its expression, thus repressing the apoptosis of neuronal cells. Mechanistically, FOXO3a could bind to the promoter region of SPRY2, consequently inducing its transcription and promoting the expression of the downstream target gene ZEB1. Altogether, our study revealed that overexpression of MeCP2 can protect mice against ischemic brain injury via disruption of the FOXO3a/SPRY2/ZEB1 signaling axis. Our results identify ectopic expression of MeCP2 as a therapeutic target in ischemic stroke.
JONGHO CHOI,임창환,Feng Luan,Min-Hyuk Kim,HYUN-KYO JUNG 대한의용생체공학회 2012 Biomedical Engineering Letters (BMEL) Vol.2 No.2
Purpose In this paper, we investigated the influence of orientation and activation area of extended cortical current sources upon the solutions of magnetoencephalography (MEG) inverse problems. Methods Extensive simulation studies were performed with artificial MEG datasets generated using a realistic head geometry model. Results Our simulation studies demonstrated that as the source activation area was extended beyond a threshold level, the radial component of cortical sources was weakened and thus the accuracy of MEG inverse problem was enhanced. Conclusions These are important findings suggesting that one may not need to be concerned too much about the insensitivity of MEG to radial sources in many practical MEG measurements.
Xiang Li,Zhaoling Li,Xiaonan Dang,Dan Luan,Feng Wang 한국섬유공학회 2018 Fibers and polymers Vol.19 No.3
In this work, plasticized spinning PAN fibers were treated at low carbonization temperature for the first time. The properties of treated fibers were characterized by elemental analysis (EA), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) respectively. The SEM results show that cross section of the pre-carbonized fibers is circular with no apparent skin-core structure. During the pre-carbonization process (320-380 oC), fracture mode of the fibers gradually changes from ductile to brittle and fibril diameter gradually decreases. Pre-carbonization temperature at 350 oC significantly accelerates chemical reactions. The FTIR results show that a stable oxygen structure is generated as treated at 320 oC.