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Po-Ju Lai,Sheng-Fen Wang,Tsung-Ting Tsai,Yun-Da Li,Ping-Yeh Chiu,Ming-Kai Hsieh,Fu-Cheng Kao 대한척추신경외과학회 2021 Neurospine Vol.18 No.4
Objective: Surgical treatment of severe infectious spondylodiskitis remains challenging. Although minimally invasive percutaneous endoscopic drainage and debridement (PEDD) may yield good results in complicated cases, outcomes of patients with extensive structural damage and mechanical instability may be unsatisfactory. To address severe infectious spondylodiskitis, we have developed a surgical technique called percutaneous endoscopic interbody debridement and fusion (PEIDF), which comprises endoscopic debridement, bone-graft interbody fusion, and percutaneous posterior instrumentation. Methods: Outcomes of PEIDF in 12 patients and PEDD in 15 patients with infectious spondylodiskitis from April 2014 to July 2018 were reviewed retrospectively. Outcome were compared between 2 kinds of surgical procedures. Results: Patients in PEIDF group had significantly lower rate of revision surgery (8.3% vs. 58.3%), better kyphosis angle (-5.73°±8.74 vs. 1.07°±2.70 in postoperative; 7.09°±7.23 vs. 0.79°±4.08 in kyphosis correction at 1 year), and higher fusion rate (83.3% vs. 46.7%) than those who received PEDD. Conclusion: PEIDF is an effective approach for treating infectious spondylodiskitis, especially in patients with spinal instability and multiple medical comorbidities.
중국 패션디자인 전공 대학생의 주도적 성격이 진로결정자기효능감을 매개로 진로준비행동에 미치는 영향
왕분(Fen Wang),김주경(Ju-Kyoung Kim) 학습자중심교과교육학회 2023 학습자중심교과교육연구 Vol.23 No.14
목적 본 연구에서는 중국 패션 디자인 전공 대학생들의 주도적 성격이 진로준비행동에 미치는 영향에서 진로결정자기효능감의 매개효과를 분석하였다. 방법 이를 위하여 중국 광시성 및 후난성에 소재한 대학에 재학중인 패션 디자인 전공 대학생 539명을 대상으로 주도적 성격, 진로결정자기효능감, 진로준비행동을 측정하고, 주도적 성격이 진로준비행동에 이르는 경로에서 진로결정자기효능감의 매개효과를 분석하였다. 결과 일반적 특성에 따른 진로준비행동의 차이는 학년 및 전공성적에 따라 유의한 차이가 있었고, 모든 변인 간에는 통계적으로 유의미한 정적 상관이 확인되었다. 중국 패션 디자인 전공 대학생의 주도적 성격이 진로준비행동에 미치는 직접 효과는 확인되지 않았고, 진로결정자기효능감을 매개로 한 간접효과가 확인되어 완전 매개효과를 확인하였다. 결론 주도적 성격은 진로준비행동에 직접적인 영향을 미치지 못하며, 진로결정자기효능감을 매개로 간접효과를 미친다는 점에서 주도적 성격에 기반한 진로결정자기효능감 형성을 통해 대학생이 구체적이고 실천적인 진로준비행동을 이행해나갈 수 있도록 하는 것이 필요하다. Objectives This study analyzed the mediating effect of career decision self-efficacy in the influence of initiative personality on career preparation behavior of Chinese college students majoring in fashion design. Methods Initiative personality, career decision self-efficacy, and career preparation behavior were measured for 539 college students majoring in fashion design who are attending universities in Guangxi and Hunan provinces, China, and career decision self-efficacy in the path leading from initiative personality to career preparation behavior. Results As a result of the analysis, there were significant differences in career preparation behavior according to general characteristics according to grade and major grades, and statistically significant static correlations were confirmed between all variables. The direct effect of the initiative personality of Chinese college students majoring in fashion design on career preparation behavior was not confirmed. Conclusions The initiative personality has no direct effect on career preparation behavior, but has an indirect effect through career decision self-efficacy. Therefore, it is necessary to enable college students to carry out specific and practical career preparation behaviors through the formation of career decision self-efficacy based on the leading personality.
Hai-Yan Chen,Yue-Feng Guan,Xue-Yong Huang,Yu-Ting Wu,Fen-Fei Wang,Ju-Fang Gao,Que Zhou,Zhong-Nan Yang,Jia-Yao Liu,Hong-Xia Zhang 한국식물학회 2012 Journal of Plant Biology Vol.55 No.3
We have characterized a new male-sterile mutant in Arabidopsis that exhibits conditional sterility but has restored fertility when drought-stressed. This mutant,multiple impairments in male reproduction 1 (mimr1),shows pleiotropic defects in both vegetative and reproductive development. Examination with dissecting and scanning electron microscopes revealed that its pollen grains are not effectively released from the anther locule after dehiscence, and anther differentiation is defective. Growth of the style and stamen filaments are also abnormal. Histological analysis demonstrated that these phenomena are due not only to a noticeably reduced extension of the stamen but also greater elongation of the pistil. Genetic analysis indicated that mimr1 is a single locus recessive nuclear mutant. The mutation can be mapped to a locus strongly linked to a 1200-kb region on Chromosome 3. Meta-analysis of expression patterning presented several candidate genes in that region. No mutants with similar phenotypes have previously been reported, suggesting that mimr1 is a novel male-sterile locus. Characterization of MIMR1 will provide further insights into the molecular basis for the development of plant reproductive organs.
Guo, Wei-Qiang,Li, Liang-Zhi,He, Zhuo-Yang,Zhang, Qi,Liu, Jia,Hu, Cui-Ying,Qin, Fen-Ju,Wang, Tao-Yun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Atractylis lancea (Thunb.) DC. (AL), an important medicinal herb in Asia, has been shown to have anti-tumor effects on cancer cells, but the involved mechanisms are poorly understood. This study focused on potential effects and molecular mechanisms of AL on the proliferation of the Hep-G2 liver cancer cell line in vitro. Cell viability was assessed by MTT test in Hep-G2 cells incubated with an ethanol extract of AL. Then, the effects of AL on apoptosis and cell cycle progression were determined by flow cytometry. Telomeric repeat amplification protocol (TRAP) assays was performed to investigate telomerase activity. The mRNA and protein expression of human telomerase reverse transcriptase (hTERT) and c-myc were determined by real-time RT-PCR and Western blotting. Our results show that AL effectively inhibits proliferation in Hep-G2 cells in a concentrationand time-dependent manner. When Hep-G2 cells were treated with AL after 48h,the $IC_{50}$ was about 72.1 ${\mu}g/mL$. Apoptosis was induced by AL via arresting the cells in the G1 phase. Furthermore, AL effectively reduced telomerase activity through inhibition of mRNA and protein expression of hTERT and c-myc. Hence, these data demonstrate that AL exerts anti-proliferative effects in Hep-G2 cells via down-regulation of the c-myc/hTERT/telomerase pathway.
Xiong, Wei,Jiang, Yong-Xin,Ai, Yi-Qin,Liu, Shan,Wu, Xing-Rao,Cui, Jian-Guo,Qin, Ji-Yong,Liu, Yan,Xia, Yao-Xiong,Ju, Yun-He,He, Wen-Jie,Wang, Yong,Li, Yun-Fen,Hou, Yu,Wang, Li,Li, Wen-Hui Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8
Background: Preoperative 5-fluorouracil (5-FU)-based chemoradiotherapy is a standard treatment for locally advanced colorectal cancer (CRC). However, CRC cells often develop chemoradiation resistance (CRR). Recent studies have shown that long non-coding RNA (lncRNA) plays critical roles in a myriad of biological processes and human diseases, as well as chemotherapy resistance. Since the roles of lncRNAs in 5-FU-based CRR in human CRC cells remain unknown, they were investigated in this study. Materials and Methods: A 5-FU-based concurrent CRR cell model was established using human CRC cell line HCT116. Microarray expression profiling of lncRNAs and mRNAs was undertaken in parental HCT116 and 5-FU-based CRR cell lines. Results: In total, 2,662 differentially expressed lncRNAs and 2,398 mRNAs were identified in 5-FU-based CRR HCT116 cells when compared with those in parental HCT116. Moreover, 6 lncRNAs and 6 mRNAs found to be differentially expressed were validated by quantitative real time PCR (qRT-PCR). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis for the differentially expressed mRNAs indicated involvement of many, such as Jak-STAT, PI3K-Akt and NF-kappa B signaling pathways. To better understand the molecular basis of 5-FU-based CRR in CRC cells, correlated expression networks were constructed based on 8 intergenic lncRNAs and their nearby coding genes. Conclusions: Changes in lncRNA expression are involved in 5-FU-based CRR in CRC cells. These findings may provide novel insight for the prognosis and prediction of response to therapy in CRC patients.