Ovarian cancer risk score predicts chemo-response and outcome in epithelial ovarian carcinoma patients

Hsiao-Yun Lu,Yi-Jou Tai,Yu-Li Chen,Ying-Cheng Chiang,Heng-Cheng Hsu,Wen-Fang Cheng 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.2

Objective: Cytoreductive surgery followed by adjuvant chemotherapy is a standard frontlinetreatment for epithelial ovarian cancer (EOC). We aimed to develop an ovarian cancer riskscore (OVRS) based on the expression of 10 ovarian-cancer-related genes to predict thechemoresistance, and outcomes of EOC patients. Methods: We designed a case-control study with total 149 EOC women including 75chemosensitives and 74 chemoresistants. Gene expression was measured using thequantitative real-time polymerase chain reaction. We tested for correlation between theOVRS and chemosensitivity or chemoresistance, disease-free survival (DFS), and overallsurvival (OS), and validated the OVRS by analyzing patients from the TCGA database. Results: The chemosensitive group had lower OVRS than the chemoresistant group (5 vs. 15, p≤0.001, Mann-Whitney U test). Patients with disease relapse (13 vs. 5, p<0.001, Mann Whitney U test) or disease-related death (13.5 vs. 6, p<0.001) had higher OVRS than thosewithout. OVRS ≥10 (hazard ratio=3.29; 95% confidence interval=1.94–5.58; p<0.001) was theonly predictor for chemoresistance in multivariate analysis. The median DFS (5 months vs. 24 months) and OS (39 months vs. >60 months) of patients with OVRS ≥10 were significantlyshorter than those of patients with OVRS <9). The high OVRS group also had significantlyshorter median OS than the low OVRS group in 255 patients in the TCGA database (39 vs. 49months, p=0.046). Conclusions: Specific genes panel can be clinically applied in predicting the chemoresistanceand outcome, and decision-making of epithelial ovarian cancer.

Negative Corona Onset Characteristic of the UHV Conductors Based on the Corona Cage

Yun-Peng Liu,Lei Zhu,Fang-Cheng Lv,Xiongjie Xie 대한전기학회 2014 Journal of Electrical Engineering & Technology Vol.9 No.6

Negative corona onset characteristics of the stranded conductors based on the ultra-high voltage (UHV) corona cage were studied in the paper. Based on the corona self-sustaining criterion in extreme uneven electric fields and the secondary emission process of the photoelectrons, the corona onset calculation model in the UHV corona cage is established and the corona current tests of the single LGJ900-75, 6 bundle LGJ900-75, 8 bundle LGJ400-35 conductors in dry and rain conditions were done in the UHV corona cage, and the rain rates are 2.4 mm/h, 20 mm/h and 30 mm/h. Corona onset electric field strength is gained by E-I tangent method, and the onset electric field strength in dry condition proves that the calculation model can be used to calculate the corona onset characteristics of the bundle conductors in the UHV corona cage. A further analysis proves that: the negative corona onset voltage of the conductor increases with the bundle number and the diameter of the sub conductor, but decreases with the bundle space in the corona cage. The onset electric field strength is influenced little by bundle space and bundle number, but decreases with the increase of the diameter of the sub-conductor. The surface irregularity coefficient decreases with the rain rate.

Corona generated Radio Interference of the 750 kV AC Bundle Conductors in Sandy and Dusty Weather Condition in the High Altitude Area

Yun-Peng Liu,Lei Zhu,Fang-Cheng Lv,Bao-Quan Wan,Chun-Ming Pei 대한전기학회 2014 Journal of Electrical Engineering & Technology Vol.9 No.5

Sandy and dusty weather condition often occurs in the high altitude areas of China, which may greatly influence the corona generated radio interference (RI) characteristics of the bundle conductors of 750 kV AC power transmission lines. Corona generated RI of the conductors of the 750 kV AC power transmission lines used in practice is measured by EMI receiver with a coupling circuit and a coupling capacitor connected between the high voltage side and the earth side in fine and sandy and dusty condition. The measuring frequency is 0.5 MHz, and the quasi-peak detection is used. RI excitation function is calculated based on the corona RI current measured by the EMI receiver. Corona generated RI characteristics were analyzed from sand concentration and sand particle size. The test result shows that the corona generated RI excitation function is influenced by the sandy and dusty condition. Corona discharge of the conductors is more serious in sandy and dusty condition with an ultraviolet (UV) detector. Corona generated RI excitation function increases with the increase of sand concentration and also increases with the increase of particle size.

Negative Corona Onset Characteristic of the UHV Conductors Based on the Corona Cage

Liu, Yun-Peng,Zhu, Lei,Lv, Fang-Cheng,Xie, Xiongjie The Korean Institute of Electrical Engineers 2014 Journal of Electrical Engineering & Technology Vol.9 No.6

Negative corona onset characteristics of the stranded conductors based on the ultra-high voltage (UHV) corona cage were studied in the paper. Based on the corona self-sustaining criterion in extreme uneven electric fields and the secondary emission process of the photoelectrons, the corona onset calculation model in the UHV corona cage is established and the corona current tests of the single LGJ900-75, 6 bundle LGJ900-75, 8 bundle LGJ400-35 conductors in dry and rain conditions were done in the UHV corona cage, and the rain rates are 2.4 mm/h, 20 mm/h and 30 mm/h. Corona onset electric field strength is gained by E-I tangent method, and the onset electric field strength in dry condition proves that the calculation model can be used to calculate the corona onset characteristics of the bundle conductors in the UHV corona cage. A further analysis proves that: the negative corona onset voltage of the conductor increases with the bundle number and the diameter of the sub conductor, but decreases with the bundle space in the corona cage. The onset electric field strength is influenced little by bundle space and bundle number, but decreases with the increase of the diameter of the sub-conductor. The surface irregularity coefficient decreases with the rain rate.

Relationship of Work Stress, Professional Commitment and Job Satisfaction among Nurse Practitioners in Taiwan

Hui-Fang Yeh,Chien-Lin Kuo,Su-Fen Cheng,Kuei-Yun Lu 한국간호과학회 2009 한국간호과학회 학술대회 Vol.2009 No.10

Equilibrium Risk Decision Model for Bidding Electricity Quantity Deviation of Cascade Hydropower Stations

Liu Fang,Xu Yun,Zhu Dan-Dan,Wei Si-Ming,Tang Cheng-Peng 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.2

There is a common phenomenon in China where the upstream and downstream hydropower stations of Cascade Hydropower Stations (CHS) belong to diferent operating entities. When independently participating in market bidding, upstream and downstream hydropower station information sharing blocked is likely to lead to the water fow mismatch of bidding volume, and resulting in no water can be used or water-abandond of downstream power plant. To make up bidding electricity shortfall of downstream station in day-ahead power market, a balance mechanism is proposed, in which downstream station through power contract transaction in the days or system punishment to balance electricity deviation. Power contract transaction includes centralized contract market and negotiated transaction with upstream station, system unbalancing penalty also as virtual transactions, then the problem is switched to electricity deviation optimal allocation in the trading portfolio. For price volatility of all transaction types, trading portfolio risk decision model of downstream power stations deviation electricity based CVaR framework is builded, which achieving minimum CVaR risk of downstream power plant electricity deviation as well as meetting preset expectation loss constraint. Finally, through the analysis of a CHS in southwestern China, it is shown that the model and method proposed in this paper can efectively reduce the imbalance between the winning electricity and incoming water matching of downstream power stations, and efectively improve the stability of hydropower consumption and power market operation

Corona generated Radio Interference of the 750 kV AC Bundle Conductors in Sandy and Dusty Weather Condition in the High Altitude Area

Liu, Yun-Peng,Zhu, Lei,Lv, Fang-Cheng,Wan, Bao-Quan,Pei, Chun-Ming The Korean Institute of Electrical Engineers 2014 Journal of Electrical Engineering & Technology Vol.9 No.5

Sandy and dusty weather condition often occurs in the high altitude areas of China, which may greatly influence the corona generated radio interference (RI) characteristics of the bundle conductors of 750 kV AC power transmission lines. Corona generated RI of the conductors of the 750 kV AC power transmission lines used in practice is measured by EMI receiver with a coupling circuit and a coupling capacitor connected between the high voltage side and the earth side in fine and sandy and dusty condition. The measuring frequency is 0.5 MHz, and the quasi-peak detection is used. RI excitation function is calculated based on the corona RI current measured by the EMI receiver. Corona generated RI characteristics were analyzed from sand concentration and sand particle size. The test result shows that the corona generated RI excitation function is influenced by the sandy and dusty condition. Corona discharge of the conductors is more serious in sandy and dusty condition with an ultraviolet (UV) detector. Corona generated RI excitation function increases with the increase of sand concentration and also increases with the increase of particle size.

Identification of Homer1 as a Potential Prognostic Marker for Intrahepatic Cholangiocarcinoma

Wu, San-Yun,Yu, Ming-Xia,Li, Xiao-Gai,Xu, Shu-Fang,Shen, Ji,Sun, Zhen,Zhou, Xin,Chen, Xing-Zhen,Tu, Jian-Cheng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

Background: The aim of the present study was to analyze whether Homer1 is a potential prognostic marker for intrahepatic cholangiocarcinoma (ICC). Materials and Methods: The expression of Homer1 in ICC tissue was detected with immunohistochemistry and levels of protein in ICC and paratumor tissues were evaluated by Western blotting. Survival analysis by the Kaplan-Meier method was performed to assess prognostic significance. Results: Homer1 expression was high in 67.4% (58/86) of ICC samples, and there was significant difference between ICC and adjacent noncancerous tissues (p<0.001); high expression was associated with poor histologic differentiation (p=0.019), TNM stage (p=0.014), lymph node metastasis (p=0.040), and lymphatic invasion (p=0.025). On Kaplan-Meier analysis, a comparison of survival curves of low versus high expressors of Homer1 revealed a highly significant difference in OS (p=0.001) and DFS (p=0.006), indicating that high expression of Homer1 was linked with a worse prognosis. Multivariate analyses showed that Homer1 expression was an independent risk factor predicting overall survival[Hazard ratio(HR), 7.52; 95% confidence interval (CI), 2.63-21.47; p=0.002] and disease-free survival (HR, 11.56; 95%CI, 5.17-25.96; p<0.001) in ICC. Conclusions: Homer1 promotes lymphatic invasion and associates with lymph node metastasis and poor prognosis of ICC. The current study shows that Homer1 may be an independent prognostic factor for ICC patients after curative resection, and it provides an important basis for screening/treating high-risk patients.

Diverse genetic spectrum among patients who met the criteria of hereditary breast, ovarian and pancreatic cancer syndrome

Po-Han Lin,Yun-Wen Tien,Wen-Fang Cheng,Ying-Cheng Chiang,Chien-Huei Wu,Karen Yang,Chiun-Sheng Huang 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.5

Objective: Genetic high-risk assessment combines hereditary breast, ovarian and pancreatic cancer into one syndrome. However, there is a lack of data for comparing the germline mutational spectrum of the cancer predisposing genes between these three cancers. Methods: Patients who met the criteria of the hereditary breast, ovarian and pancreatic cancer were enrolled and received multi-gene sequencing. Results: We enrolled 730 probands: 418 developed breast cancer, 185 had ovarian cancer, and 145 had pancreatic cancer. Out of the 18 patients who had two types of cancer, 16 had breast and ovarian cancer and 2 had breast and pancreatic cancer. A total of 167 (22.9%) patients had 170 mutations. Mutation frequency in breast, ovarian and pancreatic cancer was 22.3%, 33.5% and 17.2%, respectively. The mutation rate was significantly higher in patients with double cancers than those with a single cancer (p<0.001). BRCA1 and BRCA2 were the most dominant genes associated with hereditary breast and ovarian cancer, whereas ATM was the most prevalent gene related to hereditary pancreatic cancer. Genes of hereditary colon cancer such as lynch syndrome were presented in a part of patients with pancreatic or ovarian cancer but seldom in those with breast cancer. Families with a history of both ovarian and breast cancer were associated with a higher mutation rate than those with other histories. Conclusion: The mutation spectrum varies across the three cancer types and family histories. Our analysis provides guidance for physicians, counsellors, and counselees on the offer and uptake of genetic counseling.

Modeling and Simulation of the Magnetic Method for High Voltage Direct Current Inspection Robot

Xian-jin Xu,Cheng-hui Liu,Yu Yan,Hao-da Chen,Lei Fang,Yun-long Wang,Long-hui Wu 한국자기학회 2018 Journal of Magnetics Vol.23 No.3

In order to solve the slipping problem of a two-arm-wheel combined inspection robot, a maglev system based on the magnetic field of a high voltage direct current (HVDC) is proposed. The magnetic system comprises of two parts: a magnetic levitation system and a magnetic drive system. The levitation component overcomes the gravity of the robot by the Ampere force generated by current-carrying coils in the magnetic field of HVDC. The drive component utilizes the Ampere force generated by current-carrying coils in the magnetic field of HVDC as the driving force. Simulation results of the model are compared with the calculated values. The results show that the magnetic levitation method and the magnetic drive method are theoretically feasible, and the model is accurate and effective, which is of great practical significance to the physical realization of the inspection robot.