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Target-Agnostic Detection of Stances Toward Entities in News Articles
Eugene Jang,Wonsuk Yang,Jong C. Park 한국HCI학회 2021 한국HCI학회 학술대회 Vol.2021 No.1
Automated detection of opinionated statements in news articles can help readers quickly understand different perspectives in different articles. A system that performs word-level detection of stances towards entities can be used to pinpoint instances of opinionated statements. Such a system should look to find all opinions, as opposed to focusing on only one stance target. This research utilizes BERT-based BIO-tagging models to achieve both identification and classification of word-level target-agnostic stance in news articles. Alternative scoring methods are suggested to score inexact span matches. Some challenges due to BIO-tagging are discussed with outputs from the experiments.
Cho, Jang-Hee,Yoon, Young-Deuk,Jang, Hye Min,Kwon, Eugene,Jung, Hee-Yeon,Choi, Ji-Young,Park, Sun-Hee,Kim, Yong-Lim,Kim, Hyung-Kee,Huh, Seung,Won, Dong-Il,Kim, Chan-Duck Wolters Kluwer Health 2015 Medicine Vol.94 No.44
<P><B>Abstract</B></P><P>The clinical significance of circulating T-lymphocyte subsets and human leukocyte antigen (HLA)-DR-positive monocytes in the peripheral blood of kidney transplant recipients (KTRs) remains unclear. We examined the efficacy of enumerating these cells for the immunologic monitoring of KTRs.</P><P>Blood samples were obtained before transplantation, 2 weeks after transplantation and at diagnosis, and 2 weeks after treating biopsy-proven acute cellular rejection and cytomegalovirus (CMV) infection. Serial flow cytometric analysis was performed using peripheral blood obtained from 123 patients to identify the frequencies of HLA-DR<SUP>+</SUP>, CD3<SUP>+</SUP>, CD4<SUP>+</SUP>, CD8<SUP>+</SUP>, and CD25<SUP>+</SUP> T-lymphocytes and HLA-DR-positive monocytes.</P><P>Frequencies of CD4<SUP>+</SUP>CD25<SUP>+</SUP>/CD4<SUP>+</SUP> T cells, CD8<SUP>+</SUP>CD25<SUP>+</SUP>/CD8<SUP>+</SUP> T cells, and HLA-DR-positive monocytes were significantly lower at 2 weeks after transplantation than before transplantation (all <I>P</I> < 0.001). This decrease was not correlated with clinical parameters. The frequency of CD4<SUP>+</SUP>CD25<SUP>+</SUP>/CD4<SUP>+</SUP> T cells was significantly higher in KTRs with acute rejection than in KTRs at 2 weeks after transplantation (9.10% [range 4.30–25.6%] vs 5.10% [range 0.10–33.3%]; <I>P</I> = 0.024). However, no significant differences were observed between stable KTRs and KTRs with CMV infection. Analysis of the receiver operating characteristic curve adjusted by covariates showed that acute rejection could be predicted with 75.0% sensitivity and 68.4% specificity by setting the cutoff value of CD4<SUP>+</SUP>CD25<SUP>+</SUP>/CD4<SUP>+</SUP> T cell frequency as 5.8%.</P><P>Circulating T-lymphocyte and monocyte subsets showed significant and consistent changes in their frequencies after immunosuppression. Of the various immune cells examined, circulating levels of CD4<SUP>+</SUP>CD25<SUP>+</SUP> T cells might be a useful noninvasive immunologic indicator for detecting acute rejection.</P>
( Jang Soo Han ),( So Dug Lim ),( Won Hyeok Choi ),( Sung Chul Hong ),( Jung Hee Park ),( Eugene Park ),( Mi Jin Hong ),( Cho I Lee ),( Jung Hwan Park ),( Jong Ho Lee ),( Jong Oh Song ),( Young Il Jo 대한신장학회 2013 Kidney Research and Clinical Practice Vol.32 No.1
Immunoglobulin A (IgA) nephropathy associated with cirrhosis is the most common form of secondary IgA nephropathy (IgAN). Cirrhosis-related IgAN is usually clinically silent with a rare occurrence of gross hematuria, unlike in cases of idiopathic IgAN. Especially, acute tubular necrosis (ATN) associated with gross hematuria is very rare in cirrhosis-related IgAN, although acute renal failure is a frequently reported complication in advanced cirrhosis. Herein, we report an unusual case of ATN requiring renal replacement therapy, associated with gross hematuria in a patient with nonalcoholic, hepatitis B virus-associated cirrhosis. Results of a histopathological analysis revealed obstruction of the lumen of renal tubules by red blood cell casts, a marked tubular necrosis, and IgA deposition in the mesangium. The patient`s renal function and gross hematuria were clearly improved after lamivudine treatment.
Metabolism in embryonic and cancer stemness.
Jang, Hyonchol,Yang, Jaemoon,Lee, Eugene,Cheong, Jae-Ho Pharmaceutical Society of Korea 2015 Archives of Pharmacal Research Vol.38 No.3
<P>Cells constantly adjust their metabolic state in response to extracellular signals and nutrient availability to meet their demand for energy and building blocks. Recently, there has been significant research into the metabolic aspects of embryonic stem cells/pluripotent stem cells (ESCs/PSCs) and cancer stem cells (CSCs), which has revealed the unique metabolic status of different stem cell lineages. While ESCs and CSCs were largely thought to harbor similar metabolic states, recent evidence demonstrates that their metabolic dependency is distinctly different. The glucose metabolism of ESCs largely depends on glycolysis, including a one-carbon pathway during differentiation. While proliferating cancer cells share the glycolytic phenotype of ESCs, the mitochondria-centric oxidative phosphorylation constitutes an important metabolic circuit of CSCs under metabolic stress, indicating the dynamic nature of metabolic plasticity. In this review, we catalogued metabolic signatures of cellular 'stemness' to provide insights into the therapeutic potential of ESCs and CSCs.</P>
Towards clinical use of a laser-induced microjet system aimed at reliable and safe drug delivery
Jang, Hun-jae,Yu, Hyeonju,Lee, Seonggeun,Hur, Eugene,Kim, Yoonkwan,Lee, Seol-Hoon,Kang, Naegyu,Yoh, Jack J. SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS 2014 JOURNAL OF BIOMEDICAL OPTICS Vol.19 No.5