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J-curve relationship between corrected QT interval and mortality in acute heart failure patients
Chan Soon Park,Hyun-Jai Cho,Eue-Keun Choi,이상은,김민석,김재중,Jin-Oh Choi,Eun-Seok Jeon,Kyung-Kuk Hwang,Shung Chull Chae,Sang Hong Baek,Seok-Min Kang,Byung-Su Yoo,Dong-Ju Choi,Youngkeun Ahn,Kye-Hoon Kim,Myeon 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.6
Background/Aims: This study investigated the prognostic power of corrected QT (QTc) interval in patients with acute heart failure (AHF) according to sex. Methods: We analyzed multicenter Korean Acute Heart Failure registry with patients with AHF admitted from 2011 to 2014. Among them, we analyzed 4,990 patients who were followed up to 5 years. Regarding QTc interval based on 12 lead electrocardiogram, patients were classified into quartiles according to sex. Results: During follow-up with median 43.7 months, 2,243 (44.9%) patients died. The relationship between corrected QT interval and all-cause mortality followed a J-curve relationship. In Kaplan-Meier analysis, both sex had lowest mortality in the second QTc quartile. There were significant prognostic differences between the second and the fourth quartiles in male (log-rank p = 0.002), but not in female (log-rank p = 0.338). After adjusting covariates, the third (hazard ratio [HR], 1.185; 95% confidence interval [CI], 1.001 to 1.404; p = 0.049) and the fourth (HR, 1.404; 95% CI, 1.091 to 1.535; p = 0.003) quartiles demonstrated increased risk of mortality compared to the second quartile in male. In female, however, there was no significant difference across quartiles. QTc interval was associated with 5-year all-cause mortality in J-shape with nadir of 440 to 450 ms in male and 470 to 480 ms in female. Conclusions: QTc interval was an independent predictor of overall death in male, but its significance decreased in female. The relationship between QTc interval and all-cause mortality was J-shaped in both sex.
펨토초 레이저와 미세각막절삭기를 이용한 라식에서 각막내피세포의 변화 비교
김선아,최은수,이태헌,박종일,이경헌,Sun-A Kim,M,D,Eue-Su Choi,M,D,Tae-Hun Lee,M,D,Jong-Il Park,M,D,Kyung-Hun Lee,M,D 대한안과학회 2005 대한안과학회지 Vol.46 No.12
Purpose: To compare the corneal endothelial cell change in Femtosecond laser and microkeratome LASIK operation. Methods: This study involved 31 eyes (16 patients) that had LASIK using a femtosecond laser (group 1). The control group comprised 32 eyes (16 patients) that had conventional LASIK using microkeratome. We measured the endothelial cell using a non-contact specular microscope preoperatively and at postoperative 1, 2 and 6 months. Results: The preoperative and postoperateive 1, 2, and 6 months cell densities were, respectively: (group 1) 3039±335.2, 3012.9±373.0, 3008.2±240.2, 3009.1±250.5; (group 2) 2984.8±334.4, 2972.7±290.0, 2968±323.2, 2968±319.1. The coefficients of variation were, respectively: (group 1) 32.6±5.3, 33±7.2, 32.2±5.9, 31.7±5.8; (group 2) 32.3±5.3, 33.6±6.2, 35.5±4.8, 34.1±5.1. Respective hexagonality measurements were: (group 1) 59.2±11.7, 56±12.1 55.1±13.5, 57.2±11.6; (group 2) 57.6±9.8, 57.4±10.7, 56.5±11.6, 57.1±11.1. Conclusions: There was no statistical difference in corneal endothelial change between the two groups (p>0.05). LASIK using the femtosecond laser seemed to be a safe choice when considering corneal endothelial change.