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자궁경부암으로의 진행에 따른 vascular endothelial growth factor (VEGF), matrix metalloproteinases (MMPs)의 발현
유선영 ( Sun Young Yu ),조용 ( Yong Cho ),임소이 ( So Yi Lim ),박영한 ( Young Han Park ),이용우 ( Yong Woo Lee ),최영희 ( Young Hee Choi ),노의선 ( Eu Sun Ro ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.5
목적: 본 연구는 자궁경부 침윤암으로의 진행에서 VEGF 및 MMPs의 발현에 대하여 알아보고자 하였다. 방법: 자궁경부상피내종양 11예, 상피내암 25예, 미세침윤암 19예, 침윤암 26예와 정상자궁경부조직 6예 등 총 87예를 대상으로 하여. 조직의 각각에 조직배열방법을 이용하여 VEGF와 MMP-2, MMP-9의 발현을 면역 조직화학염색법으로 조사하였다. 결과: VEGF와 MMP-2는 정상조직으로부터 침윤성 암으로 진행할수록 발현이 의미 있게 증가하였다 (p<0.05). MMP-9도 암의 진행에 따라 전반적으로 증가하는 양상을 보였으나 통계적으로 유의하지는 않았다 (p>0.05). VEGF와 MMP-2의 증가양상은 상호간에 유의한 상관관계가 있었다. 결론: VEGF와 MMP-2는 자궁경부침윤암으로의 진행에 있어서 각각 또는 같이 소정의 역할을 하는 것으로 사료된다. Objective: To evaluate the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) in the progression of cervical cancer. Methods: A total 87 specimens of uterine cervix, representing 6 normal epithelium, 11 intraepithelial neoplasm, 25 cervical carcioma in situ (CIS), 19 cervical microinvasive carcinoma and 26 cervical invasive carcinoma, were evaluated. All specimens were prepared with tissue array method which can allow evaluation many specimens in one slide. The protein expressions of VEGF and MMPs (MMP-2, MMP-9) were evaluated by immunohistochemical staining. Results: The protein expressions of VEGF and MMP-2 were increased significantly with the progression of cervical cancer (p<0.05), but there was no statistically significant difference in MMP-9 expression (p>0.05). The VEGF and MMP-2 expressions revealed positive correlations with the progression of cervical cancer. Conclusions: The VEGF, MMP-2 in each or together may play a role in the progression of cervical cancer.
MicroRNA-23a: A Novel Serum Based Diagnostic Biomarker for Lung Adenocarcinoma
( Yu Mi Lee ),( Hyun Jung Cho ),( Soo Young Lee ),( Seong Cheol Yun ),( Ji Hye Kim ),( Shin Yup Lee ),( Sun Jung Kwon ),( Eu Gene Choi ),( Moon Jun Na ),( Jae Ku Kang ),( Ji Woong Son ) 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.71 No.1
Background: MicroRNAs (miRNAs) have demonstrated their potential as biomarkers for lung cancer diagnosis. In recent years, miRNAs have been found in body fluids such as serum, plasma, urine and saliva. Circulating miRNAs are highly stable and resistant to RNase activity along with, extreme pH and temperatures in serum and plasma. In this study, we investigated serum miRNA profiles that can be used as a diagnostic biomarker of non-small cell lung cancer (NSCLC). Methods: We compared the expression profile of miRNAs in the plasma of patients diagnosed with lung cancer using an miRNA microarray. The data from this assay were validated by quantitative real-time PCR (qRT-PCR). Results: Six miRNAs were overexpressed and three miRNAs were underexpressed in both tissue and serum from squamous cell carcinoma (SCC) patients. Sixteen miRNAs were overexpressed and twenty two miRNAs were underexpressed in both tissue and serum from adenocarcinoma (AC) patients. Of the four miRNAs chosen for qRT-PCR analysis, the expression of miR-23a was consistent with microarray results from AC patients. Receiver operating characteristic (ROC) curve analyses were done and revealed that the level of serum miR-23a was a potential marker for discriminating AC patients from chronic obstructive pulmonary disease (COPD) patients. Conclusion: Although a small number of patients were examined, the results from our study suggest that serum miR-23a can be used in the diagnosis of AC.
MicroRNA-23a: A Novel Serum Based Diagnostic Biomarker for Lung Adenocarcinoma
Lee, Yu-Mi,Cho, Hyun-Jung,Lee, Soo-Young,Yun, Seong-Cheol,Kim, Ji-Hye,Lee, Shin-Yup,Kwon, Sun-Jung,Choi, Eu-Gene,Na, Moon-Jun,Kang, Jae-Ku,Son, Ji-Woong The Korean Academy of Tuberculosis and Respiratory 2011 Tuberculosis and Respiratory Diseases Vol.71 No.1
Background: MicroRNAs (miRNAs) have demonstrated their potential as biomarkers for lung cancer diagnosis. In recent years, miRNAs have been found in body fluids such as serum, plasma, urine and saliva. Circulating miRNAs are highly stable and resistant to RNase activity along with, extreme pH and temperatures in serum and plasma. In this study, we investigated serum miRNA profiles that can be used as a diagnostic biomarker of non-small cell lung cancer (NSCLC). Methods: We compared the expression profile of miRNAs in the plasma of patients diagnosed with lung cancer using an miRNA microarray. The data from this assay were validated by quantitative real-time PCR (qRT-PCR). Results: Six miRNAs were overexpressed and three miRNAs were underexpressed in both tissue and serum from squamous cell carcinoma (SCC) patients. Sixteen miRNAs were overexpressed and twenty two miRNAs were underexpressed in both tissue and serum from adenocarcinoma (AC) patients. Of the four miRNAs chosen for qRT-PCR analysis, the expression of miR-23a was consistent with microarray results from AC patients. Receiver operating characteristic (ROC) curve analyses were done and revealed that the level of serum miR-23a was a potential marker for discriminating AC patients from chronic obstructive pulmonary disease (COPD) patients. Conclusion: Although a small number of patients were examined, the results from our study suggest that serum miR-23a can be used in the diagnosis of AC.
Contribution of Convex Surfaces to Magnetostatic Interaction in Granular Medium
Jehyun Lee,Suess, D.,Schrefl, T.,Eu Sun Yu,You Sub Lee,Kyu Hwan Oh,Fidler, J. IEEE 2009 IEEE transactions on magnetics Vol.45 No.6
<P>Finite element micromagnetic studies on the magnetic behaviors of granular structures are performed to investigate the magnetostatic contributions of the curved surfaces of grains with various film thicknesses. From the result, it is found that the magnetization reversal process in one grain is much faster when the grains have convex surfaces. The magnetization vectors of all convex models are stabilized in shorter time by factor of 10 compared to those of flat models. And, the reversals of each grain are carried out by nucleation and domain wall propagation in the entire granular structure, whereas the grains in flat model are individually reversed. Moreover, the magnetization behaviors of the convex models are closer to the experimental results. Since the geometric and magnetic conditions are same for the two models, the only origin of the more realistic magnetic behavior is the magnetostatic interaction between the grains, enhanced by introducing the convex surfaces. From the further analysis, it is found that the convex surface induces pinning field that suppress other parts' reversal.</P>
권혁민 ( Hyuk Min Kwon ),유선영 ( Sun Young Yu ),노의선 ( Eu Sun Ro ),이성원 ( Sung Won Lee ),조용 ( Yong Cho ),임소이 ( So Yi Lim ),김흥철 ( Heung Chul Kim ) 대한주산의학회 2007 Perinatology Vol.18 No.4
Retroperitoneal hemorrhage caused by intra-abdominal vascular injury during pregnancy or puerperium is rare, but a very fatal complication. Massive retroperitoneal hemorrhage causes the high mortality rate of mother and fetus. But the difficulty of diagnosis and rarity may delay prompt treatment. We experienced a case of massive retroperitoneal hemorrhage, which was caused by a suspected left lumbar artery aneurysm rupture on the fifth day of vaginal delivery. The patient was successfully treated by surgery and arterial embolization. We reported this case with a brief review of literature.
신종플루 예방 접종 후 천식 악화로 발생한 자발성 종격동기종
양동주 ( Dong Ju Yang ),최유진 ( Eu Gene Choi ),이만 ( Mahn Lee ),이유미 ( Yu Mi Lee ),권선중 ( Sun Jung Kwon ),손지웅 ( Ji Woong Son ),나문준 ( Moon Jun Na ) 대한천식알레르기학회 2011 천식 및 알레르기 Vol.31 No.3
Background: The 2009 Influenza A virus, H1N1 subtype, was identified as the cause of outbreaks of febrile respiratory infection. The World Health Organization and Centers for Disease Control and Prevention considered addressing pandemic H1N1 vaccination in an effort to control future outbreaks. The safety of the H1N1 influenza vaccine is generally ascertained. However, adverse events may occur in a few patients, especially patients with underlying diseases. Spontaneous pneumomediastinum caused by asthma exacerbation after H1N1 vaccination has not yet been reported. Case History: A-16-years-old male presented with cough, sputum and dyspnea after H1N1 influenza vaccination. Results: Chest X-ray and chest CT showed pneumomediastinum and subcutaneous emphysema. The patient was treated with oxygen, inhalation of a bronchodilator and intravenous aminophylline. Eight days after admission, there was no further evidence of pneumomediastinum. Conclusion: We report a case of spontaneous pneumomediastinum caused by asthma exacerbation after H1N1 Influenza vaccination in stable asthma patient. (Korean J Asthma Allergy Clin Immunol 2011;31:226-229)