Evaluation of the effects of bupivacaine combined with sugammadex on the duration of the nociceptive blockade in sciatic nerve blocks: a controlled, double-blind animal study

Tasargol Omer,Darbaz Isfendiyar,Ergene Osman,Zabitler Feride,Deniz Aziz,Kose Selin Guven,Kose Halil Cihan,Tulgar Serkan 대한마취통증의학회 2023 Korean Journal of Anesthesiology Vol.76 No.2

Background: Animal and other experimental studies have demonstrated increased block time and quality when α- and β-cyclodextrin drugs are combined with local anesthetics. However, to our knowledge, no study has utilized γ-cyclodextrins in such a combination. In the present study, we used an animal model to evaluate the effects of different doses of the combined administration of γ-cyclodextrin (sugammadex) and bupivacaine on the duration of sciatic nerve blocks in rats. Methods: Sciatic nerve blocks were performed with a 0.20 ml mixture in all groups. For the non-experimental groups, this mixture consisted of 0.2 ml saline (Sham group), 0.2 ml sugammadex (Group S), or 0.16 ml bupivacaine 0.5% and 0.04 ml saline (Group B). For the experimental groups, 0.16 ml bupivacaine 0.5% was administered along with 0.01 ml sugammadex and 0.03 ml saline (Group BS1), 0.02 ml sugammadex and 0.02 ml saline (Group BS2), or 0.04 ml sugammadex (Group BS4). Proprioception, nociception, and motor function were evaluated until the sciatic block was completely reversed.Results: Motor, proprioceptive, and nociceptive blockades occurred within 5 min in all experimental groups. In Group BS4, the duration of the motor, proprioceptive, and nociceptive blockades was significantly increased compared with the other experimental groups. However, in Groups BS1 and BS2, only the duration of the nociceptive blockade was significantly increased.Conclusions: The combined administration of sugammadex and bupivacaine for sciatic nerve blocks in rats led to a significant increase in the duration of motor, proprioceptive, and nociceptive blockades.

The Role of Extra-Anatomic Bypass in the Surgical Treatment of Acute Abdominal Aortic Occlusion

Gokhan Ilhan,Şahin Bozok,Şaban Ergene,Sedat Ozan Karakisi,Nebiye Tufekci, M.D.,Hızır Kazdal,Sabri Ogullar,Seref Alp Kucuker 대한흉부외과학회 2015 Journal of Chest Surgery (J Chest Surg) Vol.48 No.3

Background: Aortic occlusion is rare catastophic pathology with high rates of mortality and severe morbidity. In this study, we aimed to share our experience in the management of aortic occlusion and to assess the outcomes of extra-anatomic bypass procedures. Methods: Eighteen patients who had undergone extra-anatomic bypass interventions in the cardiovascular surgery department of our tertiary care center between July 2009 and May 2013 were retrospectively evaluated. All patients were preoperatively assessed with angiograms (conventional, computed tomography, or magnetic resonance angiography) and Doppler ultrasonography. Operations consisted of bilateral femoral thromboembolectomy, axillo-bifemoral extra-anatomic bypass and femoropopliteal bypass and were performed on an emergency basis. Results: In all patients during early postoperative period successful revascularization outcomes were obtained; however, one of these operated patients died on the 10th postoperative due to multiorgan failure. The patients were followed up for a mean duration of 21.2±9.4 months (range, 6 to 36 months). Amputation was not warranted for any patient during postoperative follow-up.. Conclusion: To conclude, acute aortic occlusion is a rare but devastating event and is linked with substantial morbidity and mortality in spite of the recent advances in critical care and vascular surgery. Our results have shown that these hazardous outcomes may be minimized and better rates of graft patency may be achieved with extra-anatomic bypass techniques tailored according to the patient.

Infrapatellar Fat Pad-Derived Stem Cell-Based Regenerative Strategies in Orthopedic Surgery

( Pinar Yilgor Huri ),( Seren Hamsici ),( Emre Ergene ),( Gazi Huri ),( Mahmut Nedim Doral ) 대한슬관절학회 2018 대한슬관절학회지 Vol.30 No.3

Infrapatellar fat pad is a densely vascularized and innervated extrasynovial tissue that fills the anterior knee compartment. It plays a role in knee biomechanics as well as constitutes a source of stem cells for regeneration after knee injury. Infrapatellar fat pad-derived stem cells (IPFP-ASCs) possess enhanced and age-independent differentiation capacity as compared to other stem cells, which makes them a very promising candidate in stem cell-based regenerative therapy. The aims of this review are to outline the latest advances and potential trends in using IPFP-ASCs and to emphasize the advantages over other sources of stem cells for applications in orthopedic surgery.

Shape-Controlled Synthesis of Single-Crystalline Nanopillar Arrays by Template-Assisted Vapor−Liquid−Solid Process

Ergen, Onur,Ruebusch, Daniel J.,Fang, Hui,Rathore, Asghar A.,Kapadia, Rehan,Fan, Zhiyong,Takei, Kuniharu,Jamshidi, Arash,Wu, Ming,Javey, Ali American Chemical Society 2010 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.132 No.40

<P>Highly regular, single-crystalline nanopillar arrays with tunable shapes and geometry are synthesized by the template-assisted vapor−liquid−solid growth mechanism. In this approach, the grown nanopillars faithfully reproduce the shape of the pores because during the growth the liquid catalyst seeds fill the space available, thereby conforming to the pore geometry. The process is highly generic for various material systems, and as an example, CdS and Ge nanopillar arrays with square, rectangular, and circular cross sections are demonstrated. In the future, this technique can be used to engineer the intrinsic properties of NPLs as a function of three independently controlled dimensional parameters - length, width and height.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2010/jacsat.2010.132.issue-40/ja1052413/production/images/medium/ja-2010-052413_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja1052413'>ACS Electronic Supporting Info</A></P>

Angiotensin-I converting enzyme gene polymorphism in Turkish type 2 diabetic patients

H . Arzu Ergen,Husrev Hatemi,Bedia Agachan,Hakan Camlica,Turgay Isbir 생화학분자생물학회 2004 Experimental and molecular medicine Vol.36 No.4

Non-insulin dependent diabetes melitus is often associated with some complications such as nephropathy, retinopathy and neuropathy. Genes of the renin angiotensin system are potential candidate genes for diabetic complications. We investigated the relationship betwen angio-phism in type 2 diabetic patients with and with-out diabetic nephropathy. Seventy five patients (25 type 2 diabetic patients with nephropathy, 50 type 2 diabetic patients without nephropathy) and 37 healthy controls were studied. Gene polymorphism of ACE was determined by PCR (polymerase chain reaction) amplification using allele-spesific primers. The frequencies of ACE D, ID and II genoypes among the patients with type 2 diabetic patients were found 48%, 42%, 10% whereas in control subjects, 27%, 60%, ing DD genotype without nephropathy increased 1.77 fold than control subjects (P< 0.05). There is no significant corelation between diabetic nephropathy and ACE gene polymorphism. But we found that ACE DD genotype increased significantly in type 2 diabetic patients com-pared to control subjects (P< 0.05).

Methylene Tetrahydrofolate Reductase C677T Mutation and Left Ventricular Hypertrophy in Turkish Patients with Type II Diabetes Mellitus

Yilmaz, Hulya,Agachan, Bedia,Ergen, Arzu,Karaalib, Zeynep Ermis,Isbir, Turgay Korean Society for Biochemistry and Molecular Biol 2004 Journal of biochemistry and molecular biology Vol.37 No.2

This study was designed to investigate, in the Turkish population, the association of methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism and left ventricular hypertrophy (LVH) in patients with type II diabetes mellitus. Our study included 249 patients with type II diabetes mellitus (102 men, 147 women) and 214 healthy volunteers as controls (91 men, 123 women). MTHFR C677T genotypes were determined by polymerase chain reaction, restriction fragment length polymorphism techniques. No differences were observed in the distribution of MTHFR genotypes or allele frequencies in the cases versus the controls. The frequency of the MTHFR-mutated allele (T) was 31.7% in the type II diabetes mellitus versus 31.1% of the controls. The homozygous mutation (T/T) in the MTHFR gene was identified in 12% of the type II diabetes mellitus versus 9.3% of the controls. Patients with the TT genotype showed a higher prevalence of LVH when compared to patients with the CC and CT genotypes (p = 0.01). The MTHFR gene C677T mutation may be a possible risk factor for the development of LVH in the type II diabetic patients.

Methylene Tetrahydrofolate Reductase C677T Mutation and Left Ventricular Hypertrophy in Turkish Patients with Type 2 Diabetes Mellitus

( Hulya Yilmaz ),( Bedia Agachan ),( Arzu Ergen ),( Zeynep Ermis Karaalib ),( Turgay Isbir ) 생화학분자생물학회 2004 BMB Reports Vol.37 No.2

This study was designed to investigate, in the Turkish population, the association of methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism and left ventricular hypertrophy (LVH) in patients with type II diabetes mellitus. Our study included 249 patients with type II diabetes mellitus (102 men, 147 women) and 214 healthy volunteers as controls (91 men, 123 women). MTHFR C677T genotypes were determined by polymerase chain reaction, restriction fragment length polymorphism techniques. No differences were observed in the distribution of MTHFR genotypes or allele frequencies in the cases versus the controls. The frequency of the MTHFR-mutated allele (T) was 31.7% in the type II diabetes mellitus versus 31.1% of the controls. The homozygous mutation (T/T) in the MTHFR gene was identified in 12% of the type II diabetes mellitus versus 9.3% of the controls. Patients with the TT genotype showed a higher prevalence of LVH when compared to patients with the CC and CT genotypes (p = 0.01). The MTHFR gene C677T mutation may be a possible risk factor for the development of LVH in the type II diabetic patients

Load balancing in 5G heterogeneous networks based on automatic weight function

Gures Emre,Shayea Ibraheem,Saad Sawsan Ali,Ergen Mustafa,El-Saleh Ayman A,Ahmed Nada M.O. Sid,Alnakhli Mohammad 한국통신학회 2023 ICT Express Vol.9 No.6

Load balancing is a major challenge in heterogeneous networks (HetNets) consisting of 5G and 6G ultra-dense small cells with long-term evaluation advanced (LTE-A) networks. A key factor in achieving efficient load balancing during user mobility is creating appropriate optimisation for handover control parameters (HCP). This paper proposes a coordinated load balancing algorithm for LTE-A/fifth generation (5G) HetNets. The algorithm automatically optimises HCP settings for a given user based on three bounded functions (the signal-to-interference-plus-noise ratio (SINR) of the user equipment (UE), the number of physical resource blocks (PRBs) per UE and the UE’s speed) as well as their automatic weight levels. A two-step target cell determination strategy is implemented according to the cell load level and RSRP criteria, ensuring that users are handed over to low-loaded target cells. A new HO procedure that considers the pilot signal power is also proposed, which includes the number of PRBs per UE and the RSRP. Cells with freer PRBs are prioritised in user association to provide load balance and enhanced throughput. The proposed load balancing algorithm is compared with five other load balancing algorithms selected from the literature. The simulation results reveal that under various mobile speed scenarios, the proposed load balancing scheme enhances network performance in terms of load level, throughput, spectral efficiency and call dropping ratio (CDR).

Evaluation of Internal Auditory Canal Structures in Tinnitus of Unknown Origin

Cahit Polat,Murat Baykara,Burhan Ergen 대한이비인후과학회 2014 Clinical and Experimental Otorhinolaryngology Vol.7 No.3

Objectives. The aim of the present study was to evaluate the internal auditory canal (IAC) and the nerves inside it to define possible structural differences in cases with subjective tinnitus of unknown origin. Methods. Cases applying to the ear, nose and throat department with the complaint of tinnitus with unknown origin and having normal physical examination and test results were included in the study (n=78). Patients admitted to the radi- ology clinic for routine cranial magnetic resonance imaging (MRI) and whose MRI findings revealed no pathologies were enrolled as the control group (n=79). Data for the control group were obtained from the radiology department and informed consent was obtained from all the patients. Diameters of the IAC and the nerves inside it were mea- sured through enhanced images obtained by routine temporal bone MRIs in all cases. Statistical evaluations were performed using Student t-test and statistical significance was defined as P<0.05. Results. Measurements of IAC diameters revealed statistically significant differences between the controls and the tinnitus group (P<0.05). Regarding the diameters of the cochlear nerve, facial nerve, inferior vestibular nerve, superior ves- tibular nerve, and total vestibular nerve, no statistically significant difference was found between the controls and the tinnitus group. Conclusion. Narrowed IAC has to be assessed as an etiological factor in cases with subjective tinnitus of unknown origin.

The Early Histological Effects of Intravesical Instillation of Platelet- Rich Plasma in Cystitis Models

M. İrfan Dönmez,Kubilay İnci,Naciye Dilara Zeybek,H. Serkan Doğan,Ali Ergen 대한배뇨장애요실금학회 2016 International Neurourology Journal Vol.20 No.3

Purpose: To evaluate the early histological effects of the intravesical instillation of platelet-rich plasma (PRP) in rabbit models of interstitial and hemorrhagic cystitis. Methods: Thirty-six rabbits were classified into 6 groups: saline (S), S+PRP, hydrochloric acid (HCl), HCl+PRP, cyclophosphamide (CyP), and CyP+PRP. At 48 hours after induction, PRP was prepared and intravesically administered to the S+PRP, HCl+PRP, and CyP+PRP groups. Bladder sections were stained with toluidine blue for mast cell counting and with hematoxylin and eosin for histopathology and mitotic index determination. The proliferation index was determined by proliferating cell nuclear antigen (PCNA) immunolabeling. The nonparametric Mann-Whitney U-test was used for statistical analysis. Results: No abnormalities were observed in the S group, whereas increased interstitial edema and increased average mitotic and proliferation indices were observed in the S+PRP group (P=0.023, P=0.004, and P=0.009, respectively). Intense epithelial loss, hemorrhage, and leukocyte infiltration were detected in the HCl and HCl+PRP groups, whereas a significantly increased average mitotic index was observed in the HCl+PRP group (P=0.002). When compared with its CyP counterpart, a significant reduction in hemorrhage and an increase in leukocyte infiltration and mitotic index were observed in the CyP+PRP group (P=0.006, P=0.038, and P=0.002, respectively). In addition, PCNA staining revealed a significantly increased proliferation index in the HCl+PRP and CyP+PRP groups (P=0.032 and P=0.015, respectively). Conclusions: The intravesical instillation of PRP increased the mitotic index in the saline and cyclophosphamide groups while decreasing macroscopic bleeding.