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      • SCOPUSKCI등재
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        Relationship between G-protein ${\beta}$3 Subunit C825T Polymorphism and Citalopram Responses in Korean Patients with Major Depressive Disorder

        Kang, Rhee-Hun,Hahn, Sang-Woo,Choi, Myoung-Jin,Lee, Hwa-Young,Chang, Hun-Soo,Jeong, Yoo-Jung,Paik, Jong-Woo,Lim, Se-Won,Kim, Young-En,Lee, Min-Soo The Korean Society of Toxicogenomics and Toxicopro 2008 Molecular & cellular toxicology Vol.4 No.4

        This study aimed to determine the relationship between the C825T polymorphism in the G-protein ${\beta}$3-subunit (GNB3) gene and the response to citalopram in a Korean population with major depressive disorder (MDD). Citalopram was administered for 8 weeks to the 84 MDD patients who completed this study. All subjects were examined using the Structured Clinical Interview for DSM-IV, and the severity of depression was assessed using the 21-item Hamilton Depression Rating (HAMD-21) scale. A main effect of an interaction of genotype with time on the decrease in the HAMD-21 score during the 8-week study period was not found. ANOVA revealed no significant effects of the GNB3 C825T polymorphism on the decrease in the HAMD-21 score at each time period. Although the C825T polymorphism of the GNB3 gene may affect the pathogenesis of MDD, our results do not support the hypothesis that this polymorphism is involved in the therapeutic response to citalopram in Korean patients with MDD.

      • KCI등재

        운동과 식이요법의 병행이 신체구성의 추이에 미치는 영향

        장혁기,김재훈,전태원,김용권,이복은,한구석,진영수 대한스포츠의학회 1998 대한스포츠의학회지 Vol.16 No.1

        The purpose of this study was to investigate the effect of the aerobic exercise and weight training combined with low-calorie diet on the changes of the body composition during 12 weeks. The subjects were selected with 10 females over 30% body fat without risk factor during training. They did not have attended in any obese therapy course before. Exercise regimen was composed with aerobic exercise and weight training program, 2hrs·day-1, 4days·week-1. The intensity of aerobic exercise and weight training were 50% of HRR, 50% of 1RM(10 rep., 3sets) respectively. The calorie restrict regimen was LCD(low-calorie diet) of 1000∼1500 kcal·day-1(approximately 15 kcal per kg). The body composition was measured to the weight, %body fat, FFM, WHR at pre-test, 3, 6, 9 and 12week. The one-way repeated ANOVA was used and Duncan was treated for the post hoc testing(p<.05). 1. Body weight was decreased from pre-test to 12week by 11.8±4.0kg. The changes of the weight was significantly decreased among from pre-test to 3, 3 to 6 and 6 to 9 week(p<.01). There was not significantly different during 9 to 12 week(p<.05). 2. %Body fat was decreased from pre-test to 12week by 10.8±3.2%. The change of %body fat was significantly decreased among from pre-test to 3, 3 to 6 and 9 to 12 week(p<.01). There was not significantly different during 6 to 9 week(p<.05). 3. FFM was decreased from pre-test to 12 week by 4.6±4.7kg. The change of FFM was significantly decreased during the whole test(p<.05). 4. WHR was decreased by 4.8±5.8 from pre-test to 12 week. The change of WHR was significantly decreased from 3 to 6 week(p<.01). There was not significantly different from pre-test to 3, 6 to 9 to 12 week(p<.05).

      • SCOPUSKCI등재

        한국인 A 형 간염 환자에서 A 형 간염 바이러스의 유전자형에 관한 연구

        권오상,송기준,박상훈,송진원,김재선,김종헌,변관수,이창홍,연종은,백락주,박영태 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.3

        $quot;목적: 한국에서 과거 A형 간염은 낙후된 개인위생 및 자연환경으로 유소아기에 불현성 감염으로 앓고 지나가게 되어 청소년 및 성인에서 HAV에 대한 항체 보유율이 매우 높고 성인에서의 급성 A형 간염은 매우 드물게 보고되었다. 그러나 고도의 경제성장과 더불어 식생활, 위생상태의 개선, 상하수도의 보급 등으로 유소아기의 A형 간염 이환율이 현격히 감소하면서 청소년 및 성인에서 HAV 항체가 없는 인구집단 즉 HAV에 감염되면 현증 간염이 발생할 수 있는 인구 집단이 증가되어 최근 수 년 사이에 현증 A형 간염이 폭발적으로 증가하게 되었다. 이에 저자는 HAV의 유전자형을 알아보고 이미 보고된 각국의 HAV와 연관성을 알아보고자 본 연구를 시행하였다. 대상과 방법: 1994년부터 1998년까지 한국에서 산발적으로 발생한 18예의 A형 간염 환자의 혈청에서 HAV RNA를 추출, 역전사-중화효소 연쇄반응법(RT-PCR)으로 증폭하여 직접 염기서열의 분석을 통해 국내 HAV 사이에 염기서열, 아미노산의 차이 등을 알아보고 세계 각국에서 보고되었던 HAV 분리주들과 비교하였다. 결과: HAV 게놈의 특정부위인 VP1/2A 연결부위 168 bp 길이에서 시행한 염기서열 분석 결과 한국에서 분리된 18예의 HA이러스는 최근 해외에서 유입된 바이러스일 가능성은 적으며 따라서 장기간 국내에서 토착화된 바이러스일 것으로 생각된다. $quot;Background/Aims: Studies of genotypes and changes in nucleotide and amino acid sequences of hepatitis A virus (HAV) may provide valuable information on the epidemiological aspects of a particular region. In Korea the prevalence of anti-HAV in the 1 - 20 year age group declined from 60% in 1980 to 9% in 1995. As a result this age group has a high risk of HAV infection. Actually over 1,500 cases of clinically overt hepatitis A occurred in 1998 while few cases of clinical hepatitis A had been reported until the early 1990s. The aims of this study are to determine the genotypes of HAV which have been circulating in Korea and to define the phylogenetic relationships of geographically defined isolates. Method: From 1994 - 1998 a total of 18 serum specimens was obtained from patients in Korea with sporadic form acute hepatitis A. The HAV nucleic acid from serum specimens was subjected to genomic sequence analysis following viral RNA extraction, reverse transcription and amplification of the cDNA by PCR. DNA sequencing was performed in both directions of each PCR product. Results: All isolates clustered within the subgenotype IA irrespective of the geographic locations and timing of the clinical hepatitis. Among 18 Korean isolates, 9 isolates had 2 amino acid sequence changes and 2 isolates had 1 amino acid sequence change. These changes in the amino acid sequences are unique and have never been reported in HAV subgenotype IA. Conclusions: All isolated HAV had genotype (IA). Eleven of 18 isolates had unique changes in amino acid sequences. These data indicate that the endemic HAV has been circulating in Korea over a long period of time.

      • SCOPUSKCI등재

        Geosynchronous Magnetic Field Response to Solar Wind Dynamic Pressure

        Park, Jong-Sun,Kim, Khan-Hyuk,Lee, Dong-Hun,Lee, En-Sang,Jin, Ho 한국우주과학회 2011 Journal of Astronomy and Space Sciences Vol.28 No.1

        The present study examines the morning-afternoon asymmetry of the geosynchronous magnetic field strength on the dayside (magnetic local time [MLT] = 06:00~18:00) using observations by the Geostationary Operational Environmental Satellites (GOES) over a period of 9 years from February 1998 to January 2007. During geomagnetically quiet time (Kp < 3), we observed that a peak of the magnetic field strength is skewed toward the earlier local times (11:07~11:37 MLT) with respect to local noon and that the geosynchronous field strength is larger in the morning sector than in the afternoon sector. That is, there is the morning-afternoon asymmetry of the geosynchronous magnetic field strength. Using solar wind data, it is confirmed that the morning-afternoon asymmetry is not associated with the aberration effect due to the orbital motion of the Earth about the Sun. We found that the peak location of the magnetic field strength is shifted toward the earlier local times as the ratio of the magnetic field strength at MLT = 18 (B-dusk) to the magnetic field strength at MLT = 06 (B-dawn) is decreasing. It is also found that the dawn-dusk magnetic field median ratio, B-dusk/B-dawn, is decreasing as the solar wind dynamic pressure is increasing. The morning-afternoon asymmetry of the magnetic field strength appears in Tsyganenko geomagnetic field model (TS-04 model) when the partial ring current is included in TS- 04 model. Unlike our observations, however, TS-04 model shows that the peak location of the magnetic field strength is shifted toward local noon as the solar wind dynamic pressure grows in magnitude. This may be due to that the symmetric magnetic field associated with the magnetopause current, strongly affected by the solar wind dynamic pressure, increases. However, the partial ring current is not affected as much as the magnetopause current by the solar wind dynamic pressure in TS-04 model. Thus, our observations suggest that the contribution of the partial ring current at geosynchronous orbit is much larger than that expected from TS-04 model as the solar wind dynamic pressure increases.

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