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Hwang, Doyeon,Jeong, Hee-Jin,Kwon, Jin-Kyung,Kim, Hohyun,Kang, Si-Yong,Kang, Byoung-Cheorl Cambridge University Press 2014 Plant genetic resources Vol.12 No.1
<P>Induction of mutations using chemical mutagens has proved to be a useful tool in crop improvement and has advantages over transgenic approaches in view of legislative restrictions and intellectual property. Among the chemical mutagens, ethyl methanesulfonate (EMS) has been widely used to generate novel traits. In this study, we constructed an EMS mutant population consisting of 3945 M2 mutant lines using a Korean landrace of <I>Capsicum annuum</I> ‘Yuwol-cho’. In total, 1480 M2 mutant lines were evaluated for novel traits. The mutant lines showed phenotypic variations such as plant growth (small size and dwarfism), development of leaves (variegation, colour and morphological changes), flowers (inflorescence, morphological and organ colour changes), and fruits (morphological and colour changes). Most of these mutant phenotypes were inherited recessively. Many of the mutant phenotypes were unique in pepper, while some were similar to those of known mutants in other plant species. These mutant lines will be useful for the study of gene function in <I>C. annuum</I>.</P>
Development of an EMS Mutant Population in Capsicum
Doyeon Hwang,Hee-Jin Jeong,Goeun Han,Jin-Kyung Kwon,Byoung-Cheorl Kang 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
Mutant populations generated by ethyl methanesulfonate (EMS) have been used for crop improvement and functional genomics. Since pepper is very recalcitrant to be transformed, EMS mutagenesis can be a very useful to generate useful alleles and to characterize the function of genes. We have been developing a mutant population aiming at 5,000 mutants by treating EMS on seeds of C. annuum ‘Yuwolcho’. A total of 4,300 M1 mutants have been developed until now. Among the 4,300 M1 population, almost 800 M2 mutant lines have been phenotyped and evaluated to confirm the effect of EMS. We categorized seven key organ development and subdivided them into twenty secondary categories. Among them, 50 and 72 families have been shown variations in plant growth and leaf development, respectively. In addition, we detected nucleotide variations using HRM analysis in eIF4E and putative aminotransferase genes. These results demonstrated that our mutant population can be very useful for study function of genes in near future.
Prognostic Impact of β-Blocker Dose After Acute Myocardial Infarction
Hwang, Doyeon,Lee, Joo Myung,Kim, Hyun Kuk,Choi, Ki Hong,Rhee, Tae-Min,Park, Jonghanne,Park, Taek Kyu,Yang, Jeong Hoon,Song, Young Bin,Choi, Jin-Ho,Hahn, Joo-Yong,Choi, Seung-Hyuk,Koo, Bon-Kwon,Kim, Y UNKNOWN 2019 CIRCULATION JOURNAL Vol.83 No.2
Effects of Statin Intensity on Clinical Outcome in Acute Myocardial Infarction Patients
Hwang, Doyeon,Kim, Hyun Kuk,Lee, Joo Myung,Choi, Ki Hong,Kim, Jihoon,Rhee, Tae-Min,Park, Jonghanne,Park, Taek Kyu,Yang, Jeong Hoon,Song, Young Bin UNKNOWN 2018 Circulation journal Vol.82 No.4
<P>Conclusions: When adequate LDL-C level is achieved, patients on a low-moderate-intensity statin dose have similar cardiovascular outcomes to those on high-intensity statins.</P>
Physiologic Assessment after Coronary Stent Implantation
Doyeon Hwang,Seokhun Yang,Jinlong Zhang,Bon-Kwon Koo 대한심장학회 2021 Korean Circulation Journal Vol.51 No.3
The presence of myocardial ischemia is a prerequisite for the benefit of coronary revascularization. In the cardiac catheterization laboratory, fractional flow reserve and non-hyperemic pressure ratios are used to define the ischemia-causing coronary stenosis, and several randomized studies showed the benefit of physiology-guided coronary revascularization. However, physiology-guided revascularization does not necessarily guarantee the relief of ischemia. Recent studies reported that residual ischemia might exist in up to 15–20% of cases after angiographically successful percutaneous coronary intervention (PCI). Therefore, post-PCI physiologic assessment is necessary for judging the appropriateness of PCI, detecting the lesions that may benefit from additional PCI, and risk stratification after PCI. This review will focus on the current evidence for post-PCI physiologic assessment, how to interpret these findings, and the future perspectives of physiologic assessment after PCI.
The Effects of Preoperative Aspirin on Coronary Artery Bypass Surgery: a Systematic Meta-Analysis
Doyeon Hwang,Joo Myung Lee,Tae-Min Rhee,Young-Chan Kim,Jiesuck Park,Jonghanne Park,Chul Ahn,Young Bin Song,Joo-Yong Hahn,Ki-Bong Kim,Young-Tak Lee,Bon-Kwon Koo 대한심장학회 2019 Korean Circulation Journal Vol.49 No.6
Background and ObjectivesAspirin plays an important role in the maintenance of graft patency and the prevention of thrombotic event after coronary artery bypass graft surgery (CABG). However, the use of preoperative aspirin is still under debate due to the risk of bleeding. MethodsFrom PubMed, EMBASE, and Cochrane Central Register of Controlled Trials, data were extracted by 2 independent reviewers. Meta-analysis using random effect model was performed. ResultsWe performed a systemic meta-analysis of 17 studies (12 randomized controlled studies and 5 non-randomized registries) which compared clinical outcomes of 9,101 patients who underwent CABG with or without preoperative aspirin administration. Preoperative aspirin increased chest tube drainage (weighted mean difference 177.4 mL, 95% confidence interval [CI], 41.3–313.4; p=0.011). However, the risk of re-operation for bleeding was not different between the preoperative aspirin group and the control group (3.2% vs. 2.4%; odds ratio [OR], 1.23; 95% CI, 0.94–1.60; p=0.102). There was no difference in the rates of all-cause mortality (1.6% vs. 1.5%; OR, 0.98; 95% CI, 0.64–1.49; p=0.920) and myocardial infarction (MI) (8.7% vs. 10.4%; OR, 0.83; 95% CI, 0.66–1.04; p=0.102) between patients with and without preoperative aspirin administration. ConclusionsAlthough aspirin increased the amount of chest tube drainage, it was not associated with increased risk of re-operation for bleeding. In addition, the risks of early postoperative all-cause mortality and MI were not reduced by using preoperative aspirin.
Characterization of an ethyl methane sulfonate (EMS) mutant lines in C.annuum.
Doyeon Hwang,Hee-Jin Jeong,Jin-Kyung Kwon,Si-Yong Kang,Byoung-Cheorl Kang 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07
Mutant lines induced by ethyl methane sulfonate (EMS) have been used for crop improvement and functional genomics. Since pepper is very recalcitrant to be transformed, EMS mutagenesis could be an alternative method to generate useful mutant lines and to characterize the function of genes. We have developed mutant lines consisting of about 3,938 M2 mutant lines using Korea local landrace, C. annuum ‘Yuwolcho’. Yuwolcho has suitable traits for mutagenesis such as early flowering and maturation, large number of seeds per fruit, and susceptibility to various diseases. Up to now, 917 M2 mutant lines were evaluated to confirm the effect of EMS. M2 mutant lines have shown variations in plant stature (small size, dwarfism, and early death), leaf development (light color, variegation and morphological change) and flower (inflorescence, morphological change) and fruit (size and color). We observed the largest morphological variation in leaf development. Most of these mutant phenotypes were inherited recessively. In addition, we are applying cel1-based TILLING to identify useful mutant lines. We will apply cel1-based TILLING to identify useful mutant lines. We are expecting that these mutant lines will be very useful to study the function of genes in C. annuum.
차량용 SoC의 신뢰성 향상을 위한 CAN 통신 기반의 고장진단 플랫폼 설계
황도연(Doyeon Hwang),김두영(Dooyoung Kim),박성주(Sungju Park) 대한전자공학회 2015 전자공학회논문지 Vol.52 No.10
전자 산업의 발달과 함께 많은 전자 제어 장치가 차량 내부에 탑재됨에 따라 차량의 기능을 검증하는 것은 더더욱 어려워지고 있다. 차량의 기능 오작동은 인명손실의 우려가 있기 때문에 차량에 있어서 신뢰성은 무엇보다 중요하게 고려되어야 한다. 본 논문에서는 차량의 신뢰성 향상을 위한 CAN 통신 기반의 고장 진단 플랫폼을 제안한다. 양산 이후에도 독립적인 테스트 경로를 통한 구조적 테스트를 실시함으로써 차량의 신뢰성은 크게 증가할 것이다. 또한, 별도의 테스트 핀이 필요하지 않기 때문에 테스트 비용을 절감할 수 있다. To verify the function of vehicle is becoming more and more difficult because many electronic control units have been embedded in vehicle with development of electronics industry. The reliability of vehicle should be considered above all important because malfunction of vehicle can cause damage of human life. In this paper, defect diagnosis platform based on CAN network is proposed to improve the reliability of vehicle. Reliability of vehicle is significantly increased by adopting the structural test via dedicated test path after manufacturing. Besides, the test cost is reduced because additional test pins are not required.