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Drug stabilization and controlled release from AB3 type tetra block copolymer based polymersome
Dooyong Jeong,서석진,나건 한국약제학회 2012 Journal of Pharmaceutical Investigation Vol.42 No.2
In order to increase the bioavailability of hydrophilic unstable drugs, polymersomes from AB3 type tetra block copolymers composing of poly(ethylene glycol)-b-(3) poly(lactic acid) (EO-3LA) as a water-soluble drug delivery carrier have been investigated due to its unique properties such as high stability and high water soluble drug loading efficiency. The sizes of EO-3LA polymersomes determined by dynamic light scattering were ranged in 190–220 nm with monodispersion. Its polymeric layer with 10–20 nm at the outershell was observed by field emission scanning electron microscopy. The polymersomes showed low critical aggregation concentrations (9.2–14.9 ug/ml). Anthocyanin was employed as a model drug for unstable drug in this study. The anthocyanin loading contents of EO-3LA polymersomes are depending on PLLA content in the polymers. The high loading contents (6.6–7.0 wt%) of the polymersomes are due to their tight and rigid polymeric membranes. The polymeric membrane in EO-3LA polymersomes contributed to improve drug stability on various pHs. Moreover,this property induced sustained anthocyanin release pattern from the polymersome. Therefore, the polymersome has potential as a drug carrier for water-soluble and unstable drugs.
Park, Dooyong,Ju, Youngsan,Kim, Jeong-Hoon,Ahn, Hyungwoong,Lee, Chang-Ha Elsevier Science B.V 2019 Separation and purification technology Vol.223 No.-
<P><B>Abstract</B></P> <P>To evaluate candidate adsorbents for the recovery of nitrous oxide (N<SUB>2</SUB>O) from adipic acid off-gases, the equilibrium and kinetics of N<SUB>2</SUB>O and O<SUB>2</SUB> adsorption on activated carbon (AC) and of N<SUB>2</SUB>O, O<SUB>2</SUB>, and N<SUB>2</SUB> adsorption on a carbon molecular sieve (CMS) were evaluated at 293, 308, and 323 K under pressures up to 1000 kPa using a high-pressure volumetric system. Adsorption amount of N<SUB>2</SUB>O on AC and CMS exceeded those of N<SUB>2</SUB> and O<SUB>2</SUB>, and the adsorption isotherms for O<SUB>2</SUB> and N<SUB>2</SUB> were similar. The experimental N<SUB>2</SUB>O and O<SUB>2</SUB> uptakes on AC and CMS were fitted to a non-isothermal adsorption model, whereas the model was ineffective for predicting N<SUB>2</SUB> uptake on CMS. The isothermal dual-resistance model, considering surface barrier resistance and pore diffusion, adequately predicted N<SUB>2</SUB> uptake on CMS. The rate of adsorption of N<SUB>2</SUB>O on AC was much lower than that of O<SUB>2</SUB> and N<SUB>2</SUB> whereas the rate of adsorption on CMS flowed the order: O<SUB>2</SUB> > N<SUB>2</SUB>O ≫ N<SUB>2</SUB>, even though N<SUB>2</SUB>O has higher adsorption affinity and smaller kinetic diameter than O<SUB>2</SUB>. The Lewis structure of N<SUB>2</SUB>O was also found to influence the adsorption kinetics.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Adsorption of N<SUB>2</SUB>O on activated carbon and carbon molecular sieve was studied. </LI> <LI> The adsorbed amount of N<SUB>2</SUB>O on AC and CMS was much greater than those for O<SUB>2</SUB> and N<SUB>2</SUB>. </LI> <LI> The adsorption rate of N<SUB>2</SUB>O was slower than N<SUB>2</SUB> on AC, but much faster than N<SUB>2</SUB> on CMS. </LI> <LI> The adsorption rate of N<SUB>2</SUB>O was affected by the kinetic diameter and Lewis structure. </LI> </UL> </P>
변성 폴리아미드 수지를 혼입한 수용성 실리콘 아크릴 주차장 바닥재의 윤하중 저항성능에 관한 실험적 연구
정호성 ( Jeong Hoseong ),공준호 ( Gong Junho ),한경봉 ( Han Kyoungbong ),조두용 ( Cho Dooyong ) 한국구조물진단유지관리공학회 2018 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.22 No.1
The purpose of this experimental study is to develop the waterborne silicon acrylic finishing material of parking lots. Resistance-Wheel moving load test was conducted in order to supply basic datum for developing the material by implementing modified polyamide resin. As a result, all the specimens were satisfied by the quality standard regarding dynamic wheel load resistance which is prescribed in KS F 4937. As conclusion, this study confirmed that developed finishing material could be an optimum surface finishing material capable of applying for parking lots’ floors.
변성 폴리아미드 수지를 혼입한 수용성 실리콘 아크릴 주차장 바닥재의 부착 성능 시험에 관한 연구
정호성 ( Jeong Hoseong ),공준호 ( Gong Junho ),최진웅 ( Choi Jingwoong ),조두용 ( Cho Dooyong ) 한국구조물진단유지관리공학회 2018 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.22 No.1
The purpose of this experimental study is to develop the waterborne silicon acrylic surface finishing material of parking lots. Adhesion strength experiment was conducted in order to enhance performance of the finishing material by adopting modified polyamide resin. The results qualified the standard regarding bond strength which is prescribed in KS F 4937. They are confirmed that the strength tend to increase as the amount of polyamide increased and could be an optimum surface finishing material applicable for parking lot floor.
수용성 실리콘 아크릴 주차장 표면 바닥 마감재의 오염물질 방출량 평가
정호성 ( Jeong Hoseong ),공준호 ( Gong Junho ),최진웅 ( Chio Jinwoong ),조두용 ( Cho Dooyong ) 한국구조물진단유지관리공학회 2018 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.22 No.1
The purpose of this experimental study is to develop the waterborne silicon acrylic surface finishing material of parking lots. Pollutant emission test was conducted in order to give a guide datum for developing the material by implementing modified polyamide resin. As a result, specimens satisfied with the quality standard regarding TVOc, HCHO, Toluene which is prescribed in KS F4937. As conclusion, this study confirmed that the developed finishing material could be an optimized surface finishing material usable for parking lot floor.