http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Je‑Oh Lim,Je‑Won Ko,Tae‑Yang Jung,Woong‑Il Kim,So‑Won Pak,In‑Sik Shin,Won‑Kee Yun,Hyoung‑Chin Kim,Jeong‑Doo Heo,Jong‑Choon Kim 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3
Background Silica dioxide nanoparticles (SiONPs) have been used for various medical applications, including therapeutics and imaging, and the use of SiONPs has increased gradually over the years. However, despite an increase in the use of SiONPs, not much is known about mechanism of action of SiONPs and their pulmonary toxicity. Objective The present study investigated the pulmonary toxicity of SiONPs and explored the underlying mechanism of action, primarily focusing on thioredoxin-interacting protein (TXNIP)/NOD-like receptor pyrin domain-containing 3 (NLRP3) in SiONPs-treated mice. We investigated the toxic effects of SiONPs in the lung of BALB/c mice administered 5, 10, and 20 mg/kg SiONPs for 3 days. Results Exposure to SiONPs markedly increased inflammatory cell counts, including those of neutrophils and macrophages, and levels of inflammatory mediators, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α in a dose-dependent manner in the bronchoalveolar lavage fluid. Moreover, the inflammation was verified upon histopathological analysis. In addition, exposure to SiONPs increased the expression of TXNIP in a dose-dependent manner and, in turn, upregulated NLRP3 inflammasome proteins, which subsequently induced IL-1β production. Conclusion Collectively, exposure to SiONPs induced inflammation in the lungs of mice, which resulted in the activation of IL-1β production via the TXNIP-NLRP3 axis. Our results provide useful information on the pulmonary toxicity induced by SiONPs and provide insights into the underlying mechanism of action.
포름알데하이드에 폭로된 해부학 실습 학생들의 임파구 자매염색분체교환
백두진,주수자,김기영,이수진,심상효,손정일,심성한,송재철,조율희 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.2
Sister-chromatid exchanges measured in the peripheral lymphocytes of 15 non-smoking medical students after exposure to formaldehyde during 24-week anatomy class showed a small but significant (p=0.0468) increase when compared with samples obtained from the same individuals immediately before exposure. Mean frequencies of sister-chromatid exchange of cultured peripheral lymphocytes were 5.40±0.24 from the samples before exposure and 5.87±0.22 from the same samples after exposure. Breathing-zone air samples collected by formaldehyde monitoring kit with digital colorimeter(SKC) showed a mean concentration of 0.72±0.02 ppm formaldehyde.
흥미로운 구조를 가진 Dipyrrolylbenzene들의 합성에 관한 연구
정대일,김인식,정두희,박철우,김윤영 東亞大學校 大學院 1996 大學院論文集 Vol.21 No.-
1-(2-Aminophenyl)pyrrole 20a and 1,2-dipyrrolylbenzene 17a were synthesized by using 1,2-phenylenediamine 16a with 2,5-dimethoxytetrahydrofuran 12 in glacial acid. 1-(3-Aminophenyl)pyrrole 20b and 1,3-dipyrrolylbenzene 17b were obtained by using 1,3-phenylenediamine 16b with 2,5-dimethoxytetrahydrofuran 12 in glacial acetic acid. 1,4-Dipyrrolybenzene 17c was synthesized by using 1,4-phenylenediamine 16c with 2,5-dimethoxytetrahydrofuran 12 in glacial acetic acid. Aminophenylpyrroles 20 and dipyrrolylbenzenes 17 were respectively synthesized by the treatment of 1,2-phenylenediamine 16a, 13-phenylenediamine 16b, 1,4-phenylenediamine 16c and 2,5-dimethoxytetrahydrofuran 12 in no solvent, acrylic acid, silica-gel, acrylic acid + silica-gel + acetic acid instead of glacial acetic acid. In case of silica-gel + acetic acid among various methods reactivity about synthesis of dipyrrolylbenzene 17 was best. 9-Phenylcarbazole 15 was synthesized by treatment of 1-phenylpyrrole 13 with 2,5-dimethoxytetrahydrofuran 12 in glacial acetic acid.
Improvement of Rice Fertility of Breeding Lines in Cold Water Treatment Screening
Jin Chul Shin,Sang Bok Lee,Jong Min Jeong,Jeong Heui Lee,Jeong Il Lee,O Young Jeong,Yong Hwan Choi,Chang Ihn Yang,Im Soo Choi,Eung Gi Jeong,Woon Ho Yang,Dae Ha Seo,Jong Doo Yae 한국육종학회 2011 한국육종학회 학술발표회 발표요지 Vol.43 No.-
Jeong, Yong Jin,Koo, Won-Tae,Jang, Ji-Soo,Kim, Dong-Ha,Kim, Min-Hyeok,Kim, Il-Doo American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.2
<P>PtO2 nanocatalysts-loaded SnO2 multichannel nanofibers (PtO2-SnO2 MCNFs) were synthesized by single-spinneret electrospinning combined with apoferritin and two immiscible polymers, i.e., poly(vinylpyrrolidone) and polyacrylonitrile. The apoferritin, which can encapsulate nanoparticles within a small inner cavity (8 nm), was used as a catalyst loading template for an effective functionalization of the PtO2 catalysts. Taking advantage of the multichannel structure with a high porosity, effective activation of catalysts on both interior and exterior site of MCNFs was realized. As a result, under high humidity condition (95% RH), PtO2-SnO2 MCNFs exhibited a remarkably high acetone response (R-air/R-gas = 194.15) toward 5 ppm acetone gases, superior selectivity to acetone molecules among various interfering gas species, and excellent stability during 30 cycles of response and recovery toward 1 ppm acetone gases. In this work, we first demonstrate the high suitability of multichannel semiconducting metal oxides structure functionalized by apoferritin-encapsulated catalytic nanoparticles as highly sensitive and selective gas-sensing layer.</P>