40ㆍ50대 일부 남성근로자의 골감소증 및 골다공증 유병실태와 위험요인

장윤균,서현주,진영우,정미선,성숙희,박두용,김종순,김수근 大韓産業醫學會 2006 대한직업환경의학회지 Vol.18 No.2

목적: 최근 국내에서도 골다공증과 관련된 생활양식의 규명에 관한 연구가 이루어지고 있으나, 아직까지 남성 골다공증에 대한 연구가 활발하게 이루어지지 않아 40, 50대 남성근로자를 대상으로 유병률을 파악하고, 골감소증 및 골다공증 관련 위험요인을 확인하고자 하였다. 방법: 원자력발전소에 근무하는 40, 50대 남성 근로자 2,073명을 대상으로 2004년 3월~7월 기간동안 생활습관을 파악하기 위하여 자기기입식 전산입력 방식으로 최종학력, 흡연여부, 음주여부, 신체활동 횟수를 조사하였고, 골밀도검사, 체성분검사(체지방률, 허리-엉덩이둘레비), 신체계측(신장, 체중)을 시행하였고, 골밀도 검사는 Osteosys사의 EXE-3000을 이용하여 종골부위를 측정하였고, 체지방률, 허리-엉덩이 둘레비는 Biospace사의 Inbody 3.0을 이용하여 측정하였다. 통계분석은 골감소증 및 골다공증의 관련요인을 분석하기 위해 다중로지스틱회귀분석을 시행하였다. 결과: 연구대상자의 골감소증 및 골다공증 유병률은 22.8%와 3.0%이었으며, 골감소증 및 골다공증의 관련요인으로는 연령이 증가할수록, 흡연자이거나 과거흡연자일 경우, 체질량지수가 25 kg/m^(2) 미만일 경우, 30분 이상 신체활동 횟수가 주 3회 미만일 경우가 유의한 연관성이 있었다. 결론: 성인 남성 40, 50대의 골감소증 및 골다공증의 유병률이 높은 편이었으며, 골감소증 및 골다공증으로 이환을 예방하기 위하여 금연, 활발한 신체활동을 촉진하여 골밀도를 개선시키는 생활습관으로의 변화를 권고해야 할 것이다. Objective: This study was conducted to investigate the prevalence and risk factors of osteopenia and osteoporosis in 40-59 year-old male workers working at nuclear power plants. Methods: Bone density, body composition, and anthropometry data were analyzed for 2,073 subjects were carried out from March 2004 to July, 2004. Educational level, smoking status, drinking status and frequency of physical activity were investigated by self-reported questionnaires through internet to identify lifestyles related to bone mass density. Bone mass density was measured by EXE-3000 of Osteosys Co. And body fat percentage, and waist-to-hip ratio by inbody 3.0 of Biospace Co. Results: The prevalence of ostepeniaosteopenia and osteoporosis was 22.8% and 3.0%, respectively. According to multinominal multinomial logistic regression analysis, age, smoking status (current smoker and former smoker), low body mass index (< 25kg/m^(2)), and frequency of physical activity were significantly associated with osteopenia and osteoporosis. Conclusions: The prevalence of ostcopenia and osteoporosis wasseemed high for the, when it was inferred from subjects' age compared to the results of previous studies. The This study results suggeststhat it is necessary for 40-59 year-old male workers to stop smoking, and exercise regularly in order to prevent osteopenia and osteoporosis.

KAERI 부지 주변의 환경선량 측정을 위한 온라인 감마선량 감시시스템

이정호,박두원,이원윤,이현덕,최용호,김삼랑,홍광희,이창우 대한방사선 방어학회 1994 방사선방어학회지 Vol.19 No.2

환경감마선량 변동을 감시하기 위해 한국원자력연구소 부지 주변에 온라인 감마선량 감시망을 구성하였다. 모니터링 포스트에 설치된 전리함 검출기에 의해 측정된 자료는 무선전송방식으로 중앙통제소에 전송되어 실시간으로 감시된다. 무선전송 방식은 자료의 전송, 처리 및 자자에 신뢰도가 높고 경제적이었다. 감시시스템은 급격한 선량증가시 조기경보체제와 연결할 수 있게 하였다. On-line gamma monitoring system around KSERI-site was set up to monitor the radiation fluctuations in environment. Data on gamma exposure rates measured by the ionication chamber in the monitoring posts are transmitted to a computer of central control station with radio telemetry transmission and reliable on handing and storing of data. This monitroing system can triger an early warning system in the event of abnormal radiation levels.

관상동맥 스텐트 삽입술 후 항합요법의 무작위 비교

윤영섭,이두희,편욱범,김인재,장양수,조승연,심원흠 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.7

비소세포 폐암종에서 Cyclin D1, p21 및 p53단백의 발현과 예후와의 관계

양석우,조상호,양우익,정우희,안철민,이두연 대한병리학회 1999 Journal of Pathology and Translational Medicine Vol.33 No.12

Nortropinone 유도체로부터 Nortropane Spirohydantoin 유도체의 합성

정대일,박유미,박종훈,김윤영,정두희,김인식 東亞大學校 1998 東亞論叢 Vol.35 No.-

The nortropinones 11 (tropinone lla, N-isopropylnortropinone 11b, N-Carbethoxynortropinone 11c, N-furfurylnortropinone 11d, N-(p-methoxyphenyl)nortropinone 11e) were respectively synthesized by the treatment of acetonedicarboxylic acid 8 with, 2, 5-dimethoxytetrahydrofurane 9 in various amines 10 (methylamine 10a, N-isopropylamine 10b, ethylcarbamate 10c, furfurylamine 10d, p-anisidine 10e). The nortropane spirohydantoins 14 (tropane spirohydanttoin 14a, N-isopropylnortropane spirohydantoin 14b, N-Carbethoxynortropane spirohydantoin 14c, N-furfurylnortropane spirohydantion 14d, n_(p-methoxyphenyl) nortropane spirohydantoin 14e) were respectively synthesized by the treatment of synthesized nortropinones 11 (tropinone 11a 54%, N-isopropylnortropinone 11b 50%, N-Carbethoxynortropinone 11c 58%, N-furfurylnortropinone 11d 31%, N-(p-methoxyphenyl) nortropinone 11e, 70%) with potassium cyanide 12, ammonium carbonate 13.

유착성 관절낭염 치료에 있어서 한방 치료와 양방 치료의 임상적 고찰 : 동서협진 모델 개발을 위한 기초 연구를 중심으로

남동우,정인태,김주희,박유선,임사비나,이두익,이재동,이윤호,최도영 경희대학교 동서의학연구소 2006 東西醫學硏究所 論文集 Vol.2006 No.-

Objectives : To observe the effect of acupuncture treatment and western medical treatment on frozen shoulder patients. Methods : 39 voluntary patients were randomly assigned to the Eastern treatment group(E group, n=22) and the Western treatment group(W group, n=17). The E group received acupuncture treatment on LI15, TE14, GB21 and Master Dong's acupuncture points, Shin-gwan and Gyun-joong, twice a week for 4 weeks. The W group received suprascapular nerve block, subacromial injection and trigger point injection, twice a week for 4 weeks. Both groups were instructed to practice self exercise during their daily lives. Evaluations were made before treatment and after treatment using Constant Shoulder Assessment(CSA), Shoulder Pain and Disability Index(SPADI) and the patient's satisfaction concerning the treatment was measured by Visual Analogue Scale(VAS). The obtained data were analyzed and compared. Results : The E group showed significant improvement(p<0.05) according to the CSA and SPADI. The patient's satisfaction scored 5.67 on a scale of 10. The W group showed significant improvement(p<0.05) according to the CSA and SPADI. The patient's satisfaction scored 7.73. But the difference between the two groups were insignificant according to CSA and SPADI. Conclusion : Both acupuncture and nerve block treatment significantly improved frozen shoulder. But the difference of the two treatments was insignificant.

Thioamide와 Benzothiazole 유도체의 합성

정대일,신규하,김인식,김윤영,정두희,이용균 東亞大學校 1998 東亞論叢 Vol.35 No.-

The thioamides; {N-(6-methyl-2-pyridinecarbothionyl)-3-methoxyaminobenzene (27), N-(6-methyl-2-pyridinecarbothionyl)-4-methoxyaminobenzene (29), N-(6-methyl-2-pyridine-carbothionyl)-3-ethoxyaminobenzene (31), N-(6-methyl-2-pyridinecarbothionyl)-4-ethoxyamion-benzene (33), N-(6-methyl-2-pyridinecarbothionyl)-3-bromoaminobenzene (35), N-(6-methyl-2-pyridinecarbothionyl)4-bromoaminobenzene (37), N-(6-methyl-2-pyridinecarbothionyl)-3-chloroaminobenzene (39), N-(6-methyl-2-pyridinecarbothionyl)-4-chloroaminobenzene (41)} were synthesized by the treatment of 2,6-lutidine(22) with sulfur in aniline derivatives (23). The benzothiazole derivatives; {5-methoxy-2-(6-methylpyridy)benzothiazole (46) and 6-ethoxy-2-(6-methylpyridyl)benzothiazole (47)} were respecively synthesized by the treatment of synthesized thioamides; N-(6-methyl-2-pyridinecarbothionyl)-3-methoxy-aminobenzene (27) and N-(6-methyl-2-pyridinecarbothionyl)-4-ethoxyaminobenzene (33) with zirconium (Ⅳ) oxide catalyst in sodium carbonate solution.

Thromboxane A2 modulates migration, proliferation, and differentiation of adipose tissue-derived mesenchymal stem cells

Doo Hee Yun,송해영,이미정,Mi Ra Kim,Min Young Kim,이정섭,김재호 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.1

Prostanoid metabolites are key mediators in inflammatory responses, and accumulating evidence suggests that mesenchymal stem cells (MSCs) can be recruited to injured or inflamed tissues. In the present study, we investigated whether prostanoid metabolites can regulate migration, proliferation, and differentiation potentials of MSCs. We demonstrated herein that the stable thromboxane A2 (TxA2) mimetic U46619 strongly stimulated migration and proliferation of human adipose tissue-derived MSCs (hADSCs). Furthermore, U46619 treatment increased expression of α-smooth muscle actin (α-SMA), a smooth muscle marker, in hADSCs, suggesting differentiation of hADSCs into smooth muscle-like cells. U46619 activated ERK and p38 MAPK, and pretreatment of the cells with the MEK inhibitor U0126 or the p38 MAPK inhibitor SB202190 abrogated the U46619-induced migration, proliferation, and α-SMA expression. These results suggest that TxA2 plays a key role in the migration, proliferation, and differentiation of hADSCs into smooth muscle-like cells through signaling mechanisms involving ERK and p38 MAPK.

Single-frequency Differential GPS Accuracy Improvement via Local Area Ionospheric Time Delay Model Development

Doo Hee Yun,Changdon kee 에스케이텔레콤 (주) 1999 Telecommunications Review Vol.9 No.1

Ionospheric time delay is one of the main error sources for single-frequency DGPS applications, including time transfer and Wide Area Differential GPS (WADGPS). When ionosphere activity is peak in the year 2000 and also if the Selective Availability (SA) is turned off in the near future, ionospheric time delay will be the biggest error source. Currently, there are many attempts to develop real-time ionospheric time delay estimation techniques to reduce positioning error due to the ionospheric time delay. Klobuchar model is now widely used for ionospheric time delay calculation for single-frequency users. It uses flat surface at night time and cosine surface at daytime. However, the model was developed for worldwide ionosphere fit, it is not adequate for local area single-frequency users who want to estimate ionospheric time delay accurately. Therefore, there are needs to develop a new ionospheric time delay model which covers local region in view from one reference station with dual-frequency receiver, and send the parameters of the model to DGPS users. Since the coverage of one DGPS reference station is limited mainly by ionosphere spatial decorrelation, this basic idea also can be used to extend the coverage of DGPS. In this paper, we developed a new and practical ionospheric time delay model, which is simple to be used and does not have any singular points and divergence problem in ionospheric time delay estimation. We also developed a new SNUDGPS (Seoul National University DGPS) algorithm which minimizes the effect of the ionosphere spatial decorrelation by sending ionosphere parameters to the DGPS users. Experimental results show that the mean of SNUDGPS three-dimensional positioning error is reduced to at least half of DGPS and therefore the coverage of SNUDGPS is expected to be extended more than twice of DGPS.

Case Report : The First Case of Novel Influenza A (H1N1) Fatality in Korea

( Hee Yun Seol ),( Jung Seop Eom ),( Mi Hyun Kim ),( Woo Hyun Cho ),( Ji Eun Kim ),( Ki Uk Kim ),( Doo Soo Jeon ),( Hye Kyung Park ),( Yun Seong Kim ),( Min Ki Lee ),( Soon Kew Park ) 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.68 No.6

Here we report the first fatality caused by H1N1 influenza virus infection with acute respiratory distress syndrome in Korea. A 55-year-old man presented at our emergency department with dyspnea, fever, diffuse myalgia and malaise. Bilateral lung air-space consolidation was detected on his initial chest radiograph combined with severe hypoxemia. He was supported by mechanical ventilation and treated with antibiotics. A nasopharyngeal aspirate was positive for influenza A rapid antigen and oseltamivir was started on day 3 of admission. The nasal swab sample was positive for influenza H1N1 virus by real-time reverse-transcriptase polymerase chain reaction. Despite aggressive treatment, he had refractory hypoxemia and uncontrolled septic shock. On day 5 of admission he went into cardiac arrest and expired.