니세틸 정(아세틸 - 엘 - 카르니틴 500mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,오인준,이용복,임동구,문재동,심영순,김은아,정현철 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.1

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetile^(TM) (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^(TM) (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07±7.98 ㎏ in body weight, were divided into two groups and a randomized 2 × 2 cross-over study was employed. After one tablet containing 500 ㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_(max) and T_(max) were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_(max) and T_(max) between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^(TM) tablet. The powers (1-β) for AUC_t and C_(max) were 94.87% and 87.17%, respectively. Minimum detectable differences (△) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_(max), respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_(max), respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^(TM) tablet is bioequivalent to Nicetile^(TM) tablet.

니세틸 정(아세틸-엘-카르니틴 500 mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,김은아,정현철,심영순,임동구,오인준,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetiler^TM (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^TM (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07 7.98㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 500㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^TM tablet. The powers (1-β) for AUC_t and C_max were 94.87% and 87.17%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_max, respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^TM tablet is bioequivalent to Nicetile^TM tablet.

복강경담낭절제술에서 수술전 간담도신티그라피와 경구담낭조영술의 의의

문대혁(Dae Hyuk Moon),양승오(Seoung Oh Yang),이희경(Hee Kyung Lee),원경숙(Kyoung Sook Won),류진숙(Jin Sook Ryu),한동복(Dong Bok Han),박철민(Cheol Min Park),이문규(Moon Gyu Lee),박광민(Kwang Min Park),이승규(Sung Gyu Lee) 대한핵의학회 1997 핵의학 분자영상 Vol.31 No.1

N/A 131I-6β-iodomethyl-19-norcholesterol(NP-59) has an advantage to assess adrenal dysfunction caused by adrenal cortical disorders. The aim of this study is to evaluate the clinical usefulness of NP-59 scintigraphy in each adrenral disease. Ten patients who did eleven NP-59 adrenal scintigraphies at Dong-A University Hospital from March 1990 to December 1996 were selected as the subject. Among the subject there were 5 cases of Cushing's syndrome, 2 cases of incidentaloma, 1 case of metastatic adrenal tumor, liver cirrhosis with hirsutism and hypertension respectively. Among 5 case of Cushing's syndrome, there were 2 cases of Cushing's disease, 2 cases of adrenal adenoma and 1 case of adrenal carcinoma. There are no disagreement between clinical diagnosis and scan finding in Cushing's syndrome. In 2 incidentaloma cases, even though one is interpretated as a functioning tumor, both of 2 cases could avoid unnecessary biopsy according to scintigraphy result. One case of hirsutism, clinically adrenal originated, revealed the normal scintigraphic hirsutism was extra-adrenal origin. One case of hypertension took the study to exclude the possibility of primary aldosteronism. Normal suppression scan finding revealed that primary aldosteronism did not exist in this case. In conclusion, NP-59 scintigraphy was very useful in diagnosis and differential diagnosis of Cushing's syndrome and it could avoid unnecessary biopsy in the incidental adrenal tumor.

반도체 제조공정라인의 자기부상 컨베이어 시스템 설계

李斗馥,金東遠 홍익대학교 산업기술연구소 2002 産業技術 Vol.12 No.-

A magnetic levitation is suitable for moving materials in such a clean environment which must be kept free from even microscopic dust motes, for example, in a super clean room in semiconductor manufacturing plants or biochemical plants, delicate medical machines, because friction can be disappeared or reduced. In addition to this, another advantage of levitation is that the manipulator can operate as a rigid body rather than using joints parts. In this work, the magnetic levitation is applied to transport a single wafer between semiconductor fabrication process modules in clean rooms because it can eliminate particles and oil contamination that normally exits in conventional transport systems due to contact motions of mechanical component. The transport system consists of a carrier, levitation track, and propelling system. Levitation is achieved by using antagonistic forces produced between electromagnet tracks and permanent magnets. Stabilization is achieved by using a simple feedback control. The continuous propelling force is obtained by sending specific current patterns to the propulsion coils. The dynamic model of transport system is presented and it is verified by experiment. The system performance is experimentally investigated. The magnetically levitated wafer transport system is propelled with a reasonable speed.

한국인 태아 췌장도 발육에 관한 면역조직화학적 연구

이원복,김동창 중앙대학교 의과대학 의과학연구소 1984 中央醫大誌 Vol.9 No.4

The pancreases of Korean human fetuses aged from 13 to 40 weeks were studied immunohistochemically to observe the development of the pancreatic islet, frequency of single endocrine cell and composition of pancreatic islet. 1. The volume fractions of endocrine tissue of the fetal pancreas were higher value(from 7 to 8%). However, the relative values of the endocrine tissues that obtained from 5 to 10 month old fetuses were constant. 2. The exocrine tissue were slowly increased during the intrauterine life. On the other hand, the connective tissue were gradually decreased in the same time. 3. At the mid-term, the number of single alpha cells were similar to that of delta cells. The number of beta cell decreased in comparison with that of non-beta cells(p<0.01). At the term, the number of single alpha, beta and delta cells were not significant. These data indicated that the epithelial cells of pancreatic duct were budding during intrauterine life. 4. At the mid-term, the pancreatic islets were composed of about 36% of alpha and beta cells respectively and 28% of delta cells. At the term the pancreatic were composed of 33% of alpha cells, 41% of beta cells and 26% of delta cells, respectively. The fetal panreatic islet showed numerous delta cells but the beta cells occupied one half of the adult islets. 5. The mantle islet was one of the typical features of fetal pancreatic islet. It was composed of the central core of beta cells and peripheral zone of alpha and delta cells interposed with a few of beta cells.

형질세포치은염에 대한 증례보고

李建馥,咸日成,金東民 단국대학교 치의학연구소 1991 논문집 Vol.3 No.-

After authors experienced patients with plasma cell gingivitis, who had visited Department of Periodontics of Dental Hospital of Dnakook University from 1984 to 1990, authors selected 13 cases which were very similar with plasma cell gingivitis on clinical and histopathological aspect, and then re-examined these 13 cases about following standards, sudden onset of the lesion, no favorable result on medicinal and surgical treatment, dense infiltration of plasma cell, eosinophils in the Hematoxylin-Eosin stain, mast cells in Toluidine-Blue stain. Authors concluded that 4 cases are exactly consistent with plasma cell gingivitis. Authors studied these 4 cases about clinical and histopathological feature, and reviewed the past case report and literature. The following results were elicited. 1. Clinical sign and symptom has generalized feature in oral cavity, but when the disease occurs at the lips, the lower lips shows more severe manifestation. And the disease have a predilection for female but do not have prediliection for any age. 2. The most characteristic feature of the plasma cell gingivitis is dense plasma cell infiltration in light microscope, and other characteristic microscopic features are as followings; microvesicles in the epithelial layer, proliferation of epithelium, proliferation of papillary layer in connective tissue, dilatation of capillaries and occasional infiltration of eosinophils and mast cells. 3. Plasma cell gingivitis is specific immunological reaction that plasma cells chiefly react with certain allergen but this immunological reaction is limited on few population.

스캔 설계 법칙 검사에 관한 연구

이재훈,김형국,조경연,임동욱,민형복 成均館大學校 科學技術硏究所 1997 論文集 Vol.48 No.2

Since testing of digital circuit is becoming increasingly important, many methodologies have been introduced to enhance design for testability (DFT). DFT was taken into account in the automated test procedure and improved reliability of the design. Both tasks are well suited for scan rule checker. This paper presents a scan rule checker for gate level digital circuits. The scan rule checker deals with basic rule check, basic scan rule check, muxed scan rule check, clocked scan rule check and lssd. Scan design informations were represented in the configuration file and libraries were modeled for the scan rule checker. It is an efficient way for the design for testability methodology.

안동호 상류 운곡천의 이화학적 수질특성과 식물플랑크톤 군집 특성

이중복,이희무,이건주,박정원,박재충,김동걸,권기석 7개 국립대학교 환경연구 논문집 공동발행 위원회 2002 환경연구논문집 Vol.2 No.1

This investigation is about the characteristics of phytoplankton community and physciochemical water quality of specific 6-point the Woon-kog stream system in upsteam of the Andong Lake. DO value was showed over 8.1㎎/L at each site and COD_Mn, BOD, T-N, T-P tend to increase as they stream down and that the existence and dominance of phytoplankton was low and it was difficult to conclude the definite correlation of water quality and phytoplankton community. Finally, it seemed to be desirable that alternatives for pollutional reduction should be made and performed on the basis of the continuous monitoring of the inflow to preserve the Andong Lake.

철강 제조업체 근로자에서 효소면역측정법을 통한 B형 간염 바이러스 표지자 조사

이종영,강승원,하명화,김중구,배삼덕,김두희,남복동 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.2

포항 지역 한 철강 제조업에서 1995년 1월부터 10월 사이에 실시한 정기 건강진단을 받은 남자 근로자 11,523명을 대상으로 HBsAg 및 Anti-HBs, HBeAg 및 Auti-HBe은 EIA법으로, SGOT 및 SGPT는 반응속도법(IU)으로 검사하였다. 그리고 이들 대상자에서 교육정보, 근무 형태, 음주 및 흡연습관과 간기능 이상 여부를 조사하여 다음과 같은 결과를 얻었다. 1. B형 간염 표지자의 분포를 보면 HBsAg(+)/Anti-HBs(-)는 8.1%, HBsAg(-)/Anti-HBs(+)는 60.5% 그리고 HBsAg(+)/Anti-HBs는 0.1%이었으며, HBsAg의 양성율은 8.2%, Anti-HBs 양성율은 60.6%이었다. 2. 연령에 따라 HBsAg(+)/Anti-HBs(-)와 HBsAg(-)-HBs(+)가 유의하게 증가한 반면(p<0.05), 교육정도와 근무형태에 있어서는 통계적으로 유의한 차이가 없었다. 3. 음주율은 HBsAg(+)/Anti-HBs(-)에서 HBsAg(-)/Anti-HBs(-)와 HBsAg(-)/Anti-HBs(+)의 84.6% 및 85.7%에 비해 낮지만 73.9%나 되었고, 흡연율은 HBsAg(-)/Anti-HBs(+), HBsAg(+)/Anti-HBs(-) 및 HBsAg(-)/Anti-HBs(-)에서 54.3%, 53.7% 및 53.0%의 순서로 나타났다. HBsAg(+)/Anti-HBs(-)에서 간기능 이상자가 40.1%이었으나 HBsAg(-)Anti-HBs(-)와 HBsAg(-)/Anti-HBs(+)에서도 각각 21.9% 및 18.4%를 차지하였다. 4. HBsAg(+)에서의 e항원에 대한 표지자의 분포를 보면 HBeAg(+)/Anti-HBe(-)는 31.3%, HBeAg(-)/AntiHBe(+)는 55.0% 그리고 HBeAg(+)/Anti-HBe(+)는 1.6%이었고 HBeAg(+)/Anti-HBe(-)는 연령에 따라 감소하고 HBeAg(-)/AntiHBs(-)와 HBeAG(-)/AntiHBe(+)는 증가하였다. HBsAg 양성자중 HBeAg의 총 양성율은 32.9%로 연령이 증가할수록 유의하게 감소하였다. 본 연구는 근로자의 B형 간염 표지자 조사에 있어 Anti-HBs의 검사에서는 EIA 방법으로 실시해야 하는 근거를 제시하는 것이며, 철강산업 근로자에서는 B형간염 이외의 간장질환에도 관심을 가져야 할 것으로 보이며 음주 문제에 대한 대책마련이 시급히 이루어 져야 할 것으로 생각된다. A study for seroprevalence of Hepatitis B virus markers (HBsAg, Anti-HBs, HBeAg and Anti-HBe) by EIA method and the Liver Function Test(SGOT and SGPT) using kinetic method was carried out from January to October 1995 among male workers of a major iron and steel manufacturing company located in Pohang. The results were as follows; 1. The distribution of hepatitis B virus markers showed that the proportions of HBsAg(+)/Anti-HBs(-), HBsAg(-)/Anti-HBs(+) and HBsAg(+)/Anti-HBs(+) were 8.1%, 60.5% and 0.1%, respectively. The positive rate of HBsAg in all subjects was 8.2%, whereas that of anti-HBs was 60.6%. 2. The proportions of HBsAg(+)/Anti-HBs(-) and HBsAg(-)/Anti-HBs(+) increased significantly with age. While the distribution of hepatitis B virus markers exhibited no significant differences among the groups classified by educational background or work type. 3. The proportion of drinkers in HBsAg(+)/Anti-HBs(-)(73.9%) was significantly lower than those of HBsAg(-)/Anti-HBs(-) and HBsAg(-)/Anti-HBs(+) (84.6% and 85.7%, respectively). The proportions of smoking for the three groups of HBsAg(-)/Anti-HBs(+), HBsAg(+)/Anti-HBs(-) and HBsAg(-)/Anti-HBs(-) were 54.3%, 53.7% and 53.0%, respectively(p<0.01). The proportion of the subjects with abnormal liver function test in HBsAg(+)/Anti-HBs(-) was 40.1%, whereas those in HBsAg(-)/Anti-HBs(-) and HBsAg(-)/Anti-HBs(+) were 21.9% and 18.4%, respectively. 4. The distribution of e Ag markers among HBsAg(+) subjects showed that the proportions of HBeAg(+)/Anti-HBe(-), HBeAg(-)/Anti-HBe(+) and HBeAg(+)/Anti-HBe(+) were 31.3%, 55.0% and 1.6%, respectively. The proportion of HBeAg(+)/Anti-HBe(-) decreased significantly with age and those of HBeAg(-)/Anti-HBe(-) and HBeAg(-)/Anti-HBe(+) increased with age. The positive rate of HBeAg among HBsAg(+) subjects was 32.9%. In conclusion, as a screening method, EIA is recommended to test hepatitis B virus markers, especially when examining Anti-HBs more sensitively. For the workers of the iron and steel manufacturing company studied, liver diseases caused by other than hepatitis B should be given a special care including an education avoiding alcohol drinking.

장상피화생과 Helicobactor pylori와의 상관 관계에 관한 연구

이복희,김대수,이현숙,진영주,윤세진,송형근,성노현,정현용,이동호 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

In 1965 Lauren divided advanced gastric carcinoma into two main types-namely, "intestinal" and "diffuse" type carcinoma, which differ not only morphologically but also in their clinical and epidemiological characteristics. Moreover, a different histogenetic process has been postulated by many authors that intestinal type gastric carcinoma might arise from areas with intestinal metaplasia. Since Warren and Marshall reported the presence of Helicobacter pylori in the stomach in 1983, strong evidence has been obtained that there is a close relationship between Helicobacter pylori and chronic gastritis, atrophic gastritis, intestinal metaplasia, and intestinal type gastric carcinoma. To study the relationship between intestinal metaplasia and Helicobacter pylori infection, we performed gastroscopic biopsies and CLO tests taken from patients with epigastric pain. Only 87 patients with macroscopically suspected antral gastritis were included. The prevalence of intestinal metaplasia in gastric antral biopsies increased from 33.3% in the age group<30 years to 63.6% in the age group 60 years. When all patients were divided into two age groups-namely, (i)<50 years(n=41) and (ii)≥ 50 years(n-=46), intestinal metaplasia was found significantly more often in patients ≥ 50 years. ((i) 39.2%, (ii) 54.3%, p<0.0001). The prevalence of Helicobacter pylori in gastric antral biopsies decreased from 66.7% in the age group<30 years to 62.5%, in the age group in the age group 50 to 59 years. When all patients were divided into the same two age groups-namely(i)<50 years and (ii)≥50 years, the prevalence of Helicobacter pylori did not differ between two groups in a statistically significant way. The mean age of intestinal metaplasia positive patients who were also Helicobacter pylori positive was 48±11.0(mean±S.D.)years, whereas the mean age of intestinal metaplasia positive patients who were Helicobacter pylori negative was 52±9.7(mean±S.D.)years. In conclusion. although our data do not prove a causal relationship between Helicobacter pylori infection and the histogenesis of intestinal metaplasia, we suggest that Helicobacter pylori plays an important role in the development of intestinal metaplasia in the gastric mucosa. Whether Helicobacter pylori has to be present at all times during this process or is only necessary as a 'trigger', needs further research.