족과관절염좌 환자에 대한 동씨침법과 일반침법의 효과에 대한 비교 연구

안호진,정동화,황규선,윤기붕,김태우,문장혁,백종엽,이상무,Ahn, Ho-jin,Jeong, Dong-hwa,Hwang, Kyu-seon,Yoon, Ki-bung,Kim, Tae-woo,Moon, Jang-huyk,Baek, Jong-yeob,Lee, Sang-moo 대한침구의학회 2003 대한침구의학회지 Vol.20 No.1

Objective: The purpose of this study is to compare the effects of Dong-si acupuncture therapy and General acupuncture therapy for the patients with acute ankle sprain. Methods : This study has been carried out for 60 cases of ankle sprain patients who have visited Dong-Seo Oriental medical Hospital from May 1, 2002 to September 30, 2002. We have treated 30 cases of them by Dong-si acupuncture therapy and the other 30 cases by General acupuncture therapy. And we have compared those two group. Results : 1. There was no significant difference at the treatment period and the number of treatment times in comparing two groups. 2. The number of treatment times for good effect is that : Dong-si took $1.57{\pm}0.85$ times and General acupuncture therapy took $2.15{\pm}0.96$ times. And we have found that the effect of Dong-si acupuncture therapy is faster than the other.

석유화학공업 종사자의 유전독성 위험성 평가

안기원,박정선,서순팔,문재동,조진형 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.1

In order to evaluate the genotoxic hazard among workers potentially exposed to low level petrochemical substances, the analyses of micronuclei(MN) and sister chromatid exchanges(SCEs) in lymphocytes were performed in 46 male workers(as exposed group) and 46 nonexposed subjects(as control group). Mean frequencies of MN and SCEs(respectively, 12.9/1000 cells and 6.5/cell) in exposed group were very significantly higher than those(10.2/1000 cells and 5.4/cell) in control group. And there were also significant differences in mean frequencies of MN and SCEs adjusted for age, employment duration, smoking, and drinking between two groups. Median frequencies of MN and SCEs in exposed group were very significantly higher than those in control group. Frequencies of SCEs were higher in smokers than in non-smoker. Frequencies of MN in smokers, however, were similiar to those of non-smoker. Interaction between exposure and smoking on MN and SCEs induction was not observed. The results suggest that there is genotoxic hazard in high risk group like workers handling carcinogens in petrochemical plants and the analyses of MN and SCEs are useful biomarkers for the exposure to hazard substances even at the level below the exposure limit.

방사선조사가 당뇨 백서의 측두하악관절에 미치는 영향

안기동,황의환,이상래 대한구강악안면방사선학회 2004 Imaging Science in Dentistry Vol.34 No.2

Purpose : To investigate the histopathological changes in the temporomandibular joint in streptozotocin-induced diabetic rat following irradiation. Materials and Methods : Sprague-Dawley rats weighing about 250 gm were divided into three groups: control, diabetic, and diabetic-irradiated groups. Diabetes mellitus was induced in the rats by injecting streptozotocin. Rats in the control group were injected with citrate buffer only. After 5 days, the head and neck region of the rats in diabetic- irradiated group were irradiated with single absorbed dose of 10 Gy. The rats were killed at 1, 3, 7, 14, 21, and 28 days after irradiation. The specimen including the temporomandibular joint were sectioned and observed using a histopathological method. Results : In the diabetic group, severe bone resorption in the mandibular condyle was observed throughout the period of experiment. Necrosis of bone marrow and trabeculae was observed at 28 days after diabetic state. Atrophy and fibrosis in the retrodiscal tissue was gradually progressed during the time of the experiment. In the diabeticirradiated group, severe bone resorption in the mandibular condyle was observed during the early experimental phases, but regeneration of bone marrow was initiated at 14 days after diabetic state and irradiation. Also, calcification of abnormal trabeculae was observed at 28 days after diabetic state and irradiation. The retrodiscal tissue was degenerated in the early experimental phases, but it had been gradually regenerated during the experimental time. Conclusion : This experiment suggests that bone resorption and degeneration in the mandibular condyle are caused by the induction of diabetes, and abnormal bone formation is induced after irradiation in diabetic state.

Wolff-Parkinson-White증후군의 임상상 및 전기생리학적 소견

안신기,이문형,장양수,오동진,최인석,하종원,임세중,김병옥,정남식,심원흠,조승연,김성순 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.9

VRML을 이용한 Web기반의 가상공간 저작도구

안창규,이강우,이기동 嶺南大學校 工業技術硏究所 2004 工業技術硏究所論文集 Vol.32 No.1

In this paper, we introduce the design and implementation technique for WVRAT(Web Virtual Reality Authoring Tool) which is an easy tool for describing virtual space. The problems of the prevalent software such as, complexity of the GUI and high cost, prevent end users from widely using of VRML. Thus we propose an authoring tool for user to easily implement his own virtual space only combining the virtual objects in the network and the real data of individual server.

이소시아네이트 노출 근로자의 천식에서 이소시아네이트 원인 점유율

안연순,고동희,문기태 大韓産業醫學會 2007 대한직업환경의학회지 Vol.19 No.4

Objectives: Isocyanate-induced asthma is the most prevalent occupational asthma in Korea. The main purpose of this study was to estimate the etiologic fraction of isocyanate-related asthma in isocyanate- exposed (EFe) workers and to measure the magnitude of preventable occupational asthma. Methods: Asthma admissions from 2000 to 2005 were analyzed in a cohort containing 10,861 iso-cyanate-exposed workers and 324,618 isocyanate non-exposed workers who underwent the specialized health examination from January, 2000 to December, 2004. The cohorts of Isocyanate and noise-exposed workers were established using the same data base of Korea Occupational Safety and Health Agency (KOSHA). Asthma admissions were investigated by matching the National Health Insurance Claim Data (NHICD). The standardized rate ratio (SRR) of admission was estimated by Poisson regression method to allow unbiased comparisons across exposure and other variables such as age and sex. The etiologic fraction for the isocyanate-exposed (EFe) workers was calculated using this formula (Efe=SRR-1/SRR). Results: Twenty-eight asthma admissions among the isocyanate-exposed workers and 321 non-exposed workers were observed during 2000∼2005. The crude admission rate was 57.2 per 100,000 person-years for the isocyanate-exposed workers and 25.0 for the noise-exposed workers, Compared to the noise-exposed workers, the isocyante-exposed workers had significantly higher asthma admission (SRR=2.80 95%CI=1.89∼4.14). The etiologic fraction for the isocyanate-exposed (EFe) workers was 64%. Conclusions: This study was limited by the restriction to admission cases and the short follow-up periods. Any difference of admission accessibility between the isocyanate-exposed and non-exposed workers will lead to either over- or under-estimation of the biased etiologic fraction for the isocyanate-exposed workers. The etiologic fraction for the isocyanate-exposed workers was 64% indicated that 64% of the asthma cases occurred in the isocyanate-exposed workers are preventable through occupational health management. 목적: 이 연구의 목적은 우리나라에서 가장 중요한 직업성천식원인물질인 이소시아네이트에 노출되는 근로자를 대상으로 이들 근로자의 천식 중 이소시아네이트의 원인 점유율을 산출하는 것이다. 방법: 2000년부터 2004년까지 이소시아네이트 및 소음 특수건강진단을 받은 근로자의 전산자료를 한국산업안전공단으로부터 수집하였다(한국산업안전공단에 2000년부터 특수건강진단을 받은 근로자의 자료가 전산화되어 있음) 이들 근로자에 대하여 2000년부터 2005년까지 6년간 천식으로 입원한 근로자의 자료를 건강보험심사평가원으로부터 조회하였다. 이소시아네이트와 소음 특수건강진단 수진자에 대하여 관찰인년을 계산하고 조입원률을 계산하였다. 소음 특수건강진단 근로자를 비교집단으로 하여 포아송 회귀분석 로그- 선형 상대 위험률 모형을 적용하여 이소시아네이트 특수건강진단 수전자의 입원의 표준화비율비를 산출하고 이를 이용하여 이소시아네이트 노출 근로자의 천식 중 이소시아네이트의 원인점유율을 산출하였다. 결과: 이소시아네이트 노출 근로자의 조입원률은 10만 관찰인년당 57.2명(남성 50.4명,여성 113.0명),소음은 25.0명(남성 22.7명,여성 31.6명)으로 이소시아네이트 노출 근로자의 천식 조입원률이 2.3배 높았고,여성의 경우 3.6배 높았다. 소음 노출 근로자에 대한 이소시아네이트 노출 근로자의 천식의 표준화비율비는 2.80(95% 신뢰구간 1. 89∼4.14)으로 소음 노출근로자에 비하여 이소시아네이트 노출 근로자의 입원이 180% 많았다. 이소시아네이트의 원인점유율은 64%(95% 신뢰구간 47∼76%)로 이소시아네트 노출 근로자에서 입원한 천식의 64%는 이소시아네이트에 의한 것으로 분석되었다. 결론: 이 연구에서 이용한 자료는 천식 입원자료로 유병자료라는 제한점이 있다. 그러나 이 연구는 국내에서 처음으로 특정 물질 노출군(특히 우리나라 직업성천식의 가장 흔한 천식 유발물질인 이소시아네이트 노출군)을 대상으로 천식 중 직업(노출)의 원인점유율을 측정한 것은 의의가 있다. 이 연구에서 이소시아네이트 노출군의 천식 중 노출 회피 등을 통하여 예방 가능한 부분이 64%이고, MDI 노출군의 천식의 상대위험도와 원인점유율이 TDI 보다 높다는 사실은 이소시아네이트 노출 근로자 산업보건관리에 매우 중요한 의미가 있다고 판단된다. 향후 이 연구결과를 이소시아네이트 노출 근로자의 직업성천식 예방 및 산재 보상정책을 수립하는데 기초자료로 활용할 필요가 있다고 판단된다.

시공간 트렐리스 부호화 CDMA 시스템에서의 선택적 PRC를 사용한 레이크 수신기의 성능 분석

기영민,임은정,안철용,김동구,이석규 延世大學校 電波通信共同硏究所 2002 電波通信論文誌 Vol.6 No.1

다중 경로 페이딩 채널에서의 시공간 트렐리스 부호 (STTC, Space-Time Trellis Codes)의 성능 열화를 보완하기 위한 시공간 등화기는 수신기를 복잡하게 하는 단점이 있다. 본 논문에서는 PRC (Principal Ratio Combining) 레이크 수신기를 제안하였다. 이 수신기는 다중 경로 신호를 PRC 기법을 사용하여 컴바이닝 함으로서 수신 SINR (Signal to Interference and Noise Ratio)을 개선하는 효과를 얻는다. 또한, 본 논문에서는 모든 다중 경로 컴바이닝에 비교하여, 낮은 복잡도로 비슷한 성능을 얻을 수 있는 선택적 PRC (Hybrid Selection / Principal Ratio Combining) 구조를 제시하였다. The space-time equalizer has been used to enhance the space time code in the multipath fading channel. However it requires higher receive complexity. In this paper, the principal ratio combining (PRC) receiver for space-time trellis coded CDMA system is proposed in the multipath fading channels. It maximizes the received signal to interference and noise ratio (SINR) and reduces the complexity of the system compared to optimum ML receiver. We also present the hybrid selection / principal ratio combining (HS/PRC) scheme that can achieve the performance comparable to that of the full path PRC combining system.

방사선조사가 Streptococcus mutans에 미치는 영향

안기동,김규태,최용석,황의환 대한구강악안면방사선학회 2007 Imaging Science in Dentistry Vol.36 No.1

Purpose : To observe direct effect of irradiation on cariogenic Streptooccus mutans. Materials and Methods : S. mutans GS5 was exposed to irradiation with a single absorbed dose of 10, 20, 30, and 40 Gy. Viability and changes in antibiotic sensitivity, morphology, transcription of virulence factors, and protein profile of bacterium after irradiation were examined by pour plate, disc diffusion method, transmission electron microscopy, RT-PCR, and SDS-PAGE, respectively. Results : After irradiation with 10 and 20 Gy, viability of S. mutans was reduced. Further increase in irradiation dose, however, did not affect the viability of the remaining cells of S. mutans. Irradiated S. mutans was found to have become sensitive to antibiotics. In particular, the bacterium irradiated with 40 Gy increased its susceptibility to cefotaxime, penicillin, and tetracycline. Under the transmission electron microscope, number of morphologically abnormal cells was increased as the irradiation dose was increased. S. mutans irradiated with 10 Gy revealed a change in the cell wall and cell membrane. As irradiation dose was increased, a higher number of cells showed thickened cell wall and cell membrane and lysis, and appearance of ghost cells was noticeable. In RT-PCR, no difference was detected in expression of gtfB and spaP between cells with and without irradiation of 40 Gy. In SDS-PAGE, proteins with higher molecular masses were gradually diminished as irradiation dose was increased. Conclusion : These results suggest that irradiation affects the cell integrity of S. mutans, as observed by SDS-PAGE, and as manifested by the change in cell morphology, antibiotic sensitivity, and eventually viability of the bacterium. (Korean J Oral Maxillofac Radiol 2007; 37: 35-43)

초음파 의료영상에서 탄성 팬텀

안동기,조개영,정목근 대진대학교 첨단소재연구소 2002 첨단소재연구소논문집 Vol.5 No.-

Ultrasound elastography has drawn a lot of attention because it enables one to image the stiffness of soft tissue whose quantification can lead to differentiation of benign and malignant tissues. To start the research of elastography, we fabricated stiffness phantoms using gelatin and agar, and measured the stiffness of each phantom. Measured stiffness value is about tens kPa. and is dependent on the density of agar and gelatin, and n-propanol. We confirmed that agar-gelatin phantom is good for mimicking elasticity of biological tissue.

마우스 종양발생에서 Nitric Oxide의 역할에 관한 연구 Ⅲ : Helicobacter pylori에 의해 유발된 마우스 위암에서 염증매개인자의 역할 The role of inducible nitric oxide synthase and cyclooxygenase-2 in H. Pylori-associated gastric carcinogenesis

남기택,오상연,조현무,이국경,강진석,제정환,최미나,한상욱,김대용,장동덕,양기화,안병우 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

feficotorfer fyf☞ri(Hp)가 위암파 관련이 있다는 역학적인 증거는 많이 있지만 이에 대한 정확한 기전에 대해선 밝혀져 있지 않고 있으며 실험동물 모델도 적절하지 못한 것으로 알려져있다. 본 실험에서는 위암의 원인으로 알려져 있는 f, fyforf'(Hp)를 이용하여 마우스에서 위암 모델을 확립하고 만성염증과정 중에 생성되는 리0와 COX-2 등의 발현이 위암발생에 미치는 명향을 통하여 예방과 치료를 위한 점근을 시도하고자 하였다. 마우스를 7군으로 나누어서 1, 2, 3, 4군의 등물은 MNU를 증류수에 200ppm 농도로 음수병득 이용하띤 10주간 격주로 투여하였으며 MHU 음술 투여 1주 휴씩 후 배양한 f. fyrofi 를 약 109cru/rfll 로 맞춰 한 마리당 0.1ml 씩 이틀 간격으로 세 번에 걸쳐 하룻방 금식시킨 1, 2, 3, 5, 6, 7군기 마우스의 위장에 투입하떴다. 균 투입을 마친 후 다응 날부터 2군쏙 6군은 iNOS 억제제인 aminoguanidine(AG)을 음수병으로 툰여하였으며 3군과 7군은 COX-2 척제제인 nimesulide(NSD)를 투여하였다. 위의 종양발생양상을 샅최보면 bfNU와 Hp만을 투여한 1 관 ; (hfNU +Hp), 2군 : iNO을 inhibitor 투여군(MNU+HP+AG'1. 3군 ;CO딘-2 Inilibitor 투여군(MNU누Hp누 NSD), 4군 ,MNlf 단독투여군, 5군 ;Hp 단독투여춘, 6군 ; 러p 단독에 AG투여군, 7군 , Hp 단독에 NSD투여군의 종양발샐을은 각각 쁜.Bff(l1/16), 70.6%f12/ti), 했.9ff(7/18), 10%(1/10), Off(O/IS)0%(O/S), 0%(O/5)의 발쟁율을 보여 iNOS 억제제인 AC은 좁양발생을 억계하지 못하였으며, COX-2억제제인 NSD 는 종양발생을 유의적으로 감소시켰다. 콩양발생개수에서는 2.62±0.36, 1.41츠0.14, 0.44 르0.12, 0.10±0.10을 보여 AC와 NSD에서 유의성 있게 발생개수를 줄였다. Hp 단독투여에 의해즌는 종양발생이 나타나지 않았으며 HP+AG, Hp+ IfSD 추여군에콕 시험증료 시점에 약물에 의해 Hp의 제균효과가 있는지의 여부를 확인끓기 위하여 PCR을 이용하여 확인한 결과 모두 양성인 것으로 나타나 Hp의 제균효과에 의한 촐양발생 억제가 일어나지는 않았다. 위의 결과로 볼 때 Hp는 위암발생을 촉진하는 것으로 나타났고 딘p 감염시 매개되는 염증인자를 억제하였을 때 종양발생을 억제하는 것으로 위암 발생에서 염증매개인자는 종양을 촉진하는 것으로 나타났으며 it,705 억제제쓱 COX-』 억제제의 위알 예밭효과fl는 효과적일 것으로 사료된다 In spite of a large volume of epidemiological evidence indicating significant relationship between H. pylori infection and gastric adenocarcinoma, a doubt still exists on an elevated risk of stomach cancer by H. pylori infection due to lack of direct evidence of their exact mechanistic link. It is, therefore, essential to have an appropriate animal model for detailed analysis of the role of H. pylori played in gastric carcinogenesis. There is a wealth of evidence to support that over production of inducible nitric oxide synthase(iNOS) and cyclooxygenase-2(COX-2) is involved in the pathogensis of various cancer in both rodents and humans. The aim of this study was to establish a mouse model for H. pylori-associated gastric carcinogenesis and to identify the role of inducible nitric oxide synthase(iNOS) and cyclooxygenase-2(COX-2) played during the gastric carcinogenesis in mice. Eighty-three specific pathogen free, six-week-old male C57BL/6 mice were randomly divided into seven groups. Animals of the group 1, 2, 3, 4 were given MNU in their drinking water at the concentration of 200 p.p.m. for total five cycles of one-week regimen with one-week pause. After completion of MNU administration, they were given autoclaved distilled water for one weeks, and groups 1, 2, 3, 5, 6, 7 were inoculated with H. pylori. After completion of H. pylori. inoculation, groups 2 and 6 were given aminoguanidine in their drinking water at concentration of 1000p.p.m. and animals of group 3 and 7 were given the diet containing 200 ppm nimesulide at 12 weeks of age. All animals were killed at 50 weeks of age. The incidences of the glandular stomach tumors in the group 1, 2, 3 and 4 were 87.5%(14/16), 76.4%(13/17), 44.4(8/18), 10.0%(1/10), respectively and the tumor incidence of group 3(MNU→Hp+nimesulide) was significantly lower than those of group 1(MNU→Hp) at the value of P<0.01. The average numbers of tumors of group 2(MNU→Hp+AG : 1.41±0.24) and group 3(MNU→Hp+nimesulide : 0.44±0.12) were significantly lower than those of group 1(MNU→Hp : 2.62±0.36) at the value of P<0.05. Therefore, overproduced iNOS and COX-2 plays an important role in mice gastric carcinogenesis. We concluded iNOS and COX-2 inhibitor have good effects on gastric carcinogenesis.