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전형적인 DISIDA scan 소견의 Rotor 증후군 1예
황의태,염동한,권지혜,임종주,최창수,김태현,김학철 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2
만성의 비용혈성 직접형 고빌리루빈혈증은 Rotor 증후군과 Dubin-Johnson 증후군의 특징적인 소견으로, Rotor 증후군은 드문 양성 유전성 질환이며, Dubin-Johnson 증후군과 감별을 필요로 한다. 본 저자들은 황달을 주소로 내원한 26세 남자 환자에서 고빌리루빈혈증에 대한 검사를 시행하여 담도폐쇄 소견없이 간담도 스캔상 전형적인 Rotor 증후군의 소견 즉, 강한 심장 배후방사능이 지속되면서, 간담도계의 조영은 지연 촬영에서도 관찰되지 않으며 신장으로의 배설이 계속 관찰되는 특징적인 소견과 정상 간조직 검사 결과로 Rotor 증후군으로 진단한 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Chronic nonhemolytic conjugated hyperbilirubinemia characterizes both Rotor and Dubin-Johnson syndromes. Rotor syndrome is a rare, benign familial disorder and needs to be differentiated from Dubin-Johnson syndrome. Cholescintigraphy is a simple and informative procedure for the diagnosis, which can differentiate Rotor syndrome from Dubin-Johnson syndrome. A 26-year-old man was admitted due to asymptomatic persistent jaundice. Physical examination revealed icteric sclera without hepatosplenomegaly. Laboratory findings showed increased serum bilirubin with direct bilirubinemia. Markedly decreased hepatic uptake and poor visualization of the gallbladder and biliary tract were shown in ^(99m)Tc-DISIDA scan. Histology of the liver showed no diagnostic abnormality without pigmentation. But, we report a case of Rotor syndrome that showed characteristic cholescintigraphic findings with normal urinary total coproporphyrin excretion.
정경훈,박상일,강영주,위환,염동익 조선대학교 환경공해연구소 2006 環境公害硏究 Vol.19 No.1
The reason for the school noise problem located in the city is due to the fact that this noise is aroused by the development of industrial facilities that give too much importance to certain provinces and the cityward tendency of the population and so on. which is scattered nearby school, In addition, the indoor noise caused by the students themselves is loud. It damages the environment as would a loudspeaker, and the noise from the school itself compounded with the noise from outside raises a serious problem. Measure and analysis of the actual condition of this school noise shows its influence and effect on scholastic achievement. Noise can be felt through a man's sense, and it can be felt differently according to an individual's habit, and the time and place. That's why the physical amount, which is measured by a measuring instrument, can't display the grades of noise. The results of a survey show that students' attitudes toward noise and the students' psychological reactions are more apparent in those who take part in classes located in the south building, which is exposed to a large amount of noise from highway traffic. One important factor in the different degrees of school noise is that it becomes louder as one travels higher within the building. We can determine the different effects by comparing the scores of students from various classes. For instance, the scores of students who are exposed to this noise will be compared with those who are not. To survey how much the students themselves are effected by the noise in their studying atmospheres, we selected the north building, which the noise does not penetrate as readily as it would another building and where the measure of the noise amount(Leq, 10 min.). As a result, the classes' records will show the data between the areas where the amount of noise is high and those where the amount of noise is low. It is economically and actually difficult to make a countermeasure for the schools that are influenced by noise, but we should make plans to allocate flexible arrangements of classes and time tables, and to create a good environment for teachers to utilize their professionalism in their own subjects, a variety of teaching skills and the teaching techniques necessary to work with the various levels of the students.
The Influence of Cortisol Level on Hormone Patterns and Ovulation in the Dog
Jong-Ju Park,Hyun-Min Kim,Jin-Gu No,,Ju-Young Ji,Dong-Hyeon Yeom,Mi-Kyoung Choi,Dong-Hun Kim,Jin-Ki Park,Jae-Gyu Yoo 한국동물생명공학회(구 한국동물번식학회) 2013 Reproductive & Developmental Biology(Supplement) Vol.37 No.2s
It is generally accepted that chronic stress impairs female reproduction. It negatively affect ovarian function and the number of ovulated oocytes. Chronic stress lower the number of retrieved oocytes. Ovarian follicular development is regulated by both pituitary-derived gonadotropins and intraovarian regulatory factors. The main corticosteroids are cortisol, cortisone, 11-deoxycortisol and corticosterone, cortisol being one of the most commonly used welfare and stress physiological indicator. In this study, we investigated the effect of cortisol level on progesterone patterns and the number of ovulated oocytes in the dog. Blood samples were collected and progesterone levels were analyzed for determining ovulation time via radioimmunoassay. At the same time, serum cortisol level was measured. The day of ovulation was considered as the day when serum progesterone level was 6.0~8.0 ng/ml. In vivo matured dog oocytes were collected using flushing oviducts of mixed-breed bitches at three days after ovulation. We classified dogs as having higher cortisol level (over 8 μg/dL), medium cortisol level (4~7 μg/dL), and lower corisol level (1~3 μg/dL). The patterns of progesterone was not different in all cortisol groups. The average numbers of retrieved oocytes was not different in all cortisol groups. 9 in higher cortisol level (over 8 μg/dL), 9.5 in medium cortisol level (4~7 μg/dL), and 9.6 in lower corisol level (1~3 μg/dL). The effects of high cortisol on the competence of oocytes and steroid hormone patterns will be studied.
저항성 트레이닝 방법에 따른 엘리트 역도선수들의 근 기능 및 호르몬 반응
황동주(Hwang, Dong-Ju),염동철(Yeom, Dong-Chul),조준용(Cho, Joon-Yong) 한국체육과학회 2017 한국체육과학회지 Vol.26 No.5
Weightlifting is one of the personal competition sports that is based on the basic principle of successfully lifting the maximum weight of the barbell"s resistance by adjusting the dynamic force and body balance. In this regard, the physiological and training methodological approach based on the technical system of the weight lifting is a key factor for enhancement of the performance through scientific analysis and understanding. We investigated whether the application of training programs with different exercise intensity and repetition for 6-weeks improve muscular function and hormonal response related to the weightlifting performance in weightlifters. Eight weightliters were randomly divided into Low-load/High-Volume(LLHV) and High-Load/Low-Volume(HLLV) groups. Our data showed that body composition, muscular function, plasma hormone and cardiovascular function levels had no significant differences between types of training program. On the other hand, both types of training programs showed improved results for the overall variables after 6-weeks with a relatively higher rate of increase in the LLHV group. Taken together, it could be interpreted as a result of suggesting a possibility that the change of the training program according to the intensity and the amount of training for the weightlifting athletes who have physiological metabolic reaction fixed by the long-term training serves as an effective training intervention for enhancement of weightlifting performance.
중심정맥 카테터 제거후 발생한 기이성 공기 색전증 1 예
김주영,송재관,고윤석,임채만,김원동,서대철,엄완식 대한내과학회 1995 대한내과학회지 Vol.48 No.3
Paradoxical air embolism (PAE) can be a devastating complication which may occur in patients at risk for venous air embolism. With improved diagnostic techniques, such as echocardiography, PAE is being identified more frequently as a possible etiology in ischemic strok. A 80-year-old woman was admitted to intensive care unit with severe dyspnea and purulent sputum. Immediate after admission dyspnea was worsen, then mechanical ventilator support begun and triple-lumen central venous catheter was placed in right subclavian vein for proper nutritional supply and easy to blood sampling. Echocardiography showed no abnormal finding. On the 36th hospital day, she could spontaneous respiration with 30% oxygen by T-Piece. After 3 days she was transferred to general ward. At the next day, central venous catheter was removed, but dressing was not placed over the wound and pressure was not exerted on the area while catheter tip was processd for bacterial culture. She became tachypneic, anxious, and comatous. The blood pressure was 160/100 mmHg; heart rate, 150/ min; respiration rate, 36/min; temperature, 36.℃. Electrocardiography revealed sinus tachycardia and righ axis deviation. Partial oxygen tension of arterial blood was 42 mmHg while breathing with 3 L/min oxygen flowing through a T-piece. Chest roentgenogram was unchanged from previous film. Computed tomography of the brain showed multiple small round air density in the frontal and occipital lobe, suggestive of cerebral embolism due to paradoxical air embolism. We thought that she had a catheter in place long enough for a fibrinous tract to form that could remain open after the removal of the catheter and lack of a dressing impermeable to air would allow air to be entrained through a tract during inspiration, then this air delivered to cerebral circulation via pulmonary arteriovenous fistula.
Regulation of $I{\kappa}B$ Kinase by $G{\beta}L$ through Recruitment of the Protein Phosphatases
You, Dong-Joo,Kim, You-Lim,Park, Cho-Rong,Kim, Dong-Kyu,Yeom, Jeong-Hun,Lee, Cheol-Ju,Ahn, Curie,Seong, Jae-Young,Hwang, Jong-Ik Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.30 No.6
G protein ${\beta}$-like ($G{\beta}L$) is a member of WD repeat-containing family which are involved in various intracellular signaling events. In our previous report, we demonstrated that $G{\beta}L$ regulates TNF${\alpha}$-stimulated NF-${\kappa}$B signaling by interacting with and inhibiting phosphorylation of $I{\kappa}B$ kinase. However, $G{\beta}L$ itself does not seem to regulate IKK directly, because it contains no functional domains except WD domains. Here, using immunoprecipitation and proteomic analyses, we identified protein phosphatase 4 as a new binding partner of $G{\beta}L$. We also found that $G{\beta}L$ interacts with PP2A and PP6, other members of the same phosphatase family. By interacting with protein phosphatases, which do not directly bind to IKK${\beta}$, $G{\beta}L$ mediates the association of phosphatases with IKK${\beta}$. Overexpression of protein phosphatases inhibited TNF${\kappa}$-induced activation of NF-${\kappa}$B signaling, which is an effect similar to that of $G{\beta}L$ overexpression. Down-regulation of $G{\beta}L$ by small interfering RNA diminished the inhibitory effect of phosphatases, resulting in restoration of NF-${\kappa}$B signaling. Thus, we propose that $G{\beta}L$ functions as a negative regulator of NF-${\kappa}$B signaling by recruiting protein phosphatases to the IKK complex.