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RISS 인기검색어
- 검색키워드
- 저자 : Deqing Yang (검색결과 4 건)
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Deqing Ruan,Wenjing Liu,Yanhong Shi,Menghui Tan,Li Yang,Zhengtao Wang,Yue Zhou,Rui Wang 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.1
Endotoxic shock exhibits a considerably high mortality risk. It is defined as a systemic inflammatory response syndrome caused by a microbial infection. Radix Isatidis has anti-inflammatory, antiviral, and antipyretic effects and is used worldwide. This study investigated the antiendotoxin sepsis effects of an aqueous R. Isatidis extract (RIE) and explored the possible pharmacological molecular mechanisms. Male C57BL/6J mice were intravenously injected with 15 mg/kg lipopolysaccharide (LPS) to induce endotoxic shock. The results demonstrated that the survival rate of mice pretreated with RIE increased, and LPS-induced liver and lung damage were reduced by inhibiting inflammation. For elucidating detailed molecular mechanisms, we focused on LPS-induced transcription factors: nuclear factor-κB (NF-κB) and interferon regulatory factor 3 (IRF3). Our results demonstrated that the protective effects of RIE were strongly dependent on IRF3-induced interferon-β, not on NF-κB-induced tumor necrosis factor-α and interleukin-1β. In addition, RIE suppressed the phosphorylation of IRF3, not NF-κB. In conclusion, this study revealed the antiendotoxic properties of RIE on LPS-induced sepsis and provided mechanistic evidence for the beneficial effects of RIE.
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Baoshun Zhang,Deqing Yu,Nanxuan Luo,Changqing Yang,Yurong Zhu 대한생리학회-대한약리학회 2020 The Korean Journal of Physiology & Pharmacology Vol.24 No.5
Paeonol, quercetin, β-sitosterol, and gallic acid extracted from Moutan Cortex had been reported to possess anti-oxidative, anti-inflammatory, and antitumor activities. This work aimed to illustrate the potential anti-oxidative mechanism of monomers in human liver hepatocellular carcinoma (HepG2) cells-induced by hydrogen peroxide (H₂O₂) and to evaluate whether the hepatoprotective effect of monomers was independence or synergy in mice stimulated by carbon tetrachloride (CCl₄). Monomers protected against oxidative stress in HepG2 cells in a doseresponse manner by inhibiting the generation of reactive oxygen species, increasing total antioxidant capacity, catalase and superoxide dismutase (SOD) activities, and activating the antioxidative pathway of nuclear factor E2-related factor 2/Kelchlike ECH-associated protein 1 (Nrf2/Keap1) signaling pathway. We found that the in vitro antioxidant capacities of paeonol and quercetin were better than those of -sitosterol and gallic acid. Furthermore, paeonol apparently diminished the levels of alanine transaminase and aspartate aminotransferase, augmented the contents of glutathione and SOD, promoted the expressions of Nrf2 and heme oxygenase-1 proteins in mice stimulated by CCl₄. In HepG2 cells, paeonol, quercetin, β-sitosterol, and gallic acid play a defensive role against H₂O₂-induced oxidative stress through activating Nrf2/Keap1 pathway, indicating that these monomers have anti-oxidative properties. Totally, paeonol and quercetin exerted anti-oxidative and hepatoprotective effects, which is independent rather than synergy.
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Impact resistance performance and optimal design of a sandwich beam with a negative stiffness core
Chenhui Ren,Deqing Yang,Qing Li 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.7
Numerical analyses were carried out to investigate the response of a sandwich beam with a negative stiffness (NS) core under quasistatic compression and low-velocity impact at the center. By varying the thicknesses of face sheets and interlayers and the lengths of segments, a parametric study on the impact resistance of the sandwich beam is conducted. The maximal deflection of the top face sheet and the strain energy stored in the NS beam were recorded at the moment when the impactor’s velocity decreased to zero. Based on the impact simulation, a multi-objective optimization problem on the beam configuration was set up to find out the most efficient antideformation design at the impact velocity of 2500 mm/s. To solve the problem with the surrogate model method, an optimal Latin hypercube sampling (OLHS) technique and a two-phase differential evolution (ToPDE) algorithm were utilized to generate calculation points in the design space, respectively. Then different surrogate models including the RSM model, the Kriging model and the RBF model, were compared to give the best approximation of the original problem. In the end, the genetic algorithm (GA) dealing with discrete optimization problems was employed to obtain the optimum solutions. Results indicate that different parts of the NS beam dominate the resistance to deformation under different levels of impact intensity. The largest portion of the strain energy is stored in the four curved plates. In the obtained optimization solution, the longest segment is near the two ends and the flat plates near the top are thicker, which is instructive to the beam design on improving impact resistance.
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Wang Bo,Huang Zongfang,Yang Deqing,Ji Qinge,Cai Pumo 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.3
In the present study, preservatives and antibiotics were applied in a variety of doses to assess their effects on the beer waste-based protein bait, a product widely used to control populations of Bactrocera dorsalis (Diptera: Tephritidae). Screening was performed using the inhibition zone method against the dominant bacteria in deteriorated protein bait. Additionally, the attractiveness of the bait was assessed after respectively adding different doses of methyl eugenol, brown sugar solution, ammonium acetate, and guava essence, as determined by bio-cage tests. The results showed that the four selected preservatives had different inhibition effects at different dose levels, and that the level of inhibition increased with dose: at the highest dose of 1:1 (v:v), sodium benzoate can significantly inhibit Staphylococcus spp., potassium sorbate can significantly inhibit Lactobacillus spp., sodium nitrite can significantly inhibit Escherichia spp. and ethyl p-hydroxybenzoate can significantly inhibit Staphylococcus spp. and Xanthomonas spp. Among three antibiotics, kanamycin was the most effective in suppressing a mix of all four bacteria for all tested doses. In terms of lure performance, the addition of four substances in various ratios into the protein bait were found to have varying effects on its attractiveness to B. dorsalis females and males. Specifically, the addition of a high-dose of guava essence could significantly enhance the attractiveness of the bait. Our findings will help to enhance the effectiveness of protein bait ap plications by prolonging the quality guarantee period and improving its attractiveness toward both female and male B. dorsalis.
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