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Yanzheng Zhu,Xianfang Tong,Rongni Yang,Yurong Li,Min Du,Chun-Yi Su 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.8
Due to an increasingly serious aging society and a large number of disabled civilians, the number of residents who need rehabilitation therapy is increasing rapidly in the past few years, but the rehabilitation therapists/treatments are in short supply in reality. In recent years, with the in-depth research and technology development of rehabilitation robots, this contradiction is expected to be overcome. In this paper, the modeling mechanisms of rehabilitation robots are firstly introduced based on the pneumatic artificial muscle drive, motor drive, and cable drive, respectively. Then some typical methodologies are presented to deal with various types of control constraints, namely the nonlinearity, the parameter uncertainty, the fatigue, and the time-delay, etc. Moreover, the advantages and disadvantages of some existing control approaches and driving modes are discussed in depth, including some notable experimental results. The key challenges and shortcomings of rehabilitation robots are analyzed and summarized, and the future development of rehabilitation robots has been prospected finally.
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Yuan Lin,Zhu Yurong,Huang Shuang,Lin Lin,Jiang Xugan,Chen Shengxia 한국미생물학회 2021 The journal of microbiology Vol.59 No.8
Listeria monocytogenes is a food-borne pathogen responsible for neurolisteriosis, which is potentially lethal in immunocompromised individuals. Microglia are the main target cells for L. monocytogenes in central nervous system (CNS). However, the precise mechanisms by which they trigger neuroinflammatory processes remain unknown. The BV2 microglial cell line and a murine model of L. monocytogenes infection were used for experiments in this study. Listeria monocytogenes induced pyroptosis and nucleotide binding and oligomerization, leucine-rich repeat, pyrin domain-containing 3 (NLRP3) inflammasome activation in BV2. Pharmacological inhibition of the NLRP3 inflammasome attenuated L. monocytogenes- induced pyroptosis. Moreover, inhibition of nuclear factor kappa-B (NF-κB) and extracellular regulated protein kinases (ERK) pathways induced a decrease in caspase1 activation and mature IL-1β-17 secretion. Our collective findings support critical involvement of the NLRP3 inflammasome in L. monocytogenes-induced neuroinflammation and, to an extent, ROS production. In addition, ERK and NF-κB signaling play an important role in activation of the NLRP3 inflammasome, both in vitro and in vivo.
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Guoquan Lu,Yurong Jiang,Shuijin Zhu,Junjie Yuan,Guolin Chen 한국유전학회 2016 Genes & Genomics Vol.38 No.11
Betaine aldehyde dehydrogenase (BADH) is widely considered as a key enzyme in glycine betaine metabolism in higher plants. Several paralogous genes encoding different isozymes of BADH have been identified and characterized in some plants; however, until now, only limited information is available about BADH genes in quinoa (Chenopodium quinoa). Here, we report the molecular cloning, structural organization, phylogenetic evolution, and expression profile of a BADH gene (CqBADH1) from quinoa. The translated putative CqBADH1 protein included five conserved features of the ALDH Family 10. Comparisons between the cDNA and genomic sequences revealed that the CqBADH1 gene contained 15 exons and 14 introns. Comparative screening of introns in homologous genes demonstrated that the number and position of the BADH introns were highly conserved among the BADH genes in Amaranthaceae plants and in other more distantly related plant species. A phylogenetic analysis showed that CqBADH1 had the closest relationship with a protein from Atriplex canescens and belonged to the ALDH10 family. Expression profile analyses indicated that CqBADH1 was expressed only in root, and showed time-dependent expression profiles under NaCl-stress condition. Moreover, in quinoa, NaCl stress led to increased levels of CqBADH1 mRNAaccompanied by the accumulation of glycine betaine. This is the first study to describe a BADH gene in quinoa.
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Chen Lu,Cao Kai,Gu Yurong,Luo Chao,Mao Wei,Zhou Weijun,Zhu Jinwei,Zhang Huying 대한독성 유전단백체 학회 2021 Molecular & cellular toxicology Vol.17 No.3
Background Kaempferol (KMF) is a fl avone reported to have anti-oxidant and anti-infl ammatory activity. Objective The present study screened the eff ect of KMF in the animal model of spinal cord injury (SCI). Results KMF caused a signifi cant inhibition of spinal cord injury mediated oxidative stress and also suppressed the infl ammatory reactions. The treatment of KMF also inhibited the levels of p53, TGF-β1 and COX-2 whereas a signifi cant elevation in Bcl-2/Bax ratio was observed after the rats were treated with KMF. The in silico docking analysis suggested potential binding of KMF having lower energy with p53 confi rming the potential target of KMF. Conclusion The treatment of KMF exerted neuroprotective eff ect by improving the anti-oxidant status and infl ammatory response. The signifi cant spinal cord injury protective eff ect of KMF in rats was attributed by targeting p53 and Bcl-2/Bax ratio.
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Baoshun Zhang,Deqing Yu,Nanxuan Luo,Changqing Yang,Yurong Zhu 대한생리학회-대한약리학회 2020 The Korean Journal of Physiology & Pharmacology Vol.24 No.5
Paeonol, quercetin, β-sitosterol, and gallic acid extracted from Moutan Cortex had been reported to possess anti-oxidative, anti-inflammatory, and antitumor activities. This work aimed to illustrate the potential anti-oxidative mechanism of monomers in human liver hepatocellular carcinoma (HepG2) cells-induced by hydrogen peroxide (H₂O₂) and to evaluate whether the hepatoprotective effect of monomers was independence or synergy in mice stimulated by carbon tetrachloride (CCl₄). Monomers protected against oxidative stress in HepG2 cells in a doseresponse manner by inhibiting the generation of reactive oxygen species, increasing total antioxidant capacity, catalase and superoxide dismutase (SOD) activities, and activating the antioxidative pathway of nuclear factor E2-related factor 2/Kelchlike ECH-associated protein 1 (Nrf2/Keap1) signaling pathway. We found that the in vitro antioxidant capacities of paeonol and quercetin were better than those of -sitosterol and gallic acid. Furthermore, paeonol apparently diminished the levels of alanine transaminase and aspartate aminotransferase, augmented the contents of glutathione and SOD, promoted the expressions of Nrf2 and heme oxygenase-1 proteins in mice stimulated by CCl₄. In HepG2 cells, paeonol, quercetin, β-sitosterol, and gallic acid play a defensive role against H₂O₂-induced oxidative stress through activating Nrf2/Keap1 pathway, indicating that these monomers have anti-oxidative properties. Totally, paeonol and quercetin exerted anti-oxidative and hepatoprotective effects, which is independent rather than synergy.
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