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Artificial Slanted Nanocilia Array as a Mechanotransducer for Controlling Cell Polarity
Kim, Hong Nam,Jang, Kyung-Jin,Shin, Jung-Youn,Kang, Daeshik,Kim, Sang Moon,Koh, Ilkyoo,Hong, Yoonmi,Jang, Segeun,Kim, Min Sung,Kim, Byung-Soo,Jeong, Hoon Eui,Jeon, Noo Li,Kim, Pilnam,Suh, Kahp-Yang American Chemical Society 2017 ACS NANO Vol.11 No.1
<P>We present a method to induce cell directional behavior using slanted nanocilia arrays. NIH-3T3 fibroblasts demonstrated bidirectional polarization in a rectangular arrangement on vertical nanocilia arrays and exhibited a transition from a bidirectional to a unidirectional polarization pattern when the angle of the nanocilia was decreased from 90 degrees to 30 degrees. The slanted nanocilia guided and facilitated spreading by allowing the cells to contact the sidewalls of the nanocilia, and the directional migration of the cells opposed the direction of the slant due to the anisotropic bending stiffness of the slanted nanocilia. Although the cells recognized the underlying anisotropic geometry when the nanocilia were coated with fibronectin, collagen type I, and Matrigel, the cells lost their directionality when the nanocilia were coated with poly-D-lysine and poly-L-lysine. Furthermore, although the cells recognized geometrical anisotropy on fibronectin coatings, pharmacological perturbation of PI3K-Rac signaling hindered the directional elongation of the cells on both the slanted and vertical nanocilia. Furthermore, myosin light chain II was required for the cells to obtain polarized morphologies. These results indicated that the slanted nanocilia array provided anisotropic contact guidance cues to the interacting cells. The polarization of cells was controlled through two steps: the recognition of underlying geometrical anisotropy and the subsequent directional spreading according to the guidance cues.</P>
Humanizing the Systemis Concept For Use in Health Science Education
( Daeshik Kim ),( T. Demetr Vacalis ) 한국체육학회 1973 한국체육학회지 Vol.8 No.-
This paper attempted to briefly review the systems concept for curriculum development as described by Mager. In that model, the concept of a system, its component structures and interrelationships were discussed as they pertain to health education. In addition, a new dimension, the affective domain as it relates to the system, was explored. The systematic planning for a humanistic educational system that is relevant as well as affords a strong evaluative structure is necessary in dealing with the trial feeling-thinking student.
Shape‐Controllable Microlens Arrays via Direct Transfer of Photocurable Polymer Droplets
Kang, Daeshik,Pang, Changhyun,Kim, Sang Moon,Cho, Hye Sung,Um, Hyung Sik,Choi, Yong Whan,Suh, Kahp Y. WILEY‐VCH Verlag 2012 ADVANCED MATERIALS Vol.24 No.13
<P><B>A simple method is presented to form an array of shape‐controllable microlenses</B> by partial photocuring of an UV‐curable polymer and direct transfer. Using the transferred lens array, nanoscale metal patterns as small as 130‐nm gaps are detected under an optical microscope with a distinguishable resolution.</P>
Ultrasensitive mechanical crack-based sensor inspired by the spider sensory system
Kang, Daeshik,Pikhitsa, Peter V.,Choi, Yong Whan,Lee, Chanseok,Shin, Sung Soo,Piao, Linfeng,Park, Byeonghak,Suh, Kahp-Yang,Kim, Tae-il,Choi, Mansoo Nature Publishing Group, a division of Macmillan P 2014 Nature Vol.516 No.7530
Recently developed flexible mechanosensors based on inorganic silicon, organic semiconductors, carbon nanotubes, graphene platelets, pressure-sensitive rubber and self-powered devices are highly sensitive and can be applied to human skin. However, the development of a multifunctional sensor satisfying the requirements of ultrahigh mechanosensitivity, flexibility and durability remains a challenge. In nature, spiders sense extremely small variations in mechanical stress using crack-shaped slit organs near their leg joints. Here we demonstrate that sensors based on nanoscale crack junctions and inspired by the geometry of a spider’s slit organ can attain ultrahigh sensitivity and serve multiple purposes. The sensors are sensitive to strain (with a gauge factor of over 2,000 in the 0–2 per cent strain range) and vibration (with the ability to detect amplitudes of approximately 10 nanometres). The device is reversible, reproducible, durable and mechanically flexible, and can thus be easily mounted on human skin as an electronic multipixel array. The ultrahigh mechanosensitivity is attributed to the disconnection–reconnection process undergone by the zip-like nanoscale crack junctions under strain or vibration. The proposed theoretical model is consistent with experimental data that we report here. We also demonstrate that sensors based on nanoscale crack junctions are applicable to highly selective speech pattern recognition and the detection of physiological signals. The nanoscale crack junction-based sensory system could be useful in diverse applications requiring ultrahigh displacement sensitivity.
농촌의 사회통합 실태와 정책 개선방안(2/2차년도) - 다문화가족과 귀농 · 귀촌인 대상 심층연구
박대식(Park Daeshik),안석(An Sok),김남훈(Kim Namhoon),임지은(Lim Jieun) 한국농촌경제연구원 2019 한국농촌경제연구원 기본연구보고서 Vol.- No.-
Background of Research This study is an in-depth study on the social cohesion of rural multi-cultural families and urban-to-rural migrants. Rural multi-cultural families and urban-to-rural migrants have various socio-cultural backgrounds and they are becoming key factors in the change of Korean rural society in recent years. Therefore, rural multi-cultural families and urban-to-rural migrants are very important groups in the discussion of rural social cohesion. This study aimed to investigate the current situation of social cohesion of rural multi-cultural families and urban-to-rural migrants and suggest policy improvement measures. Method of Research This study employed several surveys among rural multi-cultural families and urban-to-rural migrants, focus group interviews, in-depth interviews, a collaborative research, and investigation of existing data. The survey was conducted among 514 rural multi-cultural families and 543 urban-to-rural migrants. Four focus group interviews on the current situation of social cohesion of rural multi-cultural families and urban-to-rural migrants were conducted. The in-depth interviews were conducted among 22 rural multi-cultural families and 16 urban-to-rural migrants. The collaborative in-depth research with the Korean Women’s Development Institute on the social cohesion of rural multi-cultural families was conducted. Existing related data were collected by searching the data of related research institutes and government organizations. Descriptive statistics such as frequencies, percentage, means and t-test, F-test and chi-square test were conducted to elucidate the current situation of social cohesion of rural multi-cultural families and urban-to-rural migrants. Finally, multiple regression was employed to identify the influential factors for the level of perceived social cohesion. Research Results and Implications Social cohesion of rural multi-cultural families and urban-to-rural migrants has been investigated through four aspects: economic aspect, socio- cultural aspect, political aspect, and comprehensive aspect. Major policy tasks to improve the social cohesion of rural multi-cultural families are as follows: 1) in the economic aspect, ① strengthening job placement and vocational education, ② actively using social economic policies, and ③ prohibiting discrimination against female marriage immigrants in economic activities; 2) in the socio-cultural aspect, ① expanding social exchange between multi-cultural families and ordinary rural residents, ② improving Korean language education, ③ strengthening family education and bilingual education, and ④ strengthening learning support and career guidance for children of multi-cultural families; 3) in the political aspect, ① expanding political participation of multi-cultural families, and ② strengthening prevention and management of discrimination. Major policy tasks to improve the social cohesion of urban-to-rural migrants are as follows: 1) in the economic aspect, ① activating the social economy with urban-to-rural migrants and indigenous people in the community, ② improving housing purchase and lease support, and ③ providing and arranging job-related information; 2) in the socio-cultural aspect, ① promoting the social exchange between urban-to-rural migrants and indigenous people in the community, ② cultivating community spirit and strengthening mutual understanding education, and ③ activating a mentor system; 3) in the political aspect, ① establishing the democratic and transparent village operation base, ② establishing a conflict mediation system and strengthening prevention and management of social conflict, and ③ promoting support for urban-to-rural migrants.
Pang, Changhyun,Kang, Daeshik,Kim, Tae-il,Suh, Kahp-Yang American Chemical Society 2012 Langmuir Vol.28 No.4
<P>We report an analysis of preload-dependent reversibleinterlockingbetween regularly arrayed, high aspect ratio (AR) polymer micro- andnanofibers. Such a reversible interlocking is inspired from the wing-lockingdevice of a beetle where densely populated microhairs (termed microtrichia)on the cuticular surface form numerous hair-to-hair contacts to maximizelateral shear adhesion. To mimic this, we fabricate various high AR,vertical micro- and nanopillars on a flexible substrate and investigatethe shear locking force with different preloads (0.1–10 N/cm<SUP>2</SUP>). A simple theoretical model is developed based on the competitionbetween van der Waals (VdW) attraction and deflection forces of pillars,which can explain the preload-dependent maximum deflection, tiltingangle, and total shear adhesion force.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2012/langd5.2012.28.issue-4/la203853r/production/images/medium/la-2011-03853r_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/la203853r'>ACS Electronic Supporting Info</A></P>