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DaeYong JEONG,Eunki Hong 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.II
A tunable polymer spatial light modulator using a poly(vinylidene fluoride-trifluoroethylenechlorofluoroethylene) terpolymer with a high electrostrictive strain was demonstrated. A thin polymer film was sandwiched between a flexible layer of metal and a rigid substrate with a metal combshaped electrode. For a 14-μm-thick polymer (with electrode/gap/electrode = 5 μm/15 μm/5 μm), a first order diffraction efficiency of 24 % was observed under an electric field of 100 V/μm. The simple fabrication makes polymer deformable mirrors promising for optical devices.r
Daeyong Shim,Hyunsik Jeong,Hyunjoong Lee,Cyuyeol Rhee,Deog-Kyoon Jeong,Suhwan Kim IEEE 2013 IEEE journal of solid-state circuits Vol.48 No.10
<P>Smaller transistors mean that capacitors are charged less uniformly, which increases the self-refresh current in the DRAMs used in mobile devices. Adaptive self-refresh using an on-chip thermometer can solve this problem. We propose an on-chip CMOS thermometer specifically designed for controlling the refresh period of a DRAM. This thermometer includes a novel temperature sensor which has been implemented and integrated into an LPDDR2 chip. The LPDDR2 chip is fabricated in a 44-nm DRAM process. The sensor has a temperature sensitivity of -3.2 mV/°C, over a range of 0°C to 110°C. Its resolution is 1.94°C and is only limited by the 6.2-mV step of the associated resistor ladder not by its own design. The linearity of the sensor permits one-point calibration, after which the errors in 61 sample circuits ranged between -1.42°C and +2.66°C. The sensor has an active area of 0.001725 mm<SUP>2</SUP> and consumes less than 0.36 μW on average with a supply of 1.1 V. At its lowest operating temperature, this thermometer reduces the IDD6 current of the LPDDR2 chip by almost half.</P>
디젤분무의 한계압력 규명을 위한 극초고압 충돌분무특성 해석
정대용(Daeyong Jeong),이종태(Jongtai Lee) 한국자동차공학회 2003 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
Impinging spray characteristics were investigated to find limit injection pressure by using ultra high pressure injection equipment. Spray radius and spray height were increased continuously with increase of injection pressure, but the rates of enhancement had a moderate increase ove<br/> 2,500bar injection pressure. Impinging spray characteristics were reversed as same tendency as free spray characteristics at 4, I 40bar. Spray radiuses and heightes of left and right side fro nozzle had little difference until 2000bar injection pressure, but remarkable difference caused by the effect of shock wave in ultra high pressure region. Above results show that the limit injection pressure of impinging spray exists around 4,OOObar.<br/>
정대용(Daeyong Jeong),이종태(Jongtai Lee) 한국자동차공학회 2002 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2002 No.5_3
Ultra high pressure injection equipment was modified to estimate and analyze the spray characteristics in ultra high injection pressure. Spray patterns were visualized and investigated by method of schlieren in UHPIE. Spray penetration and spray thickness, angle and volume were increased with the increase of injection pressure. But over 2,800bar of injection pressure region the rate of increase shows almost same and finally spray penetration and volume were decreased.
Jeong, YongJun,Lee, DaeYong,Choe, Kibaek,Ahn, Hyeji,Kim, Pilhan,Park, Ji-Ho,Kim, Yeu-Chun Elsevier 2017 Journal of industrial and engineering chemistry Vol.48 No.-
<P><B>Abstract</B></P> <P>In this study, a novel oral insulin delivery system was prepared by combining two different artificial polypeptides with insulin. Negatively charged poly(<SMALL>L</SMALL>-glutamate-<I>co</I>-<I>N</I>-3-<SMALL>L</SMALL>-glutamylsulfanilic acid) (PLGS), cationic alpha helical peptide poly-<SMALL>L</SMALL>-lysine (PLL), and insulin formed polyelectrolyte complexes (PCs) were characterized. The property of the PCs was examined by an <I>in vitro</I> study. A significantly higher amount of the loaded FITC insulin was released in the intestinal condition, suggesting the controlled release of the PCs to protect insulin in the acidic stomach condition while releasing it in the small intestine. The <I>in vitro</I> cellular uptake study with Caco-2 cells also revealed the improved penetration of the loaded FITC labeled insulin. By virtue of the cell penetration enhancing ability of PLL, the permeation of insulin in the small intestine was notably augmented. Furthermore, the feasibility of the PCs was confirmed through an <I>in vivo</I> hypoglycemic effect study. The PCs showed an improved hypoglycemic effect suggesting the success of the delivery and penetration of the loaded insulin. The blood glucose level was lowered to 80% of its initial value after the oral administration of the PCs, and the hypoglycemia lasted for more than 14h. The long lasting hypoglycemic effect of the PCs can reduce the number of administrations, and it will contribute to improving the quality of patients’ lives. The PCs provided reasonable results as a competitive candidate for oral insulin delivery. The introduction of the PCs will promote the oral delivery of charged proteins or drugs.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Lee, DaeYong,Lee, Soo-Hwan,Na, Youjin,Noh, Ilkoo,Ha, JongHoon,Yoo, Jisang,Bang, Hyun Bae,Park, Jong Hyun,Jeong, Ki Jun,Yun, Chae-Ok,Kim, Yeu-Chun Elsevier Science Publishers 2017 Journal of controlled release Vol.264 No.-
<P><B>Abstract</B></P> <P>Artificial cationic helical peptides possess an enhanced cell-penetrating property. However, their cell-penetrability is not converted by cellular environmental changes resulting in nonspecific uptake. In this study, pH-sensitive anion-donating groups were added to a helical polypeptide to simultaneously achieve tumor targeting and pro-apoptotic activity. The mitochondria-destabilizing helical polypeptide undergoing pH-dependent conformational transitions selectively targeted cancer cells consequently disrupting mitochondrial membranes and subsequently inducing apoptosis. This work presents a promising peptide therapeutic system for cancer therapy.</P> <P><B>Graphical abstract</B></P> <P>Mitochondria-destabilizing helical polypeptide undergoing a pH-activated conformational transition selectively perturbed the mitochondrial outer membranes thereby inducing pro-apoptosis.</P> <P>[DISPLAY OMISSION]</P>