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김정아,정현식,김원석,윤성수,이홍기,박찬형,박성규,김동욱,이종욱,한치화,민우성,김춘추,김동집 대한조혈모세포이식학회 1996 대한조혈모세포이식학회지 Vol.1 No.1
Background: In most solid tumors, the CD34 antigen has not been detected, so positive selection of CD34+ cells may reduce tumor cell contamination and the CD34+ cells are capable of reconstituting hematopoiesis. We tried CD34+ cell transplantation in two patients. Method: CD34+ cells from chemotherapy + G-CSF mobilized PBPCs or bone marrow were positively selected with an avidin-biotin immunoadsorption column (CEPRATE SC system). Case 1. One course of chemotherapy using cyclophosphamide(200㎎/㎡) and etoposide (4.2g/㎡), combined with G-CSF(5㎍/㎏) S.C. was used in a relapsed lymphoma patient. This patient responded to the induction chemotherapy. CD34+ cells from harvested bone marrow were selected by the CellPro immunoadsorption column. The total number of mononuclear cells loaded onto the CellPro was 2.4×10^(8)/㎏, with 1.1% CD34+ cells. After column separation, the total number of positively selected cells was 5.16×10^(6)/㎏. The number of CFU-GM was 76.8×10⁴/㎏. This patient was treated with melphalan (140㎎/㎡) and TBI (1200cGy) and the positively selected CD34+ cells were infused. The time to neutrophil recovery greater than 0.5×10^(9)/L was 19 days and the time to platelet recovery greater than 50×10^(9)/L was 21 days. Case 2. Two courses of mobilizing chemotherapy were given 4 weeks apart using taxol(210㎎/m2) and adriamycin(60㎎/m2), combined with G-CSF(5㎍/㎏) S.C. in a breast cancer patients with 7 axillary node metastasis. CD34+ cells from each single leukapheresis product were selected by the CellPro immunoadsorption column. In the first collection, the total number of nucleated cells was 4.4×10^(8)/kg, with 0.42% CD34+ cells. In the second collection, the total number of nucleated cell was 2.8× 10^(8)/㎏ with 0.43% CD34+ cells. After colum separation, the total numbers of collected cells were 4.0×106/kg and 4.8×10^(6)/kg, the total number of CD34+ cells were 1.2×10^(6)/㎏ and 0.82×10^(6)/㎏. Colonogenic assays of positively selected CD34+ cells gave rise to myeloid erythroid, and multilineage colonies, with a median of 190 CFU-GM, 190 BFU-E, and 164 CFU-GEMM per 1×10³ adsorbed cells, respectively. High-dose chemotherapy with cumulative doses of 40mg/㎡ mitoxantrone, 750mg/㎡ thioptepa, and 1000mg/㎡ carboplatin was administered. Positively selected CD34+ cells were rapidly infused 24 hours after the end of high-dose chemotherapy. The time to neutrophil recovery greater than 0.5×10^(9)/L was 16 days and the time to platelet recovery greater than 50×10^(9)/L was 20 days.
Kim, Do Hwan,Lee, Bang-Lin,Moon, Hyunsik,Kang, Hee Min,Jeong, Eun Jeong,Park, Jeong-Il,Han, Kuk-Min,Lee, Sangyoon,Yoo, Byung Wook,Koo, Bon Won,Kim, Joo Young,Lee, Wi Hyoung,Cho, Kilwon,Becerril, Hecto American Chemical Society 2009 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.131 No.17
<P>The ability to control the molecular organization of electronically active liquid-crystalline polymer semiconductors on surfaces provides opportunities to develop easy-to-process yet highly ordered supramolecular systems and, in particular, to optimize their electrical and environmental reliability in applications in the field of large-area printed electronics and photovoltaics. Understanding the relationship between liquid-crystalline nanostructure and electrical stability on appropriate molecular surfaces is the key to enhancing the performance of organic field-effect transistors (OFETs) to a degree comparable to that of amorphous silicon (a-Si). Here, we report a novel donor-acceptor type liquid-crystalline semiconducting copolymer, poly(didodecylquaterthiophene-alt-didodecylbithiazole), which contains both electron-donating quaterthiophene and electron-accepting 5,5'-bithiazole units. This copolymer exhibits excellent electrical characteristics such as field-effect mobilities as high as 0.33 cm(2)/V.s and good bias-stress stability comparable to that of amorphous silicon (a-Si). Liquid-crystalline thin films with structural anisotropy form spontaneously through self-organization of individual polymer chains as a result of intermolecular interactions in the liquid-crystalline mesophase. These thin films adopt preferential well-ordered intermolecular pi-pi stacking parallel to the substrate surface. This bottom-up assembly of the liquid-crystalline semiconducting copolymer enables facile fabrication of highly ordered channel layers with remarkable electrical stability.</P>
Therapeutic effects of selective p300 histone acetyl-transferase inhibitor on liver fibrosis
Hyunsik Kim,Soo-Yeon Park,Soo Yeon Lee,Jae-Hwan Kwon,Seunghee Byun,Mi Jeong Kim,Sungryul Yu,Jung-Yoon Yoo,윤호근 생화학분자생물학회 2023 BMB Reports Vol.56 No.2
Liver fibrosis is caused by chronic liver damage and results inthe aberrant accumulation of extracellular matrix during diseaseprogression. Despite the identification of the HAT enzyme p300as a major factor for liver fibrosis, the development of therapeuticagents targeting the regulation of p300 has not beenreported. We validated a novel p300 inhibitor (A6) on theimprovement of liver fibrosis using two mouse models, miceon a choline-deficient high-fat diet and thioacetamide-treatedmice. We demonstrated that pathological hall-marks of liverfibrosis were significantly diminished by A6 treatment throughMasson’s trichrome and Sirius red staining on liver tissue andfound that A6 treatment reduced the expression of matricellularprotein genes. We further showed that A6 treatment improvedliver fibrosis by reducing the stability of p300 proteinvia disruption of p300 binding to AKT. Our findings suggestthat targeting p300 through the specific inhibitor A6 has potentialas a major therapeutic avenue for treating liver fibrosis.
TiOX-polyanilne composite films for high-performance supercapacitors
Ahn, Jeong Min,Inamdar, Akbar I.,Jo, Yongcheol,Kim, Jongmin,Jung, Woong,Im, Hyunsik,Kim, HyungSang 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol. No.
TiOX-polyaniline (PANI) nano-composite thin films are synthesized using an electrochemical deposition technique for supercapacitor applications. The PANI-TiOX composite films show granular porous morphologies along with PANI nanofibers. The electrochemical supercapacitor properties of the PANI and the composite PANI-TiOX films are examined in a 0.5-M LiClO4 electrolyte. The pure PANI film shows a comparatively higher specific capacitance whereas the PANI-TiOX composite films are more stable with high power and energy densities. Negligible capacitance loss is obtained for the PANI-TiOX composite films over 1000 charge-discharge cycles. The composite films show considerably improved power-density and energy-density values of similar to 31.2 kW/kg and similar to 35.2 Wh/kg, respectively.
사용자 참여형 웨어러블 디바이스 데이터 전송 연계 및 딥러닝 대사증후군 예측 모델
이현식(Hyunsik Lee),이웅재(Woongjae Lee),정태경(Taikyeong Jeong) 한국산업정보학회 2020 한국산업정보학회논문지 Vol.25 No.6
본 논문은 최근 다양한 종류의 웨어러블 디바이스가 헬스케어 도메인에 급증하여 사용되고 있는 상황에서 최신 첨단 기술이 실제 메디컬 환경에서 개인의 질병예측이라는 관점을 바라본다. 사용자 참여형 웨어러블 디바이스를 통하여 임상 데이터와 유전자 데이터, 라이프 로그 데이터를 병합하여 데이터를 수집, 처리, 전송하는 과정을 걸쳐 딥뉴럴 네트워크의 환경에서 학습모델의 제시와 피드백 모델을 연결하는 과정을 제시한다. 이러한 첨단 의료 현장에서 일어나는 메디컬 IT의 임상시험 절차를 걸친 실제 현장의 경우 대사 증후군에 의한 특정 유전자가 질병에 미치는 영향을 측정과 더불어 임상 정보와 라이프 로그 데이터를 병합하여 서로 각기 다른 이종 데이터를 처리하면서 질병의 특이점을 확인하게 된다. 즉, 이종 데이터의 딥뉴럴 네트워크의 객관적 적합성과 확실성을 증빙하게 되고 이를 통한 실제 딥러닝 환경에서의 노이즈에 따른 성능 평가를 실시한다. 이를 통해 자동 인코더의 경우의 1,000 EPOCH당 변화하는 정확도와 예측치가 변수의 증가 값에 수차례 선형적으로 변화하는 현상을 증명하였다. This paper aims to look at the perspective that the latest cutting-edge technologies are predicting individual diseases in the actual medical environment in a situation where various types of wearable devices are rapidly increasing and used in the healthcare domain. Through the process of collecting, processing, and transmitting data by merging clinical data, genetic data, and life log data through a user-participating wearable device, it presents the process of connecting the learning model and the feedback model in the environment of the Deep Neural Network. In the case of the actual field that has undergone clinical trial procedures of medical IT occurring in such a high-tech medical field, the effect of a specific gene caused by metabolic syndrome on the disease is measured, and clinical information and life log data are merged to process different heterogeneous data. That is, it proves the objective suitability and certainty of the deep neural network of heterogeneous data, and through this, the performance evaluation according to the noise in the actual deep learning environment is performed. In the case of the automatic encoder, we proved that the accuracy and predicted value varying per 1,000 EPOCH are linearly changed several times with the increasing value of the variable.