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Joo Eun-Jeong,Ko Jae-Hoon,김성은,Kang Seung-Ji,Baek Ji Hyeon,Heo Eun Young,Shi Hye Jin,Eom Joong Sik,Choe Pyoeng Gyun,Bae Seongman,Ra Sang Hyun,Kim Da Young,Kim Baek-Nam,Kang Yu Min,Kim Ji Yeon,Chung Jin 대한의학회 2021 Journal of Korean medical science Vol.36 No.11
Background: Remdesivir is widely used for the treatment of coronavirus disease 2019 (COVID-19), but controversies regarding its efficacy still remain. Methods: A retrospective cohort study was conducted to evaluate the effect of remdesivir on clinical and virologic outcomes of severe COVID-19 patients from June to July 2020. Primary clinical endpoints included clinical recovery, additional mechanical ventilator (MV) support, and duration of oxygen or MV support. Viral load reduction by hospital day (HD) 15 was evaluated by calculating changes in cycle threshold (Ct) values. Results: A total of 86 severe COVID-19 patients were evaluated including 48 remdesivir-treated patients. Baseline characteristics were not significantly different between the two groups. Remdesivir was administered an average of 7.42 days from symptom onset. The proportions of clinical recovery of the remdesivir and supportive care group at HD 14 (56.3% and 39.5%) and HD 28 (87.5% and 78.9%) were not statistically different. The proportion of patients requiring MV support by HD 28 was significantly lower in the remdesivir group than in the supportive care group (22.9% vs. 44.7%, P = 0.032), and MV duration was significantly shorter in the remdesivir group (average, 1.97 vs. 5.37 days; P = 0.017). Analysis of upper respiratory tract specimens demonstrated that increases of Ct value from HD 1–5 to 11–15 were significantly greater in the remdesivir group than the supportive care group (average, 10.19 vs. 5.36; P = 0.007), and the slope of the Ct value increase was also significantly steeper in the remdesivir group (average, 5.10 vs. 2.68; P = 0.007). Conclusion: The remdesivir group showed clinical and virologic benefit in terms of MV requirement and viral load reduction, supporting remdesivir treatment for severe COVID-19.
홍고추의 유전형 및 재배환경 요인에 따른 비타민 성분의 자연변이 연구
이소영(So-Young Lee),김은하(Eun-Ha Kim),백다영(Da-Young Baek),이경민(Gyeong-Min Lee),박수윤(Soo-Yun Park),이상구(Sang-Gu Lee),류태훈(Tae-Hoon Ryu),강현중(Hyeon-Jung Kang),오선우(Seon-Woo Oh) 한국식품영양과학회 2020 한국식품영양과학회지 Vol.49 No.3
홍고추는 사람의 식이에서 주요 비타민 공급원이며, 우리나라 사람들은 홍고추를 많이 섭취하고 있다. 그러나 홍고추의 비타민 함량에 대한 품종, 재배지역 및 재배연도에 의한 성분의 자연변이 연구는 국내에서 거의 수행되지 않았다. 이를 위하여 본 연구에서는 12개 상업품종을 대상으로 2016년도와 2017년도 2년간, 2개 지역(4개의 재배환경)에서 재배 및 수확하여 홍고추 과육에서 비타민 A, 비타민 B₁, 비타민 B₂, 비타민 B₃, 비타민 B5, 비타민 E(α-, β-, δ-, γ-tocopherol) 함량을 비교 분석하였다. 고추 과육에서 분석한 비타민 함량을 통합하여 4개 재배환경에 대한 자연변이를 비교하기 위해 통계 알고리즘을 개발하고 적용한 결과, 비타민의 성분은 품종별, 지역별, 연도별로 자연변동성에 유의미한 차이를 보였다. PLS-DA를 이용한 주성분 분석과 더불어 R 통계 기법을 이용한 변동성(% variability) 분석을 실시한 결과, 비타민 성분의 자연변동성은 품종 요인보다는 재배지역이나 재배연도 또는 세 가지 통합 요인의 교호작용에 의해 더 많은 영향을 받는 것으로 확인되었다. 특히 비타민 C와 비타민 B₂, 비타민 B₃, γ-tocopherol은 주로 재배연도에 의해 성분변이가 큰 것으로 분석되었다. α-Tocopherol은 품종 요인에 의해 변이가 비교적 큰 것으로 나타났으나, 세 가지 요인의 교호작용에 의한 변이가 가장 큰 것으로 분석되었다. 비타민 B5는 품종별 요인에 의해 성분변이가 가장 크게 나타났으며, β-tocopherol은 지역 요인에 의한 성분변이가 가장 큰 것으로 나타났다. 비타민 분석 결과에 대해 품종별, 지역별, 연도별로 다변량 통계분석(PLS-DA)을 실시한 결과, 재배지역과 재배연도 요인에 의한 데이터 클러스터가 가시적으로는 뚜렷하게 구분되었으나, PC1과 PC2의 합산 분산력이 60% 미만으로 2차원의 주성분으로 전체 데이터의 분산을 설명하기에는 약간 부족한 것으로 확인되었다. 따라서 비타민 성분의 환경 요인에 의한 변동성 또는 분산력을 설명하기 위해서는 정량적 통계분석 방법인 자연변동성(% variability) 분석이 추가로 수행되어야 하는 것을 알 수 있었다. Red peppers are a remarkably rich source of vitamins in the human diet and widely consumed in Korea. However, comprehensive studies have not reported on the effects of genotype, cultivation regions, and year of cultivation on the vitamin composition of the pepper fruits. To address this, twelve commercial pepper varieties were grown at two locations in Korea during 2016 and 2017, and the concentrations of vitamin A, B₁, B₂, B₃, B5, and E (α-, β-, δ-, γ-tocopherols) in pepper pericarps were determined. Statistical analysis of the combined data showed significant differences among varieties, locations, and years for the measured components. The % variability analysis demonstrated that environment (location and year) and genotype-environment interaction contributed more to the nutritional contents than the genotype alone. Particularly, variation in vitamins A, C, B₂, B₃, and γ-tocopherol was attributed to the year of cultivation. α-Tocopherol primarily varied by the genotype-environment interaction. Vitamin B5 was the trait that the most highly affected by genotype. The location effect was significant for β-tocopherol. Partial least squares discriminant analysis (PLS-DA) results showed that the separation of vitamins was distinct by year and location. These results were supported by the % variability analysis. Our study could explain the natural variation in the vitamin compositions of peppers by genotypes and environments.
Kim, Eun Tae,Hwang, Hee Soon,Lee, Sang Min,Lee, Shin Ja,Lee, Il Dong,Lee, Su Kyoung,Oh, Da Som,Lim, Jung Hwa,Yoon, Ho Baek,Jeong, Ha Yeon,Im, Seok Ki,Lee, Sung Sill Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.9
This study was aimed to evaluate the in vitro effects of medicinal herb extracts (MHEs) on ruminal fermentation characteristics and the inhibition of protozoa to reduce methane production in the rumen. A fistulated Hanwoo was used as a donor of rumen fluid. The MHEs (T1, Veratrum patulum; T2, Iris ensata var. spontanea; T3, Arisaema ringens; T4, Carduus crispus; T5, Pueraria thunbergiana) were added to the in vitro fermentation bottles containing the rumen fluid and medium. Total volatile fatty acid (tVFA), total gas production, gas profiles, and the ruminal microbe communities were measured. The tVFA concentration was increased or decreased as compared to the control, and there was a significant (p<0.05) difference after 24 h incubation. pH and ruminal disappearance of dry matter did not show significant difference. As the in vitro ruminal fermentation progressed, total gas production in added MHEs was increased, while the methane production was decreased compared to the control. In particular, Arisaema ringens extract led to decrease methane production by more than 43%. In addition, the result of real-time polymerase chain reaction indicted that the protozoa population in all added MHEs decreased more than that of the control. In conclusion, the results of this study indicated that MHEs could have properties that decrease ruminal methanogenesis by inhibiting protozoa species and might be promising feed additives for ruminants.
Kwon Da-Eun,Han Dong-Hee,Jung Kyung-Hwan,Lee Seung-Jae,Kim Jang-Oh,Baek Cheol-Ha 한국물리학회 2023 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.82 No.8
A lead is mainly used for radiation shielding owing to high density and atomic number, but lead is a harmful substance and has disadvantages such as heavy weight and toxicity. In this study, each material chosen is tellurium trioxide (TeO3), tin dioxide (SnO2), gadolinium oxide (Gd2O3), bismuth trioxide (Bi2O3), and tungsten dioxide (WO2). Monte Carlo simulation has been carried out for calculating half-layer value and linear attenuation coefcient as shielding parameters. In addition, feasibility was evaluated by comparing lead dioxide (PbO2) with lead-free oxide one following the weight and thickness in the simulation as using various shielding performance. A result indicated that gadolinium oxide (Gd2O3) has the most lightweight value in the shielding performance of 50%, 70%, and 90% of 120 kV and 150 kV. It expected to reduce radiation dose with lightweight and provide basic data to develop the apron using proper material powder.
Identification of serum biomarkers for premature ovarian failure
Lee, Da-Hye,Pei, Chang-Zhu,Song, Jae-Yun,Lee, Kyung-Ju,Yun, Bo-Seong,Kwack, Kyu-Bum,Lee, Eun-Il,Baek, Kwang-Hyun Elsevier 2019 Biochimica et biophysica acta. Proteins and proteo Vol.1867 No.3
<P><B>Abstract</B></P> <P>Premature ovarian failure (POF) is defined when a female achieves menopause before the age of 40. Although many conditions are known to be causative for POF, the most common one is idiopathic. This study was undertaken to investigate the pathogenesis of POF using proteomic tools. Two-dimensional electrophoresis (2-DE) analysis was performed to screen for proteins differentially expressed in patients with POF. Using liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS), we identified 11 significant proteins differentially expressed in the serum of POF patients: 5 proteins with expression increased more than two folds, 5 proteins with expression decreased more than two folds, and 1 protein expressed specifically in the serum of patients with POF. The results of the 2-DE analysis were further validated by Western blotting and ELISA analyses, which 5 reproductive system-related proteins (Ceruloplasmin, Complement C3, Fibrinogen α, Fibrinogen β, and SHBG) were selected. The different expression levels for these proteins were confirmed and demonstrated the possibility of using them as biomarkers to screen POF. These pre-clinical data provide plausible translational implications for targeting the pathogenesis of POF for each protein.</P> <P><B>Highlight</B></P> <P> <UL> <LI> Ceruloplasmin, Complement C3, Fibrinogen α, Fibrinogen β, and SHBG were differentially expressed in POF patients. </LI> <LI> They can be used as provisional biomarkers for identifying POF patients. </LI> <LI> These proteins may be helpful in understanding the molecular mechanism of the causes, pathogenesis, and management of POF. </LI> <LI> This is the first identification of differentially expressed proteins in the serum of POF patients. </LI> </UL> </P>