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Xanthones from Garcinia paucinervis with in vitro anti-proliferative activity against HL-60 cells
Da-Hong Li,Chen-Xi Li,Cui-Cui Jia,Ya-Ting Sun,Chun-Mei Xue,Jiao Bai,Hui-Ming Hua,Xiao-Qiu Liu,Zhan-Lin Li 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.2
Three new xanthones, paucinervins H–J (1–3), as well as eleven known compounds (4–14), were isolated from the leaves of Garcinia paucinervis. The structures of the new compounds (1–3) were elucidated by 1D, 2D NMR spectra and HR ESIMS. In vitro antiproliferative activity against human promyelocytic leukemia HL-60 cells was tested, among which, compounds 2, 5, 6 and 7 exhibited strong growth inhibitory effects with GI50 values ranging from 1.30 to 9.08 lM, respectively. Preliminary SARs were also discussed.
Da-Hong Li,Ping Hu,Sheng-tao Xu,Chun-yan Fang,Shuang Tang,Xin-yu Wang,Xing-yan Sun,He Lian,Ying Xu,Xiao-ke Gu,Jin-yi Xu 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.7
Herein, a series of lasiokaurin derivatives were designed and synthesized. All the derivatives together with lasiokaurin and oridonin were tested for their antimicrobial and antiproliferative activity. Compound 16 showed the most promising antimicrobial activity with MICs of 2.0 and 1.0 lg/mL against Gram-Positive bacteria S. aureus and B. subtilis, respectively. All the synthetic lasiokaurin derivatives showed better antiproliferative activity than parent compound lasiokaurin 1. Compound 10 exhibited the strongest cytotoxicity with IC50 values of 0.47 and 0.20 lM against MGC-803 and CaEs-17 cells, accordingly. Moreover, it was shown to have potent antitumor activity in vivo in a murine model of MGC-803 gastric cancer. Preliminary SARs were also concluded based on obtained data. The apoptosis-inducing effects of 10 were further investigated using CaEs-17 cells. The results showed that lasiokaurin derivative 10 could induce apoptosis via mitochondria related pathway and arrest CaEs-17 cell cycle at S phase. Compound 10 could also affect apoptosisrelated proteins that was up-regulation of CDK2 and downregulation of ATM and cyclin A1.
( Sun Hee Hyun ),( Seok Young Lee ),( Shin Jung Park ),( Da Yeon Kim ),( Young Jin Chun ),( Gi Ho Sung ),( Seong Hwan Kim ),( Hyung Kyoon Choi ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.1
Metabolic alterations of Cordyceps bassiana mycelium were investigated under the following culture medium and light conditions: dextrose agar supplemented with 0.5% yeast extract (SDAY) medium with light (SL), SDAY medium without light (SD), nut medium without light (ND), and iron-supplemented SDAY medium without light (FD). The levels of asparagine, aspartic acid, glutamic acid, glutamine, histidine, lysine, ornithine, and proline were significantly higher under SD and SL conditions. The levels of most of the alcohols, saturated fatty acids, unsaturated fatty acids, fatty acid esters, sterols, and terpenes were higher under the ND condition than in the other conditions, but beauvericin was not detectable under the ND condition. The FD condition was favorable for the enhanced production of aminomalonic acid, malic acid, mannonic acid, and erythritol. Thus, the metabolic characteristics of C. bassiana can be manipulated by varying the cultivation conditions, rendering this fungus potentially favorable as a nutraceutical and medicinal resource.
Sun, Qian,Zhu, Lei,Meng, Ze-Da,Ullah, Kefayat,Ye, Shu,Oh, Won-Chun The Korean Ceramic Society 2013 한국세라믹학회지 Vol.50 No.4
ACF and ZnO modified $TiO_2$ composite materials (ZnO-ACF/$TiO_2$) were prepared by a sol-gel method. The composites were characterized by X-ray diffraction (XRD), energy dispersive X-ray (EDX) analysis and scanning electron microscope (SEM) analysis. A methyl orange (MO) solution under visible light irradiation was used to determine the photocatalytic activity. The degradation of the MO was determined using UV spectrophotometers. An increase in the photocatalytic activity was observed and attributed to an increase of the photo-absorption effect by the ZnO and the cooperative effect of the ACF.