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아스파라기나제 과민성에 대한 전처치와 급속 탈감작의 효용성
윤다혜 ( Da Hye Yoon ),강성희 ( Sung Hee Kang ),김환수 ( Hwan Soo Kim ),이재욱 ( Jae Wook Lee ),윤종서 ( Jong Seo Yoon ),정낙균 ( Nack Gyun Chung ),조빈 ( Bin Cho ) 대한천식알레르기학회 2015 Allergy Asthma & Respiratory Disease Vol.3 No.4
Purpose: L-asparaginase is a crucial chemotherapeutic agent for the treatment of acute lymphoblastic leukemia. However, hypersensitivity to L-asparaginase is common which limits its clinical use. Methods: We performed 44 cases of premedication and 3 cases of desensitization in 16 patients with hypersensitivity to L-asparaginase. Results: With premedication, 33 cases completed L-asparaginase injection with no hypersensitivity reactions. Eleven cases showed mild hypersensitivity reactions, such as urticaria. Desensitization was performed in 3 cases: in 2 cases, desensitization was successful, and in 1 case the medication was switched to Erwinia asparaginase. Conclusion: Premedication and desensitization appear to be useful in helping patients receive desired doses of L-asparaginase in pediatric patients with acute lymphoblastic leukemia. (Allergy Asthma Respir Dis 2015;3:288-293)
Case Report : A Case of Adult-Onset Still`s Disease Presenting with Periorbital Edema
( Da Lim Yoon ),( Seohyun Lee ),( So Young Park ),( You Jae Kim ),( Bon San Koo ),( Min Wook So ),( Yong Gil Kim ),( Chang Keun Lee ),( Bin Yoo ) 대한류마티스학회 2013 대한류마티스학회지 Vol.20 No.4
Adult-onset Still`s disease (AOSD) is a systemic inflammatory disorder of unknown etiology that is characterized by high-spiking fever, arthralgia, sore throat, and skin rash. The typical rash of AOSD is an evanescent, salmon- colored erythema, which is considered to be the major diagnostic criterion. Recently, other cutaneous manifestations of AOSD, such as persistent plaque and urticaria, have been reported. Here, we report a rare case of AOSD presenting with periorbital swelling and erythema. A 47-year-old woman was presented with periorbital swelling, erythema, high fever, arthritis, and a sore throat. One year prior to admission, she was diagnosed with AOSD based on the diagnostic criteria of Yamaguchi. The patient`s periorbital swelling and erythema may not have been associated with periorbital cellulitis because they did not respond to antibiotics but did improve after treatment with steroids. Considering all of her signs and symptoms with a history of AOSD, periorbital lesion was suspected as atypical cutaneous manifestation of AOSD.
과체중과 비만이 사춘기 전 소아 천식에서 폐기능과 중증도에 미치는 영향
정다빈 ( Da Bin Jung ),정지은 ( Ji Eun Jeong ),정혜리 ( Hai Lee Chung ),장윤영 ( Yoon Young Jang ) 대한천식알레르기학회 2021 Allergy Asthma & Respiratory Disease Vol.9 No.4
Purpose: Cluster analysis on pediatric asthma identifying a cluster characterized by obesity, females, and puberty showed that obe-sity is an independent risk factor for severe asthma in this cluster. In the present study, we aimed to investigate the effect of over-weight/obesity on lung function and asthma severity in prepubertal asthmatic children. Methods: One hundred fifty-five prepubertal children (aged 6-10) with asthma were enrolled and divided into 2 groups: the over-weight/obese group (body mass index [BMI] ≥85th percentile, n=44) and the normal BMI group (<85th percentile, n=111). We re-viewed their medical records and analyzed whether there were any differences in clinical features, lung function and degree of bron-chial hyperresponsiveness (BHR) between the 2 groups. The clinical factors associated with asthma severity were also investigated. Results: There was no difference in clinical features between the 2 groups. Pulmonary function tests showed that only forced vital capacity in 1 second/forced vital capacity (FEV<sub>1</sub>/FVC) was significantly lower in the overweight/obese group than in the normal BMI group (P=0.032). There was no difference in dysanapsis and BHR between the 2 groups. There were significantly more children with moderate-to-severe asthma in the overweight/obese group compared to the normal BMI group (P=0.018). In multivariate logistic regression analysis, overweight/obesity has been identified as an independent risk factor of affecting asthma severity (odds ratio, 2.44; P=0.018), in addition to the already known risk factor, FEV<sub>1</sub>. Conclusion: Our study showed that overweight/obese prepubertal asthmatic children had lower FEV<sub>1</sub>/FVC than those with normal BMI. It also suggests that overweight/obesity may be an independent risk factor for severe asthma before puberty. (Allergy Asthma Respir Dis 2021;9:231-237)
윤인진 ( Yoon In Jin ),이의균 ( Lee Eui Kyun ),서지원 ( Seo Ji Won ),정다빈 ( Jeong Da Bin ) 대한인지재활학회 2022 대한인지재활학회지 Vol.11 No.1
목적: 본 증례는 척수근육위축증 유형Ⅱ로 진단 받은 아동의 인지기능 발달에 대해 알아보고자 하였다. 연구방법: 본 연구의 대상 아동은 생후 15개월에 척수근육위축증 유형Ⅱ로 진단 받아 재활의학과로 의뢰되었고, 생후 15개월부터 45개월까지 본 기관과 다른 기관에서 물리치료, 작업치료, 언어치료 등을 지속하여 받았다. 아동의 전반적인 발달을 확인하기 위해 생후 15개월, 21개월, 26개월, 28개월, 42개월에 시행된 덴버발달선별검사Ⅱ와 생후 33개월에 시행된 베일리영유아발달검사Ⅱ의 결과를 확인하였다. 결과: 덴버발달선별검사Ⅱ 결과, 개인사회성영역에서 생후 15개월, 21개월, 26개월에 정상, 38개월에 의심스러운 발달, 42개월에 정상을 보였고, 미세운동적응영역에서 생후 15개월, 21개월, 26개월, 38개월, 42개월에 정상을 보였다. 언어영역에서 생후 15개월, 21개월에 정상을 보였으나 26개월, 38개월, 42개월에는 의심스러운 발달을 보였다. 생후 33개월에 시행된 베일리영유아발달검사Ⅱ에서 정신 발달연령 26개월, 정신발달지수 78점으로 정신영역에서 약간 지연을 보였다. 결론: 본 증례를 통해 척수근육위축증 유형Ⅱ 아동에게서 인지기능 발달지연이 발생할 수 있음을 확인할 수 있었다. 이를 근거로 척수근육위축증 유형Ⅱ 아동에게 운동기능을 위한 평가와 치료적 접근뿐만 아니라 인지기능 발달을 확인하기 위한 평가와 치료적 접근도 중요한 중재라는 것을 보고하는 바이다. Purpose: The purpose of this report was to investigate the cognitive development on spinal muscular atrophy typeⅡ(SMAⅡ). Methods: The subject was diagnosed with SMAⅡ at 15 months and referred to the Department of Pediatric Rehabilitation Medicine. From 15 to 45 months, he was participated in physical therapy, occupational therapy, and speech therapy at many institutions. He was evaluated the Denver Developmental Screening TestⅡ(DDSTⅡ) at 15, 21, 26, 28, and 42 months and the Bayley scales of infant development II at 33 months. Results: The results of personal-social on DDSTⅡ were normal at 15, 21, and 26 months, suspicious development at 38 months, and normal at 42 months. The results of fine motor-adaptive on DDSTⅡ were normal at all age. The results of language on DDSTⅡ were normal at 15 and 21 months, but suspicious development at 26, 38, and 42 months. The results of the Bayley scales of infant development II at 33 months was mildly delayed performance on mental scale. Conclusion: We were able to identify that cognitive developmental delay may occur in child with SMAⅡ. We suggest that not only evaluation and therapeutic approaches for motor function but also cognitive development are important interventions for children with SMAⅡ.
통합 리뷰 감정 분석을 통한 맞춤형 도서 비교 및 평가 시스템 설계
유다빈 ( Da-bin Yu ),유혜진 ( Hye-jin Ryu ),김나라 ( Na-ra Kim ),김윤희 ( Yoon-hee Kim ) 한국정보처리학회 2015 한국정보처리학회 학술대회논문집 Vol.22 No.1
아직까지도 도서 구매자의 대다수는 도서를 구매할 시 오프라인 서점을 이용하며, 외부 의견은 도서 구매 결정에 커다란 영향을 미치는 것으로 나타났다. 이에 따라 대표적 외부 의견인 도서의 리뷰를 가공·분석하여 제공하는 모바일 기반의 시스템의 필요성이 대두되었다. 하지만 현재 마켓에 등록된 애플리케이션의 대다수는 도서에 대한 사용자의 리뷰를 제공하지 않거나 분류·분석되지 않은 상태의 리뷰를 제공한다. 따라서 본 논문에서는 각 도서의 리뷰를 수집하여 리뷰의 긍정·부정적 감정 추이를 분석하고 그 결과를 리뷰 핵심어에 따라 분류된 도서 평가 기준 별로 제공하며 이를 통해 사용자의 도서 구매 결정과 여러 도서간의 도서 선택에 도움을 줄 수 있는 모바일 애플리케이션을 설계하였다.