Alterite et reversibilite La pertee ethique dans la theorisation d'Antoine Culioli

Francoise Colas 프랑스학회 1996 프랑스학연구 Vol.14 No.-

Gold-based hybrid nanomaterials for biosensing and molecular diagnostic applications

Kim, Jung Eun,Choi, Ji Hye,Colas, Marion,Kim, Dong Ha,Lee, Hyukjin Elsevier 2016 Biosensors & bioelectronics Vol.80 No.-

<P><B>Abstract</B></P> <P>The properties of gold nanomaterials are particularly of interest to many researchers, since they show unique physiochemical properties such as optical adsorption of specific wavelength of light, high electrical conductance with rich surface electrons, and facile surface modification with sulfhydryl groups. These properties have facilitated the use of gold nanomaterials in the development of various hybrid systems for biosensors and molecular diagnostics. Combined with various synthetic materials such as fluorescence dyes, polymers, oligonucleotides, graphene oxides (GO), and quantum dots (QDs), the gold-based hybrid nanomaterials offer multi-functionalities in molecular detection with high specificity and sensitivity. These two aspects result in the increase of detection speed as well as the lower detection limits, having shown that this diagnosis method is more effective than other conventional ones. In this review, we have highlighted various examples of nanomaterials for biosensing and molecular diagnostics. The gold-based hybrid systems are categorized by three distinct detection approaches, in which include (1) optical, such as surface plasmon resonance (SPR), RAMAN, and surface-enhanced Raman scattering (SERS), (2) fluorescence, such as förster resonance energy transfer (FRET) and nanomaterial surface energy transfer (NSET), and (3) electrochemical, such as potentiometic, amperometric, and conductometric. Each example provides the detailed mechanism of molecular detection as well as the supporting experimental result with the limit of detection (LOD). Lastly, future perspective on novel development of gold-based hybrid nanomaterials is discussed as well as their challenges.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Gold-based hybrid materials offer multi-functionalities in molecular detection. </LI> <LI> Gold-based hybrid materials offer enhanced sensitivity and detection limit. </LI> <LI> Gold-based hybrid materials are categorized by three distinct detection approaches. </LI> <LI> Mechanism and limit of molecular detection of hybrid materials are provided. </LI> </UL> </P>

Direct AC voltage control for grid-forming inverters

Qoria, Taoufk,Li, Chuanyue,Oue, Ko,Gruson, Francois,Colas, Frederic,Guillaud, Xavier The Korean Institute of Power Electronics 2020 JOURNAL OF POWER ELECTRONICS Vol.20 No.1

Grid-forming inverters usually use inner cascaded controllers to regulate output AC voltage and converter output current. However, at the power transmission system level where the power inverter bandwidth is limited, i.e., low switching frequency, it is difficult to tune controller parameters to achieve the desired performances because of control loop interactions. In this paper, a direct AC voltage control-based state-feedback control is applied. Its control gains are tuned using a linear quadratic regulator. In addition, a sensitivity analysis is proposed to choose the right cost factors that allow the system to achieve the imposed specifications. Conventionally, a system based on direct AC voltage control has no restriction on the inverter current. Hence, in this paper, a threshold virtual impedance has been added to the state-feedback control in order to protect the inverter against overcurrent. The robustness of the proposed control is assessed for different short-circuit ratios using small-signal stability analysis. Then, it is checked in different grid topologies using time domain simulations. An experimental test bench is developed in order to validate the proposed control.

Enzymatic Synthesis of Self-assembled Dicer Substrate RNA Nanostructures for Programmable Gene Silencing

Jang, Bora,Kim, Boyoung,Kim, Hyunsook,Kwon, Hyokyoung,Kim, Minjeong,Seo, Yunmi,Colas, Marion,Jeong, Hansaem,Jeong, Eun Hye,Lee, Kyuri,Lee, Hyukjin American Chemical Society 2018 NANO LETTERS Vol.18 No.7

<P>Enzymatic synthesis of RNA nanostructures is achieved by isothermal rolling circle transcription (RCT). Each arm of RNA nanostructures provides a functional role of Dicer substrate RNA inducing sequence specific RNA interference (RNAi). Three different RNAi sequences (GFP, RFP, and BFP) are incorporated within the three-arm junction RNA nanostructures (Y-RNA). The template and helper DNA strands are designed for the large-scale in vitro synthesis of RNA strands to prepare self-assembled Y-RNA. Interestingly, Dicer processing of Y-RNA is highly influenced by its physical structure and different gene silencing activity is achieved depending on its arm length and overhang. In addition, enzymatic synthesis allows the preparation of various Y-RNA structures using a single DNA template offering on demand regulation of multiple target genes.</P> [FIG OMISSION]</BR>

Maximization of ICRF power by SOL density tailoring with local gas injection

Jacquet, P.,Goniche, M.,Bobkov, V.,Lerche, E.,Pinsker, R.I.,Pitts, R.A.,Zhang, W.,Colas, L.,Hosea, J.,Moriyama, S.,Wang, S.-J.,Wukitch, S.,Zhang, X.,Bilato, R.,Bufferand, H.,Guimarais, L.,Faugel, H.,H IOP 2016 Nuclear fusion Vol.56 No.4

<P>Experiments have been performed under the coordination of the International Tokamak Physics Activity (ITPA) on several tokamaks, including ASDEX Upgrade (AUG), JET and DIII-D, to characterize the increased Ion cyclotron range of frequency (ICRF) antenna loading achieved by optimizing the position of gas injection relative to the RF antennas. On DIII-D, AUG and JET (with the ITER-Like Wall) a 50% increase in the antenna loading was observed when injecting deuterium in ELMy H-mode plasmas using mid-plane inlets close to the powered antennas instead of divertor injection and, with smaller improvement when using gas inlets located at the top of the machine. The gas injection rate required for such improvements (~0.7  ×  10<SUP>22</SUP> el s<SUP>−1</SUP> in AUG, ~1.0  ×  10<SUP>22</SUP> el s<SUP>−1</SUP> in JET) is compatible with the use of this technique to optimize ICRF heating during the development of plasma scenarios and no degradation of confinement was observed when using the mid-plane or top inlets compared with divertor valves. An increase in the scrape-off layer (SOL) density was measured when switching gas injection from divertor to outer mid-plane or top. On JET and DIII-D, the measured SOL density increase when using main chamber puffing is consistent with the antenna coupling resistance increase provided that the distance between the measurement lines of sight and the injection location is taken into account. Optimized gas injection was also found to be beneficial for reducing tungsten (W) sputtering at the AUG antenna limiters, and also to reduce slightly the W and nickel (Ni) content in JET plasmas. Modeling the specific effects of divertor/top/mid-plane injection on the outer mid-plane density was carried out using both the EDGE2D-EIRENE and EMC3-EIRENE plasma boundary code packages; simulations indeed indicate that outer mid-plane gas injection maximizes the density in the mid-plane close to the injection point with qualitative agreement with the AUG SOL density measurements for EMC3-EIRENE. Field line tracing for ITER in the 15 MA <I>Q</I> <SUB>DT</SUB>  =  10 reference scenario indicates that the planned gas injection system could be used to tailor the density in front the antennas. Benchmarking of EMC3-EIRENE against AUG and JET data is planned as a first step towards the ITER SOL modelling required to quantify the effect of gas injection on the SOL density in front of the antennas.</P>

The Strange Familiarity of Korean Poetry

Cola´s, Santiago 국제비교한국학회 2002 비교한국학 Comparative Korean Studies Vol.10 No.2

Anti-Ulcerogenic Mechanisms of the Sesquiterpene Lactone Onopordopicrin-Enriched Fraction from Arctium lappa L. (Asteraceae): Role of Somatostatin, Gastrin, and Endogenous Sulfhydryls and Nitric Oxide

Ana Beatriz Albino de Almeida,Anderson Luiz-Ferreira,Maı´ra Cola,Luciana Di Pietro Magri,Leonia Maria Batista,Joseilson Alves de Paiva,Jose´ Roberto Trigo,Alba R.M. Souza-Brito 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.4

Arctium lappa L. has been used in folk medicine as a diuretic, depurative, and digestive stimulant and in dermatological conditions. The mechanisms involved in the anti-ulcerogenic activity of the sesquiterpene onopordopicrin (ONP)-enriched fraction (termed the ONP fraction), obtained from A. lappa leaves, were studied. The gastroprotective mechanism of the ONP fraction was evaluated in experimental in vivo models in rodents, mimicking this disease in humans. ONP fraction (50mg/kg, p.o.) significantly inhibited the mucosal injury induced by ethanol/HCl solution (75%), indomethacin/bethanecol (68.9%), and stress (58.3%). When the ONP fraction was investigated in pylorus ligature, it did not induce alteration in the gastric volume but did modify the pH and total acid concentration of gastric juice. ONP fraction significantly increased serum somatostatin levels (82.1 – 4.1 vs. control group 12.7 – 4 pmol/L) and decreased serum gastrin levels (62.6 – 6.04 vs. control group 361.5 – 8.2 lU/mL). Mucus production was not significantly altered by the ONP fraction. Gastroprotection by the ONP fraction was completely inhibited by N-ethylmaleimide treatment and did not modify the effect in the animals pretreated with l-NG-nitroarginine methyl ester. These results suggest an antisecretory mechanism involved with the antiulcerogenic effect of the ONP fraction. However, only endogenous sulfhydryls play an important role in gastroprotection of the ONP fraction.

Baccharis trimera (Less.) DC: An Innovative Cardioprotective Herbal Medicine Against Multiple Risk Factors for Cardiovascular Disease

Marılia Moraes Queiroz Souza,Gustavo Ratti da Silva,Itarua Machri Cola,Aniely Oliveira Silva,Maysa Isernhagen Schaedler,Lucas Pires Guarnier,Rhanany Alan Calloi Palozi,Lorena Neris Barboza,Jacqueline 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.6

Cardiovascular disease (CVD) is the leading cause of death worldwide and among its modifiable risk factors are dyslipidemia, diabetes, and smoking. Experimental models evaluated this risk factors singly, however, there is a lack of models that agglomerate these risk factors, resembling real patients and elucidating the pathophysiology of CVD. Moreover, few studies have investigated the cardioprotective effects of Baccharis trimera, a species with lipid-lowering effects. In this study, ethanol-soluble fraction of B. trimera was characterized by liquid chromatography–mass spectrometry. Diabetes was induced by streptozotocin in Wistar rats that also received 0.5% cholesterol-enriched chow and were exposed to the smoke of nine cigarettes, 5 days/week, for 4 weeks. During the last 2 weeks, the animals were treated with vehicle (C−), B. trimera, or simvastatin plus insulin. At the end, cholesterol, triglyceride, urea, and creatinine levels; blood pressure (BP); heart rate (HR); abdominal aortic morphometry; vascular reactivity; renal and cardiac oxidative status; and histopathological changes were evaluated. The agglomerate of risk factors promoted alterations contrary to those described in the literature for the isolated risk factors. The C− group exhibited oxidative stress, increase in biochemical parameters, and thickening of the wall of the abdominal aorta. HR, systolic, diastolic, and mean BP decreased, and vascular reactivity was altered. Cardiac and renal histopathological changes were observed. Treatment with B. trimera reversed these changes and this effect may be partially attributable to lipid-lowering action and to the inhibition of free radical generation. B. trimera has cardioprotective effects in this model, with no toxicity.

Effects of essential oils on biological attributes of Trichogramma galloi adults

Alcántara-de la Cruz Ricardo,Parreira Douglas Silva,Dimaté Francisco Andreas Rodríguez,Batista Lorena Duarte,Ribeiro Rafael Coelho,Zanuncio José Cola 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.2

Bioactivity of nine essential oils (EOs) was studied on Anagasta kuehniella eggs in relation to the longevity of females, parasitism and emergence rates and sex ratio in the generations parental, F 1 and F 2 of Trichogramma galloi in comparison to a trade formulation of Azadirachta indica. There was no F 1 and F 2 progeny with Zingiber officinale being the most harmful. The greatest reductions in the parasitism rates (57, 43 and 28%) in the parental generation was caused by Allium sativum, Carapa guianensis and A. indica, respectively. In addition, A. sativum reduced the longevity (4.7 days) in the parental generation and emergence (33%) of F 1 . Tested EOs did not affect the sex ratio in the generations F 1 and F 2 and emergence in the F 2 . Allium sativum and Z. officinale were nonselective to T. galloi; while A. indica, C. guianensis and P. nigrum oils may compromise the progeny; therefore, their use must be avoided. Citrus sinensis, Mentha piperita, Origanum vulgare, Syzygium aromaticum and Thymus vulgare were selective to T. galloi, and these EOs are promising for IPM programs.