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오연희,이창욱,김승현,이성우,정병욱,이준희,박동일,권영무,신현종 동국대학교 경주대학 1996 東國論集 Vol.15 No.-
Morgagni 탈장은 횡격막의 전내측 부위의 발달이상으로 열공을 통하여 장관이나 대망과 같은 복강내 구조물이 흉곽내로 빠져나가는 드문 질환으로 알려져 있다. 저자들은 호흡곤란을 주소로 내원하여 방사선학적 검사와 수술로 확진된 1례를 보고한다. Morgagni hernia is improperly located abdominal viscera into the thoracic cavity through the foramen of Morgagni which is a congenital defect at the anterornedial portion of diaphragm. We report a case of Morgagni hernia diagnosed by radiologic examination and operation.
목초액의 엽면살포가 선학초(Agrimonia pilosa L.)의 종자수량에 미치는 영향
정대수,신상현,김현경,오주성,이용호 東亞大學校 大學院 2002 大學院論文集 Vol.27 No.-
Agrimonia pilosa L. has been used as a medicinal plant in traditional folk remedy, and it shows inereasing tendency at various sections such as medicine-making material, functional food, and agricultural chemicals using plant or extract. The treatment was 400times solution(50㎖), 600times solution(33.3㎖), 800times solution(25㎖), 1,000times solution(20㎖) and 1,200times solution(16.7㎖) level with foliar application of wood extraction in Agrimonia pilosa L. The results obtained through these experiments were summarized as follows; plant height, stem number, leaves was increased with 800times solution(25㎖) foliar application of wood extraction. Among foliar application of wood vinergar soution diluted by 800-1,200 times was most effective considering growth and yield as compared other dilutions and control plot.
톨루엔 노출 근로자에서 요중마뇨산 배설농도로 평가한 호흡보호구 착용효과에 관한 연구
김범석,박정일,임현우,김형아,오상용 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.4
목적 : 보호구 착용 효과에 대한 실제적, 구체적자료를 제시함으로서 예방목적의 보호구 사용에 대한 근로자들의 인식을 제고시키기 위함이다. 방법 : 서울시내에 소재한 일부 그라비아 인쇄소에서 톨루엔이 함유된 잉크 및 희석제를 취급하는근로자 26명을 대상으로 본 연구를 수행하였다. 유기가스용 방독마스크 미착용 상태와 유기가스용 방독마스크 착용후 작업환경 중 톨루엔 개인노출농도와 요중 마뇨산 시간별 농도를 측정, 비교하였다. 결과 : 그라비아 인쇄소의 공기중 톨루엔 개인노출농도는 유기가스용 방독마스크 미착용일과 착용일에서 각각 147.52+57.34 ppm 및 134.55+52.44ppm으로 통계학적으로 유의한 차이는 없었다. 방독마스크 미착용일파 착몽일의 작업종료 후 요중 마뇨산 농도의 기하평균값은 각각 1.5) 10.33:1 g/L 및0.49(0.14) 하였으며 두 일간에 유의한 차이를 보였단. 방독마스크 미착용일에서 요중 마뇨산 농도는 근무시작 4시간 후(오후 작업시작전, 13:00)부터 유의하게 증가하기 시작하였으며, 착용일에서는 근무종료시까지 유의한 증가를 보이지 않았다. 유기가스용 방독마스크 착용 효과를 톨루엔 대사산물인 요중마뇨산 농도로 평가하면 착용시 농도가 미착용시에비하여 89.3% 감소하였다. 보호구 미착용일에 있어서 공기중 톨루엔 개인노출농도와 요중 마뇨산 농도는 유의한 상관성을 나타났으며 회귀방정식은 Y(요중 마뇨산, g/L) =0. OO7x (공기중 톨루엔, ppm)+0.665로 계산되었다. 결론 : Fit Test등 올바른 보호구 착용 교육을 통한 전 작업시간에 걸친 유기가스용 방독마스크 보호구 착용은 직업적인 톨루엔 노출의 호흡기 흡수를거의 대부분 차단하였다. Objectives : This study was carried out in order to raise workers' recognition of the effects of respirator use by providing concrete and practical data. Methods : Twenty-six workers who dealt with toluene based ink and diluents at a gravure printing office in Seoul were investigated. The toluene exposure level and urinary hippuric acid level were monitored under respirator non-wearing (RNW) and under respiratory wearing (RW) conditions. Results : The mean concentrations of toluene exposed to each worker through the air of gravure printing office were 147.52±57.34 and 134.55±52.44 ppm on respirator non-wearing day and respirator wearing day, respectively. There was no significant difference in toluene exposure concentration for the two days. The mean concentration of urinary hippuric acid in RNW and RW groups were 1.51 (0.53) g/L and 0.49 (0.14) g/L, respectively, as measured at the end of the workday. There was a significant difference seen in urinary hippuric acid concentration between the two days. The urinary hippuric acid concentration began to increase at 4 hours after the start of the workday (13:00) in RNW. However, there was no significant increase until the end of the workday in the case of RW. The urinary hippuric acid concentration in RW reduced 89.3% as compared with the concentration seen in RNW. There was a significant correlation between the toluene concentration and the urinary hippuric acid concentration in RNW. The regression equation was Y (urinary hippuric acid concentration, g/L) = 0.007 ×χ(toluene concentration in the air, ppm) + 0.665. Conclusions : Our results indicate that the respirator intercepted most toluene that may have been absorbed Into the respiratory organs, and suggested that properly wearing a respiratory such as wearing the respirator during the entire workday and performing a proper fit test played an important role in the protection from toluene exposure
Propylthiouracil에 의한 중증 급성간염 1예
임종주,심미령,이명수,김태현,오석규,안선호,박무림,김남호,박병현,조성구 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.2
PTU에 의한 간염의 발생은 매우 드물게 발생하는 것으로 알려져 있으나 저자들은 Graves씨 병으로 진단 받고 propylthiouracil 투여를 받고있던 환자에서 중증의 급성 간염이 발생한 1예를 경험하였기에 보고하는 바이다. Propylthiouracil is widely used to treat patients with hyperthyroidism. This drug has been associated with severe hepatotoxicity rarely. We presented the case of jaundice and profound liver dysfunction from a 23-year old woman treated with propylthiouracil for hyperthyroidism. Viral, metabolic, and autoimmune liver disease could be excluded and liver biopsy revealed a pattern of acute hepatitis. After discontinuing the drug, there was a progressive resolution of hepatic symptoms and decrease in biochemical data of the liver. Despite propylthiouracil induced hepatitis in rare case, patients receiving propylthiouracil are exposed to develope severe hepatotoxicity. Therefore it might be advisable to monitor level of the transaminase on regular base from patients receiving propylthiouracil.
Effect of 2,3,3',4,4'-Pentachlorobiphenyl (PCB#105) on Rat Testes
Chung-Kil Won,Oh-Sung Park,Dae-yong Han,Phil-Ok Koh,Jae-Hyeon Cho,Eun-Hee Kim,Gon-Sup kim 한국실험동물학회 2007 Laboratory Animal Research Vol.23 No.3
This study was conducted to examine the effect of 2,3,3',4,4'-pentachlorobiphenyl (PCB#105) on the reproductive function of male rats. PCB#105 (0.01, 0.1, 0.5 ㎍/㎏/day) in corn oil was orally administrated to adult male rats for 10 weeks. The body and testicular weights, and the serum levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), were measured at 2, 4, 6, 8 and 10 weeks of PCB treatment. The morphological changes in the rat testes were than analyzed by light microscopy (LM) and transmission electron microscopy (TEM). The results showed that PCBs caused no significant change in the body weights but caused a marked decrease in their testicular weights. A decrease in the serum LH and FSH levels of the PCB-treated rats was also observed. Moreover, the morphological studies that were conducted on the PCB-treated rats revealed that the size of their seminiferous tubules slightly decreased (LM), and that their nuclear membrane was damaged when 0.1 ㎍/㎏/day PCB was administered to them for 10 weeks (TEM). These results suggest that the reproductive function of the adult male rats is sensitive to PCB, and that may affect their LH and FSH secretion.