콩 단백 성분 및 연령이 암컷 흰쥐의 혈장 지질 농도와 인지질 지방산 패턴에 미치는 영향

정은정(Eun-Jung Chung),김수연(Soo-Yeon Kim),김지영(Ji-Young Kim),안지영(Ji-Young Ahn),박정화(Jung-Wha Park),차명화(Myung-Hwa Cha),이양자(Yang-Cha Lee Kim) 한국식품영양과학회 2003 한국식품영양과학회지 Vol.32 No.2

혈중 지질농도는 식이단백질 종류보다는 연령의 영향을 많이 받아, young군보다 old군의 총 콜레스테롤, TG, HDL-콜레스테롤, LDL+VLDL-콜레스테롤 및 AI 모두 높았다. 한편 콩 단백질군에서 HDL-콜레스테롤 수준이 증가하고, LDL+VLDL-콜레스테롤와 AI는 감소하여, 심혈관질환에 대한 콩 단백질의 유익한 효과를 확인할 수 있었다. 식이단백질에 의해 유의한 영향을 받은 혈장 인지질의 지방산조성중 22:0, 18:1ω9, ∑MUFA 조성은 카제인군에서 콩 단백질군 보다 높았으며, 반대로 ∑SFA 조성은 카제인군에서 낮았다. 연령에 의해 혈장 인지질 지방산 조성에 있어 유의한 차이를 보인 지방산 중 22:0, 18:1ω9, 22:1, 18:3ω3 및 22:4ω6는 young군에서 높은 반면에, 22:6ω3, ∑ω3, 18:2ω6, 20:4ω6, ∑ω6 및 ∑PUFA의 조성비율은 old군에서 높게 나타났다. 이와 같이 식이 단백질의 종류보다 연령의 영향력이 더 많이 나타난 것은 혈중 콜레스테롤 수준이 식이 단백질보다는 연령의 영향을 더 크게 받았기 때문으로 생각된다. 혈장 인지질 지방산의 대사지표 중 Δ7-desaturation index(16:0⇒16:1ω7)와 Δ9-desaturation index(18:0⇒18:1ω9)가 식이 단백질의 영향을 받아 카제인군에 비해 콩 단백질군에서 유의하게 낮았다. Δ7- 및 Δ9-desaturation index만이 식이 단백질의 영향을 받은 것은 식이 단백질보다 desaturase 활성에 더 큰 영향력을 미치는 콜레스테롤이 식이에 첨가되었기 때문이라 생각된다. Δ-4 desaturation index (22:4ω6⇒22:5ω6)는 young군에 비해 old군에서 높았으며, elongation index(20:4 ω6⇒22:4ω6)는 old군에서 낮았다. 대부분의 elongation과 desaturation 단계는 연령에 따라 유의한 차이를 보이지 못하였으나, ω3계 지방산의 전체적인 elongation-desaturation 단계를 나타내는 ∑products-fatty acid(ω3)/α-LNA(ω3) 비율이 old군에서 young군보다 유의하게 높아, 연령에 따른 PUFA 대사의 변화가 관찰되었다. 이상에서와 같이, 콩 단백질의 섭취로 흰쥐 혈장 인지질의 ∑MUFA 조성은 낮고 ∑SFA 조성은 높아 다른 지질 강화성분의 섭취와 유사한 결과를 나타내었다. 혈중 콜레스테롤 수준이 높은 old군에서 체내 막조직의 유동성을 유지하기 위해 PUFA의 합성 특히 ω3계 지방산의 elongation-desaturation이 증가하여 총 PUFA 조성이 young군보다 높았다. 연구결과로 이소플라본을 포함한 콩 단백질의 혈중 지질저하 기전에 대해 체계적인 설명은할 수 없지만, 콩 단백질이 혈장 지방산의 조성을 변화시킴으로써 간접적으로 심혈관계 질환에 대해 유익한 효과를 미침을 알 수 있었다. 한편, 이러한 혈관의 건강과 관련된 콩의 유익한 효과는 이소플라본과 같은 콩의 특정 성분의 단독효과라기보다는 콩 단백질과의 복합효과에 의한 것이라는 주장은 매우 설득력 있다고 생각된다. Effects of soy protein concentrate (SPC) containing isoflavone and casein diets on plasma phospholipid (PLs)-fatty acid patterns were investigated in 7- & 40- wk old female rats. Diets containing 16% SPC (soy/young: SY, soy/old: SO) and casein (casein/young: CY, casein/ old: CO) supplemented with 0.5% cholesterol were fed for 4 wks. Fatty acid compositions of plasma PLs were determined by TLC and GLC. Compared to the dietary protein effects, age effects on serum lipids were more profound. The levels of total cholesterol (Chol.), triglyceride, HDL-Chol., (LDL+VLDL)-Chol. and atherogenic index (AI) were higher in older groups (OC & OS) than younger groups (YC & YS). Soy groups had higher HDL-Chol. level and lower (LDL+VLDL)-Chol. and AI, compared with casein groups. The compositions of C22:0, C18:1ω9 and sum of MUFA in plasma PLs were significantly higher in casein group (CY & CO) than soy group (SY & SO), but those of sum of SFA were higher in soy group. The compositions of C22:0, C18:1ω9, C22:1, C18:3ω3 and C22:4ω6 were higher and those of C22:6ω3, sum ofω3, C18:2ω6 C20:4ω6, sum ofω6 and sum of PUFA were lower in plasma PLs of younger rats. The average P/S and ω3/ω6 ratio in older group was higher. The Δ-7 desaturation index (16:0⇒16:1ω7) and Δ-9 desaturation index (18:0⇒18 : 1ω9) were lower in soy group than casein group, while Δ-6 and Δ-5 desaturation index were not affected by dietary protein. The Δ-4 desaturation index (22:4ω6⇒22:5ω6) were higher and, elongation index (20:4ω6⇒22:4ω6) were lower in older group. The ratio of the products of ω3 fatty acid series/precursor of ω3 fatty acid series (C18:3) was significantly higher in older group, which in- dicated that age affected the plasma PUFA metabolism. On the other hand, older rats had higher serum cholesterol level compared with younger rats. Taken together, these changes in fatty acid composition might cause minimal changes in the membrane fluidity induced by the increase serum cholesterol level.

香粧크림의 製造와 그效用

鄭魯華,朴英福 梨花女子大學校 藥學硏究所 1961 梨花藥學硏究 Vol.- No.2

성장기 아동에 있어 gonial angle의 변화와 IMPA 변화에 관한 누년적 연구

정진수,유영규,손병화,김영준 대한치과교정학회 1999 대한치과교정학회지 Vol.29 No.4

Gonial angle은 부정교합 환자의 진단과 치료계획 수립시 중요하게 이용되고 있으며, 두 개 안면 복합체의 성장방향과 안모형의 분류 그리고 하악골의 형태학적 및 기능적인 면을 연구하는데 사용되어왔다. 또한 임상적인 치료에 있어 하악 절치의 위치는 치료의 안정성과 하안면부의 심미적인 면에서 중요하며 전후방적인 절치의 위치는 치열궁 장경에 영향을 미쳐 치료계획 중 발치 결정의 중요한 기준으로 사용되고 있다. 저자는 연세대학교 치과 대학 교정과에 소장되어있는 E 여자학교 사범대학 부속초등학교 졸업생 중에서 전신질환이 없고 발육상태가 양호한 소년 15명과 소녀 19명을 대상으로, 7세부터 15세까지 만 9년간 누년적으로 촬영한 측모두부방사선 규격사진을 이용하여, gonial angle의 연령에 따른 변화양상과 gonial angle의 변화가 하악절치의 위치에 미치는 영향에 관한 누년적 연구를 하여 다음과 같은 결론을 얻었다. 1. 성장에 따른 gonial angle의 누년적 변화양상은 25명에서는 감소를, 9명은 일정하게 유지되거나 증가하는 양상을 보였다. 2. Gonial angle이 감소한 이동에서는 IMPA가 증가하는 경향을 보였으며, gonial angle이 일정하게 유지 되거나 증가 한 아동에서는 IMPA가 점진적으로 감소하는 경향을 보였다. 3. Interincisal angel은 gonial angle의 변화 양상에 관계없이 감소하는 경향을 보였다. The study was undertaken to investigate the growth change of gonial angle and interrelationship between the growth change of gonial angle and IMPA in the longitudinal data from 7 years to 15 years. By analyzing the serial lateral cephalograms of 15 meals and 19 females of 7 years old to 15 years old who had no abnomality in growth and development and no history of orthodontic treatment, the following conclusion were obtained. 1. Gonial angle gradually decreased with aging in 25 children and in 9 children increased or maintained. 2. There was a tendency that children who decreased gonial angle with aging showed gradual increase ofIMPA and children who increased or maintained gonial angle with aging showed decrease of IMPA. 3. There was a tendency that regardless of the change of gonial angle, interincisal angle decreased with aging.

한국 여성사 정립을 위한 인물 유형 연구 : from Ancient Times to Tae-han Che-guk(大韓帝國) 고대에서 대한제국 시대까지

정세화,최숙경,이배용,장필화,김영미,박진숙 이화여대 한국여성연구소 1988 여성학논집 Vol.5 No.-

This study is an attempt to analyse the types of women recorded in historical documents. The categories are broadly divided in three areas; political, social and familial spheres. In the political sphere, three queens in Shilla period, the only period in Korean history when a queen was the supreme ruler, and women who had a formal right to be involved in the determination of soverign successor, to assume regency, and who had various informal political influence. In the social sphere, women's economic and religeous activities were examined. Also women specialists such as medicine women, shamans and kisaeng (entertainers) are examined in this category. In the familial sphere, conjugal relationships of first (legitimate) wives and concubines, and women's status and activities are investigated. The gradual establishment of patriarchal system initiated by the state, and the conflict of women's interests in the process was analysed. As a result of this preliminary analyses, it became clear that the social position of women in Korean history was constricted with the growth of the power of the state. In the case of ancient Korea and Koryo period women's status in the family was comparatively higher and their personal activities were freer although their political and social activities were restricted. As time progressed, the establishment and reinforcement of partriarchal system of the state based on confucian ideology had crucial importance on the position of women in society. The system of family was restructured and carefully monitored, and the members of the family were closely controlled. The state sought the material and ideological bases of the power through these control. As a result, the status of women became more structurally subjugated to make heads of the family, especially after the mid Choson dynasty.

濟州硏究의 現況과 展望 : 考古學的 側面

鄭永和 제주대학교 탐라문화연구소 1984 탐라문화 Vol.0 No.3

청소년의 엽기문화와 교육적 함의

정영애,김진화 昌原大學校 人文科學硏究所 2001 人文論叢 Vol.8 No.-

소아의 연령별 Propionibacterium acnes에 대한 균체응집항체 및 동종혈구응집항체간의 비교연구

정화영,정상인,최철순,양용태 중앙대학교 의과대학 의과학연구소 1984 中央醫大誌 Vol.9 No.3

In general, the concentration of maternal IgG globulin in serum of the neonates falls rapidly within the first few months after birth and the production of IgM globulin develops in the maturing infants during the course of exposure to various antigens in the environment. The development of natural antibodies, ie., isohemagglutinins, IgM class, to ABO blood group substances and agglutinins, Ig class, to normal flora, in the early stage of life is important since not only they may act as bactericidal substances in nonspecific manners, but also could be immunological barometers on the normal function of humoral immune system. The high concentration of isohemagglutinins to human A or B blood group antigens and agglutinating antibodies to some of normal flora such as Propionibacterium acnes or Staphylococcus aureus were observed in normal human sera. It has been known that the serum concentration of IgM globulin usually reached adult levels by one year of age, while that of IgG globulins by five to six years of age. However, the levels of isohemagglutinins to A and B group substances and agglutinating to Propionibacterium acnes in children's sera and the ages in which the concentrations of their antibodies reached to abult levels are not clarified. In this study, the concentrations of isohemagglutinins to A and B blood group antigens and agglutinating antibodies to P.acnes serotype Ⅰ and serotype Ⅱ in the sera of 163 normal children, ranged from 0 day to 15 years of age, were measured by means of microtitration technique. The results obtained are as follows: 1. In the sera of 163 children under 15 years of age, there observed no significant difference in the titers of agglutinating antibodies to P. acnes serotype Ⅰ andⅡ. 2. Of 75 sera of children under one year of age, the numbers of sera in which agglutinating antibodies were not detectable or less than 1:4 to P. acnes serotype Ⅰ were 67(89.6%) and to serotype Ⅱ 53(70.7%), respectively. 3. Agglutinating antibody to P. acnes serotype Ⅰ in the children's sera reached adult levels by 7 years of age, but 100 percentages of antibody detection was observed only in the age group of 15 years old, whereas the adult levels of isohemagglutinins to A and B blood group antigens were observed in the age group of 6 months old. 4. No correlation were observed in normal children's sera between agglutinating antibody titre to P. acnes serotype Ⅰ and isohemagglutinin titre. These results indicated that the isohemagglutinins to ABO blood substances appeared in the earlier stage of life than did agglutinating antibodies to P. acnes.

독작문 교수에 있어서 독일어와 한국어 동사의 지배의 불일치에 의한 방해현상에 대하여 : 의존문법을 중심으로

정화영,박정환 釜山大學校 1994 人文論叢 Vol.45 No.1

Tomato 中의 Lycopenen의 檢索

車榮華,鄭順子 梨花女子大學校 藥學硏究所 1961 梨花藥學硏究 Vol.- No.2

늑막삼출액을 동반한 다발성골수종 1예

김용화,주기산,서영환,조경상,김상도,정춘해 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.2

Pleural effusion in a patient with multiple myeloma due to plasma cell involvement of the pleura has been reported infrequently. We report a case of multiple myeloma with pleural involvement presenting bone pain and dyspnea in a 69-year-o1d woman. On the physical examination, the patient looked chronically ill with bedridden state. There was a palpable mass on the left posterior lower chest, firm but not tender and decreased breathing sound in the left lower lung. Laboratory finding revealed amemia, elevation of ESR, globulin, and calcium. X-ray of the chest showed pleural effusion in the left lower lung, and multiple pathologic fractures in the both ribs. X-ray of the skull, and pelvis revealed multiple punched-out osteolytic fractures in the both ribs. X-ray of the skull, and pelvis revealed multiple punched-out osteolytic lesion, and compression fracture in the lumber spine. Serum and urine electrophoresis revealed a M-spike. Serum and urine immunoelectrophoresis demonstrated an IgA-kappa monoclonal protein. Thoracentesis revealed serosanguinous fluid but not containing atypical plasma cells. Bone marrow examination showed 16.7% of immature plasma cells. With first cycle of melphalan, prednisone chemotherapy, improvement of pain and disappearance of pleural effusion was observed.