흉추 경막외강으로 침윤한 흉선종 1례 : Metstasis to Thoracic Epidural Space

최정훈,백욱성,박대곤,오경구,최천식,배상도 高麗病院 1987 高醫 Vol.10 No.-

휘발성 미량유기오염물질의 광분해에 관한 연구

이춘식,최장승,안종수,박현건,성낙창,박승조 동아대학교 환경문제연구소 1998 硏究報告 Vol.21 No.1

This study was carried out photolysis of Trace Volitile Organic Pollutants(BTEX) in the water. The experiment results were summarized as follows : 1. Benzene of removal efficiency were revealed 90% on illumination time of 20minute for bezene concentration range 0.01ppm-0.06ppm by 450W medium pressure mecury lamp of photon energy photolysis reaction, and were revealed 93% phomoxidaton on illumination time 30minute in 0.lppm of reactant benzene. Toluene of removal efficiency were revealed each 97.7%, 98.3%. 97.7%, 87.396 on illumination time of 20minute for toluene each of concentration 0.0lppm, 0.03ppm, 0.06ppm. 0.1ppm by 450W low pressure mecury lamp of photon energy photolysis reaction, and reactant toluene was disappeared on illumination time 30minute. 2. Ethylbenzene of removal efficiency get the better photolysis on the treatment contrast ethylbenzene with benzene and photolysis removal efficiency was above 90% in ethylbenzene concentration range 0.0lppm-0.lppm on illumination time l0minute. 3. Photolysis removal efficiency of m, p-Xylene were researched better result 93% on the about l0minute of illumination time m, p-Xylene concentration range 0.01ppm-0.06ppm, removal efficiency was 97% in higher concentration of 0.2ppm and illumination time 20minute. 4. Photolysis removal efficiency of o-Xylene were researched better result 95% on the about l0minute of illumination time m, p-Xylene concentration range 0.0lppm-0.lppm, and reactant o-Xylene was disappeared on illumination time about 20minute by 450W m d u m pressure mecury lamp.

Effect of Acute Ethanol Intoxication on Hepatic Rhodanese Activity in Rats with Extrahepatic Cholestasis

곽춘식,--,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.2

Liver and serum rhodanese activities were determined in acute ethanol intoxicated rats with extrahepatic cholestasis induced by common bile duct ligation (CBD) to manifest the biochemical background of alcohol drinking hazard under the hepatobiliary disease. Liver cytosolic and microsomal rhodanese activities and these Vmax values in CBD ligated rats with acute ethanol intoxication were found to be decreased much more than that in CBD ligation alone. However, the difference of Km value on above hepatic enzyme was not found between the experimental groups. On the other hand, serum rhodanese activity in CBD ligated rats with acute ethanol intoxication was greater increased more than that in CBD ligation alone. These results indicate that the biosynthesis of the hepatic rhodanese decreases and the serum rhodanese activity increases in cholestasis combined with acute ethanol intoxication. reflecting damage of aggravated hapatocytic membrane. Accordingly, the resulting data supported the fact that alcoholic drinks were enzymologically harmful to the hepatobiliary disease.

갑상선암에서 MAGE 1-6 mRNA를 검출하는MAGE common primer의 의의

남철우,최영식,박요한,이강대 고신대학교의과대학 2006 고신대학교 의과대학 학술지 Vol.21 No.2

Background: MAGE (melanoma antigen gene) was named as cancer/testis specific antigens since their expression is only detected in the testis or cancer cells. Because of their relatively specific expression in the cancer cells, they have been considered as the early diagnosis of several cancers, or the appropriate targets for the specific immunotherapy mediated by cytotoxic T lymphocytes. Therefore, there were many reports about the expression of MAGE genes in various types of malignant tumors, but only a few reports in human thyroid neoplasms. The purpose of this study was to determine whether the MAGE common primers expressed in different histological types of thyroid tumors and to see the clinical usefulness of MAGE common primers on the thyroid tumors. Methods: Fifty-nine patients who underwent thyroidectomy at Kosin Medical Center from January, 2001 to April, 2002 were included in the study. Of the 59 patients 40 were papillary carcinoma, 4 follicular carcinoma, 3 medullary carcinoma, 1 anaplastic carcinoma, 4 nodular hyperplasia, 3 adenomatous goiter, and 4 follicular adenoma. Total cellular mRNA was extracted from those 48 cancer tissues, 11 benign tissues and additional eleven normal control thyroid tissues. Nested reverse transcriptase-polymerase chain reactions (nested RT-PCR) with the MAGE common primers designed to detect MAGE 1-6 genes were employed in this study. With probes confirmed by DNA sequencing. Results: Of those 48 cases of thyroid carcinomas 10 cases (20.8%) were expressed MAGE common primers. In the 40 papillary carcinoma, MAGE common primers were expressed in 17.5%. In the four follicular carcinoma, they were expressed in two cases, and in one case of one anaplatic carcinoma. However, in the three cases of medullary carcinoma, MAGE gene was not expressed. None of 11 benign tumors and 11 normal tissues expressed any of these MAGE common primers. The sensitivity of MAGE common primers in thyroid tumors was 20.8% and the specificity was 100%. Conclusion: These results suggested that MAGE common primers were expressed low in the malignant thyroid tumors but it was not expressed in benign tumors and normal tissues. It is suggested that MAGE common primers can be used for preoperative differential diagnosis of follicular carcinoma from benign follicular adenoma which cannot be made by fine needle aspiration cytology of thyroid tissue. However, further study is needed for clinical application of MAGE common primers expression as tumor markers in the thyroid tumors.

Catechol-O-Methyltransferase Activity from Regenerating Liver after Partial Hepatectomy in Rats

곽춘식,--,-- 대한의생명과학회 2005 Biomedical Science Letters Vol.11 No.1

The change of catechol-O-methyltransferase (COMT) activity during regeneration of rat liver was studied. Cytosolic, mitochondrial and microsomal COMTs activities were estimated in regenerating rat livers over a period of ten days after 70% (median and left lateral lobes) partial hepatectomy. The values of Km and Vmax in the hepatic enzymes were also measured. The activities of cytosolic and microsomal COMTs in regenerating rat liver after partial hepatectomy were found to be significantly increased between the second and the third day. Whereas the mitochondrial COMT activity did not change. The Vmax values of the cytosolic and microsomal COMTs in the regenerating rat liver were significantly increased at the second day after partial hepatectomy, however, the Km values of the above hepatic enzymes did not vary in all the experimental groups. Therefore, the results suggest that the biosynthesis of COMT was increased during the regeneration of rat liver.

天然洗劑의 生物分解에 관한 硏究

이춘식,최종수,박승조 동아대학교 환경문제연구소 1993 硏究報告 Vol.16 No.1

We were investigated with biodegradation of natural detergent by using jar-test, column test and activated sluge process. We were studied the BOD loading rate, the removal rate of organic material, the relationship between F/M, ratio, BOD and SS, SRT and MI, VSS/MLSS ratio. The results are summarized below. 1. In case of column height 160cm, suspended solid removal rate was 60.93%, COD, BOD and SS removal rate were 40%, 33% and 87% repectively in jar-test. In this case dosage of coagulant was 40.9g/㎥ alum, 4.5g lime/㎥ and 0.4g/㎥ polymer. 2. Wastewater containing natural detergent concentrationabout 600-1300mg/l was treated with activated sludge process and then removal rate of BOD is 80% in winter atmospheric temperature. In this case BOD concentration was about 10mg/l. 3. Wastewater containing natural detergent was treated with activated sludge process and then BOD volumetric loading rate is 0.3-0.8kg BOD/㎥·d. In this case BOD removal rate was about 90 %, MLVSS/MLSS ratio was 0.4-0.5 and SVI is 60-200.

관개방법에 따른 논에서의 수문 및 수질특성에 미치는 영향

전지홍,윤춘경,최진규,윤광식 한국육수학회 2005 생태와 환경 Vol.38 No.1

관개방법이 논에서의 수문 및 수질특성에 미치는 영향을 파악하기 위하여 관개용수가 풍부한 지표수 관개지역과 관개용수가 부족한 지하수관개지역에서의 물수지 및 영양물질수지 분석을 실시하였다. 지표수 관개논은 영농기간동안 지속적으로 관개가 이루어졌으나, 지하수 관개논은 영농초기에만 이루어졌으며 그 이후에는 강우에 의해 담수심이 유지되어 지표유출은 지표수 관개논에 비해상대적으로 낮은 빈도를 나타내었다. 지표수의 영양물질 농도는 시비에 의해 크게 영향을 받는 것으로 나타났으며, 특히 다량의 시비가 이루어지는 영농초기(5~6월 중순)에는 높은 영양물질 농도를 나타내어 이 시기에 논에서 유출이 이루어진다면 하류 수계에 영향을 줄 것으로 판단되었다. 물수지 분석결과 지하수 관개논의 관개량, 지표유출량 등이 상대적으로 지표수 관개논에 비해 낮은 값을 나타내었다. 영양물질수지분석 결과 대부분의 유입은 시비에 의해 이루어졌으며, 유출은 지표유출이 많은 비중을 차지하였으나 지표유출과 침투유출사이의 비율은 토양의 특성에 좌우되는 것으로 판단된다. 외부에서의 유입을 제외하고 시스템내에서의 유출입만 고려한다면, 물관리가 효율적으로 이루어진 지하수 관개논에서 낮은 부하량을 나타내었다. 그러나 기비가 이루어지고 인위적인 낙수나 강우에 의한 유출이 발생할 경우, 높은 부하량 뿐만 아니라 고농도의 영양물질질이 수계로 유입되는 것으로 나타났다. 논에서의 비점오염관리를 위한 대안으로 현재 시행되고 있는 시비량 감소 뿐 아니라, 효율적인 물관리기법 개발이 포함되어야 할 것으로 판단된다. 특히 영농초기의 강우특성과 논에서의 담수기능을 고려해 볼 때 시비에 의한 높은 영양물질 농도를 나타내는 논 표면수의 유출을 효율적으로 억제할 수 있을 것으로 판단된다. 물꼬높이의 증가와 천수간단관개 영농초기의 강우에 의한 유출을 억제시킴으로써 부족한 관개용수의 절약 뿐만아니라 하류수계의 수질보호에 기여를 할 것으로 판단되며, 다양한 조건에 따른 환경적인 측떤 뿐 아니라 벼의 생리적인 측면은 장기적인 모니터링을 통해 반드시 고려되어 야 할 것이다. The comparison of water balance and nutrient loading from paddy field with different irrigation management were carried out during 1999-2002 at two different sites; one is irrigated with groundwater and the other is irrigated with surface water. For the surface water irrigated paddy field, irrigation was performed continuously during growing season. Whereas, initial irrigation with groundwater was applied during initial growing season, and the ponded water depth was maintained by natural precipitation since initial irrigation. The runoff frequency of groundwater irrigated paddy field was less than that of surface water irrigated paddy field. The nutrient concentration of ponded water was high by fertilization at early cultural periods, so reducing surface drainage during fertilization period can reduce nutrient loading from paddy fields. Amount of irrigation water to surface water irrigated paddy field was higher than to groundwater irrigated paddy field and evapotranspiration was similar because it is influenced by climate. Overall input in and output from paddy field irrigated with goundwater were less than that with surface water. This study indicate that efficient water management can reduce surface drainage outflow, save water, and protect water quality. It might be important BMPs for paddy field.

스키시즌권 구매자들의 스키장별 선호도 조사

장현철,김경식,방준현,최천진,엄정식,김응준,이루지 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.2

The purpose of this study was to examine the perception and preference of skiers in a bid to provide ski resorts with useful information about successful positioning strategy. The subjects in this study were 9,722 skiers who purchased season tickets from N web site that sold ski season tickets. Their online purchasing route and page view were analyzed to find out what factors affected their purchase of ski season tickets. The findings of this study were as follows: First, 78 percent of the people investigated were make, and 22 percent were female. By age, the largest group was in their 20s(5,344 skiers), followed by those in their 30s(3,434), those in their 40s(631) and teenagers(229). Second, their page view rate with Yangji recorded highest with 24%, followed by Sungwoo Resort with 23% and Chonmasan with 13 percent. Third, by geographic area, the skiers from southern Gyeonggi province bought the largest number of tickets for the 2002/2003 season, followed by Gangweon province residents and northem Gyeonggi province dwellers. In the case of the 2003/2004 season, those from Gangweon provinece pruchased the most tickets, followed by southern Gyeonggi province dwellers and north Gyeonggi province residents.

기업의 배당정책 결정요인에 대한 실증연구 : -중국 상해증권거래소의 상장기업을 대상으로-

김천희, 최창훈, 우춘식 숭실대학교 2009 숭실경영연구 Vol.1 No.1

본 연구에서는 1998년부터 2007년까지의 기간에서 중국 상해증권거래소의 상장기업 중에서 표본의 선정방법에 따라 A주 기업 208개를 선정하여 어떤 재무요인이 배당정책의 결정에 영향을 미치는가를 분석하는데 연구의 목적을 두었다. 연구결과를 요약하면 다음과 같다. 첫째, 수익성을 대변하는 변수인 주당순이익의 회귀계수가 배당의 유형과 관계없이 유의한 양(+)의 값을 보임으로써 수익성이 배당정책에 양(+)의 영향을 미치는 것으로 나타났다. 둘째, 기업의 투자기회와 성장기회를 대변하는 변수인 M/B비율과 총자산증가율이 A주의 주식배당과 혼합배당정책에 유의한 양(+)의 영향을 미치는 것으로 나타났다. 투자기회가 많고 성장성이 높은 기업에서 많은 배당을 지급한다는 가설을 지지하는 증거를 발견할 수 있었다. 셋째, 전기배당률의 회귀계수가 A주의 현금배당과 혼합배당에서 유의한 양(+)의 값을 보임 으로써 배당의 안정성이 배당정책에 의미 있는 영향을 미치는 것으로 나타났다. 넷째, 배당의 잔여이론을 대변하는 부채비율과 가처분현금흐름 비율이 부분적으로 배당정책에 영향을 미치는 것으로 나타났다. 다섯째, 소유구조를 대변하는 국유주 비율, 법인주 비율과 유통주 비율에서는 일관된 결론을 얻을 수 없었다. 따라서 소유권구조가 배당정책에 의미 있는 영향을 미친다고 보는 데는 한계가 있는 것으로 판단된다. The purpose of this study was to analyze which financial factors had an affect on deciding divided policy. According to some sampling criteria, in the purpose of this study 208 firms from A shares are selected and the dividend and financial data from the Shanghai Stock Exchange were used. A multiple regression analysis were adopted to empirically test the major purpose of this study with cash dividend ratio, stock dividend ratio and mixed dividend ratio as dependent variables and with the identified some determinant variables as explanatory variables. The results are summarized as follows. First, the empirical tests showed that the earning per share had significantly positive relationship with dividend policy. The regression coefficient of the earning per share had positive value in all type of dividend group. According to this results, the companies with more profit tend to distribute more dividend. Second, M/B ratio and growth rate of total assets, representing firm's investment and growth opportunities significantly affected stock dividend policy from A shares firm. It was supported the residual theory of dividend policy was supported. Company had more investments and growth opportunities, the more dividend was paid. Third, the former dividend ratio has significantly positive relationship with cash dividend policy and mixed dividend policy in sample firms of A shares. It indicates that the stability of dividend has significant influence on dividend policy. Keywords: cash dividend, stock dividend, mixed dividend, residual theory of dividend stability of dividend

동종 조혈모세포이식 후 발생한 치명적 홍역 폐렴 1예

백창렬,이동건,최정현,정현화,조유경,박훈준,이승훈,박윤희,이교영,민우성,김춘추,신완식 대한감염학회 2001 감염 Vol.33 No.4

As a result of the enlarging pool of unvaccinated children and young adults, there has been an increase in measles in our countries. In these situation, it has been reported that measles associated pneumoinia is easily complicated with fatal respiratory failure, espycially in immunocompromised patients. Herein we report the case of lethal measles pneumonia after allogenic hematopoietic stem cell transplantation in adults proven by autopsy. Recently, one case of measles was encountered in 39-year-old female patients after allogenic bone marrow transplanted case (chronic myelogenous leukemia), who progressed into interstitial pneumonia pattern, despite treatment including antibiotics, immunoglobulin. The patient died of giant cell pneumonia compatible with that of measles which was comfirmed in the section of necropsy lung specimen. (Korean J Infect Dis 33:301∼309, 2001)