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Pin-Chun Lin,Chien-Hao Huang,Wei-Ren Liu 한양대학교 세라믹연구소 2014 Journal of Ceramic Processing Research Vol.15 No.3
Nitrogen-doped YAG : Ce3+ phosphors have been firstly studied by using hexamethylenetetramine (HMT) as a nitrogen source by a solid state reaction. The optimal content of HMT is by introducing 50 wt.% with precursors of Y2O3, Al2O3 and CeO2 under annealing at 1450 o C for 8 hours. The XRD data indicate that the lattice constants increase with the content of HMT. SEM morphologies demonstrate that after nitrogen doping, the surface and particle size of YAG become smoother and larger than un-treated one. The PL intensity of YAG : Ce after HMT treatment gives a incensement in range of 3.46% ~ 9.87%. The luminous efficacy of as-synthesized YAG : Ce phosphor + Blue chip was dramatically enhanced by 40%. Using the doped samples, the white LED luminous efficiency obtained 78.4 lm/W and was successfully obtained with the combination of blue LED chip, thus improving the performance of the LED. The enhancement in luminesce was resulted from the modification of its surface morphology, crystallinity and grain size.
Quadrature Oscillators with Grounded Capacitors and Resistors Using FDCCIIs
Jiun-Wei Horng,Chun-Li Hou,Chun-Ming Chang,Hung-Pin Chou,Chun-Ta Lin,Yao-Hsin Wen 한국전자통신연구원 2006 ETRI Journal Vol.28 No.4
Two current-mode and/or voltage-mode quadrature oscillator circuits each using one fully-differential secondgeneration current conveyor (FDCCII), two grounded capacitors, and two (or three) grounded resistors are presented. In the proposed circuits, the current-mode quadrature signals have the advantage of high-output impedance. The oscillation conditions and oscillation frequencies are orthogonally (or independently) controllable. The current-mode and voltage-mode quadrature signals can be simultaneously obtained from the second proposed circuit. The use of only grounded capacitors and resistors makes the proposed circuits ideal for integrated circuit implementation. Simulation results are also included.
Wei-Chun Chen,Hsueh-Chou Lai,Wen-Pang Su,Mahalakshmi Palani,Kuan-Pin Su 대한신경정신의학회 2015 PSYCHIATRY INVESTIGATION Vol.12 No.1
Interferon (IFN)-α therapy for chronic hepatitis C virus (HCV) infection is frequently associated with major depressive episodes. Bupropion, a commonly used antidepressant agent, has recently found to have strong anti-inflammatory effects in animal models. Despite of the theoretical relevancy, the antidepressant effect of bupropion in IFN-alpha-induced depression has never been studied. Ten HCV patients with IFN-α-induced depression were recruited to receive 8-week bupropion treatment and were assessed every 2 weeks for depressive symptoms by the Hamilton rating scale for depression (HAMD) and somatic symptoms by the Neurotoxicity Rating Scale (NRS). Four of the 10 patients met the criteria for remission (total HAMD scores≤7), and 5 patients met the criteria for response (at least 50% reduction in total HAMD scores). In addition, 5 patients had 50% decreases in NRS for neuropsychiatric symptoms. This preliminary open-label study suggests that bupropion is effective in treating IFN-alpha-induced depressive and somatic symptoms.
Hsu Chiao-Lin,Wu Pin-Chieh,Yin Chun-Hao,Chen Chung-Hwan,Lee King-Teh,Lin Chih-Lung,Shi Hon-Yi 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.12
Objective: This study aimed to evaluate the clinical outcomes and cost-effectiveness of dual-energy X-ray absorptiometry (DXA) for osteoporosis screening. Materials and Methods: Eligible patients who had and had not undergone DXA screening were identified from among those aged 50 years or older at Kaohsiung Veterans General Hospital, Taiwan. Age, sex, screening year (index year), and Charlson comorbidity index of the DXA and non-DXA groups were matched using inverse probability of treatment weighting (IPTW) for propensity score analysis. For cost-effectiveness analysis, a societal perspective, 1-year cycle length, 20-year time horizon, and discount rate of 2% per year for both effectiveness and costs were adopted in the incremental cost-effectiveness (ICER) model. Results: The outcome analysis included 10337 patients (female:male, 63.8%:36.2%) who were screened for osteoporosis in southern Taiwan between January 1, 2012, and December 31, 2021. The DXA group had significantly better outcomes than the non-DXA group in terms of fragility fractures (7.6% vs. 12.5%, P < 0.001) and mortality (0.6% vs. 4.3%, P < 0.001). The DXA screening strategy gained an ICER of US$ -2794 per quality-adjusted life year (QALY) relative to the non-DXA at the willingness-to-pay threshold of US$ 33004 (Taiwan’s per capita gross domestic product). The ICER after stratifying by ages of 50–59, 60–69, 70–79, and ≥ 80 years were US$ -17815, US$ -26862, US$ -28981, and US$ -34816 per QALY, respectively. Conclusion: Using DXA to screen adults aged 50 years or older for osteoporosis resulted in a reduced incidence of fragility fractures, lower mortality rate, and reduced total costs. Screening for osteoporosis is a cost-saving strategy and its effectiveness increases with age. However, caution is needed when generalizing these cost-effectiveness results to all older populations because the study population consisted mainly of women.
Cloning of OLR1 Gene in Pig Adipose Tissue and Preliminary Study on Its Lipid-accumulating Effect
Sun, Chao,Liu, Chun-wei,Zhang, Zhong-pin Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.10
In this study we cloned and characterized a novel lipid-accumulating gene, the oxidized low-density lipoprotein receptor 1 (OLR1), which is associated with lipogenesis. We analyzed the gene structure and detected the mRNA transcriptional expression levels in pig adipose tissues at different months of age (MA) and in different economic types (lean type and obese type) using real-time fluorescence quantitative PCR. OLR1 expression profile in different tissues of pig was analyzed. Finally, we studied the correlation between OLR1 and lipid metabolism related genes including peroxisome proliferator-activated $receptor{\gamma}2$ ($PPAR{\gamma}2$), fatty acid synthetase (FAS), triacylglycerol hydrolase (TGH), CAAT/enhancer binding protein $\alpha$ ($C/EBP{\alpha}$) and sterol regulatory element binding protein-1c (SREBP-1c). Results indicated that the OLR1 gene of the pig exhibited the highest homology with the cattle (84%), and the lowest with the mouse (27%). The signal peptide located from amino acid 38 to 60 and the domain from amino acid 144 to 256 were shared by the C-type lectin family. The expression level of OLR1 in pig lung was exceedingly higher than other tested tissues (p<0.01). In pig adipose tissue, the expression level of OLR1 mRNA increased significantly with growth (p<0.01). The expression level of OLR1 mRNA in obese-type pigs was significantly higher than that of lean-type pigs of the same monthly age (p<0.05). In adipose tissue, the expression of OLR1 correlated with $PPAR{\gamma}2$, FAS and SREBP-1c, but not TGH or C/EBP${\alpha}$. In conclusion, OLR1 was highly associated with fat deposition and its transcription, as suggested by high correlations, was possibly regulated by $PPAR{\gamma}2$ and SREBP-1c.