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Piao, Chun Hua,Bui, Thi Tho,Song, Chang Ho,Shin, Hee Soon,Shon, Dong-Hwa,Chai, Ok Hee Elsevier 2017 Biochemical and biophysical research communication Vol.482 No.4
<P><B>Abstract</B></P> <P> <I>Trigonella foenum-graecum,</I> a member oldest medicinal plant in the fabaceae (legumes) family, is used as a herb, spice, and vegetable, and known for its olfactory, laxative, and galactogogue effects. However, the inhibitory effect of <I>Trigonella foenum-graecum</I> on allergic inflammatory response remains unclear, therefore, we investigated the precise role of <I>Trigonella foenum-graecum</I> in the allergic asthma and revealed the effects of <I>Trigonella foenum-graecum</I> in regulating airway inflammation and its possible mechanism. Allergic asthma was initiated in BALB/c mice by sensitized with OVA emulsified in aluminum on days 1 and 14, then aerosol challenged with OVA on days 27, 28 and 29. Some mice were administered <I>Trigonella foenum-graecum</I> by oral gavage before challenge. Then mice were evaluated for the presence of airway inflammation, production of allergen-specific cytokine response and lung pathology. <I>Trigonella foenum-graecum</I> significantly ameliorated the number of inflammatory cells in BALF and alleviated lung inflammation. It also reduced the collagen deposition and goblet cells. Meanwhile, <I>Trigonella foenum-graecum</I> treatment evidently decreased the high expression of Th2 cytokines and increased the Th1 cytokines in BALF and lung homogenates. <I>Trigonella foenum-graecum</I> showed a significant inhibition of serum IgE and anti-OVA IgG<SUB>1.</SUB> In this study, our data suggest that <I>Trigonella foenum-graecum</I> has a significant anti-inflammatory effect and it may prove to be an efficacious therapeutic regent on allergic asthma.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The anti-inflammatory mechanisms of <I>Trigonella foenum-graecum</I> is proposed. </LI> <LI> The mechanism relies on suppressing proinflammatory cytokines and inflammatory cells. </LI> <LI> The <I>Trigonella foenum-graecum</I> may proves to be an efficacious therapeutic regent on allergic asthma. </LI> <LI> <I>Trigonella foenum-graecum</I> significantly ameliorated OVA-induced allergic asthma. </LI> </UL> </P>
Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model
Chun Hua Piao,Yan Jing Fan,Thi Van Nguyen,Zhen Nan Yu,Hee Soon Shin,Chang Ho Song,Ok Hee Chai 대한체질인류학회 2021 대한체질인류학회지 Vol.34 No.2
Despite studies on the anti-inflammatory effect of Fructus amomi, mature fruit of Amomum villosum Lour, have been getting increasing extensively, it remains unknown about the detailed effects of F. amomi on ovalbumin (OVA)-induced mouse asthma model. In this study, we examined the effect of F. amomi on OVA-induced asthma by analyzing Th1/Th2 cytokine production, histopathologic changes, and focusing on the NF-κB signaling. Oral administration of F. amomi reduced the number of inflammatory cells especially eosinophils and improved airway and pulmonary inflammation in the lungs of OVA-challenged mice. In addition, F. amomi significantly downregulated the overproduction of tumor necrosis factor-α, IL-1β, IL-4, IL-5 and the levels of OVA-specific both IgE and IgG1 and increased the secretion of interferon-γ and OVA-specific IgG2a. Moreover, F. amomi suppressed the increase of total NF-κB level and the phosphorylation of IκB-α and NF-κB by OVA. F. amomi may have therapeutic effect for allergic asthma by modulating Th1/Th2 cytokine imbalance and inhibiting NF-κB signaling activation.
Neuroprotective Effect of Wogonin: Potential Roles of Inflammatory Cytokines
Piao, Hua-Zi,Jin, Shun-Ai,Chun, Hyang-Sook,Lee, Jae-Chul,Kim, Won-Ki The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.9
Wogonin (5,7-dihydroxy-8-methoxyflavone), an active component originated from the root of Scutellaria baicalensis Georgi, has been reported to possess antioxidant and anti-inflamma-tory properties. In this study, we investigated the neuroprotective effect of wogonin in a focal cerebral ischemia rat model. Wogonin markedly reduced the infarct volume after 2 h middle cerebral artery occlusion followed by 22 h reperfusion. Wogonin decreased the production of nitric oxide and inflammatory cytokines such as TNF-$\alpha$ and IL-6 in lipopolisaccharide-stimu-lated microglial cells. While wogonin reduced the activity of NF-$textsc{k}$B, it did not change the activ-ity of mitogen-activated protein kinases family members, p38, ERK and JNK. The lipopolisaccharide-stimulated production of NO and cytokines was significantly blocked by vari-ous kinds of NF-$textsc{k}$B inhibitors such as N-acetyl cysteine, pyrrolidinedithiocarbamate and MG-132. The data may indicate that wogonin has neuroprotective effect by preventing the over-activation of microglial cells, possibly by inactivating NF-$textsc{k}$B signaling pathway
Anti-allergic Effects of Caffeine in an Allergic Rhinitis Mouse Model
Yan Jing Fan,Chun Hua Piao,Thi Van Nguyen,Zhen Nan Yu,Ok Hee Chai,Chang Ho Song 대한체질인류학회 2020 대한체질인류학회지 Vol.33 No.1
Caffeine (1, 3, 7-trimethylxanthine) is one of the most widely consumed pharmacologically active products worldwide. Caffeine exhibits various pharmacological activities in central nervous, cardiovascular, and respiratory systems. Additionally, caffeine exhibited anti-inflammatory effects in lipopolysaccharide-challenged rats. However, to our knowledge, the potential anti-inflammatory activity of caffeine in allergic rhinitis (AR) has not yet been investigated. Therefore, in this study, we aimed to examine the anti-allergic effects of caffeine in ovalbumin (OVA)-induced AR in mice. We showed that caffeine attenuated the nasal symptoms, including rubbing and sneezing. It reduced the thickness of the nasal mucosa and alleviated goblet cell hyperplasia in the nasal mucosa. In addition, caffeine ameliorated the inflammation in the lungs and decreased OVA-specific immunoglobulin E (IgE) and IgG1 levels in the serum. It also reduced T helper type 2 (Th2) cytokine (interleukin (IL)-4 and IL-5) levels and elevated Th1 cytokine (IL-12 and IFN-γ) levels in the nasal lavage fluid. Collectively, we suggest that caffeine might have therapeutic effects in AR owing to its anti-inflammatory activities.