http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Bui, Thi Tho,Piao, Chun Hua,Hyeon, Eunjin,Fan, Yanjing,Van Nguyen, Thi,Jung, Sun Young,Choi, Dae Woon,Lee, So-young,Shin, Hee Soon,Song, Chang Ho,Chai, Ok Hee EDITIONS SCIENTIFIQUES ELSEVIER 2019 BIOMEDICINE AND PHARMACOTHERAPY Vol.109 No.-
<P><B>Abstract</B></P> <P> <I>Piper nigrum</I> L. is commonly used as a traditional medicine and food in many countries. It has been reported to have anti-oxidant, anti-bacterial, anti-tumor, anti-mutagenic, anti-diabetic, and anti-inflammatory properties. However, the effect of <I>P. nigrum</I> on allergic rhinitis (AR) has been unclear. In the present study, an OVA-induced AR mice model were established to investigate the anti-allergic, anti-inflammation properties of <I>P. nigrum</I> fruit extract (PNE). Oral administrations of PNE inhibited the allergic nasal symptoms including rubbing and sneezing in the early-phage of AR. In both NALF and nasal tissue, PNE suppressed the inflammatory cells accumulation, specifically with eosinophils in NALF. Additionally, PNE prevented the activation of STAT3 and NFκBp65 signaling in the cytoplasm which led to increasing the synthesis of the anti-inflammatory Th1 cytokines and suppressing the inflammatory Th2, Th17 cytokines. These obtained results suggest that PNE has the promising strategy for immunotherapy in allergic rhinitis disease.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The anti-allergic rhinitis effect of <I>Piper nigrum</I> is investigated. </LI> <LI> <I>Piper nigrum</I> ameliorates nasal symptoms and mucosal swelling. </LI> <LI> <I>Piper nigrum</I> prevents the activation of STAT3 and NFκBp65 signaling. </LI> <LI> <I>Piper nigrum</I> provides a promising strategy for immunotherapy for allergic rhinitis treatment. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Thi Tho Bui,Chun Hua Piao,김수미,송창호,신희순,이창현,채옥희 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.7
Asthma is a chronic inflammatory disease of bronchial airway, which is characterized by chronic airway inflammation, airway edema, goblet cell hyperplasia, the aberrant production of the Th2 cytokines, and eosinophil infiltration in the lungs. In this study, the therapeutic effect and the underlying mechanism of Citrus tachibana leaves ethanol extract (CTLE) in the ovalbumin (OVA)-induced allergic asthma and compound 48/80-induced anaphylaxis were investigated. Oral administration of CTLE inhibited OVA-induced asthmatic response by reducing airway inflammation, OVA-specific IgE and IgG1 levels, and increasing OVA-specific IgG2a levels. CTLE restored Th1/Th2 balance through an increase in Th2 cytokines tumor necrosis factor-α, interleukin (IL)-4, and IL-6 and decreases in Th1 cytokines interferon-γ and IL-12. Furthermore, CTLE inhibited the total level of NF-κB and the phosphorylation of IκB-α and NF-κB by OVA. In addition, CTLE dose-dependently inhibited compound 48/80-induced anaphylaxis via blocking histamine secretion from mast cells. The anti-inflammatory mechanism of CTLE may involve the modulation of Th1/Th2 imbalance via inhibiting the NF-κB signaling and histamine secretion. Taken together, we suggest that CTLE could be used as a therapeutic agent for patients with Th2-mediated or histamine-mediated allergic asthma.
Bui, Thi Tho,Kwon, Da-Ae,Choi, Dae Woon,Jung, Sun Young,Lee, So-Young,Piao, Chun Hua,Hyeon, Eunjin,Fan, Yanjing,Yeon, Sung Hum,Son, Rak-Ho,Shon, Dong-Hwa,Song, Chang Ho,Shin, Hee Soon,Chai, Ok Hee Elsevier 2019 Phytomedicine Vol.55 No.-
<P><B>ABSTRACT</B></P> <P><B>Background</B></P> <P> <I>Rosae Multiflorae</I> fructus has potent antioxidative, analgesic, and anti-inflammatory properties.</P> <P><B>Purpose</B></P> <P>We investigated the immunomodulatory effect of <I>Rosae Multiflorae</I> fructus extract (RMFE) on allergic inflammation in an allergic rhinitis (AR) mouse model.</P> <P><B>Methods</B></P> <P>Mice were sensitized and intranasally challenged with ovalbumin (OVA), the Th1/Th2-related cytokines and histopathology were examinated after RMFE treatments. Primary cell culture from spleen and NALT was performed to evaluate RMFE effect on Th1/Th2 responses. Four active components of RMFE were determined using HPLC and then tested the inhibition on Th2 response.</P> <P><B>Results</B></P> <P>Oral administration of RMFE inhibited the accumulation of eosinophils in nasal lavage fluid (NALF) and the nasal mucosa, goblet cells in the nasal epithelium, and mast cells in the respiratory region of the nasal cavity. Thus, the swelling of the nasal epithelium, nasal-associated lymphoid tissue (NALT), and lung tissue were ameliorated. Furthermore, the RMFE suppressed Th2-related cytokines, such as IL-4, IL-5, and IL-13 in NALF, NALT, and splenocytes, whereas the Th1-associated cytokine IL-12 was up-regulated by RMFE. We also revealed the active components of RMFE, such as ellagic acid, hyperoside, isoquercitrin, and miquelianin. They may inhibit IL-4 secretion in allergic responses.</P> <P><B>Conclusion</B></P> <P>RMFE may have therapeutic potential for treating AR by modulating the relationships between Th1/Th2 responses.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Bui, Thi Tho,Piao, Chun Hua,Hyeon, Eunjin,Fan, Yanjing,Choi, Dae Woon,Jung, Sun Young,Jang, Byung-Hyun,Shin, Hee Soon,Song, Chang Ho,Chai, Ok Hee Institute for Advanced Research in Asian Science a 2019 The American journal of Chinese medicine Vol. No.
<P><I>Bupleurum chinense</I> is distributed in East Asia and has been used as a traditional herbal medicine for more than a thousand years. Though <I>B. chinense</I> has been reported to have immunomodulatory, anti-inflammatory, anti-oxidant, hepato-protective, antipyretic, analgesic and antifibrotic effects, its specific effect on allergic rhinitis disease has not been clarified. In this study, we investigated the anti-allergic and anti-inflammation effects of <I>B. chinense</I> extract (BCE) in an ovalbumin (OVA)-induced allergic rhinitis (AR) mouse model. Oral administration of BCE in a dose-independent manner regulated the balance of Th1/Th2/Treg cell differentiation in AR mice. Accordingly, BCE attenuated the expression of Th2-related cytokines such as IL-4, IL-5 and IL-13 in nasal lavage fluid (NALF) and nasal tissue and up-regulated the secretion of Th1/Treg cells including IL-10, IL-12 and IFN-<TEX>$ \gamma $</TEX>. Also, BCE inhibited the formation and migration of eosinophils to the nasal mucosa and NALF, as well as suppressed CCL24, an eosinophil-specific chemoattractant in NALF. The levels of anti-OVA specific IgE and anti-OVA specific IgG1 were decreased, and as a result, the allergic response was attenuated by BCE via inhibiting mast cells accumulation in nasal mucosa and serum histamine release. The nasal allergy symptoms, nasal mucosal swelling, epithelial barrier disruption and mucus hyperplasia were obviously ameliorated. These results suggest that BCE may have therapeutic potential for treating allergic rhinitis through modulating the accumulation and activation of important leukocytes in the immune system such as Th1, Th2, Treg, eosinophils and mast cells.</P>
Bui, Thi Tho,Piao, Chun Hua,Song, Chang Ho,Shin, Hee Soon,Shon, Dong-Hwa,Chai, Ok Hee Elsevier 2017 Cellular immunology Vol.322 No.-
<P><B>Abstract</B></P> <P> <I>Piper nigrum</I> (Piperaceae) is commonly used as a spice and traditional medicine in many countries. <I>P. nigrum</I> has been reported to have anti-oxidant, anti-bacterial, anti-tumor, anti-mutagenic, anti-diabetic, and anti-inflammatory properties. However, the effect of <I>P. nigrum</I> on allergic asthma has not been known. This study investigated the effect of <I>P. nigrum</I> ethanol extracts (PNE) on airway inflammation in asthmatic mice model. In the ovalbumin (OVA)-induced allergic asthma model, we analysed the number of inflammatory cells and cytokines production in bronchoalveolar lavage fluid (BALF) and lung tissue; histological structure; as well as the total immunoglobulin (Ig)E, anti-OVA IgE, anti-OVA IgG<SUB>1</SUB> and histamine levels in serum. The oral administration (200 mg/kg) of PNE reduced the accumulation of inflammatory cells (eosinophils, neutrophils in BALF and mast cells in lung tissue); regulated the balance of the cytokines production of Th1, Th2, Th17 and Treg cells, specifically, inhibited the expressions of GATA3, IL-4, IL-6, IL-1β, RORγt, IL-17A, TNF-α and increased the secretions of IL-10, INF-γ in BALF and lung homogenate. Moreover, PNE suppressed the levels of total IgE, anti-OVA IgE, anti-OVA IgG<SUB>1</SUB> and histamine release in serum. The histological analysis showed that the fibrosis and infiltration of inflammatory cells were also ameliorated in PNE treated mice. On the other hand, PNE inhibited the allergic responses via inactivation of rat peritoneal mast cells degranulation. These results suggest that PNE has therapeutic potential for treating allergic asthma through inhibiting Th2/Th17 responses and mast cells activation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The anti-allergic effect of <I>Piper nigrum</I> is examined. </LI> <LI> The mechanism bases on inhibiting Th2/Th17 responses and mast cells activation. </LI> <LI> <I>Piper nigrum</I> significantly inhibited proinflammatory cytokines and inflammatory cells. </LI> <LI> <I>Piper nigrum</I> provide a promising strategy for immunotherapy for allergic asthma treatment. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Thi Tho Bui,Chun Hua Piao,Chang Ho Song,Chang-Hyun Lee,Hee Soon Shin,Ok Hee Chai 대한해부학회 2017 Anatomy & Cell Biology Vol.50 No.2
Asthma is characterized by chronic inflammation, goblet cell hyperplasia, the aberrant production of the Th2 cytokines, and eosinophil infiltration into the lungs. In this study, we examined the effects of baicalein, wogonin, and Scutellaria baicalensis ethanol extract on ovalbumin (OVA)-induced asthma by evaluating Th1/Th2 cytokine levels, histopathologic analysis, and compound 48/80-induced systemic anaphylaxis and mast cell activation, focusing on the histamine release from rat peritoneal mast cells. Baicalein, wogonin, and S. baicalensis ethanol extract also decreased the number of inflammatory cells especially eosinophils and downregulated peribronchial and perivascular inflammation in the lungs of mice challenged by OVA. Baicalein, wogonin, and S. baicalensis ethanol extract significantly reduced the levels of tumor necrosis factor α, interleukin (IL)-1β, IL-4, IL-5 and the production of OVA-specific IgE and IgG1, and upregulated the level of interferon-γ and OVA-specific IgG2a. In addition, oral administration of baicalein, wogonin, and S. baicalensis ethanol extract inhibited compound 48/80-induced systemic anaphylaxis and plasma histamine release in mice. Moreover, baicalein, wogonin, and S. baicalensis ethanol extract suppressed compound 48/80-induced mast cell degranulation and histamine release from rat peritoneal mast cells. Conclusively, baicalein and wogonin as major flavonoids of S. baicalensis may have therapeutic potential for allergic asthma through modulation of Th1/Th2 cytokine imbalance and histamine release from mast cells.
Nguyen Thi Mai Tho,Bui The Huy,Dang Nguyen Nha Khanh,Ho Nguyen Nhat Ha,Vu Quang Huy,Ngo Thi Tuong Vy,Do Manh Huy,Duong Phuoc Dat,Nguyen Thi Kim Phuong 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.12
Novel highly active visible-light photocatalysts in the form of zinc bismuth oxide (ZnBi2O4) and graphite hybrid composites were prepared by coupling via a co-precipitation method followed by calcination at 450 oC. The asprepared ZnBi2O4-graphite hybrid composites were tested for the degradation of rhodamine B (RhB) solutions under visible-light irradiation. The existence of strong electronic coupling between the two components within the ZnBi2O4- graphite heterostructure suppressed the photogenerated recombination of electrons and holes to a remarkable extent. The prepared composite exhibited excellent photocatalytic activity, leading to more than 93% of RhB degradation at an initial concentration of 50mg·L1 with 1.0 g catalyst per liter in 150min. The excellent visible-light photocatalytic mineralization of ZnBi2O4-1.0graphite in comparison with pristine ZnBi2O4 could be attributed to synergetic effects, charge transfer between ZnBi2O4 and graphite, and the separation efficiency of the photogenerated electrons and holes. The photo-induced h+ and the superoxide anion were the major active species responsible for the photodegradation process. The results demonstrate the feasibility of ZnBi2O4-1.0graphite as a potential heterogeneous photocatalyst for environmental remediation.