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A Novel, Reactive Green Iron Sulfide (Sulfide Green Rust) Formed on Iron Oxide Nanocrystals
Jones, Christopher J.,Chattopadhyay, Soma,Gonzalez-Pech, Natalia I.,Avendano, Carolina,Hwang, Nina,Lee, Seung Soo,Cho, Minjung,Ozarowski, Andrew,Prakash, Arjun,Mayo, J. T.,Yavuz, Cafer,Colvin, Vicki. American Chemical Society 2015 Chemistry of materials Vol.27 No.3
<P>Iron oxide nanocrystals are of great scientific and technological interest. In this work, these materials are the starting point for producing a reactive nanoparticle whose surface resembles that of natural green rusts. Treatment of iron oxide nanoparticles with cysteamine leads to the reduction of iron and the formation of a brilliant green aqueous solution of nanocrystals rich in iron(II). These materials remained crystalline with magnetic and structural features of the original iron oxide. However, new low-angle X-ray diffraction peaks as well as vibrational features characteristic of cysteamine were found in the nanocrystalline product. X-ray absorption spectroscopy (XAS), X-ray photoemission (XPS) and Mössbauer spectroscopies indicated the presence of an iron(II)-rich phase with high sulfur content analogous to the iron–oxygen structures found in natural green rusts. Electron microscopy found that these structural components remained associated with the nonreduced iron oxide cores. These sulfur-rich analogs of natural green rusts are highly reactive and were able to rapidly degrade a model organic dye in water. This observation suggests possible actuation with a cysteamine treatment of inert and magnetic iron oxide particles at the point-of-use for environmental remediation.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/cmatex/2015/cmatex.2015.27.issue-3/cm5028942/production/images/medium/cm-2014-028942_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cm5028942'>ACS Electronic Supporting Info</A></P>
Akiro H. Duey,Christopher Gonzalez,Eric A. Geng,Pierce J. Ferriter Jr,Ashley M. Rosenberg,Ula N. Isleem,Bashar Zaidat,Paul M. Al-Attar,Jonathan S. Markowitz,Jun S. Kim,Samuel K. Cho 대한척추신경외과학회 2022 Neurospine Vol.19 No.4
Objective: Subsidence following anterior cervical discectomy and fusion (ACDF) may lead to disruptions of cervical alignment and lordosis. The purpose of this study was to evaluate the effect of subsidence on segmental, regional, and global lordosis. Methods: This was a retrospective cohort study performed between 2016–2021 at a single institution. All measurements were performed using lateral cervical radiographs at the immediate postoperative period and at final follow-up greater than 6 months after surgery. Associations between subsidence and segmental lordosis, total fused lordosis, C2–7 lordosis, and cervical sagittal vertical alignment change were determined using Pearson correlation and multivariate logistic regression analyses. Results: One hundred thirty-one patients and 244 levels were included in the study. There were 41 one-level fusions, 67 two-level fusions, and 23 three-level fusions. The median follow-up time was 366 days (interquartile range, 239–566 days). Segmental subsidence was significantly negatively associated with segmental lordosis change in the Pearson (r = -0.154, p = 0.016) and multivariate analyses (beta = -3.78; 95% confidence interval, -7.15 to -0.42; p = 0.028) but no associations between segmental or total fused subsidence and any other measures of cervical alignment were observed. Conclusion: We found that subsidence is associated with segmental lordosis loss 6 months following ACDF. Surgeons should minimize subsidence to prevent long-term clinical symptoms associated with poor cervical alignment.
Study of Salting Effect of Inorganic Salts on Nano- and Giant Polymersomes
Obed Andres Solis-Gonzalez,Christopher Chi Wai Tse,Patrick J. Smith,J. Patrick A. Fairclough 한국고분자학회 2022 Macromolecular Research Vol.30 No.9
The salting effect, of kosmotropic and chaotropic salts, on nanoscale and giant-poly(ethylene oxide)16-block-poly(butylene oxide)22 polymersomes was studied. Nanovesicles were studied by dynamic light scattering and transmission electron microscopy and their aggregates (i.e., gel-like structures) by optical microscopy. Giant polymersomes were formed using drop-on-demand inkjet printing and subsequently observed using an optical microscope. The kosmotropic salts were found to strongly influence both vesicle aggregation and giant vesicle (above 3 μm) formation at high salt concentrations (i.e., ~0.5M for nanovesicle aggregation and 0.23 M for giant polymersomes) where the salting effect dominates. Chaotropic salts have very little effect in both systems. The ionic specificity effect essentially determined the outcome of experiments since the type of anion provides different ion/water/ poly(ethylene oxide) interactions and different osmotic stress values, which can be considered the main driving forces and lead the effects observed in experiments (nanovesicle aggregate experiments and abundant giant vesicle formation experiments). The applications of the present work may be lead to better methodologies to produce gel scaffolds for biomaterials or giant unilamellar polymersomes.
홍남기,이용호,Kenichi Tsujita,Jorge A. Gonzalez,Christopher M. Kramer,Tomas Kovarnik,George N. Kouvelos,Hiromichi Suzuki,한경도,이찬주,박성하,이병완,차봉수,강은석 대한내분비학회 2018 Endocrinology and metabolism Vol.33 No.2
Background: Ezetimibe-statin combination therapy has been found to reduce low density lipoprotein cholesterol levels and the risk of major adverse cardiovascular events (MACEs) in large trials. We sought to examine the differential effect of ezetimibe on MACEs when added to statins according to the presence of diabetes. Methods: Randomized clinical trials with a sample size of at least 50 participants and at least 24 weeks of follow-up that compared ezetimibe-statin combination therapy with a statin- or placebo-controlled arm and reported at least one MACE, stratified by diabetes status, were included in the meta-analysis and meta-regression. Results: A total of seven trials with 28,191 enrolled patients (mean age, 63.6 years; 75.1% men; 7,298 with diabetes [25.9%]; mean follow-up, 5 years) were analysed. MACEs stratified by diabetes were obtained from the published data (two trials) or through direct contact (five trials). No significant heterogeneity was observed among studies (I2=14.7%, P=0.293). Ezetimibe was associated with a greater reduction of MACE risk in subjects with diabetes than in those without diabetes (pooled relative risk, 0.84 vs. 0.93; Pheterogeneity=0.012). In the meta-regression analysis, the presence of diabetes was associated with a greater reduction of MACE risk when ezetimibe was added to statins (β=0.87, P=0.038). Conclusion: Ezetimibe-statin combination therapy was associated with greater cardiovascular benefits in patients with diabetes than in those without diabetes. Our findings suggest that ezetimibe-statin combination therapy might be a useful strategy in patients with diabetes at a residual risk of MACEs.
Dhruv S. Shankar,Edward S. Mojica,Christopher A. Colasanti,Anna M. Blaeser,Paola F. Ortega,Guillem Gonzalez-Lomas,Laith M. Jazrawi 대한견주관절학회 2023 대한견주관절의학회지 Vol.26 No.1
Background: The purpose of this study was to identify predictors of the time from initial presentation to total shoulder arthroplasty (TSA) in patients with primary glenohumeral osteoarthritis (OA) and rotator cuff (RTC) arthropathy who were conservatively managed with corticosteroid injections. Methods: We conducted a retrospective cohort study of patients who underwent TSA from 2010 to 2021. Kaplan-Meier survival analysis was used to estimate median time to TSA for primary OA and RTC arthropathy patients. The Cox proportional hazards model was used to identify significant predictors of time to TSA and to calculate hazard ratios (HRs) with 95% confidence intervals (CIs). Statistical significance was set at P<0.05. Results: The cohort included 160 patients with primary OA and 92 with RTC arthropathy. In the primary OA group, median time to TSA was 15 months. Significant predictors of shorter time to TSA were older age at presentation (HR, 1.02; 95% CI, 1.00–1.04; P=0.03) and presence of moderate or severe acromioclavicular joint arthritis (HR, 1.45; 95% CI, 1.05–2.01; P=0.03). In the RTC arthropathy group, median time to TSA was 14 months, and increased number of corticosteroid injections was associated with longer time to TSA (HR, 0.87; 95% CI, 0.80–0.95; P=0.003). Conclusions: There are distinct prognostic factors for progression to TSA between primary OA patients and RTC arthropathy patients managed with corticosteroid injections. Multiple corticosteroid injections are associated with delayed time to TSA in RTC arthropathy patients.
Kim Jun Ho,Reinaldo Abdala-Júnior,Luciana Munhoz,Arthur Rodriguez Gonzalez Cortes,Plauto Christopher Aranha Watanabe,Claudio Costa,Emiko Saito Arita 대한영상치의학회 2020 Imaging Science in Dentistry Vol.50 No.2
Purpose: This study compared 2 cone-beam computed tomography (CBCT) systems in the detection of mechanically simulated peri-implant buccal bone defects in dry human mandibles. Materials and Methods: Twenty-four implants were placed in 7 dry human mandibles. Peri-implant bone defects were created in the buccal plates of 16 implants using spherical burs. All mandibles were scanned using 2 CBCT systems with their commonly used acquisition protocols: i-CAT Gendex CB-500 (Imaging Sciences, Hatfield, PA, USA; field of view [FOV], 8 cm×8 cm; voxel size, 0.125 mm; 120 kVp; 5 mA; 23 s) and Orthopantomograph OP300 (Intrumentarium, Tuusula, Finland; FOV, 6 cm×8 cm; voxel size, 0.085 mm; 90 kVp; 6.3 mA; 13 s). Two oral and maxillofacial radiologists assessed the CBCT images for the presence of a defect and measured the depth of the bone defects. Diagnostic performance was compared in terms of the area under the curve (AUC), accuracy, sensitivity, specificity, and intraclass correlation coefficient. Results: High intraobserver and interobserver agreement was found (P<0.05). The OP300 showed slightly better diagnostic performance and higher detection rates than the CB-500 (AUC, 0.56±0.03), with a mean accuracy of 75.0%, sensitivity of 81.2%, and specificity of 62.5%. Higher contrast was observed with the CB-500, whereas the OP300 formed more artifacts. Conclusion: Within the limitations of this study, the present results suggest that the choice of CBCT systems with their respective commonly used acquisition protocols does not significantly affect diagnostic performance in detecting and measuring buccal peri-implant bone loss.
Sunil Amin,Dennis J. Yang,Aimee L. Lucas,Susana Gonzalez,Christopher J. DiMaio 대한소화기내시경학회 2017 Clinical Endoscopy Vol.50 No.4
Background/Aims: Options for the endoscopic management of symptomatic pancreatic fluid collections (PFCs) include transmural drainage (TM) alone, transpapillary drainage (TP) alone, or a combination of both drainage method (CD). There have been conflicting reports about the best method. This study performed a meta-analysis to determine whether CD presents an added clinical benefit over TM. Methods: The included studies compared TM with CD and reported clinical success for both methods. A random-effects model was used to determine the pooled odds ratios (ORs) and the 95% confidence intervals (CIs) for the following outcomes: technical success, clinical success, complications, and recurrence. Results: Nine studies involving a combined total of 604 drainage procedures—373 TMs (62%) and 231 CDs (38%)—were included. CD showed no additional benefit over TM in terms of technical success (OR, 1.12; 95% CI, 0.37–3.37; p=0.85), clinical success (OR, 1.11; 95% CI, 0.65–1.89; p=0.70), recurrence (OR, 1.49; 95% CI, 0.53–4.21; p=0.45), or complications (OR, 1.15; 95% CI, 0.61–2.18; p=0.67). Conclusions: Pancreatic duct (PD) stenting provides no additional clinical benefit for the TM of PFCs (particularly pseudocysts). Patients undergoing the TM of symptomatic pseudocysts may not require endoscopic retrograde pancreatography (ERP).