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Shang-Hui Yang,Jian-Shian Lin,Fuh-Shyang Juang,Ding-Chin Chou,Ming-Hua Chung,Chen-Ming Chen,Lung-Chang Liu 한국물리학회 2013 Current Applied Physics Vol.13 No.5
In this paper, white light emitting diodes (LEDs) with good color rendering indices (CRI) and high luminous efficiencies have been fabricated by the encapsulation of mixed and double-deck phosphors. Experimental results revealed that white LEDs with the encapsulation of double-deck phosphors exhibited better CRI and higher luminous efficiencies than those with the encapsulation of mixed phosphors because no secondary excitation took place. The hue, CRI, and luminous efficiencies of white LEDs with double-deck phosphors under 200 mA were CIEx,y =(0.357, 0.348), 90, and 62.3 lm/W,respectively while the hue, CRI, and luminous efficiencies of white LEDs with mixed phosphors under 200 mA were CIEx,y = (0.366, 0.354), 89, and 56.5 lm/W, respectively.
Chu-Chung Chou,Jai-Sing Yang,Hsu-Feng Lu,Siu-Wan Ip,Chyi Lo,Chih-Chung Wu,Jing-Pin Lin,Nou-Ying Tang,Jing-Gung Chung,Ming-Jen Chou,Ying-Hock Teng,Dar-Ren Chen 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.8
Dietary polyphenols have been correlated with a reduced risk of developing cancer. Quercetin (a natural polyphenolic compound) induced apoptosis in many human cancer cell lines, including breast cancer MCF-7 cells. However, the involvement of possible signaling pathways and the roles of quercetin in apoptosis are still undefined. The purpose of this study was to investigate the effects of quercetin on the induction of the apoptotic pathway in human breast cancer MCF-7 cells. When MCF-7 cells were treated with quercetin for 24 and 48 h and at various doses (10-175 μM), cell viability decreased significantly in time- and dose-dependent manners. Exposure of MCF-7 cells to 10-175 μM quercetin resulted in an approximate 90.25% decrease in viable cells. To explicate the mechanism underlying the antiproliferative effect of quercetin, cell cycle distribution and apoptosis in MCF-7 cells was investigated after exposure to 150 μM quercetin for 6-48 h. Quercetin caused a remarkable increase in the number of S phase (14.56%to 61.35%) and sub-G1 phase cells (0.1% to 8.32%) in a dose- and time-dependent manner. Quercetin caused S phase arrest by decreasing the protein expression of CDK2, cyclins A and B while increasing the p53 and p57 proteins. Following incubation with quercetin for 48 h, MCF-7 cells showed apoptotic cell death by the decreased levels of Bcl-2 protein and ΔΨ m and increased activations of caspase-6, -8 and -9. Moreover, quercetin increased the AIF protein released from mitochondria to nuclei and the GADD153 protein translocation from endoplasmic reticulum to the nuclei. These data suggested that quercetin may induce apoptosis by direct activation of the caspase cascade through the mitochondrial pathway in MCF-7 cells.
Grey Neural Network-Based Forecasting System for Vision-Guided Robot Trajectory Tracking
Shih-Hung Yang,Chung-Hsien Chou,Chen-Fang Chung,Wen-Pang Pai,Tse-Han Liu,Yung-Sheng Chang,Jung-Che Li,Huan-Chan Ting,Yon-Ping Chen 제어로봇시스템학회 2011 제어로봇시스템학회 국제학술대회 논문집 Vol.2011 No.10
This paper presents a grey neural network-based forecasting system (GNNFS) in solving the prediction problem. GNNFS adopts a grey model to predict the signal and a neural network (NN) to forecast the prediction error of the grey model. A sequential batch learning (SBL) is developed to adjust the weights of the NN. The proposed GNNFS is applied to a binocular robot, called an Eye-Robot, for human-robot interaction which involved predicting the trajectory of a participant’s hand and tracking the hand. By applying the SBL, the GNNFS can gradually learn to predict the trajectory of the hand and track it well. The experimental results show that the GNNFS can carry out the SBL in real-time for vision-guided robot trajectory tracking.
Hung-An Chen,Chun-Ching Chiu,Chih-Yang Huang,Li-Jeng Chen,Chun-Chou Tsai,Tsai-Ching Hsu,Bor-Show Tzang 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.7
Lactoferrin (LF) has beneficial effects against various diseases. However, the effects of LF on liver fibrosis in systematic lupus erythematosus (SLE) are unknown. In this study, NZB/W F1 mice were utilized to investigate the effects of LF on SLE. Experiments reveal that LF significantly increases glutathione and 1,1-diphenyl-2-picryl-hydrazyl levels and significantly decreased malondialdehyde levels in both serum and liver in NZB/W F1 mice. LF also lowered matrix metalloproteinase-9 activity and liver inflammatory indices, such as aminotransferase and alanine aminotransferase. Notably, significantly decreased expression of fibrotic related molecules, including transforming growth factor (TGF)-β1, tumor necrosis factor-α, interleukin-1β, and TGF-β1 receptor, were observed in the livers of NZB/W F1 mice that had been treated with LF. Significantly, suppressed Smad2/3 signaling, α-smooth muscle actin, and collagen deposition were also detected. These findings reveal that LF has beneficial effects on SLE by increasing antioxidant activities and ameliorating liver inflammation and fibrosis, suggesting the therapeutic effectiveness of LF against SLE.
( Chien Hui Wu ),( Wei Chen Chien ),( Han Kai Chou ),( Jung Woo Yang ),( Hong Ting Victor Lin ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.9
One-step sulfuric acid saccharification of the red alga Pterocladiella capillacea was optimized, and various detoxification methods (neutralization, overliming, and electrodialysis) of the acid hydrolysate were evaluated for fermentation with the thermotolerant yeast Kluyveromyces marxianus. A proximate composition analysis indicated that P. capillacea was rich in carbohydrates. A significant galactose recovery of 81.1 ± 5% was also achieved under the conditions of a 12% (w/v) biomass load, 5% (v/v) sulfuric acid, 121°C, and hydrolysis for 30 min. Among the various detoxification methods, electrodialysis was identified as the most suitable for fermentable sugar recovery and organic acid removal (100% reduction of formic and levulinic acids), even though it failed to reduce the amount of the inhibitor 5-HMF. As a result, K. marxianus fermentation with the electrodialyzed acid hydrolysate of P. capillacea resulted in the best ethanol levels and fermentation efficiency.
Arrigoni Battaia, F.,Chen, Chian-Chou,Fumagalli, M.,Cai, Zheng,Calistro Rivera, G.,Xu, Jiachuan,Smail, I.,Prochaska, J. X.,Yang, Yujin,De Breuck, C. Springer-Verlag 2018 Astronomy and astrophysics Vol.620 No.-
<P>In the hierarchical model of structure formation, giant elliptical galaxies form through merging processes within the highest density peaks known as protoclusters. While high-redshift radio galaxies usually pinpoint the location of these environments, we have recently discovered at <I>z</I> ∼ 2−3 three enormous (> 200 kpc) Lyman-<I>α</I> nebulae (ELANe) that host multiple active galactic nuclei (AGN) and that are surrounded by overdensities of Lyman-<I>α</I> emitters (LAE). These regions are prime candidates for massive protoclusters in the early stages of assembly. To characterize the star-forming activity within these rare structures - both on ELAN and protocluster scales - we have initiated an observational campaign with the <I>James Clerk Maxwell</I> Telescope (JCMT) and the Atacama Pathfinder EXperiment (APEX) telescopes. In this paper we report on sensitive SCUBA-2/JCMT 850 and 450 <I>μ</I>m observations of a ∼128 arcmin<SUP>2</SUP> field comprising the ELAN MAMMOTH-1, together with the peak of the hosting BOSS1441 LAE overdensity at <I>z</I> = 2.32. These observations unveil 4.0 ± 1.3 times higher source counts at 850 <I>μ</I>m with respect to blank fields, likely confirming the presence of an overdensity also in obscured tracers. We find a strong detection at 850 <I>μ</I>m associated with the continuum source embedded within the ELAN MAMMOTH-1, which - together with the available data from the literature - allow us to constrain the spectral energy distribution of this source to be of an ultra-luminous infrared galaxy (ULIRG) with a far-infrared luminosity of LFIR<SUP>SF</SUP> = 2.4−2.1<SUP>+7.4</SUP>×10<SUP>12</SUP><I>L</I>⊙, and hosting an obscured AGN. Such a source is thus able to power a hard photoionization plus outflow scenario to explain the extended Lyman-<I>α</I>, He II<I>λ</I>1640, and C IV<I>λ</I>1549 emission, and their kinematics. In addition, the two brightest detections at 850 <I>μ</I>m (<I>f</I>850 > 18 mJy) sit at the density peak of the LAEs’ overdensity, likely pinpointing the core of the protocluster. Future multiwavelength and spectroscopic datasets targeting the full extent of the BOSS1441 overdensity have the potential to firmly characterize a cosmic nursery of giant elliptical galaxies, and ultimately of a massive cluster.</P>
DISCOVERY OF AN X-RAY-EMITTING CONTACT BINARY SYSTEM 2MASS J11201034−2201340
Hu, Chin-Ping,Yang, Ting-Chang,Chou, Yi,Liu, L.,Qian, S.-B.,Hui, C. Y.,Kong, Albert K. H.,Lin, L. C. C.,Tam, P. H. T.,Li, K. L.,Ngeow, Chow-Choong,Chen, W. P.,Ip, Wing-Huen American Astronomical Society 2016 The Astronomical journal Vol.151 No.6
<P>We report the detection of orbital modulation, a model solution, and the X-ray properties of a newly discovered contact binary, Two Micron All Sky Survey (2MASS) J11201034-2201340. We serendipitously found this X-ray point source outside the error ellipse when searching for possible X-ray counterparts of 7-ray millisecond pulsars among the unidentified objects detected by the Fermi Gamma-ray Space Telescope. The optical counterpart of the X-ray source (unrelated to the 7-ray source) was then identified using archival databases. The long-term Catalina Real-Time Transient Survey detected a precise signal with a period of P = 0.28876208 (56) days. A follow-up observation made by the Super Light Telescope of Lulin Observatory revealed the binary nature of the object. Utilizing archived photometric data of multi-band surveys, we construct the spectral energy distribution (SED), which is well fit by a K2V spectral template. The fitting result of the orbital profile using the Wilson Devinney code suggests that 2MASS J11201034-2201340 is a short-period A-type contact binary and the more massive component has a cool spot. The X-ray emission was first noted in observations made by Swift, and then further confirmed and characterized by an XMM-Newton observation. The X-ray spectrum can be described by a power law or thermal Bremsstrahlung. Unfortunately, we could not observe significant X-ray orbital modulation. Finally, according to the SED, this system is estimated to be 690 pc from Earth with a calculated X-ray intensity of (0.7 - 1.5) x 10(30) erg s(-1), which is in the expected range of an X-ray emitting contact binary.</P>
( Chien Hui Wu ),( Wei Chen Chien ),( Kai Chou Han ),( Jung Woo Yang ),( Hong Ting Victor Lin ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.9
Screening of a gene library from Paenibacillus sp. PBS-2 generated in Escherichia coli led to the identification of a clone with lipolytic activity. Sequence analysis showed an open reading frame encoding a polypeptide of 378 amino acid residues with a predicted molecular mass of 42 kDa. The esterase displayed 69% and 42% identity with the putative β-lactamases from Paenibacillus sp. JDR-2 and Clostridium sp. BNL1100, respectively. The esterase contained a Serx- x-Lys motif that is conserved among all β-lactamases found to date. The protein PBS-2 was produced in both soluble and insoluble forms when E. coli cells harboring the gene were cultured at 18°C. The enzyme is a serine protein and was active against p-nitrophenyl esters of C2, C4, C8, and C10. The optimum pH and temperature for enzyme activity were pH 9.0 and 30°C, respectively. Relative activity of 55% remained at up to 5°C with an activation energy of 5.84 kcal/mol, which indicates that the enzyme is cold-adapted. Enzyme activity was inhibited by Cd2+, Cu2+, and Hg2+ ions. As expected for a serine esterase, activity was inhibited by phenylmethylsulfonyl fluoride. The enzyme was remarkably active and stable in the presence of commercial detergents and organic solvents. This cold-adapted esterase has potential as a biocatalyst and detergent additive for use at low temperatures.