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Dosimetry of a new P-32 ophthalmic applicator.
Choi, Chang Heon,Han, Hyon Soo,Son, Kwang-Jae,Park, Ul Jae,Lee, Jun Sig,Wee, Won Ryang,Ha, Sung Whan,Kim, Il Han,Ye, Sung-Joon The American Association of Physicists in Medicine 2011 Medical physics Vol.38 No.11
<P>The potential of P-32 ophthalmic applicator irradiation after pterygium excision has been demonstrated as an alternative to Sr???Y-90 irradiation. This study aimed to provide the clinical dosimetry for this new applicator.</P>
Ye, Byeong Hyeok,Kim, Eun Jung,Baek, Seung Eun,Choi, Young Whan,Park, So Youn,Kim, Chi Dae The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.4
${\alpha}$-Iso-cubebene (ICB) is a dibenzocyclooctadiene lignin contained in Schisandra chinensis (SC), a well-known medicinal herb that ameliorates cardiovascular symptoms, but the mechanism responsible for this activity has not been determined. To determine the role played by ICB on the regulation of vascular tone, we investigated the inhibitory effects of ICB on vascular contractile responses by adrenergic ${\alpha}$-receptor agonists. In addition, we investigated the role on myosin light chain (MLC) phosphorylation and cytosolic calcium concentration in vascular smooth muscle cells (VSMC). In aortic rings isolated from C57BL/6J mice, ICB significantly attenuated the contraction induced by phenylephrine (PE) and norepinephrine (NE), whereas ICB had no effects on KCl (60 mM)-induced contraction. In vasculatures precontracted with PE, ICB caused marked relaxation of aortic rings with or without endothelium, suggesting a direct effect on VSMC. In cultured rat VSMC, PE or NE increased MLC phosphorylation and increased cytosolic calcium levels. Both of these effects were significantly suppressed by ICB. In conclusion, our results showed that ICB regulated vascular tone by inhibiting MLC phosphorylation and calcium flux into VSMC, and suggest that ICB has anti-hypertensive properties and therapeutic potential for cardiovascular disorders related to vascular hypertension.
Han, Ye Jin,Je, Ju Hui,Kim, So Hyoung,Ahn, Sung Min,Kim, Ha Neui,Kim, Yu Ri,Choi, Young Whan,Shin, Hwa Kyoung,Choi, Byung Tae Institute for Advanced Research in Asian Science a 2014 The American journal of Chinese medicine Vol.42 No.4
<P>Dried roots of Gastrodia elata have traditionally been used in Korean medicine for the treatment of neurological disorders such as scotodinia, paralysis, and epilepsy. In our study, we attempted to investigate the neuroprotective effects of methanol extract from G. elata (MEGE) against glutamate-mediated oxidative stress and to explore underlying neuroprotective mechanisms. Analyses for cell viability, lactate dehydrogenase (LDH), flow cytometry, Western blot, and reactive oxygen species (ROS) were performed in HT22 hippocampal cells. Pretreatment with MEGE resulted in a potent neuroprotective effect against oxidative glutamate toxicity and these effects were exerted mainly by the abrogation of glutamate-induced apoptotic death. Treatment with glutamate resulted in a significant expression of both phosphorylated p38 and dephosphorylated phosphatidylinositol-3-kinase (PI3K). However, pretreatment with MEGE resulted in the inhibition of these expressions. In the inhibitor studies, treatment with PI3K inhibitor LY294002 resulted in the abrogation of the neuroprotective effect of MEGE. In addition, pretreatment with MEGE also resulted in the suppression of the glutamate-induced production of ROS. Treatment with MEGE and anti-oxidant N-acetyl-L-cysteine (NAC) resulted in the enhanced phosphorylation of both PI3K and cAMP responsive element binding protein (CREB), and, in particular, treatment with MEGE resulted in significantly enhanced expression of mature brain-derived neurotrophic factor (BDNF). These results suggest that the extract from G. elata mainly exerted neuroprotective effects through the up-regulation of the PI3K signaling pathway in association with BDNF and may be a useful therapeutic agent for treatment of oxidative neuronal death.</P>
만성 B형 간염 환자에서 재조합형 알파 인터페론(Intron-A)의 효과
김동환,최예원,박승욱,신호균,김학양,김진한,박충기,임규성,유재영 대한내과학회 1990 대한내과학회지 Vol.38 No.4
We evaluated the effect of recombinant alpha interferon(Intron-A, Schering) in 30 patients with chronic hepatitis B. They included 24 men and six women, ages 17 to 53 years(mean 37), with elevated serum AST and ALT; 41 to 789 U/㎗(mean 275) and 78 to 689 U/㎗(mean 280), respectively. All patients had serum hepatitis B surface antigen(HBeAg) longer than three years, and hepatitis B e antigen(HBeAg). Liver biopsies before therapy revealed chronic active heaptitis(CAH) in 80% and active cirrhosis in 20%. The patients were randomized into two groups: those who received Intron-A(16 patients) and those who had no therapy(14 patients). Intron-A was administered in doses of 3 million units(MU) every other day for four months and followed-up longer than one and half years. The ALT level returned to normal in 15 of 16(94%) treated patients during therapy, and 4/16 subsequently lost HBV-DNA and HBeAg. In 3/16(19%), serum ALT rebounded and HBeAg reappeared at the 21st week in one and the 54th week in the others. Serum HBeAg persisted in nine of 16 cases(56%), but serum ALT returned to normal level in five patients. In contrast, 3/14(21%) untreated patients showed improvement of serum ALT level at the 6th, 24th and 52nd week of follow-up, respectively, and two subsequently lost HBV -DNA and HBeAg. But nine of 14(64%) patients showed multiple episodes of serum ALT fluctuation during the follow-up period. This study shows that the alternate-day interferon alpha therapy for four months may be effective in some patients with chronic hepatitis B. But because of relatively low significant effect in the treated patients, compared with the untreated, studies with larger number of patients are ncessary to evaluate the duration and the dosage of interferon alpha.
Byeong Hyeok Ye,Eun Jung Kim,Seung Eun Baek,Young Whan Choi,So Youn Park,Chi Dae Kim 대한생리학회-대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.4
α-Iso-cubebene (ICB) is a dibenzocyclooctadiene lignin contained in Schisandra chinensis (SC), a well-known medicinal herb that ameliorates cardiovascular symptoms, but the mechanism responsible for this activity has not been determined. To determine the role played by ICB on the regulation of vascular tone, we investigated the inhibitory effects of ICB on vascular contractile responses by adrenergic α-receptor agonists. In addition, we investigated the role on myosin light chain (MLC) phosphorylation and cytosolic calcium concentration in vascular smooth muscle cells (VSMC). In aortic rings isolated from C57BL/6J mice, ICB significantly attenuated the contraction induced by phenylephrine (PE) and norepinephrine (NE), whereas ICB had no effects on KCl (60 mM)-induced contraction. In vasculatures precontracted with PE, ICB caused marked relaxation of aortic rings with or without endothelium, suggesting a direct effect on VSMC. In cultured rat VSMC, PE or NE increased MLC phosphorylation and increased cytosolic calcium levels. Both of these effects were significantly suppressed by ICB. In conclusion, our results showed that ICB regulated vascular tone by inhibiting MLC phosphorylation and calcium flux into VSMC, and suggest that ICB has anti-hypertensive properties and therapeutic potential for cardiovascular disorders related to vascular hypertension.
Wonmo Sung,Jong Min Park,Chang Heon Choi,Sung Whan Ha,Sung-Joon Ye 대한방사선종양학회 2012 Radiation Oncology Journal Vol.30 No.1
Purpose: To evaluate the effect of common three photon energies (6-MV, 10-MV, and 15-MV) on intensity-modulated radiation therapy (IMRT) plans to treat prostate cancer patients. Materials and Methods: Twenty patients with prostate cancer treated locally to 81.0 Gy were retrospectively studied. 6-MV, 10-MV, and 15-MV IMRT plans for each patient were generated using suitable planning objectives, dose constraints, and 8-field setting. The plans were analyzed in terms of dose-volume histogram for the target coverage, dose conformity, organs at risk (OAR) sparing, and normal tissue integral dose. Results: Regardless of the energies chosen at the plans, the target coverage, conformity, and homogeneity of the plans were similar. However, there was a significant dose increase in rectal wall and femoral heads for 6-MV compared to those for 10-MV and 15-MV. The V<sub>20 Gy</sub> of rectal wall with 6-MV, 10-MV, and 15-MV were 95.6%, 88.4%, and 89.4% while the mean dose to femoral heads were 31.7, 25.9, and 26.3 Gy, respectively. Integral doses to the normal tissues in higher energy (10-MV and 15-MV) plans were reduced by about 7%. Overall, integral doses in mid and low dose regions in 6-MV plans were increased by up to 13%. Conclusion: In this study, 10-MV prostate IMRT plans showed better OAR sparing and less integral doses than the 6-MV. The biological and clinical significance of this finding remains to be determined afterward, considering neutron dose contribution.
( Jongmin Lee ),( Young Kyoon Kim ),( Ye Young Seo ),( Eun Kyoung Choi ),( Dong Soo Lee ),( Yeon Sil Kim ),( Sook Hee Hong ),( Jin Hyoung Kang ),( Kyo Young Lee ),( Jae Kil Park ),( Sook Whan Sung ),( 대한결핵 및 호흡기학회 2018 Tuberculosis and Respiratory Diseases Vol.81 No.4
Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a standard procedure to evaluate suspicious lymph node involvement of lung cancer because computed tomography (CT) and <sup>18</sup>F-fluorodeoxyglucose positron emission tomography-CT (PET-CT) have limitations in their sensitivity and specificity. There are a number of benign causes of false positive lymph node such as anthracosis or anthracofibrosis, pneumoconiosis, old or active tuberculosis, interstitial lung disease, and other infectious conditions including pneumonia. The purpose of this study was to evaluate possible causes of false positive lymph node detected in chest CT or PET-CT. Methods: Two hundred forty-seven patients who were initially diagnosed with lung cancer between May 2009 and December 2012, and underwent EBUS-TBNA to confirm suspicious lymph node involvement by chest CT or PET-CT were analyzed for the study. Results: Of 247 cases, EBUS-TBNA confirmed malignancy in at least one lymph node in 189. The remaining 58 patients whose EBUS-TBNA results were negative were analyzed. Age ≥65, squamous cell carcinoma as the histologic type, and pneumoconiosis were related with false-positive lymph node involvement on imaging studies such as chest CT and PET-CT. Conclusion: These findings suggest that lung cancer staging should be done more carefully when a patient has clinically benign lymph node characteristics including older age, squamous cell carcinoma, and benign lung conditions.