http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Chih-Jen Yang,Yu-Jung Huang,Cheng-Yuan Wang,Chuan-Sheng Wang,Pei-Hui Wang,Jen-Yu Hung,Tung-Heng Wang,Hseng-Kuang Hsu,Hurng-Wern Huang,S.P. Anand Kumar,Ming-Shyan Huang,Ching-Feng Weng 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1
Toona sinensis is a traditional Chinese herb, and the extracts of T. sinensis leaf possess a variety of biological functions. This study attempted to test the antiproliferative effect of TSL-1 (a bioactive fraction of T. sinensis) in H441 cells (lung adenocarcinoma). The data showed that the antiproliferative effect of TSL-1 on H441 cells is prominent using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. TSL-1-induced apoptosis was confirmed by cell morphology, sub-G1 peak accumulation, cleavage of poly(ADP)-ribose polymerase, and propidium iodide-annexin V double staining. Furthermore, decreased Bcl-2 accompanied by increased Bax (in western blotting) was found with TSL-1 treatment of H441 cells. TSL-1 treatment-induced G1 arrest was concurrent with the down-regulation of protein levels of cyclin D1 and cyclin-dependent kinase 4 in H441 cells. Peroral and intraperitoneal administrations of TSL-1 were performed to evaluate the therapeutic efficacy, and peroral administration of TSL-1 was also used to elucidate the therapeutic efficacy in the H441 cell xenograft model in vivo. The data revealed that TSL-1 treatment inhibited H441 tumor growth in both therapeutic and preventive experiments. Taken together, these results demonstrate that TSL-1 possesses the capability of preventing and alleviating lung cancer proliferation in vitro and in vivo with proven nephrological and hepatic safety and has the potential to be developed as an anti–lung cancer drug.
Yuan-Ping Luh,Liao-Chuan Huang,Hao-Jan Lu,Chih-Hsing Chu 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.7 No.3
Mixed production is a practical solution to realize the idea of mass product customization. The production system needs to adapt to raw materials of product variants appearing in the production line, and thus to properly complete the manufacturing task. Such system autonomy is a core competence in smart manufacturing. This paper presents a smart manufacturing solutionfor shoe sole gluing in mixed production environment. The solution automatically guides a 5-axis CNC dispensing machine to perform the gluing task of a sole randomly placed on the worktable without use of fi xturing. A single RGB-D camera is used to capture the color and depth data of the work environment. A two-stage algorithm is implemented to provide the intelligence required by the solution using the captured data as input. The LINEMOD method fi rst determines a rough pose from training data of all shoe soles at pre-defi ned orientations. A trimmed interactive closest point (ICP) method then refi nes the pose using the rough one as the initial solution. Pre-determined working paths are transformed into the correct location around the sole with the refi ned pose. The corresponding motion commands drive the dispenser controller to complete the gluing task without collision. Test results of real shoe soles validate the eff ectiveness of the proposed solution. This work contributes to smart manufacturing in the shoe making industry, which has been less studied in the past.
Chih-Hsing Chu,Yu-Wang Liu,Pai-Chia Li,Liao-Chuan Huang,Yuan-Ping Luh 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.7 No.5
This study presents a programming by demonstration (PbD) interface in augmented reality for motion planning in a three-axis CNC glue dispenser. The interface assists a human planner to effectively determine dispenser motion in a planning task. An augmented reality application prompts the planner with instructive information in a video of real environment while guiding the machine in 3D space to dispense glue on a work part. The purpose involves facilitating the generation of the dispenser’s motion commands by enhancing individual spatial reasoning between the dispenser’s tip and the work part. CAD models are not required prior to the planning task, thus eliminating the use of motion planning software. Test results demonstrate the effectiveness of the proposed interface with respect to accelerating the process of the dispenser PbD. The study shows the practical value of augmented reality as a cost-effective interfacing technology for human–machine collaborations in smart manufacturing.
On Establishing a New Fee Schedule for General Surgical Procedure Using Fuzzy MCDM
Hung, Chih-Young,Huang, Yuan-Huei,Chang, Pei-Yeh,Wang, Kuei-Ing,Chang, King-Jen,Liu, Yi-Hsin Korean Institute of Industrial Engineers 2005 Industrial Engineeering & Management Systems Vol.4 No.2
In this research a model for establishing a new, rational fee schedule for general surgical procedures in a national health insurance program is developed. A fuzzy multiple criteria decision-making (FMCDM) model is proposed. The relative values of eleven surgical procedures were obtained through an empirical study based on the FMCDM model. Consequently, a new fee schedule obtained from the FMCDM model. This new fee schedule is more convincing than previous schedule and more persuasive to the references for the policy setting.
The Development of Embedded Bundling Machinery for Cabbage Roll
( Wen-luh Huang ),( Jia-jyun Huang ),( Chih-cheng Pai ),( Zi-yuan Xue ),( Yu-hsuan Wu ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
The traditional process of cabbage roll at present is to use the manpower to excavate cabbage stem, to invert the hot water to heat(70-80℃) to shell leaf and cool it down, patting the cabbage leaf stem and then put the stuffing on the leaf, rolling the leaf and tying a knot by hand finally. Most processes of production are hand-made. The human resource cost is high and the production capacity is limited. Therefore, our project is designed to develop and research for the tying and bundling machinery for cabbage roll. Our machinery is mainly composed of U-type platform for cabbage roll, hook for calabash melon wire, adjustable varying speed motor, insert machinery, Single acting cylinder,Programmable Logic Controller(PLC) and others elements. According to our test results, the embedded machinery operates fine, not only bundling a single cabbage spent less than 6 seconds, but also passing the 6 hours cooking test. The wire lead won’t be dropout. The bundled cabbage roll achieved the same standard specification of cabbage roll that the 7-11 convenience stores’re selling now. At the same time, we tried different wire materials and different process (bundling and tying) to make questionnaire. According to our statistical results, no matter the texture, process(bundling and tying)and taste, the bundling process is all better than the traditional tying process, and preference of wires materials shows the most respondents choose the calabash melon which account for 45.9%, the second and third choice is konjac jelly, leek(16.5%)and Dried bamboo shoot (15.3%), others account for 5.8%. Finally we find that this embedded bundling machinery’s feature and performance will satisfy with the Mechanization demands for the food factory.
Lan Ting-Yuan,Lin Yen-Chun,Tseng Tai-Chung,Yang Hung-Chih,Kao Jui-Hung,Cheng Chiao-Feng,Lee Tai-Ju,Huang Shang-Chin,Lu Cheng-Hsun,Li Ko-Jen,Hsieh Song-Chou 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.2
Background/Aims: Rituximab is known to be associated with high hepatitis B virus (HBV) reactivation rate in patients with resolved HBV infection and hematologic malignancy. However, data regarding HBV reactivation (HBVr) in rheumatic patients receiving rituximab is limited. To assess the HBVr rate in hepatitis B surface antigen (HBsAg)-negative patients receiving rituximab for autoimmune diseases in a large real-world cohort. Methods: From March 2006 to December 2019, 900 patients with negative HBsAg receiving at least one cycle of rituximab for autoimmune diseases in a tertiary medical center in Taiwan were retrospectively reviewed. Clinical outcome and factors associated with HBVr were analyzed. Results: After a median follow-up period of 3.3 years, 21 patients developed HBVr, among whom 17 patients were positive for hepatitis B core antibody (anti-HBc) and four were negative. Thirteen patients had clinical hepatitis flare, while eight patients had HBsAg seroreversion without hepatitis. Old age, anti-HBc positivity, undetectable serum hepatitis B surface antibody level at rituximab initiation and a higher average rituximab dose were associated with a higher HBVr rate. There was no significant difference in the HBVr risk between rheumatoid arthritis and other autoimmune diseases. Among anti-HBc-negative patients, subjects without HBV vaccination at birth had an increased risk of HBVr (4/368, 1.1%) compared with those who received vaccination (0/126, 0%). Conclusions: In HBV endemic areas where occult HBV is prevalent, anti-HBc-negative patients, may still be at risk for HBVr after rituximab exposure. HBVr may still be considered in HBsAgnegative patients developing abnormal liver function after rituximab exposure, even in patients with negative anti-HBc.
Yun-Chieh Tsai,Yu-Chen Lin,Chun-Chih Huang,Oliver B. Villaflores,Tzong-Yuan Wu,Shih-Ming Huang,Ting-Yu Chin 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.5
Aging and lifestyle factors, including high-sugar and high-fat diets, promote a systemic metabolic imbalance that promotes neurodegeneration. Hericium erinaceus has long been used in traditional Chinese medicine. Recently, its functional activities, such as antimetabolic dysfunction, antineuroinflammatory activities, and stimulation of nerve growth factor (NGF) synthesis, have been revealed. This study demonstrated that Hericium erinaceus mycelium (HEM) and an isolated diterpenoid derivative, erinacine A (EA), may reverse spatial learning disabilities in aging mice (15 months old) fed with a high-fat and high-sucrose diet (HFSD). Aging mice were randomly assigned to one of four treatment groups: (1) a chow diet (control), (2) an HFSD, and an HFSD supplemented with either (3) HEM or (4) EA for 18 weeks. The Morris water maze (MWM) and Y-maze were used for behavioral assessments. Both HEM- and EA-treated mice had shorter mean daily escape latencies than HFSD-treated mice in the MWM. In addition, HEM-treated mice had a slightly increased exploratory time and frequency in the novel arm in the Y-maze. Quantitative PCR revealed that both HEM- and EA-treated mice exhibited reduced messenger RNA (mRNA) expression of tumor necrosis factor-α, interleukin-1β, and HEM-treated mice exhibited increased mRNA expression of NGF and NeuN in the hippocampus. Moreover, HEM and EA also decreased body weight, abdominal fat, plasma glucose, serum and liver total cholesterol, and liver triacylglycerol. Thus, HEM may be a potential health-promoting supplement for minimizing the progression of aging and obesity-induced neurodegeneration by reducing metabolic abnormalities and neuroinflammatory cytokines and increasing neurogenesis factors.