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Chih-Hao Chiu,Yun-Wen Tong,Jen-Fang Yu,Kin Fong Lei,Alvin Chao-Yu Chen 한국바이오칩학회 2020 BioChip Journal Vol.14 No.4
Periosteal cells are the major cell sources of skeletal progenitors for fracture callus. In order to promote bone repair and cartilage formation, besides the application of exogenous growth factors, physical stimulation is an alternative approach to guide cell differentiation. Investigation of appropriate conditions is essential for forming bone and cartilage. In this work, a membrane-type micro-system was developed to provide cell culture environment and cell stretching stimulation during culture course. Circular and oval culture wells were designed to respectively generate uniform and non-uniform 2-axial tensile strain for stretching primary rabbit periosteal cells. Cell orientation and differentiation were studied after cycling stretching for 2 days. The cells aligned to the stretching axis with high tensile strain in the oval culture wells; while the cells expressed random orientation in the circular culture wells. Different responses were significantly shown when the cells were respectively stimulated by uniform and non-uniform 2-axial tensile strains. On the other hand, osteogenic differentiation was shown when the cells were under either uniform or non-uniform 2-axial tensile strain. However, only non-uniform 2-axial tensile strain could induce mature osteoblasts. In addition, the result revealed chondrocytes could be differentiated only under a large and nearly single dimensional tensile strain. In summary, differentiation of the periosteal cells is highly influenced by 2-dimensional distribution of the tensile strain. This work provides some in-sights of the control of axial tensile strain for periosteal cell differentiation.
( Yu Hsin Lin ),( Chih Hung Tsai ),( Ching En Lee ),( Chung Ching Chiu ) 한국품질경영학회 2007 The Asian Journal on Quality Vol.8 No.2
Constructing an effective production control policy is the most important issue in wafer fabrication factories. Most of researches focus on the input regulations of wafer fabrication. Although many of these policies have been proven to be effective for wafer fabrication manufacturing, in practical, there is a need to help operators decide which lots should be pulled in the right time and to develop a systematic way to alleviate the long queues at the bottleneck workstation. The purpose of this study is to construct a photolithography workstation dispatching rule (PADR). This dispatching rule considers several characteristics of wafer fabrication and influential factors. Then utilize the weights and threshold values to design a hierarchical priority rule. A simulation model is also constructed to demonstrate the effect of the PADR dispatching rule. The PADR performs better in throughput, yield rate, and mean cycle time than FIFO (First-In-First-Out) and SPT (Shortest Process Time).
Lin, Yu-Hsin,Tsai, Chih-Hung,Lee, Ching-En,Chiu, Chung-Ching The Korean Society for Quality Management 2007 The Asian Journal on Quality Vol.8 No.2
Constructing an effective production control policy is the most important issue in wafer fabrication factories. Most of researches focus on the input regulations of wafer fabrication. Although many of these policies have been proven to be effective for wafer fabrication manufacturing, in practical, there is a need to help operators decide which lots should be pulled in the right time and to develop a systematic way to alleviate the long queues at the bottleneck workstation. The purpose of this study is to construct a photolithography workstation dispatching rule (PADR). This dispatching rule considers several characteristics of wafer fabrication and influential factors. Then utilize the weights and threshold values to design a hierarchical priority rule. A simulation model is also constructed to demonstrate the effect of the PADR dispatching rule. The PADR performs better in throughput, yield rate, and mean cycle time than FIFO (First-In-First-Out) and SPT (Shortest Process Time).
Ming-Chih Chiu,Tzu-Yu Chou,Mei-Hwa Kuo 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.1
Freshwater ecosystems are affected by a variety of anthropogenic stressors. Temporal variability of bioticcommunities in these ecosystems makes it difficult to accurately assess the impacts of specific stressors, whichhas seldom been considered in understudied regions of Asia. We studied the seasonal effects of anthropogenicstressors on stream macroinvertebrates based on sampling every three months over two years at five stream sitesin central Taiwan. Several macroinvertebrate metrics (taxon richness, Shannon diversity index, and relativeabundance of Trichoptera) were lower during the wet season than the dry season. The presence of dams causedchanges in the structure of macroinvertebrate communities, decreased the seasonal variability in relativeabundances of Trichoptera, as well as resulted in lower dissolved inorganic nitrogen concentrations and largersubstrate size. The presence of urban areas had less or no influence on environmental factors and structuralchanges. However, significantly lower total abundance, taxon richness, and relative abundance of Trichopteraoccurred in the presence of either dams and/or urban areas. One key management implication from the presentstudy is that bioassessment utilizing macroinvertebrates should be facilitated by awareness of the potential roleof temporal factors on the effects of anthropogenic stressors, especially in monsoonal Asia.
Kumar, Sudhir,Jagielski, Jakub,Kallikounis, Nikolaos,Kim, Young-Hoon,Wolf, Christoph,Jenny, Florian,Tian, Tian,Hofer, Corinne J.,Chiu, Yu-Cheng,Stark, Wendelin J.,Lee, Tae-Woo,Shih, Chih-Jen American Chemical Society 2017 NANO LETTERS Vol.17 No.9
<P>Pure green light-emitting diodes (LEDs) are essential for realizing an ultrawide color gamut in next-generation displays, as is defined by the recommendation (Rec.) 2020 standard. However, because the human eye is more sensitive to the green spectral region, it is not yet possible to achieve an ultrapure green electroluminescence (EL) with a sufficiently narrow bandwidth that covers >95% of the Rec. 2020 standard in the CIE 1931 color space. Here, we demonstrate efficient, ultrapure green EL based on the colloidal two-dimensional (2D) formamidinium lead bromide (FAPbBr(3)) hybrid perovskites. Through the dielectric quantum well (DQW) engineering, the quantum-confined 2D FAPbBr(3) perovskites exhibit a high exciton binding energy of 162 meV, resulting in a high photoluminescence quantum yield (PLQY) of similar to 92% in the spin-coated films. Our optimized LED devices show a maximum current efficiency (eta(CE)) of 13.02 cd A(-1) and the CIE 1931 color coordinates of (0.168, 0.773). The color gamut covers 97% and 99% of the Rec. 2020 standard in the CIE 1931 and the CIE 1976 color space, respectively, representing the 'greenest' LEDs ever reported. Moreover, the device shows only a similar to 10% roll-off in eta(CE) (11.3 cd A(-1)) at 1000 cd m(-2). We further demonstrate large-area (3 cm(2)) and ultraflexible (bending radius of 2 mm) LEDs based on 2D perovskites.</P>