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Fan, Gang,Zhang, Lin,Yi, Lu,Jiang, Zhi-Qiang,Ke, Yang,Wang, Xiao-Shan,Xiong, Ying-Ying,Han, Wei-Qin,Zhou, Xiao,Liu, Chun,Yu, Xie Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8
Purpose: To retrospective assess the potential predictors for relapse and create an effective clinical mode for surveillance after orchidectomy in clinical stage I non-seminomatous germ cell testicular tumors (CSI-NSGCTs). Materials and Methods: We analyzed data for CSI-NSGCTs patients with non-lymphatic vascular invasion, %ECa < 50% (percentage of embryonal carcinoma < 50%), and negative or declining tumor markers to their half-life following orchidectomy (defined as low-risk patients); these patients were recruited from four Chinese centers between January 1999 and October 2013. Patients were divided into active surveillance group and retroperitoneal lymph node dissection (RPLND) group according to different therapeutic methods after radical orchidectomy was performed. The disease-free survival rates (DFSR) and overall survival rates (OSR) of the two groups were compared by Kaplan-Meier analysis. Results: A total of 121 patients with CSI-NSGCT were collected from four centers, and 81 low-risk patients, including 54 with active surveillance and 27 with RPLND, were enrolled at last. The median follow-up duration was 66.2 (range 6-164) months in the RPLND group and 65.9 (range 8-179) months in the surveillance group. OSR was 100% in active surveillance and RPLND groups, and DFSR was 89.8% and 87.0%, respectively. No significant difference was observed between these two groups ($X_2=0.108$, P=0.743). No significant difference was observed between the patients with a low percentage of embryonal carcinoma (<50%) and those without embryonal carcinoma (87.0% and 91.9%, $X_2=0.154$, P=0.645). No treatment-related complications were observed in the active surveillance group whereas minor and major complications were observed in 13.0% and 26.1% of the RPLND group, respectively. Conclusions: Active surveillance resulted in similar DFSR and OSR compared with RPLND in our trial. Patients with low-risk CSI-NSGCTs could benefit from risk-adapted surveillance after these patients were subjected to radical orchidectomy.
SEDs and Beaming Effect for Fermi Blazars
Jun-Hui Fan,Jiang-He Yang,Yi Liu,Yu-Hai Yuan,Cao Lin,Hu-Bing Xiao 한국우주과학회 2016 Journal of Astronomy and Space Sciences Vol.33 No.2
In this work, based on our previous calculations of spectral energy distributions for a sample of Fermi blazars (Fan et al. 2015a), we calculated the radio loudness and performed correlation analyses. Our analysis results show that radio loudness is closely anti-correlated with synchrotron peak frequency and positively correlated with gamma-ray luminosity, suggesting that the gamma-ray emissions are strongly beamed.
The mechanical properties of rock salt under cyclic loading-unloading experiments
Chen, Jie,Du, Chao,Jiang, Deyi,Fan, Jinyang,He, Yi Techno-Press 2016 Geomechanics & engineering Vol.10 No.3
Rock salt is a near-perfect material for gas storage repositories due to its excellent ductility and low permeability. Gas storage in rock salt layers during gas injection and gas production causes the stress redistribution surrounding the cavity. The triaxial cyclic loading and unloading tests for rock salt were performed in this paper. The elastic-plastic deformation behaviour of rock salt under cyclic loading was observed. Rock salt experienced strain hardening during the initial loading, and the irreversible deformation was large under low stress station, meanwhile the residual stress became larger along with the increase of deviatoric stress. Confining pressure had a significant effect on the unloading modulus for the variation of mechanical parameters. Based on the theory of elastic-plastic damage mechanics, the evolution of damage during cyclic loading and unloading under various confining pressure was described.
Up-regulation of Thy-1 Promotes Invasion and Metastasis of Hepatocarcinomas
Cheng, Bian-Qiao,Jiang, Yi,Li, Dong-Liang,Fan, Jing-Jing,Ma, Ming Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
Increasing evidence has revealed that thy-1 was a potential stem cell marker of liver cancer, but no data have been shown on how thy-1 regulates the pathophysiology of liver cancer, such as proliferation, apoptosis, invasion and migration. We previously demonstrated that thy-1 was expressed in about 1% of hepg2 cells, thy-1+hepg2 cells, but not thy-1-, demonstrating high tumorigenesis on inoculation $0.5{\times}10^5$ cells per BACA/LA mouse after 2 months. In the present study, our results showed that higher expression of thy-1 occurs in 72% (36/50 cases) of neoplastic hepatic tissues as compared to 40% (20/50 cases) of control tissues, and the expression of thy-1 is higher in poorly differentiated liver tumors than in the well-differentiated ones. In addition, thy-1 expression was detected in 85% of blood samples from liver cancer patients, but none in normal subjects or patients with cirrhosis or hepatitis. There was a significant negative correlation between thy-1expression and E-cadherin expression (a marker of invasion and migraton), but not between thy-1 expression and AFP expression in all the liver cancer and blood samples. We further investigated the relationship between thy-1 and E-cadherin in liver cancer hepg2 cell line which was transfected with pReceiver-M29/thy-1 eukaryotic expression vector followed by aspirin treatment. Lower expression of E-cadherin but higher expressions of thy-1 were detected in hepg2 cells transfected with pReceiver-M29/thy-1. Taken together, our study suggested that thy-1 probably regulates liver cancer invasion and migration.
Step-up and Step-down Asymmetrical 24-Pulse Autotransformer Rectifier
Lu Zhang,Hong-juan Ge,Fan Jiang,Guang Yang,Yi Lin 전력전자학회 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.5
The existing 24-pulse autotransformer rectifier unit (ATRU) needs interphase reactors for parallel work of the rectifier bridges, and its output voltage cannot be regulated. Aiming at these problems, a step-up and step-down asymmetrical 24-pulse ATRU is proposed in this paper. The connections and turns ratios among transformer windings are well designed. In addition, a 15-degree phase difference is formed between two of the 24 voltage vectors produced by the transformer, which makes the four rectifier bridge groups produce a 24-pulse DC voltage without interphase reactors. Meanwhile, by adding extended winding to each phase of the transformer, wide-range regulation of the ATRU output voltage can be realized, and the reasonable voltage regulation range is between 0.2 and 1.6. The superposition of the voltage vectors and the principle of the voltage regulation are analyzed in detail. Furthermore, the turns ratio of the windings, winding current, output voltage, and kilovolt-ampere rating are all derived. Finally, the simulations and experiments are carried out, and the correctness of the principle and theoretical analysis of the new 24-pulse ATRU are verified.
Wang, Feige,Wu, Xue-Bing,Fan, Xiaohui,Yang, Jinyi,Cai, Zheng,Yi, Weimin,Zuo, Wenwen,Wang, Ran,McGreer, Ian D.,Ho, Luis C.,Kim, Minjin,Yang, Qian,Bian, Fuyan,Jiang, Linhua IOP Publishing 2015 ASTROPHYSICAL JOURNAL LETTERS - Vol.807 No.1
<P>We report the discovery of an ultra-luminous quasar J030642.51+185315.8 (hereafter J0306+1853) at redshift 5.363, which hosts a supermassive black hole with M-BH = (1.07 +/- 0.27) x 10(10) M-circle dot. With an absolute magnitude M-1450 = -28.92 and a bolometric luminosity L-bol similar to 3.4 x 10(14) L-circle dot, J0306+1853 is one of the most luminous objects in the early universe. It is not likely to be a beamed source based on its small flux variability, low radio loudness, and normal broad emission lines. In addition, a z = 4.986 damped Ly alpha system (DLA) with [M/H] = -1.3 +/- 0.1, among the most metal-rich DLAs at z greater than or similar to 5, is detected in the absorption spectrum of this quasar. This ultra-luminous quasar puts strong constraints on the bright end of the quasar luminosity function and massive end of the black hole mass function. It will provide a unique laboratory for the study of BH growth and the co-evolution between a BH and the host galaxy with multi-wavelength follow-up observations. The future high-resolution spectra will give more insight into the DLA and other absorption systems along the line of sight of J0306+1853.</P>
Step-up and Step-down Asymmetrical 24-Pulse Autotransformer Rectifier
Zhang, Lu,Ge, Hong-juan,Jiang, Fan,Yang, Guang,Lin, Yi The Korean Institute of Power Electronics 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.5
The existing 24-pulse autotransformer rectifier unit (ATRU) needs interphase reactors for parallel work of the rectifier bridges, and its output voltage cannot be regulated. Aiming at these problems, a step-up and step-down asymmetrical 24-pulse ATRU is proposed in this paper. The connections and turns ratios among transformer windings are well designed. In addition, a 15-degree phase difference is formed between two of the 24 voltage vectors produced by the transformer, which makes the four rectifier bridge groups produce a 24-pulse DC voltage without interphase reactors. Meanwhile, by adding extended winding to each phase of the transformer, wide-range regulation of the ATRU output voltage can be realized, and the reasonable voltage regulation range is between 0.2 and 1.6. The superposition of the voltage vectors and the principle of the voltage regulation are analyzed in detail. Furthermore, the turns ratio of the windings, winding current, output voltage, and kilovolt-ampere rating are all derived. Finally, the simulations and experiments are carried out, and the correctness of the principle and theoretical analysis of the new 24-pulse ATRU are verified.
Lin Shuang-Zhe,Wu Wei-Jie,Cheng Yu-Qing,Zhang Jian-Bin,Jiang Dai-Xi,Ren Tian-Yi,Ding Wen-Jin,Liu Mingxi,Chen Yuan-Wen,Fan Jian-Gao 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Macrophages are immune cells crucial for host defense and homeostasis maintenance, and their dysregulation is involved in multiple pathological conditions, such as liver fibrosis. The transcriptional regulation in macrophage is indispensable for fine-tuning of macrophage functions, but the details have not been fully elucidated. Prolyl endopeptidase (PREP) is a dipeptidyl peptidase with both proteolytic and non-proteolytic functions. In this study, we found that Prep knockout significantly contributed to transcriptomic alterations in quiescent and M1/M2-polarized bone marrow-derived macrophages (BMDMs), as well as aggravated fibrosis in an experimental nonalcoholic steatohepatitis (NASH) model. Mechanistically, PREP predominantly localized to the macrophage nuclei and functioned as a transcriptional coregulator. Using CUT&Tag and co-immunoprecipitation, we found that PREP was mainly distributed in active cis-regulatory genomic regions and physically interacted with the transcription factor PU.1. Among PREP-regulated downstream genes, genes encoding profibrotic cathepsin B and D were overexpressed in BMDMs and fibrotic liver tissue. Our results indicate that PREP in macrophages functions as a transcriptional coregulator that finely tunes macrophage functions, and plays a protective role against liver fibrosis pathogenesis.