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Chung, Yi-Chan,Hsu, Yao-Wen,Chiu, Chung-Ching,Chen, Ching-Piao,Tsai, Chih-Hung The Korean Society for Quality Management 2008 The Asian Journal on Quality Vol.9 No.3
This study explores the influence of Taiwan's high-tech manufacturers' innovative strategy and innovation motivation concerning the implementation of innovative activities, as well as the influence of innovative activities implementation on business performance. The two intermediate variables, industry group and enterprise scale are also considered. Through a review of the relevant literature, a theoretical model of the influence relationship is developed, while an empirical analysis is simultaneously conducted on Taiwan's high-tech manufacturers. The research result shows that the internal driving force of innovative activities has a significant impact on the level of implementing technological innovative activities and cultural innovative activities. The external driving force of innovative activities has a significant impact on the level of implementing market innovative activities and management innovative activities. Companies adopting self-developed technology and purchased as well as self-developed technology strategies, perform better than those adopting purchased new technology or those with neither purchased nor self-developed technology strategies, at implementing technological innovative activities and cultural innovative activities. The level of implementing innovative activities has a significant influence on business performance (cost reduction and product/service differentiation). For the intermediate variables of "industry group" and "enterprise scale", it is proven in this study that they have no significant influence on the level of innovative activity implementation or business performance.
Hsu, Yao-Wen,Chung, Yi-Chan,Chen, Ching-Piao,Tsai, Chih-Hung The Korean Society for Quality Management 2008 The Asian Journal on Quality Vol.9 No.2
Each amusement park has a wayfinding system, while symbols are important mediums to guide tourists to find their destinations. It is very important that whether the meanings of symbols recognized by tourists immediately. This paper mainly discusses the recognition of graphic symbols in amusement park, and proposes the improvement suggestions. Materials for this study were drawn from 20 different graphic symbols of a theme amusement park in Taiwan. The testees were required to evaluate the design of graphic symbols based on symbolic meaning and graphics recognition to summarize the confusion matrix. The results show that there are three groups of graphic symbols easy to be confused, and five symbols not meeting a criterion of 67% correct responses. The reasons were discussed, and improvement and relevant suggestions have been proposed, which may be helpful to redesign of symbols.
A Study of the Ergonomics Evaluation of a Water Heater's Case Manufacturing Factory
Hsu, Yao-Wen,Chung, Yi-Chan,Chiu, Chung-Ching,Chen, Ching-Piao,Tsai, Chih-Hung The Korean Society for Quality Management 2008 The Asian Journal on Quality Vol.9 No.1
Unnatural working postures usually cause musculoskeletal problems for workers in work field, especially in traditional industry. Many analysis and survey methodologies have been developed to identify unnatural postures and disorder risks in workplaces. The Ovako Working Posture Analyzing System (OWAS) and Nordic Musculoskeletal Questionnaire (NMQ) are the representative methods and applied widely. This study applied the both tools to investigate the work field of a manufacturing factory of the water heater's case. We divided the manufacturing process into nine workshops, took the pictures of working motions by DV camera and analyzed the postures on OWAS. From the OW AS results, we could identify the risks level of musculoskeletal symptoms as four Action Categories (AC). And from the comparison of OWAS and NMQ results, we could provide the suggestions to improve the working methods and environment. From the results of OWAS, we found that the operators' head/neck and back were above AC3 in some workshops. If the situation continued in long period, the operators might have the risk to get musculoskeletal symptoms. From the investigation of NMQ, we also found that the percentage of aches on neck, shoulders and lower back were higher than other parts of body. The correlation between aches and jobs was more than 75%. So we provided some suggestions to improve: work rotation and adjustment of work surface/height to fit in with Ergonomics. Then the risks of musculoskeletal symptoms would be reduced.
Yi Chan Chung,Yao Wen Hsu,Chung Ching Chiu,Ching Piao Chen,Chih Hung Tsai 한국품질경영학회 2008 The Asian Journal on Quality Vol.9 No.3
This study explores the influence of Taiwan`s high-tech manufacturers` innovative strategy and innovation motivation concerning the implementation of innovative activities, as well as the influence of innovative activities implementation on business performance. The two intermediate variables, industry group and enterprise scale are also considered. Through a review of the relevant literature, a theoretical model of the influence relationship is developed, while an empirical analysis is simultaneously conducted on Taiwan`s high-tech manufacturers. The research result shows that the internal driving force of innovative activities has a significant impact on the level of implementing technological innovative activities and cultural innovative activities. The external driving force of innovative activities has a significant impact on the level of implementing market innovative activities and management innovative activities. Companies adopting self-developed technology and purchased as well as self-developed technology strategies, perform better than those adopting purchased new technology or those with neither purchased nor self-developed technology strategies, at implementing technological innovative activities and cultural innovative activities. The level of implementing innovative activities has a significant influence on business performance (cost reduction and product/service differentiation). For the intermediate variables of "industry group" and "enterprise scale", it is proven in this study that they have no significant influence on the level of innovative activity implementation or business performance.
Exendin-4 improves resistance to Listeria monocytogenes infection in diabetic db/db mice
Hsien Yueh Liu,Chih-Yao Chung,Wen-Chin Yang,Chih-Lung Liang,Chi-Young Wang,Chih-Yu Chang,Cicero Lee-Tian Chang 대한수의학회 2012 Journal of Veterinary Science Vol.13 No.3
The incidence of diabetes mellitus is increasing among companion animals. This disease has similar characteristics in both humans and animals. Diabetes is frequently identified as an independent risk factor for infections associated with increased mortality. In the present study, homozygous diabetic (db/db) mice were infected with Listeria (L.) monocytogenes and then treated with the anti-diabetic drug exendin-4, a glucagon-like peptide 1 analogue. In aged db/db mice, decreased CD11b+ macrophage populations with higher lipid content and lower phagocytic activity were observed. Exendin-4 lowered high lipid levels and enhanced phagocytosis in macrophages from db/db mice infected with L. monocytogenes. Exendin-4 also ameliorated obesity and hyperglycemia, and improved ex vivo bacteria clearance by macrophages in the animals. Liver histology examined during L. monocytogenes infection indicated that abscess formation was much milder in exendin-4-treated db/db mice than in the control animals. Moreover, mechanistic studies demonstrated that expression of ATP binding cassette transporter 1, a sterol transporter, was higher in macrophages isolated from the exendin-4-treated db/db mice. Overall, our results suggest that exendin-4 decreases the risk of infection in diabetic animals by modifying the interaction between intracellular lipids and phagocytic macrophages.
( Shih-wen Hsu ),( Chien-yio Lin ),( Chuang-wei Wang ),( Wen-hung Chung ),( Chih-hsun Yang ),( Yao-yu Chang ) 대한피부과학회 2018 Annals of Dermatology Vol.30 No.5
We studied a family with Gorlin-Goltz syndrome. The novel mutations of our cases were located on the 21st exon of the PTCH1 gene (c.3450C>G). The father, who received a strategic 56-day vismodegib treatment for disease control, was the first patient with Gorlin syndrome treated with the hedgehog inhibitor in Taiwan. The lesions regressed gradually, with scar formation, and were subsequently removed via a wide excision. Further details are provided below. (Ann Dermatol 30(5) 597∼601, 2018)