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Increased expression of connexin43 on the aortic valve in the hypercholesterolemic rabbit model.
Wang, Young Pil,Choe, Misun,Choi, Si Young,Jin, Ung,Kim, Chi Kyung,Seo, Eun Joo,Cho, Il Jin,Park, Chan Beom Taylor Francis 2009 Journal of investigative surgery Vol.22 No.2
<P>BACKGROUND: Aortic valve sclerosis is associated with increased risk of cardiovascular death and myocardial infarction. However, the relevance of connexin43 in aortic valve sclerosis remains unclear. We hypothesized that the mechanism regulating aortic valve sclerosis is associated with the alteration of cell-to-cell communication. METHODS: Twenty male New Zealand rabbits were divided into two groups. Group 1 (n = 10) were fed a normal chow diet, while those in group 2 (n = 10) received a diet containing 1% cholesterol for 12 weeks. After utanizing the animals, the aortic valves were excised for analysis. RESULTS: Myofibroblasts and macrophages were more highly expressed in the cholesterol diet group. Osteopontin and connexin43 were found to concentrate within the endothelial layer on the aortic side of the valve leaflets in the cholesterol diet group. A real-time polymerase chain reaction revealed increased connexin43 and osteopontin mRNA levels in the hypercholesterolemic aortic valves. CONCLUSIONS: The present study demonstrates that hypercholesterolemia increases the expression of connexin43 in the rabbit aortic valve. The results suggest that alterations in gap junctional intercellular communication via connexin43 gap junctions may play a role in the development of aortic valve sclerosis.</P>
왕규창,고영초,김현집,심보성,지제근 대한신경외과학회 1981 Journal of Korean neurosurgical society Vol.10 No.1
Suprasellar germinomas have been defined as a distinct group from the clinical as well as therapeutic points of view. Germinomas of such location constitute less than a third of the total intracranial tumors of similar nature. The tumor has a tendency of direct infiltrative growth and distant drop metastasis through the cerebrospinal fluid pathway. Occasionally it metastasizes outside central nervous system. We experienced a case of suprasellar germinoma with intrasellar extension and brain stem involvement in a 25 year old man, which could be diagnosed with CT scan before autopsy.
Valve Replacement with St. Jude Medical Valve
Wang, young-Pil,Jo, Keon-Hyon,Kwack, Moon-Sub,Lee, Sun-Hee,Cho, Kyu-Do,Kim, Chi-Kyung,Kim, Se-Wha 가톨릭 의과학연구원 1997 가톨릭 의과학연구원 국제학술대회 Vol.1 No.-
Consequently, overall mortality was 10.3%(37/357) during follow-up period. Actuarial survival rates after 6 yrs were 94.6% for MVR. 96.8% for AVR. 95.8% for DVR and 100% for TVR. In conclusion, the st. Jude Medical prosthesis can be considered to be an effective valve with a low rate of valve-related complication when there is correct anticoagulant therapy. Our group continues to use the St. Jude Medical Valve in all patients requiring Valve replacement except in those who can not take warfarin anticoagulation.
왕규창,정영섭,한대희,지제근 대한신경외과학회 1983 Journal of Korean neurosurgical society Vol.12 No.2
Optic sheath meningioma arises from the arachnoid "cap" cell of optic nerve sheath and comprises most of primary orbital meningioma. It usually brings early visual loss, papilledema, and proptosis. The authors experienced a case of intraorbital optic sheath meningioma associated with a small skull hemangioma in the right parietal area, who presented only mild visual disturbance. The meningioma was removed transcranially without visual or cosmetic deformities except transient ptosis.
지지격자가 있는 봉다발과 축방향으로 평행한 유동의 압력손실에 관한 실험적 연구
이치영(Chi Young Lee),신창환(Chang Hwan Shin),박주용(Ju Yong Park),인왕기(Wang Kee In) 대한기계학회 2012 大韓機械學會論文集B Vol.36 No.7
지지격자가 있는 봉다발과 축방향으로 평행한 유동에서, 봉다발 마찰계수와 지지격자 손실계수를 평가하였다. 시험부는 외경 9.5 mm, 길이 2000 mm 인 봉 25 개를 5×5 정사각 구조로 배열하여 제작하였으며, 봉 중심간 거리와 봉 외경의 비는 1.35 였다. 지지격자로는 plain 지지격자, split-vane 지지격자, hybrid-vane 지지격자를 이용하였다. 지지격자가 없는 봉다발의 마찰계수는 기존 상관식과 비교적 잘 일치하였다. 지지격자가 있는 봉다발 실험의 경우, hybrid-vane 지지격자에서 봉다발 마찰계수 및 지지격자손실계수가 가장 크게 측정되었으며, 이는 지지격자의 유동단면 막음비 증가와 혼합날개 형상에 의한 유동 교란이 증가되기 때문인 것으로 판단된다. Re=5×105 조건에서 plain 지지격자, split-vane 지지격자, hybrid-vane 지지격자의 손실계수는 약 0.79, 0.80, 0.88 로 예측되었다. The friction factor in a rod bundle and the loss coefficient at a spacer grid were examined. As a test section, 25 smooth rods, 9.5 mm in diameter and 2000 mm in length, were prepared and installed in a 5 × 5 square array in a square channel. In this case, the P/D (Pitch-to-Diameter ratio) was 1.35. In this work, plain (i.e., no mixing vanes), split-vane, and hybrid-vane spacer grids were tested. In a bare rod bundle (i.e., no spacer grid), the measured friction factors were in good agreement with the previous correlations. Among the spacer grids tested, the hybrid-vane spacer grid presented the largest friction factor in the rod bundle and loss coefficient. This may be because of the flow pattern change induced by large relative plugging of the flow cross section and mixing vane geometry. At Re = 5 × 105, the predicted loss coefficients of plain, splitvane, and hybrid-vane spacer grids were approximately 0.79, 0.80, and 0.88, respectively.
경수로핵연료 열수력 연구개발 분석 및 연산학 협력 성과
인왕기(Wang Kee In),신창환(Chang Hwan Shin),이치영(Chi Young Lee),이찬(Chan Lee),전태현(Tae Hyun Chun),오동석(Dong Seok Oh) 대한기계학회 2016 大韓機械學會論文集B Vol.40 No.12
가압경수로에 장전되는 핵연료집합체는 연료 봉 다발과 지지격자 및 상하단 고정체로 구성되어 있다. 고온 고압의 냉각수는 원자로 하부로 유입되어 연료 봉 사이로 형성된 부수로를 따라 노심 상부로 흐른다. 경수로핵연료의 주요 열수력 성능인자는 정상운전시 압력강하 및 임계열속이며 사고시에는 급랭 시간이다. 한국원자력연구원에서는 경수로핵연료의 성능을 향상시키고 국산화를 위해 고성능 경수로핵연료, 이중냉각 핵연료 및 사고저항성 핵연료를 개발하였다. 경수로핵연료의 열수력 핵심기술을 개발하기 위해 압력강하실험, 난류 유동혼합/열전달 실험, 임계열속 및 급랭 시험을 수행하였으며 전산유체역학 방법도 활용하였다. 더불어 사용후핵연료의 임시저장을 위한 건식저장 용기의 열유동에 대한 전산유체해석을 수행하였다. 한편, 경수로핵연료의 열수력 기반기술을 개발하고 실용화를 위해 대학 및 산업체와 협력연구도 진행하였다. The fuel assembly for pressurized water reactor (PWR) consists of fuel rod bundle, spacer grid and bottom/top end fittings. The cooling water in high pressure and temperature is introduced in lower plenum of reactor core and directed to upper plenum through the subchannel which is formed between the fuel rods. The main thermalhydraulic performance parameters for the PWR fuel are pressure drop and critical heat flux in normal operating condition, and quenching time in accident condition. The Korea Atomic Energy Research Institute (KAERI) has been developing an advanced PWR fuel, dual-cooled annular fuel and accident tolerant fuel for the enhancement of fuel performance and the localization. For the key thermal-hydraulic technology development of PWR fuel, the KAERI LWR fuel team has conducted the experiments for pressure drop, turbulent flow mixing and heat transfer, critical heat flux(CHF) and quenching. The computational fluid dynamics (CFD) analysis was also performed to predict flow and heat transfer in fuel assembly including the spent fuel assembly in dry cask for interim repository. In addition, the research cooperation with university and nuclear fuel company was also carried out to develop a basic thermalhydraulic technology and the commercialization.