Mapping Signals That Are Important for Nuclear and Nucleolar Localization in MCRS2

Chung-Wen Kuo,Shih-Tung Liu,Wen-Hung Wang 한국분자세포생물학회 2011 Molecules and cells Vol.31 No.6

MCRS2 is an oncoprotein that is sequestered in the nu-cleolus. When in the nucleolus, it promotes the transcrip-tion of the rRNA gene. MCRS2 also brings proteins into the nucleolus to change their function. This study analyzes the sequence of MCRS2 and determines that the nuclear localization signal, which has the sequence KRKK, is situ-ated between amino acids 66 and 69. Meanwhile, MCRS2 contains a bipartite nucleolar localization signal, which comprises a KKSK motif, located between amino acids 133 and 136, and a downstream 152-amino acid region, from amino acid 314 to 465. The results of this study are impor-tant to understand the function of MCRS2.

Research on Using Six Sigma Tool to Reduce the Core Process Time

Chung, Yi-Chan,Yen, Tieh-Min,Hsu, Yau-Wen,Tsai, Chih-Hung,Chen, Ching-Piao The Korean Society for Quality Management 2008 The Asian Journal on Quality Vol.9 No.1

When facing the global severe competition, the enterprises all try their best to upgrade the quality, reduce the costs to reach the goal of customer satisfaction. Motorola was the earliest firm creating the term Six Sigma (6 ${\sigma}$); GE was the enterprise successfully fulfilling Six Sigma. The success of these two firms revealed the prominent effects and became the world-class model enterprises. The main purpose of promoting Six Sigma activity was to reduce the possible defects in the business process to the least through designing and monitoring business process in order to reach the goals such as the best quality and efficiency, the lowest costs, the shortest circular process time, maximum profits and customer satisfaction. This research used the Six Sigma technique to improve the business process of ceramics manufacturing plant and find out the major factors of slower core task time by the analytical process of Process Mapping, Pareto Chart, Simu18 simulation software and figures and proposed the improvement measures. Through the confirmation of the case companies, it successfully reduced the core process time and the organizational costs and increased the capacity.

Research on Current Execution of Customer Support Knowledge Management System of Medical Appliances Industry

Chung, Yi-Chan,Tsai, Chih-Hung,Tien, Shiaw-Wen,Lin, Lin-Yi The Korean Society for Quality Management 2007 The Asian Journal on Quality Vol.8 No.3

Customer Support Knowledge of Customer Support Organization is one of the important assets of enterprises and "Customer Support Knowledge Management" is also the critical aspect of Business Knowledge Management; however, the attributes of Customer Support Knowledge are complicated, diverse, renewed rapidly and difficult to be managed. Thus, in order to design a successful Customer Support Knowledge Management System, apart from the consideration of "human" and "information technology" aspects, the concerns of attributes and Customer Support Knowledge and industry characteristics should be involved for meeting the requirements of Customer Support Organization and allowing the organization to acquire the competitive advantage of "Differentiation Service". This research used the "Customer Support Knowledge Management System" in a high-tech industry as an example and treated the end users of medical instruments in different types of hospitals in Taiwan which have received the support service of our company in recent six months as the population. The end users were mostly the nursing executives or ultrasonic wave technical personnel in intensive care unit and they had similar educational background and incomes and adopted the medical instruments such as physical supervision system, ultrasonic wave system, heart start or ECG machine produced by our company; the research method was to randomly treat the investigation results of the telephone customers' satisfaction from respective 30 end users in the population three months before and after this system execution as the samples and use hypotheses to validate if the end users' customer satisfaction significantly improved in terms of "Remote Support," "On-site Support," "Service Turn Around time," "Technical Competence" and "Manner" in order to understand the influence and managerial significance of execution of "Customer Support Knowledge Management System" on Customer Support Organization.

The Compensation of Machine Vision Image Distortion

Chung, Yi-Chan,Hsu, Yau-Wen,Lin, Yu-Tang,Tsai, Chih-Hung The Korean Society for Quality Management 2004 The Asian Journal on Quality Vol.5 No.1

The measured values of a same object should remain constant regardless of the object's position in the image. In other words, its measured values should not vary as its position in the image changes. However, lens' image distortion, heterogeneous light source, varied angle between the measuring apparatus and the object, and different surroundings where the testing is set up will all cause variation in the measurement of the object when the object's position in the image changes. This research attempts to compensate the machine vision image distortion caused by the object's position in the image by developing the compensation table. The compensation is accomplished by facilitating users to obtain the correcting object and serves the objective of improving the precision of measurement.

Research on the Operational Performance of ISO 14000-Certified Taiwan's Manufacturers

Chung, Yi-Chan,Tsai, Chih-Hung,Hsu, Yau-Wen The Korean Society for Quality Management 2005 The Asian Journal on Quality Vol.6 No.1

This research topic evaluates the effectiveness and importance of environmental protection in the 21st century in light of the increasing demand on the earth's natural resources and the pressures on economic and industrial development to provide dynamic power. As the world and our fellow citizens become more conscious of environmental protection, companies are under greater pressure whilst pursuing economic growth. Therefore, domestic manufacturers have been devoting efforts to promote environmental management. This research conducts survey using questionnaires on the operational performance of the manufacturers who have ISO 14000 series accreditation and certification. The survey considers five dimensions/functions within a manufacturer, financial management, human resources management, production management, and marketing management. A total of 35 indices are used for analysis of the effects that the location, history, industry, number of employees, amount of capital, and revenue may have on the performance. This research targets the manufacturers approved of ISO 14000 series certification by Environment Administration Association. The statistical methods deployed are descriptive statistics, T-test, and single factor analysis of variance used for analysis. The conclusions reveal that a certain level of performance has been achieved in every dimension. After T-test, all the indices have reached a significant level. The indications are that ISO 14001 benefits all manufacturers the level of benefits however varies from company to company.

Seasonal yeast compositions in Forcipomyia taiwana (Diptera: Ceratopogonidae)

Hung-Wei Chen,Jui-Yu Chou,Chung-Chi Lin,Yu-Der Wen,Wei-Lung Wang 한국응용곤충학회 2016 Journal of Asia-Pacific Entomology Vol.19 No.2

Forcipomyia taiwana, a biting midge, is one of the most annoying blood-sucking pests in Taiwan. The larvae of Forcipomyia species feed primarily on algae, and the adults feed on nectar for nutrition. After mating with male adults, females bite humans and digest blood for the formation and development of their eggs. The bites often cause human itching, swelling, skin lesion and even fatal shock. Harassment from this biting pest has become a serious problem and has influenced the quality of outdoor recreational activities. Thus, it is necessary to understand the ecology of F. taiwana to develop an effective control strategy. This study showed the seasonal variation of yeast compositions in the interior of F. taiwana. Furthermore, we found that Aureobasidium spp. appeared the most during collection times and these yeasts are able to decompose the cellulose, a major component in the cell wall of algae and Oomycete fungi. These fungi infect a broad range of host and have adverse effect on fitness of the biting midges. Thus, Aureobasidium spp. play a crucial role in the defense system of F. taiwana against pathogens. The study provides useful information that could be used in the development of biocontrol strategy in the future.

Research on Correlation between Innovative Activities & Development Strategies of New Product and Development Performance in Taiwan's High-tech Companies

Chung, Yi-Chan,Tsai, Chih-Hung,Deng, Wei-Jaw,Chen, Wen-Chin The Korean Society for Quality Management 2006 The Asian Journal on Quality Vol.7 No.2

Due to the advancement of technology and rapidly changing environment of the market, the life cycle of high-tech products is becoming shorter. The enterprise must constantly innovate and select correct development strategy of new product in order to respond to customers' demands for upgrading operational performance of industry. Development of new product is the critical activity for enterprise's survival and growth. This research focuses on the effects of Taiwan high-tech companies' introduction of innovative activity and development strategy of new product on development performance of new product for analysis and exploration. The result findings reveal that: (1) High execution degree of innovative activity has positive effect on the implementation of development strategy of new product; (2) The companies with better implementation of development strategy of new product reveal better development performance; (3) The companies with higher degree of execution of innovative activity and better execution of development strategy of new product reveal better development performance of new product.

Research on the Relationship Between the OHSAS 18000 System Implementation and Competitiveness in Taiwan's Industries

Chung, Yi-Chan,Chiu, Chung-Ching,Tsai, Chih-Hung,Hsu, Yau-Wen The Korean Society for Quality Management 2006 The Asian Journal on Quality Vol.7 No.3

In recent years, the labor consciousness is gradually valued. During the process of pursuing sustainable operation, the enterprises treat occupational hazard risk as the waste of cost. The purpose of OHSAS 18000 occupational security and health management system is to systematically establish the business managerial measures in terms of occupational security and calamity prevention. This research proceeded with questionnaire analysis with respect to the relationship between the OHSAS 18000 system implementation and competitiveness in Taiwan's industries. The research result revealed that there was significant relationship between Taiwan firms' execution of OHSAS 18000 system and industry competitiveness. Thus, the enterprises can decide the proper managerial plans according to the result of their own risk evaluation to prevent the happening of accidents and reduce the operational cost. They can thus completely control business occupational hazard risk through "systematic" management.

A System Dynamics Study of Enterprise Value $Creation{\sim}$ the Example of Taiwan's SMEs

Chung, Yi-Chan,Tsai, Chih-Hung,Tien, Shiaw-Wen,Lin, Yu-Hsin,Lin, Ja-Lin The Korean Society for Quality Management 2006 The Asian Journal on Quality Vol.7 No.1

With the globalization of economy, industries are facing increasingly greater challenges. Business integration, both internally and externally, is undoubtedly an important topic. However, how does an enterprise create its own value will be the key to an enterprise's success in the future. Therefore, this study bases on the evaluation of company value to assess the key factors and competitive strategies of an enterprise. Yet, only with stable enterprise performance can the company value be correctly evaluated. This will be an important issue for enterprise performance and business strategy. Subject of this study are mainly small and medium-sized (enterprises (SMEs). Model construction for SME value assessment is established through the system dynamics approach. Scholars' opinions on literature validation and application of Delphi Method are explored through literature review on local and foreign studies, in order to compile the relevant perspectives and indices for enterprise value creation. Hence model construction of the value creation system is established, and the correlation between the perspectives and related factors is explored to understand the overall dynamics model of SMEs' value creation system. Consequently, a research method based on the system dynamics perspective is provided for the study of enterprise value creation is provided, as policy reference for improvement of decision-making and value creation.

MR Imaging of Pregnancy Luteoma: a Case Report and Correlation with the Clinical Features

Hung-Wen Kao,Ching-Jiunn Wu,Kuo-Teng Chung,Sheng-Ru Wang,Cheng-Yu Chen 대한영상의학회 2005 Korean Journal of Radiology Vol.6 No.1

We report here on a 26-year-old pregnant female who developed hirsutism and virilization during her third trimester along with a significantly elevated serum testosterone level. Abdominal US and MR imaging studies were performed, and they showed unique imaging features that may suggest the diagnosis of pregnancy luteoma in the clinical context. After the delivery, the serum testosterone level continued to decrease, and it returned to normal three weeks postpartum. The follow-up imaging findings were closely correlated with the clinical presentation.