Methylome-wide Association Study of Patients with Recent-onset Psychosis

Yan-Hong Piao,Yin Cui,Fatima Zahra Rami,Ling Li,Maryam Karamikheirabad,Shi Hyun Kang,Sung-Wan Kim,Jung-Jin Kim,Bong Ju Lee,Young-Chul Chung 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.3

Objective: Dysregulation of gene expression through epigenetic mechanisms may have a vital role in the pathogenesis of schizophrenia (SZ). In this study, we investigated the association of altered methylation patterns with SZ symptoms and early trauma in patients and healthy controls. Methods: The present study was conducted to identify methylation changes in CpG sites in peripheral blood associated with recent-onset (RO) psychosis using methylome-wide analysis. Lifestyle factors, such as smoking, alcohol, exercise, and diet, were controlled. Results: We identified 2,912 differentially methylated CpG sites in patients with RO psychosis compared to controls. Most of the genes associated with the top 20 differentially methylated sites had not been reported in previous methylation studies and were involved in apoptosis, autophagy, axonal growth, neuroinflammation, protein folding, etc. The top 15 significantly enriched Kyoto Encyclopedia of Genes and Genomes pathways included the oxytocin signaling pathway, long-term depression pathway, axon guidance, endometrial cancer, long-term potentiation, mitogen-activated protein kinase signaling pathway, and glutamatergic pathway, among others. In the patient group, significant associations of novel methylated genes with early trauma and psychopathology were observed. Conclusion: Our results suggest an association of differential DNA methylation with the pathophysiology of psychosis and early trauma. Blood DNA methylation signatures show promise as biomarkers of future psychosis.

Prospective randomized trial comparing efficacy and safety of intravenous and intra-articular tranexamic acid in total knee arthroplasty

Li Moses Man-Lung,Kwok Jojo Yan-Yan,Chung Kwong-Yin,Cheung Kin-Wing,Chiu Kwok-Hing,Chau Wai-Wang,Ho Kevin Ki Wai 대한슬관절학회 2020 대한슬관절학회지 Vol.32 No.-

Total knee arthroplasty (TKA) is associated with significant perioperative blood loss and postoperative allogenic blood transfusion. Tranexamic acid (TXA) reversibly blocks lysine binding sites on plasminogen molecules and inhibits plasmin formation. Comparisons of the efficacy and safety of intra-articular and intravenous TXA in primary TKA have not previously been reported.A prospective randomized trial was conducted in 150 patients who underwent TKA, and these patients were randomized into three groups. Patients in Group A were injected by intra-articular TXA according to body weight (20 mg/kg). Patients in Group B received a standard dose of intra-articular TXA (2000 mg), and those in Group C were infused with TXA according to body weight (20 mg/kg) before tourniquet deflation and again 3 h later. Baseline characteristics and data collected at blood transfusion were compared. Differences among four time points (baseline, day 0, day 2, and day 5) were carried out using ANOVA. The hemoglobin levels at postoperative day 5 were 10.6 g/dL for Group A, 10.6 g/dL for Group B, and 10.7 g/dL for Group C. The drain output was 399 ml for Group A, 314 ml for Group B, and 305 ml for Group C ( p = 0.03). Group C had significantly less drain output than Group A after post hoc comparisons ( p = 0.05), whereas no significant difference was observed between Group A and B ( p = 0.09) or between Group B and C. The weight-adjusted dose of TXA administered intravenously significantly reduced the drain output but not the total blood loss when compared with the weight-adjusted dose of TXA administered intra-articularly. No significant difference was observed in the other parameters among the three groups. The Joint CUHK-NTEC CREC, CRE-2013.644-T . Registered 1 March 2014.

Generation of entangled states of two superconducting-quantum-interference-devices(SQUIDs) in cavity QED

Yan Li,Shou Zhang,Chung-In Um,Kyu-Hwang Yeon 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.46 No.2

We prose a scheme for generating entangled states for two supercorductiong quantum interfer-ence un a thermal with assistanse of a microwave pulse.

Lrfn2-Mutant Mice Display Suppressed Synaptic Plasticity and Inhibitory Synapse Development and Abnormal Social Communication and Startle Response

Li, Yan,Kim, Ryunhee,Cho, Yi Sul,Song, Woo Seok,Kim, Doyoun,Kim, Kyungdeok,Roh, Junyeop Daniel,Chung, Changuk,Park, Hanwool,Yang, Esther,Kim, Soo-Jeong,Ko, Jaewon,Kim, Hyun,Kim, Myoung-Hwan,Bae, Yong- Society for Neuroscience 2018 The Journal of neuroscience Vol.38 No.26

<P>SALM1 (SALM (synaptic adhesion-like molecule), also known as LRFN2 (leucine rich repeat and fibronectin type III domain containing), is a postsynaptic density (PSD)-95-interacting synaptic adhesion molecule implicated in the regulation of NMDA receptor (NMDAR) clustering largely based on in vitro data, although its in vivo functions remain unclear. Here, we found that mice lacking SALM1/LRFN2 (Lrfn2(-/-) mice) show a normal density of excitatory synapses but altered excitatory synaptic function, including enhanced NMDAR-dependent synaptic transmission but suppressed NMDAR-dependent synaptic plasticity in the hippocampal CA1 region. Unexpectedly, SALM1expression was detected in both glutamatergic and GABAergic neurons and Lrfn2(-/-) CA1 pyramidal neurons showed decreases in the density of inhibitory synapses and the frequency of spontaneous inhibitory synaptic transmission. Behaviorally, ultrasonic vocalization was suppressed in Lrfn2(-/-) pups separated from their mothers and acoustic startle was enhanced, but locomotion, anxiety-like behavior, social interaction, repetitive behaviors, and learning and memory were largely normal in adult male Lrfn2(-/-) mice. These results suggest that SALM1/LRFN2 regulates excitatory synapse function, inhibitory synapse development, and social communication and startle behaviors in mice.</P>

MET Gene Copy Number Gain is an Independent Poor Prognostic Marker in Korean Stage I Lung Adenocarcinomas

Jin, Yan,Sun, Ping-Li,Kim, Hyojin,Seo, An Na,Jheon, Sanghoon,Lee, Choon-Taek,Chung, Jin-Haeng Springer - Society of Surgical Oncology 2014 Annals of Surgical Oncology Vol.21 No.2

Estimating patient-specific and anatomically correct reference model for craniomaxillofacial deformity via sparse representation.

Wang, Li,Ren, Yi,Gao, Yaozong,Tang, Zhen,Chen, Ken-Chung,Li, Jianfu,Shen, Steve G F,Yan, Jin,Lee, Philip K M,Chow, Ben,Xia, James J,Shen, Dinggang Published for the American Association of Physicis 2015 Medical physics Vol.42 No.10

<P>A significant number of patients suffer from craniomaxillofacial (CMF) deformity and require CMF surgery in the United States. The success of CMF surgery depends on not only the surgical techniques but also an accurate surgical planning. However, surgical planning for CMF surgery is challenging due to the absence of a patient-specific reference model. Currently, the outcome of the surgery is often subjective and highly dependent on surgeon's experience. In this paper, the authors present an automatic method to estimate an anatomically correct reference shape of jaws for orthognathic surgery, a common type of CMF surgery.</P>

ROS1 gene rearrangement and copy number gain in non-small cell lung cancer.

Jin, Yan,Sun, Ping-Li,Kim, Hyojin,Park, Eunhyang,Shim, Hyo Sup,Jheon, Sanghoon,Kim, Kwhanmien,Lee, Choon-Taek,Chung, Jin-Haeng Springer International 2015 Virchows Archiv Vol.466 No.1

<P>ROS1 has attracted much attention as a possible oncogenic driver and ROS1-rearranged tumors show sensitivity to most ALK inhibitors. We aimed to clarify the prevalence of ROS1 gene rearrangement and investigate the clinical implications of ROS1 gene copy number gain (CNG) in non-small cell lung cancer (NSCLC) patients. We carried out fluorescent in situ hybridization with ROS1 and centromere enumeration 6 probes and immunohistochemistry for ROS1 protein expression. ROS1 rearrangement was detected in 3 of 375 samples (0.8 %); all of whom were female, never-smokers, and harbored an adenocarcinoma component. ROS1 gene CNG was found in 18 cases (4.8 %). ROS1 gene CNG was significantly associated with shorter disease-free survival (DFS, 12 vs. 58 months; p = 0.003) and shorter overall survival (OS, 40 vs. 67 months; p <0.001) than the group without CNG. Multivariate analysis confirmed that ROS1 gene CNG was significantly associated with poorer DFS (hazard ratio [HR]=2.16, 95 % confidence interval [CI] = 1.22-3.81, p = 0.008), and OS ([HR] = 2.53, 95 % [CI] = 1.31-4.89, p = 0.006). ROS1 protein overexpression was observed in 5.0 % (18 out of 357), of which 2 cases harbored ROS1 gene rearrangement. There was no statistically significant correlation between ROS1 gene CNG and protein overexpression. This study demonstrated ROS1 gene rearrangement was detected in 0.8 % of surgically resected NSCLC; and ROS1 gene CNG is an independent poor prognostic factor. This survival analyses may contribute to future studies on the utility of ROS1-targeted therapy for patients.</P>

중국 교사자격제도의 의제설정 과정 분석

여유연(Li Yu Yan),장선희(Jang Seon Hee),정제영(Chung Jae Young) 한국비교교육학회 2018 比較敎育硏究 Vol.28 No.4

본 연구는 1978년부터 2018년까지 중국 교사자격제도의 의제설정 과정을 어느 집단이 주도하였는지에 대해 Cobb과 Elder(1972)와 Cobb 등(1976)의 이론모형을 활용하여 분석하였다. 1978년부터 2018년까지 약 40여 년의 기간을 교사자격제도 도입기(1978∼1992), 교사자격제도 과도기(1993∼1998), 교사자격제도 안정기(1999∼현재)로 구분하여 시기별 교사자격제도의 의제설정과정을 분석하였다. 연구 결과, 중국 교사자격제도의 의제설정 과정을 주도한 집단은 시기에 따라 다르게 나타났다. 교사자격제도 도입기는 정책결정자 및 정부가 주도한 ‘내부접근형’, 교사자격제도 과도기는 중국 정부 및 교육부가 주도한 ‘동원형’, 교사자격제도 안정기는 대중매체, 연구자, 정부 등 다양한 집단이 주도한 ‘외부주도형’으로 나타났다. 이를 통해 중국 교사자격제도의 의제설정 과정이 중국 사회의 발전정도에 따라 민주화되는 방향으로 변화하고 있으며, 중국교사자격에 대한 질 관리도 강화되고 있음을 확인하였다. The purpose of this study is to analyze which group led the process of agenda setting of teacher’s certification system in China from 1978 to 2018 using the Cobb & Elder’s theoretical model. The period of about 40 years from 1978 to 2018 is divided into the introduction period of teacher’s certification period (1978∼1992), transition period (1993∼1998), and stabilization stage (1999∼2018). The agenda setting process was analyzed. As a result, the group that led the process of agenda setting of the Chinese teacher’s certification system varied according to the period. The introduction period of teacher’s certification system was analyzed as ‘Inside Access Model’ led by policy makers and government, and the transition period was confirmed as ‘Mobilization Model’ led by Chinese government and Ministry of Education. The stabilization period was analyzed as ‘Outside Initiative Model’ led by various groups such as mass media, researchers, and government. It was found that the process of agenda setting of teacher’s certification system had been changing toward democratization according to the degree of development of Chinese society, and the quality control of teacher certifications had been strengthened.

Automated bone segmentation from dental CBCT images using patch-based sparse representation and convex optimization : Segmentation of CBCT image

Wang, Li,Chen, Ken Chung,Gao, Yaozong,Shi, Feng,Liao, Shu,Li, Gang,Shen, Steve G. F.,Yan, Jin,Lee, Philip K. M.,Chow, Ben,Liu, Nancy X.,Xia, James J.,Shen, Dinggang Published for the American Association of Physicis 2014 Medical physics Vol.41 No.4

<P>Cone-beam computed tomography (CBCT) is an increasingly utilized imaging modality for the diagnosis and treatment planning of the patients with craniomaxillofacial (CMF) deformities. Accurate segmentation of CBCT image is an essential step to generate three-dimensional (3D) models for the diagnosis and treatment planning of the patients with CMF deformities. However, due to the poor image quality, including very low signal-to-noise ratio and the widespread image artifacts such as noise, beam hardening, and inhomogeneity, it is challenging to segment the CBCT images. In this paper, the authors present a new automatic segmentation method to address these problems.</P>

중국 소비자의 모바일 결제서비스에 대한 만족도 및 지속사용의도 결정요인에 관한 실증적 연구

범염려 ( Yan-li Fan ),정재은 ( Jae-eun Chung ),문희철 ( Hee-cheol Moon ) 한국통상정보학회 2018 통상정보연구 Vol.20 No.1

본 논문은 세계 모바일 결제서비스 시장에서 점유율 1위를 달성한 중국 시장의 모바일 결제서비스 현황고찰을 연구배경 만족도 및 지속사용의도 결정요인에 대한 탐구에 목적을 두고 있다. 이를 위해 중국의 사용자를 대상으로 설문조사를 이행하였으며, SPSS 24.0을 활용한 회귀분석으로 결과를 도출하였다. 실증분석 결과 모바일 결제서비스의 특성 중 편리성이 가장 영향을 크게 미치는 변수로 나타났다. 이러한 결과는 서비스 제공자들이 신규 사용자의 유치 및 단골 고객의 유지를 위해 사용자의 편리성을 도모하는 방향으로 서비스를 개선할 경우 더욱 만족도와 지속사용의도를 높일 수 있음을 시사하는 것이다. As the number of smart-phone user increases, the size of mobile payment market has been steadily growing. The purpose of this study is to examine the factors influencing adoption of mobile payment services especially in Chinese market. The research model was designed based on the Post Acceptance Model and hypotheses were set. And we examined how the characteristics of mobile payment services and the user's environmental characteristics effect on perceived usefulness and customer satisfaction. Also the relationship between perceived usefulness, customer satisfaction, and continuous use intention was studied. The research model was examined using multiple regression analysis through SPSS 24.0. First, except security, every variables were confirmed that they have a positive effects on both customer satisfaction and perceived usefulness. On the other hand, security has a positive effect on customer satisfaction, but not on perceived usefulness. Second, perceived usefulness has a positive effect on customer satisfaction and continuous use intention. Third, customer satisfaction was confirmed that it performs a partial intermediary role in this research model. This study can provide insightful guidelines to related companies by deriving factors that may effect on customer satisfaction and intention to continue using mobile payment service.