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Osteomyelitis on the Mandibular Malunion and Nonunion Site: A Case Report
Song, Chi-Woong,Yoon, Hyun-Joong,Lee, Sang-Hwa Korean Academy of Dental Science 2013 Journal of korean dental science Vol.6 No.2
The proper management of mandibular fractures involves reduction, rigid fixation, and immobilization to allow bone healing. Nonunion or malunion at the fractured sites is a well-known complication of fracture when the treatments are inappropriate. We present a case of left mandibular fracture due to shrapnel during the Korean War. The patients did not receive appropriate treatment at that time, so nonunion and malunion developed. Sixty years after the accident, mandibular osteomyelitis on the fracture site developed due to dental-origin inflammation. The treatment was based on relatively conservative care, such as saucerization and administration of antibiotics. There was no complication during the short-term follow-up. We present the case with literature review.
Cervical Necrotizing Fasciitis Caused by Dental Infection
Song, Chi-Woong,Yoon, Hyun-Joong,Jung, Da-Woon,Lee, Sang-Hwa Korean Association of Maxillofacial Plastic and Re 2014 Maxillofacial Plastic Reconstructive Surgery Vol.36 No.2
Necrotizing fasciitis (NF) is defined as rapidly progressive necrosis of subcutaneous fat and fascia. Although NF of the face is rare, its mortality rate is nearly 30%. It usually originates from dental infection and can lead to involvement of the neck, mediastinum, and chest wall. Complications resulting from pre-existing systemic diseases can increase the mortality rate. Known complication factors for NF include diabetes, malnutrition, advanced age, peripheral vascular disease, renal failure, and obesity. Here, we report a case of NF originating from dental infection in an 88-year-old woman already diagnosed with hypertension, thoracic aortic aneurysm, and renal diseases. Such conditions limited adequate surgical and antibiotic treatment. However, interdisciplinary treatment involving multiple departments was implemented with good results.
( Song I Chun ),( Jee Hyun Cho ),( Young Il Yang ),( Jung Woog Shin ),( Woon Jae Shin ),( Chi Woong Mun ) 한국조직공학·재생의학회 2012 조직공학과 재생의학 Vol.9 No.2
The purpose of this study was to produce a metabolomic profile of a human mesenchymal stem cell (hMSC) pellet sample to identify biomarkers of adipogenic differentiation using nuclear magnetic resonance (NMR) spectroscopy. hMSC adipogenesis was monitored over four cycles of differentiation; one cycle consisted of treatment with adipogenic induction medium for 3 days followed by adipogenic maintenance medium for 1 day. Adipogenesis in control hMSCs was confirmed by Oil Red O staining. A NMR micro-imaging machine with a zqpr pulse (total volume) sequence was used to examine the metabolic changes in the cell pellet samples. Several lipid peaks were predominant among the various metabolite peaks in the NMR spectroscopy data. In particular, the lipid methylene (-[CH2]n-) signal at 1.3 ppm increased 3.6-fold during the first cycle, 15.7-fold during the second cycle, and 28.3-fold during the third cycle. Our findings indicate that NMR spectral peaks related to lipid metabolites can be used as a biomarker of hMSC adipogenesis.
Development of Axial Power Distribution Monitoring System Using Two-Level Encore Detector
Chi, Sung-Goo,Song, Jae-Woong,Ahn, Dwak-Hwan,Kuh, Jung-Eui Korean Nuclear Society 1989 Nuclear Engineering and Technology Vol.21 No.4
The Axial Power Distribution Monitoring System(APDMS) program was developed to calculate a detailed axial power distribution using two-level excore detector, cold leg temperature and control rod position signals. The unnormalized two-level excore detector signals were corrected for the rod shadowing factor determined by control rod position and for the temperature shadowing factor calculated based on cold leg temperature. A shape annealing matrix was then applied to the corrected excore detector response to yield peripheral power. After the core average power was obtained using linear relationship bet-ween core average and peripheral power, the boundary point power correction coefficient was applied to core average power in order to obtain boundary power for both upper and lower core axial boundaries. Then, the axial power distribution was synthesized by spline approximation. In spite of burnup, power level, control rod postion and axial offset changes, the comparisons of axial power distributions between BOXER simulation program and APDMS results showed good agreements within 5% root mean square error for Kori Unit 3 Cycle 4.
Lee, Ji Woong,Yan, Hailong,Jang, Hyeong Bin,Kim, Hong Ki,Park, Sung-Woo,Lee, Sungyul,Chi, Dae Yoon,Song, Choong Eui WILEY-VCH Verlag 2009 Angewandte Chemie Vol.48 No.41
<B>Graphic Abstract</B> <P>Achiral polyether derivatives have been shown to dramatically accelerate S<SUB>N</SUB>2 reactions by the simultaneous activation of both the nucleophile (KF) and electrophile (sulfonate; see picture). By using chiral variants as catalysts, the desilylative kinetic resolution of the silyl ethers of racemic secondary alcohols has been achieved. Density functional calculations provide detailed insight into the modes of action of this type of organic promoter. <img src='wiley_img/14337851-2009-48-41-ANIE200903903-content.gif' alt='wiley_img/14337851-2009-48-41-ANIE200903903-content'> </P>
Lee, Ji-Woong,Oliveira, Maria Teresa,Jang, Hyeong Bin,Lee, Sungyul,Chi, Dae Yoon,Kim, Dong Wook,Song, Choong Eui The Royal Society of Chemistry 2016 Chemical Society reviews Vol.45 No.17
<P>Due to the tremendous interest in carbon-fluorine bond-forming reactions, research efforts in this area have been dedicated to the development of facile processes to synthesize small fluorine-containing organic molecules. Among others, PET (Positron Emission Tomography) is one of the most important applications of fluorine chemistry. Recognizing the specific requirements of PET processes, some groups have focused on fluorination reactions using alkali metal fluorides, particularly through S(N)2-type reactions. However, a common 'misconception'' about the role of protic solvents and hydrogen bonding interactions in this class of reactions has hampered the employment of these excellent promoters. Herein, we would like to review recent discoveries in this context, showing straightforward nucleophilic fluorination reactions using alkali metal fluorides promoted by protic solvents. Simultaneous dual activation of reacting partners by intermolecular hydrogen bonding and the enhancement of the 'effective fluoride nucleophilicity'', which is Nature's biocatalytic approach with the fluorinase enzyme, are the key to this unprecedentedly successful nucleophilic fluorination.</P>
Jun-Ying Zhang,Tae-Woong Bae,Kyung-Hwan Boo,Hyeon-Jin Sun,In-Ja Song,Chi-Hoa Pham,Markkandan Ganesan,Dae-Hwa Yang,Hong-Gyu Kang,Suk-Min Ko,Key-Zung Riu,Pyung-Ok Lim,Hyo-Yeon Lee 고려인삼학회 2011 Journal of Ginseng Research Vol.35 No.3
With the purpose of improving ginsenoside content in adventitious root cultures of Korean wild ginseng (Panax ginseng Meyer), the roots were treated with different dosages of γ-ray (5, 10, 25, 50, 75, 100, and 200 Gy). The growth of adventitious roots was inhibited at over 100 Gy. The irradiated adventitious roots showed significant variation in the morphological parameters and crude saponin content at 50 to100 Gy. Therefore, four mutant cell lines out of the propagation of 35 cell lines treated with 50 Gy and 100 Gy were selected on the basis of phenotypic morphology and crude saponin contents relative to the wild type control. The contents of 7 major ginsenosides (Rg<sub>1</sub>, Re, Rb<sub>1</sub>, Rb<sub>2</sub>, Rc, Rf, and Rd) were determined for cell lines 1 and 3 from 100 Gy and lines 2 and 4 from 50 Gy treatments. Cell line 2 showed more secondary roots, longer length and superior growth rate than the root controls in flasks and bioreactors. Cell line 1 showed larger average diameter and the growth rate in the bioreactor was comparable with that of the control but greater in the flask cultured roots. Cell lines 1 and 2, especially the former, showed much more ginsenoside contents than the control in flasks and bioreactors. Therefore, we chose cell line 1 for further study of ginsenoside contents. The crude saponin content of line 1 in flask and bioreactor cultures increased by 1.4 and 1.8-fold, respectively, compared to the control. Total contents of 7 ginsenoside types (Rg<sub>1</sub>, Re, Rb<sub>1</sub>, Rb<sub>2</sub>, Rc, Rf, and Rd) increased by 1.8 and 2.3-fold, respectively compared to the control. Crude saponin and ginsenoside contents in the bioreactor culture increased by about 1.4-fold compared to that the flask culture.