Update of Research on Drug Resistance in Small Cell Lung Cancer Chemotherapy

Chen, Yi-Tian,Feng, Bing,Chen, Long-Bang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

Small cell lung cancer (SCLC) is characterized by a short cell doubling time, rapid progression and early occurrence of blood-borne and lymph metastasis. The malignancy is the highest of all lung cancer types. Although SCLC has a relatively good initial response to chemotherapy as well as radiotherapy, relapse or disease progression may occur quickly after the initial treatment. Drug resistance, especially multi-drug resistance, is the most important cause of failure of SCLC chemotherapy. This article provides a brief update of research on mechanisms of drug resistance in SCLC and reversal strategies.

Low temperature oxidation characteristics analysis of ultra-heavy oil by thermal methods

Yi-Bo Li,Ya-Fei Chen,Wan-Fen Pu,Hong Dong,Hao Gao,Fa-yang Jin,Bing Wei 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.48 No.-

To study the oxidation behavior of heavy oils, low temperature oxidation experiments under differentialtemperature and pressure conditions were carried out for both heavy oils (ordinary heavy and ultraheavyoils) with thermogravimetry (TG–DTG)/differential scanning calorimeter (DSC) analyses. And theresults indicated that the differences of physical properties and oxidation reactions for the heavy oilsascribe to the SARA compositions, H/C ratio and specific oxidation path. Owing to the asphaltenescontent, the ultra-heavy oil after the oxidation has more obvious coke deposition with lower activationenergy demand to make it possible for the in-situ combustion without combustion adjuvants.

Commercial Simulation Technology Enables Wideband-CDMA Research and Development

Yi Yuan Chen,Bing Lin,Xiao Jing Lu,Min Ying Sun,Faul Washkewicz,Wei Jun Zhu 대한전자공학회 1998 CDMA International Conference and Exhibition Vol.- No.-

Gender-independent efficacy of mesenchymal stem cell therapy in sex hormone-deficient bone loss via immunosuppression and resident stem cell recovery

Bing-Dong Sui,Ji Chen,Xin-Yi Zhang,Tao He,Pan Zhao,Chen-Xi Zheng,Meng Li,Cheng-Hu Hu,Yan Jin 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

Osteoporosis develops with high prevalence in both postmenopausal women and hypogonadal men. Osteoporosis results in significant morbidity, but no cure has been established. Mesenchymal stem cells (MSCs) critically contribute to bone homeostasis and possess potent immunomodulatory/anti-inflammatory capability. Here, we investigated the therapeutic efficacy of using an infusion of MSCs to treat sex hormone-deficient bone loss and its underlying mechanisms. In particular, we compared the impacts of MSC cytotherapy in the two genders with the aim of examining potential gender differences. Using the gonadectomy (GNX) model, we confirmed that the osteoporotic phenotypes were substantially consistent between female and male mice. Importantly, systemic MSC transplantation (MSCT) not only rescued trabecular bone loss in GNX mice but also restored cortical bone mass and bone quality. Unexpectedly, no differences were detected between the genders. Furthermore, MSCT demonstrated an equal efficiency in rectifying the bone remodeling balance in both genders of GNX animals, as proven by the comparable recovery of bone formation and parallel normalization of bone resorption. Mechanistically, using green fluorescent protein (GFP)-based cell-tracing, we demonstrated rapid engraftment but poor inhabitation of donor MSCs in the GNX recipient bone marrow of each gender. Alternatively, MSCT uniformly reduced the CD3+T-cell population and suppressed the serum levels of inflammatory cytokines in reversing female and male GNX osteoporosis, which was attributed to the ability of the MSC to induce T-cell apoptosis. Immunosuppression in the microenvironment eventually led to functional recovery of endogenous MSCs, which resulted in restored osteogenesis and normalized behavior to modulate osteoclastogenesis. Collectively, these data revealed recipient sexually monomorphic responses to MSC therapy in gonadal steroid deficiency-induced osteoporosis via immunosuppression/anti-inflammation and resident stem cell recovery.

Control Design of the Brushless Doubly-Fed Machines for Stand-Alone VSCF Ship Shaft Generator Systems

Yi Liu,Wu Ai,Bing Chen,Ke Chen 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.1

This paper presents a stand-alone variable speed constant frequency (VSCF) ship shaft generator system based on a brushless doubly-fed machine (BDFM). In this system, the output voltage amplitude and frequency of the BDFM are kept constant under a variable rotor speed and load by utilizing a well-designed current vector controller to regulate the control winding (CW) current. The control scheme is proposed, and the hardware design for the control system is developed. The proposed generator system is tested on a 325 TEU container vessel, and the test results show the good dynamic performance of the CW current vector controller and the whole control system. A harmonic analysis of the output voltage and a fuel consumption analysis of the generator system are also implemented. Finally, the total efficiency of the generator system is presented under different rotor speeds and load conditions.

TOSS: Telecom Operations Support Systems for Broadband Services

Chen, Yuan-Kai,Hsu, Chang-Ping,Hu, Chung-Hua,Lin, Rong-Syh,Lin, Yi-Bing,Lyu, Jian-Zhi,Wu, Wudy,Young, Hey-Chyi Korea Information Processing Society 2010 Journal of information processing systems Vol.6 No.1

Due to the convergence of voice, data, and video, today's telecom operators are facing the complexity of service and network management to offer differentiated value-added services that meet customer expectations. Without the operations support of well-developed Business Support System/Operations Support System (BSS/OSS), it is difficult to timely and effectively provide competitive services upon customer request. In this paper, a suite of NGOSS-based Telecom OSS (TOSS) is developed for the support of fulfillment and assurance operations of telecom services and IT services. Four OSS groups, TOSS-P (intelligent service provisioning), TOSS-N (integrated large-scale network management), TOSS-T (trouble handling and resolution), and TOSS-Q (end-to-end service quality management), are organized and integrated following the standard telecom operation processes (i.e., eTOM). We use IPTV and IP-VPN operation scenarios to show how these OSS groups co-work to support daily business operations with the benefits of cost reduction and revenue acceleration.

BOARD STRUCTURE AND AGENCY COSTS

Bing sheng Yi,Chia Wei Chen,T Chotigeat People&Global Business Association 2007 Global Business and Finance Review Vol.12 No.1

Several features are used to measure board structure: board size. leadership. inside director ownership. outside director ownership, and proportion of outside directors. Among these features. only inside director ownership significantly affects agency costs. and its effect is non-linear. In addition, the paper shows that small firms tend to have lower agency costs than large firms when the CEO also acts as chairperson of the board. Direct evidence on the relationship between hoard structure and agency costs is provided: the findings have important implications to shareholders and policy makers

Resveratrol enhances the functionality and improves the regeneration of mesenchymal stem cell aggregates

Yi-Jing Wang,Pan Zhao,Bing-Dong Sui,Nu Liu,Cheng-Hu Hu,Ji Chen,Chen-Xi Zheng,An-Qi Liu,Kun Xuan,Ya-Ping Pan,Yan Jin 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

Mesenchymal stem cell (MSC)-based regeneration, specifically cell aggregate or cell sheet engineering, is a promising approach for tissue reconstruction. Considering the advantages of ease of harvest and lack of immune rejection, the application of autologous MSCs (i.e., patients’ own MSCs) in regenerative medicine has developed considerable interest. However, the impaired cell viability and regenerative potential following MSCs impacted by disease remain a major challenge. Resveratrol (RSV) exhibits reliable and extensive rejuvenative activities that have received increasing clinical attention. Here, we uncovered that resveratrol enhances the functionality and improves the regeneration of mesenchymal stem cell aggregates. Periodontal ligament MSCs (PDLSCs) from normal control subjects (N-PDLSCs) and periodontitis patients (P-PDLSCs) were investigated. Compared to N-PDLSCs, P-PDLSCs were less capable of forming cell aggregates, and P-PDLSC aggregates showed impaired osteogenesis and regeneration. These functional declines could be mimicked in N-PDLSCs by tumor necrosis factor alpha (TNF-α) treatment. Notably, a TNF-α-induced functional decline in N-PDLSC aggregates was rescued by RSV application. More importantly, in both N-PDLSCs and P-PDLSCs, RSV promoted cell aggregate formation and improved their osteogenic potential. Furthermore, as proven ectopically in vivo, the tissue regenerative capability of P-PDLSC aggregates was also enhanced after RSV treatment during aggregate formation in vitro. Finally, in a rat in situ regeneration model, we successfully applied both N-PDLSC aggregates and P-PDLSC aggregates to repair periodontal defects upon long-term functional improvements by RSV preconditioning. Together, our data unravel a novel methodology for using pharmacology (i.e., RSV)-based cell aggregate engineering to improve the functionality and facilitate the regeneration of MSCs from both healthy and inflammatory microenvironments, shedding light on improving the application of autologous MSC-mediated regenerative medicine.

TNM Stages and Prognostic Features of Colorectal and Mucinous Adenocarcinoma Patients: a Meta Analysis

Chen, Jing-Xiang,Tang, Xu-Dong,Xiang, De-Bing,Dong, Xiao-Ling,Peng, Fang-Yi,Sun, Gui-Yin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7

Aim: The significance of the mucinous adenocarcinoma in TNM staging and prognosis for colorectal tumor patients is still controversial. The aim was to provide a meta-analysis for TNM staging and prognostic features of colorectal tumors. Methods: 30 individual case-control studies were finally included into this meta-analysis, involving a total of 444,489 cancer cases and 45,050 mucinous adenocarcinomas, of relations with TNM staging and prognostic features. Results: Compared to non-mucinous adenocarcinoma patients, the TNM IV stage accounted for a larger percentage of mucinous adenocarcinomas (OR=1.48, 95%CI 1.28-1.71, POR<0.001) and the prognosis was significantly poor (HR=1.06, 95%CI 1.04-1.08, P<0.001). After heterogeneity testing, the results was similar to the holistic approach outcome (HR=1.48, 95%CI 1.35-1.62, P<0.001). Conclusion: Compared to patients with non-mucinous adenocarcinomas, mucinous adenocarcinoma patients with later TNM staging make up a big percentage, and mucinous adenocarcinoma is an independent risk factor for poor prognosis.

Control Design of the Brushless Doubly-Fed Machines for Stand-Alone VSCF Ship Shaft Generator Systems

Liu, Yi,Ai, Wu,Chen, Bing,Chen, Ke The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.1

This paper presents a stand-alone variable speed constant frequency (VSCF) ship shaft generator system based on a brushless doubly-fed machine (BDFM). In this system, the output voltage amplitude and frequency of the BDFM are kept constant under a variable rotor speed and load by utilizing a well-designed current vector controller to regulate the control winding (CW) current. The control scheme is proposed, and the hardware design for the control system is developed. The proposed generator system is tested on a 325 TEU container vessel, and the test results show the good dynamic performance of the CW current vector controller and the whole control system. A harmonic analysis of the output voltage and a fuel consumption analysis of the generator system are also implemented. Finally, the total efficiency of the generator system is presented under different rotor speeds and load conditions.