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- 저자 : Chaoqun Zhang (검색결과 4 건)
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Comparisons of Safety Factors for Slope in Nonlinear Soils
Chaoqun Hou,Rongjian Zhang,Yongxin Li,Zhibin Sun,Biao Zhang 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.10
Slope stability assessment is one of the most important issues for geotechnical engineers. In the framework of a nonlinear failure criterion, four different types of safety factors are presented and their relationships are investigated for soil slope in this study. The variational method is incorporated into the kinematic approach of limit analysis to assess the stability of soil slope with known geometric boundary, and seismic effects are considered. The seismic loads are simplified as external forces acting on the slope. A rotational failure mechanism is used to describe the sliding mode of slopes. The differential equations for the sliding surface and corresponding stress distribution are derived using the variational method and then are employed to generate the sliding surface via the fourth-order Runge-Kutta approach. To avoid the computational complexity, the energy-work balance equation of the kinematic approach, instead of the static equilibrium equation, is used to judge whether the state of the slope is critical. The safety factor is designed as the minimum factor that brings the slope in the limit state. Computational schemes are proposed to calculate the values of safety factors. The validity of the proposed approach is demonstrated through comparison with previous works. Finally, parametric study is conducted to further reveal the relationships among the four types of safety factors.
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Linking user interaction and new venture growth: the mediating role of new product development
Chaoqun Zhang,Jingjing Guo,Xiaobo Wu,Hao Jiao 기술경영경제학회 2018 ASIAN JOURNAL OF TECHNOLOGY INNOVATION Vol.26 No.2
This paper identifies both the breadth and the depth as two crucialdimensions of user interaction from an ecosystem viewpoint. Wepostulate that the breadth and the depth of user interaction arecritical to the number of new products developed anddevelopment speed, which can then lead to new venture growth. Survey data from 341 new ventures from ICT sector illustrates thatthe number of new products developed mediates therelationships between user interaction breadth, user interactiondepth and new venture growth, and development speedmediates the influence of user interaction depth on new venturegrowth. This study contributes to the literature by refining theconceptualization of user interaction, and developing atheoretically grounded research model to investigate therelationships among user interaction, new product developmentand new venture growth.
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Chaoqun Cai,Hongqiang Zhang,Jun Xie,Ligang Ma 한국물리학회 2017 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.70 No.9
Textured zinc-oxide (ZnO) thin films and Cu-doped ZnO (ZnO:Cu) thin films are deposited on glass substrates by using radio-frequency reactive magnetron sputtering. The effect of Cudoping concentration on the crystallization behavior, surface morphology, transmission spectrum, and luminescence properties of the ZnO thin films are systematically investigated by using X-ray diffraction, scanning probe microscopy and photoluminescence spectra. The results indicate that the crystallization quality, morphology, transmission, and luminescence of the ZnO films is affected by Cu-element doping. A stronger preferred orientation toward the c-axis is obtained after Cu doping at an appropriate concentration (3%). The transmittance rate gradually decreases with increasing Cu doping concentration. In the photoluminescence spectra of the samples measured at room temperature, four main emission peaks are observed: a violet peak located at about 390 nm, two blue peaks, one located at about 445 nm and the other at about 485 nm, and a green peak located at about 527 nm. The origins of these emissions are discussed in detail.
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Li Sun,Lin Zhang,Jun Chen,Chaoqun Li,Hongqin Sun,Jiangrong Wang,Hong Xiao 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2
Purpose Cancer stem cells (CSCs) are naturally resistant to chemotherapy, explaining why tumor relapse frequently occurs after initial regression upon administration of chemotherapeutic agents in most cases. A CSC population characterized by CD13 expression has been identified in hepatocellular carcinoma (HCC). In the current study, we aimed to clarify the molecular mechanism by which it escapes conventional therapies. Materials and Methods Here, we used flow cytometry to examine the percentage of CD13+ CSCs in HepG2 and HuH7 cells after chemotherapy. Using in vitro isotope labeling technique, we compared metabolic pathways between CD13+ and CD13– subpopulations. Using co-immunoprecipitation and western blotting, we determined the target expressions in protein levels under different conditions. We also performed immunohistochemistry to detect the target proteins under different conditions. Animal models were constructed to verify the potential role of tyrosine metabolism in post-chemotherapeutic relapse in vivo. Results We observed that quiescent CD13+ CSCs are enriched after chemotherapy in HCCs, and serve as a reservoir for recurrence. Mechanistically, CD13+ CSCs were dependent on aerobic metabolism of tyrosine rather than glucose as energy source. Tyrosine metabolism also generated nuclear acetyl-CoA to acetylate and stabilize Foxd3, thereby allowing CD13+ CSCs cells to sustain quiescence and resistance to chemotherapeutic agents. Conclusion These findings encourage further exploration of eliminating CD13+ cells by targeting specific metabolic pathways to prevent recurrence in HCCs.
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