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- 저자 : Yongxin Li (검색결과 15 건)
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Li Peifan,Tong Tong,Wu Yusong,Zhou Xin,Zhang Michael,Liu Jia,She Yongxin,Li Zuming,Li Yongli 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.12
This study aimed to evaluate the effects of Limosilactobacillus fermentum and Lactiplantibacillus plantarum isolated from human feces coordinating with inulin on the composition of gut microbiota and metabolic profiles in db/db mice. These supplements were administered to db/db mice for 12 weeks. The results showed that the Lactobacillaceae coordinating with inulin group (LI) exhibited lower fasting blood glucose levels than the model control group (MC). Additionally, LI was found to enhance colon tissue and increase the levels of short-chain fatty acids. 16S rRNA sequencing revealed that the abundance of Corynebacterium and Proteus, which were significantly increased in the MC group compared with NC group, were significantly decreased by the treatment of LI that also restored the key genera of the Lachnospiraceae_NK4A136_group, Lachnoclostridium, Ruminococcus_ gnavus_group, Desulfovibrio, and Lachnospiraceae_UCG-006. Untargeted metabolomics analysis showed that lotaustralin, 5-hydroxyindoleacetic acid, and 13(S)-HpODE were increased while L-phenylalanine and L-tryptophan were decreased in the MC group compared with the NC group. However, the intervention of LI reversed the levels of these metabolites in the intestine. Correlation analysis revealed that Lachnoclostridium and Ruminococcus_gnavus_group were negatively correlated with 5-hydroxyindoleacetic acid and 13(S)-HpODE, but positively correlated with L-tryptophan. 13(S)-HpODE was involved in the "linoleic acid metabolism". L-tryptophan and 5-hydroxyindoleacetic acid were involved in "tryptophan metabolism" and "serotonergic synapse". These findings suggest that LI may alleviate type 2 diabetes symptoms by modulating the abundance of Ruminococcus_gnavus_group and Lachnoclostridium to regulate the pathways of "linoleic acid metabolism", "serotonergic synapse", and" tryptophan metabolism". Our results provide new insights into prevention and treatment of type 2 diabetes.
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Yongxin Li,Yining Hu,Fu Huang,Shuqin Li,Zhibin Sun 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.8
The discrete technique combined with the upper bound approach is applied to analyze the stability of soil slopes with multiple layers in this paper. Based on the geometrical relationship derived from the normality requirement, an algorithm is proposed to determine the coordinates of discrete points on the failure surface. Specifically, these points are generated from the initial point to the terminal point. After completion of the discrete sliding surface, the sliding block is sliced by the vertical slice technique. Equations with integral form for rates of internal energy dissipation and external work are then derived. The scheme for calculation of the safety factor is presented by means of the strength reduction method and the optimization algorithm. Comparison analysis based on four examples under various conditions demonstratesthe validity of the proposed method in addressing stability problem of slopes with multiple layers.
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Multi-focus Image Fusion with Cartoon-Texture Image Decomposition
Yongxin Zhang,Hongan Li,Zhihua Zhao 보안공학연구지원센터(IJSIP) 2015 International Journal of Signal Processing, Image Vol.8 No.1
Multi-focus image fusion can fuse multiple source images with different focus settings into a single image that appears sharper. How to effectively and completely represent the source images is the key to multi-focus image fusion. A multi-component fusion method is proposed for multi-focus image fusion. The registered source images are decomposed into cartoon and texture components by cartoon-texture image decomposition. The salient features are selected from the cartoon and texture components respectively to form a composite feature space. The local features that represent the salient information of the source images are integrated to construct the fused image. According to the visual perception and objective evaluations on the fused images, the proposed method works better in extracting the focused regions and improving the fusion quality, compared with the other existing single-component fusion methods.
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Composition modulation of Cu/Cu2O/CuO nanoparticles supported on carbon for p-nitrophenol reduction
Jia Li,Wei Liu,Yongxin Ding,Likui Liu,Fang Li,Qiming Li 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.6
Porous carbon supported Cu/Cu2O/CuO ternary catalysts were fabricated by pyrolysis, in which composition modulation of Cu/Cu2O/CuO was successfully realized by adjusting annealing atmosphere. The correlation between annealing atmosphere and composition of Cu/Cu2O/CuO ternary nanoparticles was deeply investigated. XRD and SEM measurement shows that the composition proportion of Cu/Cu2O/CuO can be effectively controlled by adjusting the annealing atmosphere. HR-TEM and EDS analysis showed that Cu/Cu2O/CuO ternary nanoparticles are highly dispersed into the carbon matrix and harvest more hetero-junction active sites. The effect of Cu/Cu2O/CuO composition on their catalytic activity was investigated in catalytic reduction from p-nitrophenol to p-aminophenol. The experimental result indicated that the catalytic activity of Cu/Cu2O/CuO ternary catalysts exhibits higher catalytic activity than Cu2O/CuO or CuO particles. This work provides a new strategy for synthesizing and modulating porous carbon-supported Cu/Cu2O/CuO ternary nanoparticles.
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( Jie Li ),( You Li ),( Shengjie Wang ),( Hui Che ),( Jun Wu ),( Yongxin Ren ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.9
Bisphosphonates are the mainstay of therapy worldwide for osteoporosis. However, bisphosphonates also have limitations. The objective of this study was to determine the role of miR-101-3p/Rap1b signal pathway in osteoclast differentiation after treatment with bisphosphonates. Our results revealed that miR-101-3p was an important regulator in bisphosphonates treated-osteoclasts. When miR-101-3p was down-regulated in bone marrow-derived macrophage-like cells (BMMs), the development of mature osteoclasts was promoted, and vice versa. However, alendronate decreased multinucleated cell number regardless of whether miR-101-3p was knocked down or over-expressed. TRAP activity assay confirmed the above results. Luciferase assay indicated that miR-101-3p was a negative regulator of Rap1b. Western blot analysis revealed that protein expression level of Rap1b in BMMs transfected with OV-miR-101-3p was lower than that in BMMs transfected with an empty vector. Rap1b overexpression increased TRAP-positive multinucleated cells, while Rap1b inhibition decreased the cell numbers. In vivo data showed that miR-101-3p inhibited osteoclast differentiation in ovariectomized mice while overexpressed of Rap1b blocked the differentiation. Taken together, our data demonstrate that miR-101-3p/Rap1b signal pathway plays a key role in osteoclast differentiation after treatment with bisphosphonates. [BMB Reports 2019; 52(9): 572-576]
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Li, Na,Sun, Huaqin,Wu, Qiaqing,Tao, Dachang,Zhang, Sizhong,Ma, Yongxin Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.2
We have cloned a novel mouse zinc finger protein gene Znf313 by rapid amplification of cDNA ends (RACE) according to the homologue of human ZNF313 gene. The cDNA is 2,163 base pairs (bp) in length and encodes a 229 amino acids (aa) protein with a $C_3HC_4$ ring finger domain and three $C_2H_2$ domains. 89% and 93% nucleotide (nt) and aa sequence identity is observed with its human homologue. Revealed by Northern blot and RT-PCR, full mRNA consists of 2.16 kb and widely expresses in tissues as a single transcript, most abundantly in heart, liver, kidney and testis. The expression of Znf313 in testis is detected in all development stages. Western blot analysis also reveals that Znf313 is expressed in the tissues. Immunohistochemical staining and subcellular localization demonstrate that Znf313 is expressed both in the cytoplasm and nucleus whereas predominantly localized in the nucleus. Present data suggests that Znf313 gene might play a fundamental role in gene transcription and regulation in organism and relates to spermatogenesis.
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Stability charts and reinforcement with piles in 3D nonhomogeneous and anisotropic soil slope
Xu, Jingshu,Li, Yongxin,Yang, Xiaoli Techno-Press 2018 Geomechanics & engineering Vol.14 No.1
Soils are mostly nonhomogeneous and anisotropic in nature. In this study, nonhomogeneity and anisotropy of soil are taken into consideration by assuming that the cohesion increases with depth linearly and also varies with respect to direction at a particular point. A three-dimensional rotational failure mechanism is adopted, and then a three-dimensional stability analysis of slope is carried out with the failure surface in the shape of a curvilinear cone in virtue of the limit analysis method. A quasistatic approach is used to develop stability charts in nonhomogeneous and anisotropic soils. One can easily read the safety factors from the charts without the need for iterative procedures for safety factors calculation. The charts are of practical importance to prevent a plane failure in excavation slope whether it is physically constrained or not. Then the most suitable location of piles within the reinforced slope in nonhomogeneous and anisotropic soils is explored, as well as the interactions of nonhomogeneous and anisotropic coefficients on pile reinforcement effects. The results indicate that piles are more effective when they are located between the middle and the crest of the slope, and the nonhomogeneous coefficient as well as the anisotropic coefficient will not only influence the most suitable location for piles but also affect the calculated safety factor of existing reinforced slope. In addition, the two coefficients will interact with each other on the effect on slope reinforcement.
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Dynamic Synchronous Phasor Measurement Algorithm Based on Compressed Sensing
( Huanan Yu ),( Yongxin Li ),( Yao Du ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.1
The synchronous phasor measurement algorithm is the core content of the phasor measurement unit. This manuscript proposes a dynamic synchronous phasor measurement algorithm based on compressed sensing theory. First, a dynamic signal model based on the Taylor series was established. The dynamic power signal was preprocessed using a least mean square error adaptive filter to eliminate interference from noise and harmonic components. A Chirplet overcomplete dictionary was then designed to realize a sparse representation. A reduction of the signal dimension was next achieved using a Gaussian observation matrix. Finally, the improved orthogonal matching pursuit algorithm was used to realize the sparse decomposition of the signal to be detected, the amplitude and phase of the original power signal were estimated according to the best matching atomic parameters, and the total vector error index was used for an error evaluation. Chroma 61511 was used for the output of various signals, the simulation results of which show that the proposed algorithm cannot only effectively filter out interference signals, it also achieves a better dynamic response performance and stability compared with a traditional DFT algorithm and the improved DFT synchronous phasor measurement algorithm, and the phasor measurement accuracy of the signal is greatly improved. In practical applications, the hardware costs of the system can be further reduced.
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